3rld:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF THE Y7I MUTANT OF HUMAN CARBONIC ANHYDRASE II | ZINC METALLOENZYME, HISTIDINE LIGANDS, Y7I MUTATION, LYASE
2aw1:A (PRO46) to (TRP97) CARBONIC ANHYDRASE INHIBITORS: VALDECOXIB BINDS TO A DIFFERENT ACTIVE SITE REGION OF THE HUMAN ISOFORM II AS COMPARED TO THE STRUCTURALLY RELATED CYCLOOXYGENASE II "SELECTIVE" INHIBITOR CELECOXIB | CARBONIC ANHYDRASE, PROTEIN-INHIBITOR COMPLEX, LYASE
3efi:A (PRO46) to (TRP97) CARBONIC ANHYDRASE ACTIVATORS: KINETIC AND X-RAY CRYSTALLOGRAPHIC STUDY FOR THE INTERACTION OF D- AND L- TRYPTOPHAN WITH THE MAMMALIAN ISOFORMS I-XIV | CARBONIC ANHYDRASE, ACTIVATORS, CRYSTAL STRUCTURE, AMINOACIDS, OXO-ACID, ACETYLATION, CYTOPLASM, DISEASE MUTATION, LYASE, METAL-BINDING, POLYMORPHISM, ZINC
3eft:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN CARBONIC ANHYDRASE II AND A SPIN-LABELED SULFONAMIDE INCORPORATING TEMPO MOIETY | CARBONIC ANHYDRASE, INHIBITORS, CRYSTAL STRUCTURE, RADICALS, OXO-ACID, LYASE
2ax2:A (LEU47) to (TRP97) PRODUCTION AND X-RAY CRYSTALLOGRAPHIC ANALYSIS OF FULLY DEUTERATED HUMAN CARBONIC ANHYDRASE II | PERDEURATED HUMAN CARBONIC ANHYDRASE II PROTON TRANSFER, LYASE
4wl4:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH THE 6-HYDROXY-CHROMENE-2-THIONE INHIBITOR | LYASE
1am6:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II INHIBITOR: ACETOHYDROXAMATE | HYDROLASE, CO2 HYDRATION
3ryj:B (PRO46) to (TRP97) CARBONIC ANHYDRASE COMPLEXED WITH 4-SULFAMOYL-N-(2,2,2- TRIFLUOROETHYL)BENZAMIDE | ALPHA BETA, LYASE
3ryv:B (PRO46) to (TRP97) CARBONIC ANHYDRASE COMPLEXED WITH N-ETHYL-4-SULFAMOYLBENZAMIDE | ALPHA BETA, LYASE
3ryx:B (PRO46) to (TRP97) FLUOROALKYL AND ALKYL CHAINS HAVE SIMILAR HYDROPHOBICITIES IN BINDING TO THE HYDROPHOBIC WALL OF CARBONIC ANHYDRASE | ALPHA BETA, LYASE
3ryz:A (LEU47) to (TRP97) FLUOROALKYL AND ALKYL CHAINS HAVE SIMILAR HYDROPHOBICITIES IN BINDING TO THE HYDROPHOBIC WALL OF CARBONIC ANHYDRASE | ALPHA BETA, LYASE
3rz0:B (PRO46) to (TRP97) FLUOROALKYL AND ALKYL CHAINS HAVE SIMILAR HYDROPHOBICITIES IN BINDING TO THE HYDROPHOBIC WALL OF CARBONIC ANHYDRASE | ALPHA BETA, LYASE
3rz1:B (LEU47) to (TRP97) FLUOROALKYL AND ALKYL CHAINS HAVE SIMILAR HYDROPHOBICITIES IN BINDING TO THE HYDROPHOBIC WALL OF CARBONIC ANHYDRASE | ALPHA BETA, LYASE
3rz5:A (PRO46) to (TRP97) FLUOROALKYL AND ALKYL CHAINS HAVE SIMILAR HYDROPHOBICITIES IN BINDING TO THE HYDROPHOBIC WALL OF CARBONIC ANHYDRASE | ALPHA BETA, LYASE
3rz7:A (PRO46) to (TRP97) FLUOROALKYL AND ALKYL CHAINS HAVE SIMILAR HYDROPHOBICITIES IN BINDING TO THE HYDROPHOBIC WALL OF CARBONIC ANHYDRASE | ALPHA BETA, LYASE
3rz8:A (LEU47) to (TRP97) FLUOROALKYL AND ALKYL CHAINS HAVE SIMILAR HYDROPHOBICITIES IN BINDING TO THE HYDROPHOBIC WALL OF CARBONIC ANHYDRASE | ALPHA BETA, LYASE
2osf:A (PRO46) to (TRP97) INHIBITION OF CARBONIC ANHYDRASE II BY THIOXOLONE: A MECHANISTIC AND STRUCTURAL STUDY | CARBONIC ANHYDRASE II, THIOXOLONE, THERAPEUTIC CA INHIBITORS, ACETYLATION, CYTOPLASM, DISEASE MUTATION, LYASE, METAL-BINDING, POLYMORPHISM, ZINC
4hba:A (PRO46) to (TRP97) STRUCTURAL AND CATALYTIC CHARACTERIZATION OF A THERMAL AND ACID STABLE VARIANT OF HUMAN CARBONIC ANHYDRASE II CONTAINING AN ENGINEERED DISULFIDE BOND | HUMAN CARBONIC ANHYDRASE II, THERMAL STABILITY, LYASE
4ww6:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH 2,3,5,6- TETRAFLUORO-4-(PROPYLTHIO)BENZENESULFONAMIDE | DRUG DESIGN, LYASE, BENZENESULFONAMIDE, METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
4ww8:A (PRO45) to (TRP94) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME XII WITH 4- PROPYLTHIOBENZENESULFONAMIDE | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE, METAL-BINDING, LYASE-LYASE INHIBITOR COMPLE, LYASE
4ww8:B (PRO45) to (TRP94) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME XII WITH 4- PROPYLTHIOBENZENESULFONAMIDE | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE, METAL-BINDING, LYASE-LYASE INHIBITOR COMPLE, LYASE
4ww8:C (PRO45) to (TRP94) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME XII WITH 4- PROPYLTHIOBENZENESULFONAMIDE | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE, METAL-BINDING, LYASE-LYASE INHIBITOR COMPLE, LYASE
4hew:A (PRO46) to (TRP97) ACTIVITY ENHANCERS OF H64A VARIANT OF HUMAN CARBONIC ANHYDRASE II POSSESS MULTIPLE BINDING SITES WITHIN AND AROUND THE ENZYME STRUCTURE | HYDRATION/DEHYDRATION, HIS64ALA, LYASE
4hey:A (PRO46) to (TRP97) ACTIVITY ENHANCERS OF H64A VARIANT OF HUMAN CARBONIC ANHYDRASE II POSSESS MULTIPLE BINDING SITES WITHIN AND AROUND THE ENZYME STRUCTURE | HYDRATION/DEHYDRATION, HIS64ALA, LYASE
4hez:A (PRO46) to (TRP97) ACTIVITY ENHANCERS OF H64A VARIANT OF HUMAN CARBONIC ANHYDRASE II POSSESS MULTIPLE BINDING SITES WITHIN AND AROUND THE ENZYME STRUCTURE | HYDRATION/DEHYDRATION, HIS64ALA, LYASE
4hf3:A (PRO46) to (TRP97) ACTIVITY ENHANCERS OF H64A VARIANT OF HUMAN CARBONIC ANHYDRASE II POSSESS MULTIPLE BINDING SITES WITHIN AND AROUND THE ENZYME STRUCTURE | HYDRATION/DEHYDRATION, HIS64ALA, LYASE
1bcd:A (PRO46) to (TRP97) X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A COMPLEX BETWEEN HUMAN CARBONIC ANHYDRASE II AND A NEW TOPICAL INHIBITOR, TRIFLUOROMETHANE SULPHONAMIDE | LYASE(OXO-ACID)
1bn1:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II INHIBITOR | CO2 HYDRATION, ZINC ENZYME, LYASE
4x5s:A (HIS48) to (ALA92) THE CRYSTAL STRUCTURE OF AN ALPHA CARBONIC ANHYDRASE FROM THE EXTREMOPHILIC BACTERIUM SULFURIHYDROGENIBIUM AZORENSE. | ALPHA BACTERIAL CARBONIC ANHYDRASE, ENZYME-INHIBITOR COMPLEX, LYASE
4x5s:B (HIS48) to (ALA92) THE CRYSTAL STRUCTURE OF AN ALPHA CARBONIC ANHYDRASE FROM THE EXTREMOPHILIC BACTERIUM SULFURIHYDROGENIBIUM AZORENSE. | ALPHA BACTERIAL CARBONIC ANHYDRASE, ENZYME-INHIBITOR COMPLEX, LYASE
1bn4:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II INHIBITOR | CO2 HYDRATION, ZINC ENZYME, LYASE
1bnm:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II INHIBITOR | CO2 HYDRATION, ZINC ENZYME, LYASE
3s72:B (LEU47) to (TRP97) THE ORIGIN OF THE HYDROPHOBIC EFFECT IN THE MOLECULAR RECOGNITION OF ARYLSULFONAMIDES BY CARBONIC ANHYDRASE | ALPHA BETA, LYASE
3s73:B (PRO46) to (TRP97) THE ORIGIN OF THE HYDROPHOBIC EFFECT IN THE MOLECULAR RECOGNITION OF ARYLSULFONAMIDES BY CARBONIC ANHYDRASE | ALPHA BETA, LYASE
3s74:B (LEU47) to (TRP97) THE ORIGIN OF THE HYDROPHOBIC EFFECT IN THE MOLECULAR RECOGNITION OF ARYLSULFONAMIDES BY CARBONIC ANHYDRASE | ALPHA BETA, LYASE
3s75:B (LEU47) to (TRP97) THE ORIGIN OF THE HYDROPHOBIC EFFECT IN THE MOLECULAR RECOGNITION OF ARYLSULFONAMIDES BY CARBONIC ANHYDRASE | ALPHA BETA, LYASE
3s76:A (LEU47) to (TRP97) THE ORIGIN OF THE HYDROPHOBIC EFFECT IN THE MOLECULAR RECOGNITION OF ARYLSULFONAMIDES BY CARBONIC ANHYDRASE | ALPHA BETA, LYASE
3f7b:A (ARG46) to (TRP97) CRYSTAL STRUCTURE OF SOLUBLE DOMAIN OF CA4 IN COMPLEX WITH SMALL MOLECULE. | STRUCTURE-BASED DRUG DESIGN. SMALL MOLECULE COMPLEX. CO-CRYSTAL., CELL MEMBRANE, DISEASE MUTATION, GLYCOPROTEIN, GPI-ANCHOR, LIPOPROTEIN, LYASE, MEMBRANE, METAL-BINDING, RETINITIS PIGMENTOSA, SENSORY TRANSDUCTION, VISION, ZINC
3f8e:A (PRO46) to (TRP97) COUMARINS ARE A NOVEL CLASS OF SUICIDE CARBONIC ANHYDRASE INHIBITORS | CARBONIC ANHYDRASE, INHIBITORS, DISEASE MUTATION, LYASE, METAL- BINDING
3s8x:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH 4-{[(4- METHYL-6-OXO-1,6-DIHYDRO-2-PYRIMIDINYL) SULFANYL]ACETYL}BENZENESULFONAMIDE | DRUG DESIGN, CARBONIC ANHYDRASE, SULFONAMIDE, METAL-BINDING, LYASE- LYASE INHIBITOR COMPLEX
3s97:A (LEU80) to (GLY131) PTPRZ CNTN1 COMPLEX | CARBONIC ANHDYRASE LIKE IMMUNOGLOBULIN, CELL ADHESION COMPLEX, CELL ADHESION
3s97:B (LEU80) to (GLY131) PTPRZ CNTN1 COMPLEX | CARBONIC ANHDYRASE LIKE IMMUNOGLOBULIN, CELL ADHESION COMPLEX, CELL ADHESION
1bv3:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH UREA | CARBONATE HYDRO-LYASE
3s9t:A (LEU47) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH 2- CHLORO-5-{[(4,6-DIMETHYL-2-PYRIMIDINYL) SULFANYL]ACETYL}BENZENESULFONAMIDE | DRUG DESIGN, SULFONAMIDE, METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
3sap:A (LEU47) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH 4-{[(5- BUTYL-2-PYRIMIDINYL)SULFANYL]ACETYL}BENZENESULFONAMIDE | DRUG DESIGN, SULFONAMIDE, METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
3sax:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH 2- CHLORO-5-{[(5-ETHYL-2-PYRIMIDINYL)SULFANYL]ACETYL}BENZENESULFONAMIDE | DRUG DESIGN, SULFONAMIDE, METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
4ht0:A (LEU47) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH THE INHIBITOR. | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE, METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX, CARBON-OXYGEN LYASE ACTIVITY
4ht2:A (PRO45) to (TRP94) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME XII WITH THE INHIBITOR. | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE,METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX, CATALYTIC ACTIVITY, CARBON-OXYGEN LYASE ACTIVITY, CARBONATE DEHYDRATASE ACTIVITY, MEMBRANE
4ht2:B (PRO45) to (TRP94) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME XII WITH THE INHIBITOR. | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE,METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX, CATALYTIC ACTIVITY, CARBON-OXYGEN LYASE ACTIVITY, CARBONATE DEHYDRATASE ACTIVITY, MEMBRANE
4ht2:C (PRO45) to (TRP94) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME XII WITH THE INHIBITOR. | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE,METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX, CATALYTIC ACTIVITY, CARBON-OXYGEN LYASE ACTIVITY, CARBONATE DEHYDRATASE ACTIVITY, MEMBRANE
4ht2:D (PRO45) to (TRP94) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME XII WITH THE INHIBITOR. | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE,METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX, CATALYTIC ACTIVITY, CARBON-OXYGEN LYASE ACTIVITY, CARBONATE DEHYDRATASE ACTIVITY, MEMBRANE
3sbh:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH 4-{[(4, 6-DIMETHYL-2-PYRIMIDINYL)SULFANYL]ACETYL}BENZENESULFONAMIDE | DRUG DESIGN, SULFONAMIDE, METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
3sbi:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH 4-[(2- PYRIMIDINYLSULFANYL)ACETYL]BENZENESULFONAMIDE | DRUG DESIGN, SULFONAMIDE, METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
4hu1:B (LEU49) to (GLY100) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME XIII WITH THE INHIBITOR. | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE,METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX, CARBONATE DEHYDRATASE ACTIVITY, CARBON-OXYGEN LYASE ACTIVITY
4xe1:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH 6-SULFAMOYL-SACCHARIN | CYTOPLASM, LYASE, INHIBITOR
4xfw:A (ASP67) to (ALA113) CRYSTAL STRUCTURE OF THE MONOCLINIC FORM OF ALPHA-CARBONIC ANHYDRASE FROM THE HUMAN PATHOGEN HELICOBACTER PYLORI | HELICOBACTER PYLORI, CARBONIC ANHYDRASE, METALLO PROTEINS, LYASE
2pou:A (LEU47) to (TRP97) THE CRYSTAL STRUCTURE OF THE HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH 4,5-DICHLORO-BENZENE-1,3-DISULFONAMIDE | CARBONIC ANHYDRASE II, PROTEIN-INHIBITOR COMPLEXES, LYASE
2pov:A (LEU47) to (TRP97) THE CRYSTAL STRUCTURE OF THE HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH 4-AMINO-6-CHLORO-BENZENE-1,3-DISULFONAMIDE | CARBONIC ANHYDRASE II, PROTEIN-INHIBITOR COMPLEXES, LYASE
2pow:A (PRO46) to (TRP97) THE CRYSTAL STRUCTURE OF THE HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH 4-AMINO-6-TRIFLUOROMETHYL-BENZENE-1,3- DISULFONAMIDE | CARBONIC ANHYDRASE II, PROTEIN-INHIBITOR COMPLEXES, LYASE
1ca3:A (PRO46) to (TRP97) UNEXPECTED PH-DEPENDENT CONFORMATION OF HIS-64, THE PROTON SHUTTLE OF CARBONIC ANHYDRASE II. | LYASE(OXO-ACID)
1cah:A (PRO46) to (TRP97) STRUCTURE OF COBALT CARBONIC ANHYDRASE COMPLEXED WITH BICARBONATE | LYASE(OXO-ACID)
1cai:A (PRO46) to (TRP97) STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II | LYASE(OXO-ACID)
1caj:A (PRO46) to (TRP97) STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II | LYASE(OXO-ACID)
1cak:A (PRO46) to (TRP97) STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II | LYASE(OXO-ACID)
1cam:A (PRO46) to (TRP97) STRUCTURAL ANALYSIS OF THE ZINC HYDROXIDE-THR 199-GLU 106 HYDROGEN BONDING NETWORK IN HUMAN CARBONIC ANHYDRASE II | LYASE(OXO-ACID)
1cao:A (PRO46) to (TRP97) CRYSTALLOGRAPHIC STUDIES OF THE BINDING OF PROTONATED AND UNPROTONATED INHIBITORS TO CARBONIC ANHYDRASE USING HYDROGEN SULPHIDE AND NITRATE ANIONS | LYASE(OXO-ACID)
1can:A (PRO46) to (TRP97) CRYSTALLOGRAPHIC STUDIES OF THE BINDING OF PROTONATED AND UNPROTONATED INHIBITORS TO CARBONIC ANHYDRASE USING HYDROGEN SULPHIDE AND NITRATE ANIONS | LYASE(OXO-ACID)
1caz:A (PRO46) to (TRP97) WILD-TYPE AND E106Q MUTANT CARBONIC ANHYDRASE COMPLEXED WITH ACETATE | LYASE(OXO-ACID)
1cct:A (PRO46) to (TRP97) STRUCTURE-ASSISTED REDESIGN OF A PROTEIN-ZINC BINDING SITE WITH FEMTOMOLAR AFFINITY | LYASE (OXO-ACID)
1okm:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II COMPLEX WITH THE 1OKM INHIBITOR 4- SULFONAMIDE-[1-(4-AMINOBUTANE)]BENZAMIDE | LYASE (OXO-ACID), INHIBITOR
1cil:A (PRO46) to (TRP97) THE POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC ANHYDRASE II UPON BINDING THREE STRUCTURALLY RELATED INHIBITORS | LYASE(OXO-ACID)
1cim:A (PRO46) to (TRP97) THE POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC ANHYDRASE II UPON BINDING THREE STRUCTURALLY RELATED INHIBITORS | LYASE(OXO-ACID)
1cin:A (PRO46) to (TRP97) THE POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC ANHYDRASE II UPON BINDING THREE STRUCTURALLY RELATED INHIBITORS | LYASE(OXO-ACID)
1oq5:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II IN COMPLEX WITH NANOMOLAR INHIBITOR | 10-STRANDED, TWISTED BETA-SHEET, METAL BINDING PROTEIN
4i86:A (ASN4) to (ALA45) CRYSTAL STRUCTURE OF PILZ DOMAIN OF CESA FROM CELLULOSE SYNTHESIZING BACTERIUM | BETA-BARREL FOLD, C-DI-GMP BINDING, TRANSFERASE
1cng:A (PRO46) to (TRP97) X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE | LYASE (OXO-ACID)
1cnh:A (PRO46) to (TRP97) X-RAY CRYSTALLOGRAPHIC STUDIES OF ENGINEERED HYDROGEN BOND NETWORKS IN A PROTEIN-ZINC BINDING SITE | LYASE (OXO-ACID)
1cnw:A (PRO46) to (TRP97) SECONDARY INTERACTIONS SIGNIFICANTLY REMOVED FROM THE SULFONAMIDE BINDING POCKET OF CARBONIC ANHYDRASE II INFLUENCE BINDING CONSTANTS | LYASE (OXO-ACID)
1cny:A (PRO46) to (TRP97) SECONDARY INTERACTIONS SIGNIFICANTLY REMOVED FROM THE SULFONAMIDE BINDING POCKET OF CARBONIC ANHYDRASE II INFLUENCE BINDING CONSTANTS | LYASE (OXO-ACID)
2q1q:A (PRO46) to (TRP97) CARBONIC ANHYDRASE INHIBITORS. INTERACTION OF THE ANTIEPILEPTIC DRUG SULTHIAME WITH TWELVE MAMMALIAN ISOFORMS: KINETIC AND X-RAY CRYSTALLOGRAPHIC STUDIES | ANTIEPILEPTIC, CARBONIC ANHYDRASE, INHIBITORS, CRYSTAL STRUCTURE, LYASE
1cra:A (PRO46) to (TRP97) THE COMPLEX BETWEEN HUMAN CARBONIC ANHYDRASE II AND THE AROMATIC INHIBITOR 1,2,4-TRIAZOLE | LYASE(OXO-ACID)
1crm:A (ILE47) to (GLY98) STRUCTURE AND FUNCTION OF CARBONIC ANHYDRASES | LYASE (OXO-ACID)
4idr:X (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II PROTON TRANSFER DOUBLE MUTANT | GOLOBULAR PROTEIN, LYASE
1cvb:A (PRO46) to (TRP97) STRUCTURAL AND FUNCTIONAL IMPORTANCE OF A CONSERVED HYDROGEN BOND NETWORK IN HUMAN CARBONIC ANHYDRASE II | LYASE(OXO-ACID)
1cvc:A (PRO46) to (TRP97) REDESIGNING THE ZINC BINDING SITE OF HUMAN CARBONIC ANHYDRASE II: STRUCTURE OF A HIS2ASP-ZN2+ METAL COORDINATION POLYHEDRON | HYDROLASE
1cvd:A (PRO46) to (TRP97) STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE | LYASE(OXO-ACID)
1cve:A (PRO46) to (TRP97) STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE | LYASE(OXO-ACID)
3fw3:B (ARG46) to (TRP97) CRYSTAL STRUCTURE OF SOLUBLE DOMAIN OF CA4 IN COMPLEX WITH DORZOLAMIDE | STRUCTURE-BASED DRUG DESIGN. SMALL MOLECULE COMPLEX. CO-CRYSTAL, CELL MEMBRANE, DISEASE MUTATION, GLYCOPROTEIN, GPI-ANCHOR, LIPOPROTEIN, LYASE, MEMBRANE, METAL-BINDING, POLYMORPHISM, RETINITIS PIGMENTOSA, SENSORY TRANSDUCTION, VISION, ZINC
2ca2:A (PRO46) to (TRP97) CRYSTALLOGRAPHIC STUDIES OF INHIBITOR BINDING SITES IN HUMAN CARBONIC ANHYDRASE II. A PENTACOORDINATED BINDING OF THE SCN-ION TO THE ZINC AT HIGH P*H | LYASE(OXO-ACID)
2cbd:A (PRO46) to (TRP97) STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES | LYASE(OXO-ACID)
2cba:A (PRO46) to (TRP97) STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES | LYASE(OXO-ACID)
2cbb:A (PRO46) to (TRP97) STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES | LYASE(OXO-ACID)
2cbc:A (PRO46) to (TRP97) STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES | LYASE(OXO-ACID)
2cbe:A (PRO46) to (TRP97) STRUCTURE OF NATIVE AND APO CARBONIC ANHYDRASE II AND SOME OF ITS ANION-LIGAND COMPLEXES | LYASE(OXO-ACID)
1dcb:A (PRO46) to (TRP97) STRUCTURE OF AN ENGINEERED METAL BINDING SITE IN HUMAN CARBONIC ANHYDRASE II REVEALS THE ARCHITECTURE OF A REGULATORY CYSTEINE SWITCH | LYASE(OXO-ACID)
1dmx:A (LEU47) to (GLY98) MURINE MITOCHONDRIAL CARBONIC ANYHDRASE V AT 2.45 ANGSTROMS RESOLUTION | PROTON TRANSFER, LYASE (OXO-ACID)
1dmy:A (LEU47) to (GLY98) COMPLEX BETWEEN MURINE MITOCHONDRIAL CARBONIC ANYHDRASE V AND THE TRANSITION STATE ANALOGUE ACETAZOLAMIDE | PROTON TRANSFER, LYASE (OXO-ACID)
1dmy:B (PRO46) to (TRP97) COMPLEX BETWEEN MURINE MITOCHONDRIAL CARBONIC ANYHDRASE V AND THE TRANSITION STATE ANALOGUE ACETAZOLAMIDE | PROTON TRANSFER, LYASE (OXO-ACID)
2qo8:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF THE COMPLEX OF HCAII WITH AN INDANE-SULFONAMIDE INHIBITOR | CARBONIC ANHYDRASE II, LYASE
2qoa:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF THE COMPLEX OF HCAII WITH AN INDANE-SULFONAMIDE INHIBITOR | CARBONIC ANHYDRASE II, LYASE
2qp6:A (LEU47) to (TRP97) THE CRYSTAL STRUCTURE OF THE COMPLEX OF HCAII WITH A BIOREDUCTIVE ANTITUMOR DERIVATIVE | CARBONIC ANHYDRASE II, LYASE
4ito:A (PRO46) to (TRP97) HUMAN CA II INHIBITION BY NOVEL SULFONAMIDE | ALPHA BETA FOLD, REVERSIBLE HYDRATION OF CARBON DIOXIDE TO BICARBONATE AND PROTON, LYASE-LYASE INHIBITOR COMPLEX
4itp:A (PRO46) to (TRP97) STRUCTURE OF HUMAN CARBONIC ANHYDRASE II BOUND TO A BENZENE SULFONAMIDE | ALPHA BETA FOLD, REVERSIBLE HYDRATION OF CARBON DIOXIDE TO BICARBONATE AND PROTON, LYASE-LYASE INHIBITOR COMPLEX
3t5u:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF THE HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH N-HYDROXY BENZENESULFONAMIDE | PROTEIN-INHIBITOR COMPLEX, LYASE-LYASE INHIBITOR COMPLEX
3t5z:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF THE HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH N-METHOXY-BENZENESULFONAMIDE | PROTEIN-INHIBITOR COMPLEX, LYASE-LYASE INHIBITOR COMPLEX
4iwz:A (PRO46) to (TRP97) STRUCTURE OF HCAII IN COMPLEX WITH AN ACETAZOLAMIDE DERIVATIVE | ALPHA BETA FOLD, REVERSIBLE HYDRATION OF CARBON DI OXIDE TO BICARBONATE AND PROTON, LYASE-LYASE INHIBITOR COMPLEX
3t82:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH ACETYLATED CARBOHYDRATE SULFAMATES | ALPHA CARBONIC ANHYDRASE, LYASE-LYASE INHIBITOR COMPLEX
3t83:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH ACETYLATED CARBOHYDRATE SULFAMATES | ALPHA CARBONIC ANHYDRASE, LYASE-LYASE INHIBITOR COMPLEX
3t85:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH ACETYLATED CARBOHYDRATE SULFAMATES | ALPHA CARBONIC ANHYDRASE, LYASE-LYASE INHIBITOR COMPLEX
3tmj:A (PRO46) to (TRP97) JOINT X-RAY/NEUTRON STRUCTURE OF HUMAN CARBONIC ANHYDRASE II AT PH 7.8 | H/D EXCHANGED, JOINT NEUTRON/X-RAY REFINEMENT, LYASE
1eou:A (LEU47) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH AN ANTICONVULSANT SUGAR SULFAMATE | HYDROLASE, CO2 HYDRATION, PROTEIN-INHIBITOR COMPLEX, LYASE
3tvn:X (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II PROTON TRANSFER MUTANT | GLOBULAR PROTEIN, LYASE
3tvo:X (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II PROTON TRANSFER DOUBLE MUTANT | GLOBULAR PROTEIN, LYASE
4ygn:A (PRO46) to (TRP97) NAI--INTERACTIONS BETWEEN HOFMEISTER ANIONS AND THE BINDING POCKET OF A PROTEIN | LYASE, HOFMEISTER ANIONS, HCAII
4ygj:A (PRO46) to (TRP97) NABR--INTERACTIONS BETWEEN HOFMEISTER ANIONS AND THE BINDING POCKET OF A PROTEIN | LYASE, HOFMEISTER ANIONS, HCAII
4ygk:A (LEU47) to (TRP97) NASCN--INTERACTIONS BETWEEN HOFMEISTER ANIONS AND THE BINDING POCKET OF A PROTEIN | LYASE, HOFMEISTER ANIONS, HCAII
4ygl:A (PRO46) to (TRP97) NACLO4--INTERACTIONS BETWEEN HOFMEISTER ANIONS AND THE BINDING POCKET OF A PROTEIN | LYASE, HOFMEISTER ANIONS, HCAII
4yha:B (ASP67) to (ALA113) CRYSTAL STRUCTURE OF THE COMPLEX OF HELICOBACTER PYLORI ALPHA-CARBONIC ANHYDRASE WITH METHAZOLAMIDE | ZINC METALLOENZYME, METHAZOLAMIDE, LYASE
4yha:D (ASP67) to (ALA113) CRYSTAL STRUCTURE OF THE COMPLEX OF HELICOBACTER PYLORI ALPHA-CARBONIC ANHYDRASE WITH METHAZOLAMIDE | ZINC METALLOENZYME, METHAZOLAMIDE, LYASE
1f2w:A (PRO46) to (TRP97) THE MECHANISM OF CYANAMIDE HYDRATION CATALYZED BY CARBONIC ANHYDRASE II REVEALED BY CRYOGENIC X-RAY DIFFRACTION | PROTEIN-INHIBITOR COMPLEX, LYASE
4jsz:A (PRO46) to (TRP97) BENZENESULFONAMIDE BOUND TO HCAII H94C | LYASE-LYASE INHIBITOR COMPLEX
3u3a:X (PRO46) to (TRP97) STRUCTURE OF HUMAN CARBONIC ANHYDRASE II V143I | LYASE, ZINC METALLOENZYME, V143I, ESTERASE, SITE DIRECTED MUTAGENESIS, CO2 BINDING POCKET
3u45:X (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II V143A | LYASE, ZINC METALLOENZYME, V143A, ESTERASE, SITE DIRECTED MUTAGENESIS, HYDROPHOBIC POCKET
3u47:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II V143L | LYASE, ZINC METALLOENZYME, V143L, ESTERASE, SITE DIRECTED MUTAGENESIS
4k0t:A (PRO46) to (TRP97) STRUCTURE OF HCAIX MIMIC (HCAII WITH 5 MUTATIONS IN ACTIVE SITE) IN COMPLEX WITH CHLORZOLAMIDE | ALPHA BETA FOLD, LYASE
4k0s:A (PRO46) to (TRP97) STRUCTURE OF HCAIX MIMIC (HCAII WITH 5 MUTATIONS IN ACTIVE SITE) IN COMPLEX WITH ACETAZOLAMIDE | ALPHA BETA FOLD, LYASE
4k0z:A (PRO46) to (TRP97) STRUCTURE OF HCAIX MIMIC (HCAII WITH 5 MUTATIONS IN ACTIVE SITE) IN COMPLEX WITH METHAZOLAMIDE | ALPHA BETA FOLD, LYASE
4k13:A (PRO46) to (TRP97) STRUCTURE OF HCAIX MIMIC (HCAII WITH 5 MUTATIONS IN ACTIVE SITE) IN COMPLEX WITH DORZOLAMIDE | ALPHA BETA FOLD, LYASE
1flj:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF S-GLUTATHIOLATED CARBONIC ANHYDRASE III | CARBONIC ANHYDRASE III, GLUTATHIONE, S-GLUTATHIOLATED, S- GLUTATHIONYLATED, LYASE
2eu2:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH NOVEL INHIBITORS | CARBONIC ANHYDRASE II PROTON TRANSFER INHIBITOR, LYASE
2eu3:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH NOVEL INHIBITORS | CARBONIC ANHYDRASE II PROTON TRANSFER INHIBITOR, LYASE
3hkn:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH (2,3,4,6-TETRA-O-ACETYL- BETA-D-GALACTOPYRANOSYL) -(1-4)-1,2,3,6-TETRA-O-ACETYL-1-THIO-BETA-D- GLUCOPYRANOSYLSULFONAMIDE | CARBONIC ANHYDRASE DRUG DESIGN, DISEASE MUTATION, LYASE, METAL- BINDING
3hkq:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH 1-S-D- GALACTOPYRANOSYLSULFONAMIDE | CARBONIC ANHYDRASE DRUG DESIGN, DISEASE MUTATION, LYASE, METAL- BINDING
3hkt:A (LEU47) to (TRP97) HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH ALPHA-D- GLUCOPYRANOSYL-(1->4)-1-THIO-BETA-D- GLUCOPYRANOSYLSULFONAMIDE | CARBONIC ANHYDRASE DRUG DESIGN, ACETYLATION, CYTOPLASM, DISEASE MUTATION, LYASE, METAL-BINDING, POLYMORPHISM, ZINC
3hku:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH TOPIRAMATE | CARBONIC ANHYDRASE DRUG DESIGN, ACETYLATION, CYTOPLASM, DISEASE MUTATION, LYASE, METAL-BINDING, POLYMORPHISM, ZINC
1ray:A (PRO46) to (TRP97) THE STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH BROMIDE AND AZIDE | LYASE(OXO-ACID)
1raz:A (PRO46) to (TRP97) THE STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH BROMIDE AND AZIDE | LYASE(OXO-ACID)
3hlj:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH 3- METHYLTHIOBENZIMIDAZO[1,2-C][1,2,3]THIADIAZOL-7-SULFONAMIDE | DRUG DESIGN, CARBONIC ANHYDRASE, SULFONAMIDE, THIADIAZOLE, LYASE, DISEASE MUTATION, METAL-BINDING
1fr7:A (PRO46) to (MET97) X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT | CARBONIC ANHYDRASE, METAL BINDING, METAL SPECIFICITY, ZINC, LYASE
1fr7:B (PRO46) to (MET97) X-RAY CRYSTAL STRUCTURE OF ZINC-BOUND F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT | CARBONIC ANHYDRASE, METAL BINDING, METAL SPECIFICITY, ZINC, LYASE
2f14:A (PRO46) to (TRP97) TNE CRYSTAL STRUCTURE OF THE HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A FLUORESCENT INHIBITOR | CARBONIC ANHYDRASE II, LYASE
4yvy:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH HYDROXYLAMINE-O-SULFONAMIDE, A MOLECULE INCORPORATING TWO ZINC- BINDING GROUPS. | PROTEIN-INHIBITOR COMPLEX, LYASE
1rj5:A (VAL47) to (GLY98) CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF MURINE CARBONIC ANHYDRASE XIV | BETA-SHEET, ALPHA-HELIX, ZINC ENZYME, LYASE
1rj5:B (VAL47) to (GLY98) CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF MURINE CARBONIC ANHYDRASE XIV | BETA-SHEET, ALPHA-HELIX, ZINC ENZYME, LYASE
1rj6:A (VAL47) to (TRP97) CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF MURINE CARBONIC ANHYDRASE XIV IN COMPLEX WITH ACETAZOLAMIDE | BETA-SHEET, ALPHA-HELIX, ZINC ENZYME, LYASE
1rj6:B (VAL47) to (TRP97) CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF MURINE CARBONIC ANHYDRASE XIV IN COMPLEX WITH ACETAZOLAMIDE | BETA-SHEET, ALPHA-HELIX, ZINC ENZYME, LYASE
4ywp:A (PRO46) to (TRP97) SUCROSE BINDING SITE IN GENETICALLY ENGINEERED CARBONIC ANHYDRASE IX | ALPHA-CARBONIC ANHYDRASE, CA IX MIMIC, SUCROSE, LYASE
4yx4:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH AN INHIBITOR WITH A BENZENESULFONAMIDE GROUP (1). | PROTEIN-LIGAND-COMPLEX, LYASE
4yxo:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH AN INHIBITOR WITH A BENZENESULFONAMIDE GROUP (3). | LYASE
4kap:A (PRO46) to (TRP97) THE BINDING OF BENZOARYLSULFONAMIDE LIGANDS TO HUMAN CARBONIC ANHYDRASE IS INSENSITIVE TO FORMAL FLUORINATION OF THE LIGAND | ALPHA BETA, LYASE
4yxi:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH AN INHIBITOR WITH A BENZENESULFONAMIDE GROUP (2). | PROTEIN-INHIBITOR COMPLEX, LYASE
4yxu:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH AN INHIBITOR WITH A BENZENESULFONAMIDE GROUP (4). | LYASE
4yyt:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH AN INHIBITOR WITH A BENZENESULFONAMIDE GROUP (5). | LYASE
1g0e:A (PRO46) to (TRP97) SITE-SPECIFIC MUTANT (HIS64 REPLACED WITH ALA) OF HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH 4-METHYLIMIDAZOLE | TWISTED BETA SHEET, CHEMICAL RESCUE, 4-METHYLIMIDAZOLE, ZINC METALLOENZYME,PROTEIN LIGAND COMPLEX, LYASE
4z1e:A (PRO46) to (TRP97) CARBONIC ANHYDRASE INHIBITORS: DESIGN AND SYNTHESIS OF NEW HETEROARYL- N-CARBONYLBENZENESULFONAMIDES TARGETING DRUGGABLE HUMAN CARBONIC ANHYDRASE ISOFORMS (HCA VII, HCA IX, AND HCA XIV) | LYASE, CARBONATE DEHYDRATASE II, CARBONIC ANHYDRASE C, CARBONIC ANHYDRASE II, CA-II, CARBONATE DEHYDRATASE II- INHIBITOR COMPLEX
4z1k:A (PRO46) to (TRP97) CARBONIC ANHYDRASE INHIBITORS: DESIGN AND SYNTHESIS OF NEW HETEROARYL- N-CARBONYLBENZENESULFONAMIDES TARGETING DRUGGABLE HUMAN CARBONIC ANHYDRASE ISOFORMS (HCA VII, HCA IX, AND HCA XIV) | LYASE, CARBONATE DEHYDRATASE II, CARBONIC ANHYDRASE C, CARBONIC ANHYDRASE II, CA-II, CARBONATE DEHYDRATASE II- INHIBITOR COMPLEX
4z1n:A (PRO46) to (TRP97) CARBONIC ANHYDRASE INHIBITORS: DESIGN AND SYNTHESIS OF NEW HETEROARYL- N-CARBONYLBENZENESULFONAMIDES TARGETING DRUGGABLE HUMAN CARBONIC ANHYDRASE ISOFORMS (HCA VII, HCA IX, AND HCA XIV) | LYASE, CARBONATE DEHYDRATASE II, CARBONIC ANHYDRASE C, CARBONIC ANHYDRASE II, CA-II, CARBONATE DEHYDRATASE II- INHIBITOR COMPLEX
1g3z:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II (F131V) | CARBONIC ANHYDRASE II, F131V, LYASE
1g45:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4- (AMINOSULFONYL)-N-[(2-FLUOROPHENYL)METHYL]-BENZAMIDE | CARBONIC ANHYDRASE II, F131V, 4-(AMINOSULFONYL)-N-[(2- FLUOROPHENYL)METHYL]-BENZAMIDE, LYASE
1g4o:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4- (AMINOSULFONYL)-N-PHENYLMETHYLBENZAMIDE | CARBONIC ANHYDRASE II, F131V, 4-(AMINOSULFONYL)-N- PHENYLMETHYLBENZAMIDE, LYASE
1g53:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N- [(2,6-DIFLUOROPHENYL)METHYL]-BENZAMIDE | CARBONIC ANHYDRASE II, 4-(AMINOSULFONYL)-N-[(2,6- DIFLUOROPHENYL)METHYL]-BENZAMIDE, LYASE
1g54:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N- [(2,3,4,5,6-PENTAFLUOROPHENYL)METHYL]-BENZAMIDE | CARBONIC ANHYDRASE II, 4-(AMINOSULFONYL)-N-[(2,3,4,5,6- PENTAFLUOROPHENYL)METHYL]-BENZAMIDE, LYASE
1g6v:A (PRO46) to (TRP97) COMPLEX OF THE CAMELID HEAVY-CHAIN ANTIBODY FRAGMENT CAB- CA05 WITH BOVINE CARBONIC ANHYDRASE | ANTIBODY, ANTIGEN, COMPLEX, IMMUNOGLOBULIN, LYASE/IMMUNE SYSTEM COMPLEX
1rzb:A (PRO46) to (TRP97) X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES | LYASE(OXO-ACID)
1rzd:A (PRO46) to (TRP97) X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES | LYASE(OXO-ACID)
1rze:A (PRO46) to (TRP97) X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES | LYASE(OXO-ACID)
2fmg:A (PRO46) to (TRP97) CARBONIC ANHYDRASE ACTIVATORS. ACTIVATION OF ISOFORMS I, II, IV, VA, VII AND XIV WITH L- AND D- PHENYLALANINE AND CRYSTALLOGRAPHIC ANALYSIS OF THEIR ADDUCTS WITH ISOZYME II: STEROSPECIFIC RECOGNITION WITHIN THE ACTIVE SITE OF AN ENZYME AND ITS CONSEQUENCES FOR THE DRUG DESIGN, STRUCTURE WITH L-PHENYLALANINE | CARBONIC ANHYDRASE II, ACTIVATORS, LYASE
2fmz:A (PRO46) to (TRP97) CARBONIC ANHYDRASE ACTIVATORS. ACTIVATION OF ISOFORMS I, II, IV, VA, VII AND XIV WITH L- AND D- PHENYLALANINE, STRUCTURE WITH D-PHENYLALANINE. | CARBONIC ANHYDRASE, ACTIVATORS, CRYSTAL STRUCTURE, LYASE
2fnk:A (LEU47) to (TRP97) ACTIVATION OF HUMAN CARBONIC ANHYDRASE II BY EXOGENOUS PROTON DONORS | CARBONIC ANHYDRASE, PROTON TRANSFER, EXOGENOUS PROTON DONOR, LYASE
2fnm:A (PRO46) to (TRP97) ACTIVATION OF HUMAN CARBONIC ANHDYRASE II BY EXOGENOUS PROTON DONORS | CARBONIC ANHYDRASE, PROTON TRANSFER, EXOGENOUS PROTON DONOR, LYASE
2fnn:A (PRO46) to (TRP97) ACTIVATION OF HUMAN CARBONIC ANHYDRASE II BY EXOGENOUS PROTON DONORS | CARBONIC ANHYDRASE, PROTON TRANSFER, EXOGENOUS PROTON DONOR, LYASE
3hs4:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH ACETAZOLAMIDE | CARBONIC ANHYDRASE 2, CARBONIC ANHYDRASE II, LYASE, CA II, CA 2, ACETAZOLAMIDE, 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, DISEASE MUTATION, METAL-BINDING
2foq:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH TWO-PRONG INHIBITORS | LYASE, INHIBITOR
2fos:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH TWO-PRONG INHIBITORS | LYASE, ZINC, INHIBITOR, COPPER
2fou:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH TWO-PRONG INHIBITORS | LYASE, INHIBITOR
2fov:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH TWO-PRONG INHIBITORS | LYASE, ZINC, INHIBITOR, COPPER
3uyn:A (PRO46) to (TRP97) HCA 3 | PROTON SHUTTLE, HCA III, PROTON TRANSFER, LYASE
3uyq:A (PRO46) to (TRP97) HCA 3 | PROTON SHUTTLE, HCA III, PROTON TRANSFER, LYASE
4zao:A (PRO46) to (TRP97) GENETICALLY ENGINEERED CARBONIC ANHYDRASE IX | CA IX MIMIC, LYASE
3v2j:A (PRO46) to (TRP97) EFFECT OF SUCROSE AND GLYCEROL AS CRYOPROTECTANS, ON THE INHIBITION OF HUMAN CARBONIC ANHYDRASE II | GLYCEROL, SUCROSE, CRYOPROTECTANT, ACETAZOLAMIDE, HCA II, LYASE
3v2m:A (PRO46) to (TRP97) EFFECT OF SUCROSE AND GLYCEROL AS CRYOPROTECTANS, ON THE INHIBITION OF HUMAN CARBONIC ANHYDRASE II | GLYCEROL, SUCROSE, CRYOPROTECTANT, ACETAZOLAMIDE, HCA II, LYASE
4kni:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH 2- CHLORO-4-{[(4,6-DIMETHYLPYRIMIDIN-2-YL) SULFANYL]ACETYL}BENZENESULFONAMIDE | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE, METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
3v3f:A (PRO46) to (TRP97) KINETIC AND STRUCTURAL STUDIES OF THERMOSTABILIZED MUTANTS OF HCA II. | THERMOSTABILE, LYASE
3v3g:B (PRO46) to (TRP97) KINETIC AND STRUCTURAL STUDIES OF THERMOSTABILIZED MUTANTS OF HCA II. | THERMOSTABILE, LYASE
3v3h:B (PRO46) to (TRP97) KINETIC AND STRUCTURAL STUDIES OF THERMOSTABILIZED MUTANTS OF HCA II. | THERMOSTABILE, LYASE
3v3i:B (PRO46) to (TRP97) KINETIC AND STRUCTURAL STUDIES OF THERMOSTABILIZED MUTANTS OF HCA II. | THERMOSTABILE, LYASE
3v3j:A (LEU47) to (TRP97) KINETIC AND STRUCTURAL STUDIES OF THERMOSTABILIZED MUTANTS OF HCA II. | THERMOSTABILE, LYASE
4kp8:A (PRO45) to (TRP94) CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF HUMAN CARBONIC ANHYDRASE ISOZYME XII WITH 3-[(PYRIMIDIN-2-YLSULFANYL)ACETYL]BENZENESULFONAMIDE | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE, METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
4kp8:B (PRO45) to (TRP94) CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF HUMAN CARBONIC ANHYDRASE ISOZYME XII WITH 3-[(PYRIMIDIN-2-YLSULFANYL)ACETYL]BENZENESULFONAMIDE | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE, METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
4kp8:C (PRO45) to (TRP94) CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF HUMAN CARBONIC ANHYDRASE ISOZYME XII WITH 3-[(PYRIMIDIN-2-YLSULFANYL)ACETYL]BENZENESULFONAMIDE | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE, METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
4kp8:D (PRO45) to (TRP94) CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF HUMAN CARBONIC ANHYDRASE ISOZYME XII WITH 3-[(PYRIMIDIN-2-YLSULFANYL)ACETYL]BENZENESULFONAMIDE | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE, METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
3v5g:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH THE 4-SULFAMIDO-BENZENESULFONAMIDE INHIBITOR | LYASE-LYASE INHIBITOR COMPLEX
3v7x:A (PRO1046) to (TRP1097) COMPLEX OF HUMAN CARBONIC ANHYDRASE II WITH N-[2-(3,4- DIMETHOXYPHENYL)ETHYL]-4-SULFAMOYLBENZAMIDE | LYASE-LYASE INHIBITOR COMPLEX
4kuv:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH THE 5-(3-(4-CHLOROPHENYLSULFONYL)UREIDO)PYRIDINE-2-SULFONAMIDE INHIBITOR | LYASE, LYASE-LYASE INHIBITOR COMPLEX
4kuw:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH THE 5-(3-(4-FLUOROPHENYLSULFONYL)UREIDO)PYRIDINE-2-SULFONAMIDE INHIBITOR | LYASE, LYASE-LYASE INHIBITOR COMPLEX
4kv0:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH THE 5-(3-TOSYLUREIDO)PYRIDINE-2-SULFONAMIDE INHIBITOR | LYASE, LYASE-LYASE INHIBITOR COMPLEX
2vva:X (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE IN COMPLEX WITH CO2 | METAL-BINDING, CARBON DIOXIDE, DISEASE MUTATION, SUBSTRATE BINDING, CARBONIC ANHYDRASE, ZINC, LYASE, CYTOPLASM, ACETYLATION, POLYMORPHISM
2vvb:X (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH BICARBONATE | POLYMORPHISM, METAL-BINDING, DISEASE MUTATION, ZINC, LYASE, CYTOPLASM, ACETYLATION, BICARBONATE, SUBSTRATE BINDING, CARBONIC ANHYDRASE
2gd8:A (PRO46) to (TRP97) CRYSTAL STRUCTURE ANALYSIS OF THE HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A 2-SUBSTITUTED ESTRADIOL BIS-SULFAMATE | PROTEIN-INHIBITOR COMPLEXES, LYASE
2geh:A (PRO46) to (TRP97) N-HYDROXYUREA, A VERSATILE ZINC BINDING FUNCTION IN THE DESIGN OF METALLOENZYME INHIBITORS | CARBONIC ANHYDRASE, INHIBITORS, CRYSTAL STRUCTURE, LYASE
3ibi:A (PRO46) to (TRP97) THE CRYSTAL STRUCTURE OF THE HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH AN ALIPHATIC SULFAMATE INHIBITOR | CARBONIC ANHYDRASE II, PROTEIN-INHIBITOR COMPLEX, ALIPHATIC SULFAMATE INHIBITOR, DISEASE MUTATION, METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
3ibu:A (PRO46) to (TRP97) THE CRYSTAL STRUCTURE OF THE HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH AN ALIPHATIC SULFAMATE INHIBITOR | CARBONIC ANHYDRASE II, PROTEIN-INHIBITOR COMPLEX, ALIPHATIC SULFAMATE INHIBITOR, DISEASE MUTATION, METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
4l5u:A (PRO46) to (TRP97) THE STRUCTURAL IMPLICATIONS OF THE SECONDARY CO2 BINDING POCKET IN HUMAN CARBONIC ANHYDRASE II | ALLOSTERIC REGULATION, THERMOSTABILITY, LYASE
4l5v:A (PRO46) to (TRP97) THE STRUCTURAL IMPLICATIONS OF THE SECONDARY CO2 BINDING POCKET IN HUMAN CARBONIC ANHYDRASE II | ALLOSTERIC REGULATION, THERMOSTABILITY, LYASE
1h4n:A (PRO46) to (TRP97) H94N CARBONIC ANHYDRASE II COMPLEXED WITH TRIS | LYASE, OXO-ACID, ACETYLATION
3ieo:A (PRO46) to (TRP97) THE COUMARIN-BINDING SITE IN CARBONIC ANHYDRASE: THE ANTIEPILEPTIC LACOSAMIDE AS AN EXAMPLE | CARBONIC ANHYDRASE, ANTIEPILECTIC, DISEASE MUTATION, LYASE, METAL- BINDING, LYASE-LYASE INHIBITOR COMPLEX
3igp:A (PRO46) to (TRP97) STRUCTURE OF INHIBITOR BINDING TO CARBONIC ANHYDRASE II | CARBONIC ANHYDRASE INHIBITORS, ISOQUINOLINES, LYASE, ACETYLATION, CYTOPLASM, DISEASE MUTATION, METAL-BINDING, POLYMORPHISM, ZINC
1t9n:A (PRO46) to (TRP97) EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+ TRANSFER IN HUMAN CARBONIC ANHYDRASE II | PROTON SHUTTLE, CARBONIC ANHYDRASE, METALLOENZYME, LYASE
1h9q:A (PRO46) to (TRP97) H119Q CARBONIC ANHYDRASE II | LYASE, OXO-ACID, ACETYLATION
1tb0:X (PRO46) to (TRP97) EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+ TRANSFER IN HUMAN CARBONIC ANHYDRASE II | PROTON SHUTTLE CARBONIC ANHYDRASE METALLOENZYME, LYASE
1tbt:X (PRO46) to (TRP97) EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+ TRANSFER IN HUMAN CARBONIC ANHYDRASE II | PROTON SHUTTLE CARBONIC ANHYDRASE METALLOENZYME, LYASE
1te3:X (PRO46) to (TRP97) EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+ TRANSFER IN HUMAN CARBONIC ANHYDRASE II | PROTON SHUTTLE CARBONIC ANHYDRASE METALLOENZYME, LYASE
1teq:X (PRO46) to (TRP97) EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+ TRANSFER IN HUMAN CARBONIC ANHYDRASE II | PROTON SHUTTLE CARBONIC ANHYDRASE METALLOENZYME, LYASE
1teu:X (PRO46) to (TRP97) EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+ TRANSFER IN HUMAN CARBONIC ANHYDRASE II | PROTON SHUTTLE CARBONIC ANHYDRASE METALLOENZYME, LYASE
1tg9:A (PRO46) to (TRP97) EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+ TRANSFER IN HUMAN CARBONIC ANHYDRASE II | PROTON SHUTTLE CARBONIC ANHYDRASE METALLOENZYME, LYASE
1heb:A (PRO46) to (TRP97) STRUCTURAL CONSEQUENCES OF HYDROPHILIC AMINO-ACID SUBSTITUTIONS IN THE HYDROPHOBIC POCKET OF HUMAN CARBONIC ANHYDRASE II | LYASE(OXO-ACID)
1hed:A (PRO46) to (TRP97) STRUCTURAL CONSEQUENCES OF HYDROPHILIC AMINO-ACID SUBSTITUTIONS IN THE HYDROPHOBIC POCKET OF HUMAN CARBONIC ANHYDRASE II | LYASE(OXO-ACID)
4lhi:A (LEU47) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH 5- (PHENYLSULFONYL)THIOPHENE-2-SULFONAMIDE | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE, METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
4zwx:A (PRO46) to (TRP97) ENGINEERED CARBONIC ANHYDRASE IX MIMIC IN COMPLEX WITH GLUCOSYL SULFAMATE INHIBITOR | CARBONIC ANHYDRASE IX MIMIC, GLUCOSYL SULFAMATE, COMPLEX, LYASE-LYASE INHIBITOR COMPLEX
4zwy:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A GLUCOSYL SULFAMATE INHIBITOR | CARBONIC ANHYDRASE II, GLUCOSYL SULFAMATE, INHIBITOR COMPLEX., LYASE- LYASE INHIBITOR COMPLEX
4zwz:A (PRO46) to (TRP97) ENGINEERED CARBONIC ANHYDRASE IX MIMIC IN COMPLEX WITH A GLUCOSYL SULFAMATE INHIBITOR | CARBONIC ANHYDRASE IX MIMIC, GLUCOSYL SULFAMATE, INHIBITOR COMPLEX., LYASE-LYASE INHIBITOR COMPLEX
4zx0:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A GLUCOSYL SULFAMATE INHIBITOR | CARBONIC ANHYDRASE II, GLUCOSYL SULFAMATE, INHIBITOR COMPLEX., LYASE- LYASE INHIBITOR COMPLEX
2wd2:A (PRO46) to (TRP97) A CHIMERIC MICROTUBULE DISRUPTOR WITH EFFICACY ON A TAXANE RESISTANT CELL LINE | DISEASE MUTATION, LYASE, CANCER, HUMAN CARBONIC ANHYDRASE INHIBITORS, METAL-BINDING
2wd3:A (PRO46) to (TRP97) HIGHLY POTENT FIRST EXAMPLES OF DUAL AROMATASE-STEROID SULFATASE INHIBITORS BASED ON A BIPHENYL TEMPLATE | HUMAN CARBONIC ANHYDRASE INHIBITOR, LYASE, CANCER, BIPHENYL, TRIAZOLE, DUAL AROMATASE-STEROID SULFATASE INHIBITOR, SULFAMATE, METAL-BINDING
2hd6:A (LEU47) to (TRP97) CRYSTAL STRUCTURE OF THE HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A HYPOXIA-ACTIVATABLE SULFONAMIDE. | PROTEIN-INHIBITOR COMPLEX, LYASE
2weg:A (PRO46) to (TRP97) THERMODYNAMIC OPTIMISATION OF CARBONIC ANHYDRASE FRAGMENT INHIBITORS | METAL-BINDING, DISEASE MUTATION, LYASE, ZINC, CYTOPLASM, ACETYLATION, POLYMORPHISM
2weh:A (LEU47) to (TRP97) THERMODYNAMIC OPTIMISATION OF CARBONIC ANHYDRASE FRAGMENT INHIBITORS | METAL-BINDING, DISEASE MUTATION, LYASE, ZINC, CYTOPLASM, ACETYLATION, POLYMORPHISM
2wej:A (PRO46) to (TRP97) THERMODYNAMIC OPTIMISATION OF CARBONIC ANHYDRASE FRAGMENT INHIBITORS | METAL-BINDING, DISEASE MUTATION, ZINC, LYASE, CYTOPLASM, ACETYLATION, POLYMORPHISM
2weo:A (PRO46) to (TRP97) THERMODYNAMIC OPTIMISATION OF CARBONIC ANHYDRASE FRAGMENT INHIBITORS | METAL-BINDING, DISEASE MUTATION, ZINC, LYASE, CYTOPLASM, ACETYLATION, POLYMORPHISM
2hfw:A (PRO46) to (TRP97) STRUCTURAL AND KINETIC ANALYSIS OF PROTON SHUTTLE RESIDUES IN THE ACTIVE SITE OF HUMAN CARBONIC ANHYDRASE III | PROTON SHUTTLE, HCA III, PROTON TRANSFER, LYASE
2hkk:A (PRO46) to (TRP97) CARBONIC ANHYDRASE ACTIVATORS: SOLUTION AND X-RAY CRYSTALLOGRAPHY FOR THE INTERACTION OF ANDRENALINE WITH VARIOUS CARBONIC ANHYDRASE ISOFORMS | CARBONIC ANHYDRASE, ACTIVATORS, LYASE
2hl4:A (PRO46) to (TRP97) CRYSTAL STRUCTURE ANALYSIS OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A BENZENESULFONAMIDE DERIVATIVE | PROTEIN-INHIBITOR COMPLEX, LYASE
2hoc:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF THE HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH THE 5-(4-AMINO-3-CHLORO-5-FLUOROPHENYLSULFONAMIDO)-1,3,4-THIADIAZOLE- 2-SULFONAMIDE INHIBITOR | PROTEIN-INHIBITOR COMPLEX, LYASE
4lu3:A (LEU47) to (TRP97) THE CRYSTAL STRUCTURE OF THE HUMAN CARBONIC ANHYDRASE XIV | ZINC BINDING, GLYCOPROTEIN, MEMBRANE, LYASE-LYASE INHIBITOR COMPLEX
1i90:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II COMPLEXED WITH AL-8520 2H-THIENO[3,2- E]-1,2-THIAZINE-6-SULFONAMIDE, 4-AMINO-3,4-DIHYDRO-2-(3- METHOXYPROPYL)-, 1,1-DIOXIDE, (R) | CARBONIC ANHYDRASE II, AL-8520, LYASE
1i9m:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4- (AMINOSULFONYL)-N-[(2,4-DIFLUOROPHENYL)METHYL]-BENZAMIDE | HUMAN CARBONIC ANHYDRASE II, 4-(AMINOSULFONYL)-N-[(2,4- DIFLUOROPHENYL)METHYL]-BENZAMIDE, LYASE
1i9o:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4- (AMINOSULFONYL)-N-[(2,3,4-TRIFLUOROPHENYL)METHYL]-BENZAMIDE | HUMAN CARBONIC ANHYDRASE II, 4-(AMINOSULFONYL)-N-[(2,3,4- TRIFLUOROPHENYL)METHYL]-BENZAMIDE, LYASE
1i9q:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4- (AMINOSULFONYL)-N-[(3,4,5-TRIFLUOROPHENYL)METHYL]-BENZAMIDE | HUMAN CARBONIC ANHYDRASE II, 4-(AMINOSULFONYL)-N-[(3,4,5- TRIFLUOROPHENYL)METHYL]-BENZAMIDE, LYASE
1if5:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II COMPLEXED WITH 2,6- DIFLUOROBENZENESULFONAMIDE | CARBONIC ANHYDRASE II, 2,6-DIFLUOROBENZENESULFONAMIDE, LYASE
1if7:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II COMPLEXED WITH (R)-N-(3-INDOL-1-YL-2- METHYL-PROPYL)-4-SULFAMOYL-BENZAMIDE | CARBONIC ANHYDRASE II, (R)-N-(3-INDOL-1-YL-2-METHYL-PROPYL)- 4-SULFAMOYL-BENZAMIDE, LYASE
1if9:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II COMPLEXED WITH N-[2-(1H-INDOL-5-YL)- BUTYL]-4-SULFAMOYL-BENZAMIDE | CARBONIC ANHYDRASE II, N-[2-(1H-INDOL-5-YL)-BUTYL]-4- SULFAMOYL-BENZAMIDE, LYASE
1uga:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II[HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY PHE (A65F) | LYASE (OXO-ACID), ACETYLATION, ZINC, POLYMORPHISM, DISEASE MUTATION
1ugd:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II[HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY SER (A65S) | LYASE (OXO-ACID), ACETYLATION, ZINC, POLYMORPHISM, DISEASE MUTATION
5a6h:A (PRO46) to (TRP97) SYNTHESIS, CARBONIC ANHYDRASE INHIBITION AND PROTEIN X-RAY STRUCTURE OF THE UNUSUAL NATURAL PRODUCT PRIMARY SULFONAMIDE PSAMMAPLIN C | LYASE, CARBONIC ANHYDRASE INHIBITOR, NATURAL PRODUCT
4m2r:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH BRINZOLAMIDE | LYASE-LYASE INHIBITOR COMPLEX
4m2w:A (PRO46) to (TRP97) GENETICALLY ENGINEERED CARBONIC ANHYDRASE IX IN COMPLEX WITH DORZOLAMIDE | CARBONIC ANHYDRASE IX MIMIC, LYASE-LYASE INHIBITOR COMPLEX
4mdg:A (PRO46) to (TRP97) CLOSO CARBORANE CARBONIC ANHYDRASE INHIBITOR | CARBONIC ANHYDRASE INHIBITOR COMPLEX, LYASE-LYASE INHIBITOR COMPLEX
4mdm:A (PRO46) to (TRP97) NIDO-CARBORANE CARBONIC ANHYDRASE INHIBITOR | CARBONIC ANHYDRASE INHIBITOR COMPLEX, LYASE-LYASE INHIBITOR COMPLEX
2ili:A (PRO46) to (TRP97) REFINE ATOMIC STRUCTURE OF HUMAN CARBONIC ANHYDRASE II | PROTON TRANSFER, PROTON SHUTTLE, CARBONIC ANHYDRASE, LYASE
2iou:B (THR55) to (PRO101) MAJOR TROPISM DETERMINANT P1 (MTD-P1) VARIANT COMPLEXED WITH BORDETELLA BROCHISEPTICA VIRULENCE FACTOR PERTACTIN EXTRACELLULAR DOMAIN (PRN-E). | MTD; PRN; PERTACTIN, VIRAL PROTEIN-MEMBRANE PROTEIN COMPLEX
2x7s:A (PRO46) to (TRP97) STRUCTURES OF HUMAN CARBONIC ANHYDRASE II INHIBITOR COMPLEXES REVEAL A SECOND BINDING SITE FOR STEROIDAL AND NON-STEROIDAL INHIBITORS. | LYASE, CANCER, SULFAMATE
2x7u:A (PRO46) to (TRP97) STRUCTURES OF HUMAN CARBONIC ANHYDRASE II INHIBITOR COMPLEXES REVEAL A SECOND BINDING SITE FOR STEROIDAL AND NON-STEROIDAL INHIBITORS. | LYASE, CANCER, SULFAMATE
1jcz:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN CARBONIC ANHYDRASE XII | EXTRACELLULAR DOMAIN, HUMAN CARBONIC ANHYDRASE XII, BITOPIC MEMBRANE PROTEIN, TYPE I MEMBRANE PROTEIN, LYASE
1jcz:B (PRO46) to (TRP97) CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN CARBONIC ANHYDRASE XII | EXTRACELLULAR DOMAIN, HUMAN CARBONIC ANHYDRASE XII, BITOPIC MEMBRANE PROTEIN, TYPE I MEMBRANE PROTEIN, LYASE
5amd:A (PRO46) to (TRP97) THREE DIMENSIONAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH 2-((2-PHENYLETHYL)SULFAMOYL)-4-SULFAMOYLBENZOIC ACID | LYASE, CA II, CA 2
5amg:A (PRO46) to (TRP97) THREE DIMENSIONAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH 2-(PENTYLSULFAMOYL)-4-SULFAMOYLBENZOIC ACID | LYASE, CA II, CA 2
5aml:A (PRO46) to (TRP97) THREE DIMENSIONAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH 2-(BUT-2-YN-1-YLSULFAMOYL)-4-SULFAMOYLBENZOIC ACID | LYASE, CA II, CA 2
4mlt:A (PRO46) to (TRP97) STRUCTURE OF A MONODENTATE 3-HYDROXY-4H-PYRAN-4-THIONE LIGAND BOUND TO HCAII | LYASE
4mlx:A (LEU47) to (TRP97) STRUCTURE OF A BIDENTATE 3-HYDROXY-4H-PYRAN-4-THIONE LIGAND BOUND TO HCAII | LYASE
4mo8:A (PRO46) to (TRP97) THE CRYSTAL STRUCTURE OF THE HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH N-[2-(2-METHYL-5-NITRO-1H-IMIDAZOL-1-YL)ETHYL]SULFAMIDE | SULFAMIDE, ZINC BINDING, LYASE-LYASE INHIBITOR COMPLEX
4mty:A (PRO46) to (TRP97) STRUCTURE AT 2.1 A REOLUTION OF A HELICAL AROMATIC FOLDAMER-PROTEIN COMPLEX. | MIXED ALPHA BETA, LYASE-LYASE INHIBITOR COMPLEX
4n0x:B (PRO46) to (TRP97) ROOM TEMPERATURE CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH THIOPHENE-2-SULFONAMIDE | MIXED ALPHA/BETA, CARBONATE DEHYDRATASE, CYTOSOLIC, LYASE
4n16:A (PRO46) to (TRP97) STRUCTURE OF CHOLATE BOUND TO HUMAN CARBONIC ANHYDRASE II | CHOLATE, CHOLIC ACID, LYASE
5bnl:A (PRO46) to (TRP97) DECIPHERING THE MECHANISM OF CARBONIC ANHYDRASE INHIBITION WITH COUMARINS AND THIOCOUMARINS | HCA2, COUMARIN, INHIBITORS, LYASE
5bru:A (PRO46) to (TRP97) CATALYTIC IMPROVEMENT OF AN ARTIFICIAL METALLOENZYME BY COMPUTATIONAL DESIGN | ARTIFICIAL METALLOENZYME, OXIDOREDUCTASE
5brv:A (PRO46) to (TRP97) CATALYTIC IMPROVEMENT OF AN ARTIFICIAL METALLOENZYME BY COMPUTATIONAL DESIGN | ARTIFICIAL METALLOENZYME, OXIDOREDUCTASE
5brw:A (PRO46) to (TRP97) CATALYTIC IMPROVEMENT OF AN ARTIFICIAL METALLOENZYME BY COMPUTATIONAL DESIGN | ARTIFICIAL METALLOENZYME, LYASE, IMINE REDUCTASE, TRANSFER HYDROGENASE, OXIDOREDUCTASE
5byi:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II WITH AN AZOBENZENE INHIBITOR (1D) | CARBONIC ANHYDRASE, SULFONAMIDE, PHOTOPHARMACOLOGY, INHIBITOR, LYASE
3znc:A (ILE48) to (TRP97) MURINE CARBONIC ANHYDRASE IV COMPLEXED WITH BRINZOLAMIDE | LYASE, ZINC, MURINE, MEMBRANE, INHIBITOR
1keq:A (LEU47) to (TRP97) CRYSTAL STRUCTURE OF F65A/Y131C CARBONIC ANHYDRASE V, COVALENTLY MODIFIED WITH 4-CHLOROMETHYLIMIDAZOLE | PROTON TRANSFER, ENGINEERED RESIDUE, LYASE
1keq:B (LEU47) to (TRP97) CRYSTAL STRUCTURE OF F65A/Y131C CARBONIC ANHYDRASE V, COVALENTLY MODIFIED WITH 4-CHLOROMETHYLIMIDAZOLE | PROTON TRANSFER, ENGINEERED RESIDUE, LYASE
3zp9:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II AS A SCAFFOLD FOR AN ARTIFICIAL TRANSFER HYDROGENASE | ARTIFICIAL METALLOENZYME, LYASE, INHIBITOR, IRIDIUM PENTAMETHYLCYCLOPENTADIENYL, PIANO STOOL COMPLEX
1kwq:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH INHIBITOR 2000-07 | LYASE, ZINC, INHIBITOR
1kwr:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH INHIBITOR 0134-36 | LYASE, ZINC, INHIBITOR
5c8i:A (PRO46) to (TRP97) JOINT X-RAY/NEUTRON STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH METHAZOLAMIDE | METHAZOLAMIDE, ACETAZOLAMIDE, WATER DISPLACEMENT, LYASE
2nng:A (PRO46) to (TRP97) STRUCTURE OF INHIBITOR BINDING TO CARBONIC ANHYDRASE II | ZINC METALLOENZYME, SULFONAMIDE, LYASE
2nno:A (PRO46) to (TRP97) STRUCTURE OF INHIBITOR BINDING TO CARBONIC ANHYDRASE II | ZINC METALLOENZYME, SULFONAMIDE, LYASE
2nns:A (PRO46) to (TRP97) STRUCTURE OF INHIBITOR BINDING TO CARBONIC ANHYDRASE II | ZINC METALLOENZYME, SULFONAMIDE, LYASE
1xev:B (LEU47) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN A NEW CRYSTAL FORM | HUMAN CARBONIC ANHYDRASE II, TRANSLATIONAL SYMMETRY, X-RAY STRUCTURE, LYASE
5ca2:A (PRO46) to (TRP97) CONFORMATIONAL MOBILITY OF HIS-64 IN THE THR-200 (RIGHT ARROW) SER MUTANT OF HUMAN CARBONIC ANHYDRASE II | LYASE(OXO-ACID)
5cac:A (PRO46) to (TRP97) REFINED STRUCTURE OF HUMAN CARBONIC ANHYDRASE II AT 2.0 ANGSTROMS RESOLUTION | LYASE(OXO-ACID)
3jxh:C (GLU101) to (TRP152) CA-LIKE DOMAIN OF HUMAN PTPRG | CA-LIKE DOMAIN, ALTERNATIVE SPLICING, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PHOSPHOPROTEIN, POLYMORPHISM, PROTEIN PHOSPHATASE, TRANSMEMBRANE, CELL ADHESION
2nxr:A (PRO46) to (TRP97) STRUCTURAL EFFECTS OF HYDROPHOBIC MUTATIONS ON THE ACTIVE SITE OF HUMAN CARBONIC ANHYDRASE II | PROTON TRANSFER, HISTIDINE 64, CARBONIC ANHYDRASE, LYASE
2nxs:A (PRO46) to (TRP97) STRUCTURAL AND KINETIC EFFECTS OF HYDROPHOBIC MUTATIONS IN THE ACTIVE SITE OF HUMAN CARBONIC ANHYDRASE II | PROTON TRANSFER, HISTIDINE 64, CARBONIC ANHYDRASE, LYASE
2nxt:A (PRO46) to (TRP97) STRUCTURAL AND KINETIC EFFECTS OF HYDROPHOBIC MUTATIONS IN THE ACTIVE SITE OF HUMAN CARBONIC ANHYDRASE II | PROTON TRANSFER, HISTIDINE 64, CARBONIC ANHYDRASE, LYASE
5cjf:A (LEU47) to (TRP97) THE CRYSTAL STRUCTURE OF THE HUMAN CARBONIC ANHYDRASE XIV IN COMPLEX WITH A 1,1'-BIPHENYL-4-SULFONAMIDE INHIBITOR. | 1, 1'-BIPHENYL-4-SULFONAMIDE, LYASE, GLYCOPROTEIN, ZINC-BINDING, COMPLEX, INHIBITOR
5cjl:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A HETEROARYL-PYRAZOLE CARBOXYLIC ACID DERIVATIVE. | HUMAN CARBONIC ANHYDRASE II, INHIBITOR COMPLEX, CARBOXYLIC ACID., LYASE-LYASE INHIBITOR COMPLEX
1lg5:A (PRO46) to (TRP97) CRYSTAL STRUCTURE ANALYSIS OF THE HCA II MUTANT T199P IN COMPLEX WITH BETA-MERCAPTOETHANOL | HCAII MUTANT T199P-BME COMPLEX, LYASE
1lg6:A (PRO46) to (TRP97) CRYSTAL STRUCTURE ANALYSIS OF HCA II MUTANT T199P IN COMPLEX WITH THIOCYANATE | HCAII MUTANT T199P-SCN COMPLEX, LYASE
3k2f:A (PRO46) to (TRP97) NITRIC OXIDE-DONATING CARBONIC ANHYDRASE INHIBITORS FOR THE TREATMENT OF OPEN-ANGLE GLAUCOMA | CARBONIC ANHYDRASE, NO-DONATING AGENT, ANTIGLAUCOMA DRUG, SULFONAMIDE, XRAY CRYSTALLOGRAPHY, LYASE, ACETYLATION, CYTOPLASM, DISEASE MUTATION, METAL-BINDING, POLYMORPHISM, ZINC
5clu:A (PRO46) to (TRP97) THE CRYSTAL STRUCTURE OF THE COMPLEX OF HCAII WITH A SACCHARINE DERIVATIVE | CARBONIC ANHYDRASE II, LYASE
1lug:A (PRO46) to (TRP97) FULL MATRIX ERROR ANALYSIS OF CARBONIC ANHYDRASE | ERROR ANALYSIS, FULL-MATRIX, METALLOENZYME, LYASE
1lzv:A (PRO46) to (TRP97) SITE-SPECIFIC MUTANT (TYR7 REPLACED WITH HIS) OF HUMAN CARBONIC ANHYDRASE II | TWISTED BETA SHEET, ZINC METALLOENZYME, LYASE
1xpz:A (PRO46) to (TRP97) STRUCTURE OF HUMAN CARBONIC ANHYDRASE II WITH 4-[4-O- SULFAMOYLBENZYL)(4-CYANOPHENYL)AMINO]-4H-[1,2,4]-TRIAZOLE | CARBONIC ANHYDRASE, DUAL AROMATASE-STEROID SULFATASE INHIBITOR (DASI), ANTI-CANCER DRUG DELIVERY, LYASE
1xq0:A (PRO46) to (TRP97) STRUCTURE OF HUMAN CARBONIC ANHYDRASE II WITH 4-[(3-BROMO-4- O-SULFAMOYLBENZYL)(4-CYANOPHENYL)AMINO]-4H-[1,2,4]-TRIAZOLE | CARBONIC ANHYDRASE, DUAL AROMATASE-STEROID SULFATASE INHIBITOR (DASI), ANTI-CANCER DRUG DELIVERY, LYASE
2znc:A (PHE47) to (TRP97) MURINE CARBONIC ANHYDRASE IV | LYASE, ZINC, MURINE, MEMBRANE
3kig:A (PRO46) to (TRP97) MUTANT CARBONIC ANHYDRASE II IN COMPLEX WITH AN AZIDE AND AN ALKYNE | 10 STRANDED, TWISTED BETA-SHEETS, LYASE, DISEASE MUTATION, METAL- BINDING
3kkx:A (PRO46) to (TRP97) NEUTRON STRUCTURE OF HUMAN CARBONIC ANHYDRASE II | PROTON TRANSFER, NEUTRON, HCA II, CYTOPLASM, LYASE, METAL- BINDING, ZINC
3kne:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II H64C MUTANT IN COMPLEX WITH AN IN SITU FORMED TRIAZOLE | 10 STRANDED; TWISTED BETA-SHEETS; LYASE; ACETYLATION, METAL-BINDING, CLICK-CHEMISTRY, AZIDE, ALKYNE, LYASE
3koi:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF COBALT (III) HUMAN CARBONIC ANHYDRASE II AT PH 6.0 | CARBONIC ANHYDRASE, METALLOENZYME, COBALT SUBSTITUTION, CRYSTAL PH, LYASE
3kok:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF COBALT (II) HUMAN CARBONIC ANHYDRASE II AT PH 8.5 | CARBONIC ANHYDRASE, METALLOENZYME, COBALT SUBSTITUTION, CRYSTAL PH, LYASE
3kon:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF COBALT (II) HUMAN CARBONIC ANHYDRASE II AT PH 11.0 | CARBONIC ANHYDRASE, METALLOENZYME, COBALT SUBSTITUTION, CRYSTAL PH, LYASE
1moo:A (PRO46) to (TRP97) SITE SPECIFIC MUTANT (H64A) OF HUMAN CARBONIC ANHYDRASE II AT HIGH RESOLUTION | HIGH-RESOLUTION, 4-METHYLIMIDAZOLE, TWISTED BETA SHEET, ZINC METALLOENZYME, LYASE
1mpx:D (LEU565) to (PRO635) ALPHA-AMINO ACID ESTER HYDROLASE LABELED WITH SELENOMETHIONINE | ALPHA/BETA HYDROLASE, JELLYROLL, SELENOMETHIONINE, HYDROLASE
1ydb:A (PRO46) to (TRP97) STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II | HYDRO-LYASE
3ks3:A (PRO46) to (TRP97) HIGH RESOLUTION STRUCTURE OF HUMAN CARBONIC ANHYDRASE II AT 0.9 A | HIGH RESOLUTION, CARBONIC ANHYDRASE, SHORT HYDROGEN BOND
3kwa:A (PRO46) to (TRP97) POLYAMINES INHIBIT CARBONIC ANHYDRASES | POLYAMINES, CARBONIC ANHYDRASE II, INHIBITION, LYASE
1yo2:A (PRO46) to (TRP97) PROTON TRANSFER FROM HIS200 IN HUMAN CARBONIC ANHYDRASE II | PROTON TRANSFER HUMAN CARBONIC ANHYDRASE, LYASE
5dog:A (LEU47) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH 2- (BENZYLAMINO)-3,5,6-TRIFLUORO-4-[(2-PHENYLETHYL)THIO]BENZENE- SULFONAMIDE | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE, METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX, LYASE
5doh:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH 2-[(1S)- 2,3-DIHYDRO-1H-INDEN-1-YLAMINO]-3,5,6-TRIFLUORO-4-[(2-HYDROXYETHYL) THIO]BENZENESULFONAMIDE | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE, METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX, LYASE
5doh:B (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH 2-[(1S)- 2,3-DIHYDRO-1H-INDEN-1-YLAMINO]-3,5,6-TRIFLUORO-4-[(2-HYDROXYETHYL) THIO]BENZENESULFONAMIDE | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE, METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX, LYASE
4pq7:A (PRO46) to (TRP97) THE CRYSTAL STRUCTURE OF THE HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A SULFAMIDE INHIBITOR | SULFAMIDE, ZINC BINDING, LYASE-LYASE INHIBITOR COMPLEX
1z93:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE III:STRUCTURAL AND KINETIC STUDY OF CATALYSIS AND PROTON TRANSFER. | CARBONIC ANHYDRASE III, PROTON WIRE, CHEMICAL RESCUE, LYASE
1z97:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE III: STRUCTURAL AND KINETIC STUDY OF CATALYSIS AND PROTON TRANSFER. | CARBONIC ANHYDRASE, PROTON WIRE, CHEMICAL RESCUE, LYASE
1z9y:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II IN COMPLEX WITH FUROSEMIDE AS SULFONAMIDE INHIBITOR | 10 STRANDED, TWISTED BETA-SHEETS, LYASE, LYASE-LYASE INHIBITOR COMPLEX
5drs:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASEISOZYME II WITH 3-[(1S)- 2,3-DIHYDRO-1H-INDEN-1-YLAMINO]-2,5,6-TRIFLUORO-4-[(2-HYDROXYETHYL) SULFONYL]BENZENESULFONAMIDE | LYASE, DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE, METAL- BINDING, LYASE-LYASE INHIBITOR COMPLEX
5dsi:A (PRO46) to (TRP97) STRUCTURE OF CO2 BOUND HOLO-FORM OF HUMAN CARBONIC ANHYDRASE II WITH 0 SEC (NO) WARMING | CARBONIC ANHYDRASE II, CO2 RELEASE, INTERMEDIATE STATES, LYASE
5dsk:A (PRO46) to (TRP97) STRUCTURE OF CO2 RELEASED HOLO-FORM OF HUMAN CARBONIC ANHYDRASE II WITH 3 MIN WARMING | CARBONIC ANHYDRASE II, CO2 RELEASE, INTERMEDIATE STATES, LYASE
5dsl:A (PRO46) to (TRP97) STRUCTURE OF CO2 RELEASED HOLO-FORM OF HUMAN CARBONIC ANHYDRASE II WITH 10 MIN WARMING | CARBONIC ANHYDRASE II, CO2 RELEASE, INTERMEDIATE STATES, LYASE
5dsm:A (PRO46) to (TRP97) STRUCTURE OF CO2 RELEASED HOLO-FORM OF HUMAN CARBONIC ANHYDRASE II WITH 25 MIN WARMING | CARBONIC ANHYDRASE II, CO2 RELEASE, INTERMEDIATE STATES, LYASE
5dsn:A (PRO46) to (TRP97) STRUCTURE OF CO2 RELEASED HOLO-FORM OF HUMAN CARBONIC ANHYDRASE II WITH 1 HR WARMING | CARBONIC ANHYDRASE II, CO2 RELEASE, INTERMEDIATE STATES, LYASE
5dso:A (PRO46) to (TRP97) STRUCTURE OF CO2 BOUND APO-FORM OF HUMAN CARBONIC ANHYDRASE II WITH 0 SEC (NO) WARMING | CARBONIC ANHYDRASE II, CO2 RELEASE, INTERMEDIATE STATES, LYASE
5dsq:A (PRO46) to (TRP97) STRUCTURE OF CO2 RELEASED APO-FORM OF HUMAN CARBONIC ANHYDRASE II WITH 3 MIN WARMING | CARBONIC ANHYDRASE II, CO2 RELEASE, INTERMEDIATE STATES, LYASE
5dsr:A (PRO46) to (TRP97) STRUCTURE OF CO2 RELEASED APO-FORM OF HUMAN CARBONIC ANHYDRASE II WITH 10 MIN WARMING | CARBONIC ANHYDRASE II, CO2 RELEASE, INTERMEDIATE STATES, LYASE
1zfk:A (PRO1046) to (TRP1097) CARBONIC ANHYDRASE II IN COMPLEX WITH N-4-SULFONAMIDPHENYL-N'-4- METHYLBENZOSULFONYLUREASE AS SULFONAMIDE INHIBITOR | 10 STRANDED, TWISTED BETA-SHEETS, LYASE
1zfq:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II IN COMPLEX WITH ETHOXZOLAMIDPHENOLE AS SULFONAMIDE INHIBITOR | 10 STRANDED, TWISTED BETA-SHEETS, LYASE
4pxx:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF A HIGHLY THERMAL STABILIZED VARIANT OF HUMAN CARBONIC ANHYDRASE II | LYASE-LYASE INHIBITOR COMPLEX
1zge:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II IN COMPLEX WITH P-SULFONAMIDO-O,O'- DICHLOROANILINE AS SULFONAMIDE INHIBITOR | 10 STRANDED, TWISTED BETA-SHEETS, LYASE
1zgf:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II IN COMPLEX WITH TRICHLOROMETHIAZIDE AS SULFONAMIDE INHIBITOR | 10 STRANDED, TWISTED BETA-SHEETS, LYASE
1zh9:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II IN COMPLEX WITH N-4-METHYL-1- PIPERAZINYL-N'-(P-SULFONAMIDE)PHENYLTHIOUREA AS SULFONAMIDE INHIBITOR | 10 STRANDED, TWISTED BETA-SHEETS, LYASE
4pyy:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH INHIBITOR | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE,METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
4pzh:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH 2,3,5,6- TETRAFLUORO-4[(2-HYDROXYETHYL)SULFONYL]BENZENESULFONAMIDE | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE,METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
5dvx:A (LEU180) to (TRP229) CRYSTAL STRUCTURE OF THE CATALYTIC-DOMAIN OF HUMAN CARBONIC ANHYDRASE IX AT 1.6 ANGSTROM RESOLUTION | CARBONIC ANHYDRASE IX, CATALYTIC DOMAIN, WATER NETWORK, LYASE
5dvx:B (LEU180) to (TRP229) CRYSTAL STRUCTURE OF THE CATALYTIC-DOMAIN OF HUMAN CARBONIC ANHYDRASE IX AT 1.6 ANGSTROM RESOLUTION | CARBONIC ANHYDRASE IX, CATALYTIC DOMAIN, WATER NETWORK, LYASE
4q07:A (LEU47) to (TRP97) CRYSTAL STRUCTURE OF CHIMERIC CARBONIC ANHYDRASE IX WITH INHIBITOR | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE,METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
4q06:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF CHIMERIC CARBONIC ANHYDRASE IX WITH INHIBITOR | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE,METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
1znc:A (PHE47) to (TRP97) HUMAN CARBONIC ANHYDRASE IV | GPI-ANCHOR, MEMBRANE, LYASE, ZINC, SIGNAL
1znc:B (PHE47) to (TRP97) HUMAN CARBONIC ANHYDRASE IV | GPI-ANCHOR, MEMBRANE, LYASE, ZINC, SIGNAL
1zsb:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II MUTANT E117Q, TRANSITION STATE ANALOGUE ACETAZOLAMIDE | LYASE, OXO-ACID, ACETYLATION, ZINC, POLYMORPHISM, LYASE (OXO-ACID)
1zsc:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II MUTANT E117Q, HOLO FORM | LYASE, OXO-ACID, ACETYLATION, ZINC, POLYMORPHISM, LYASE (OXO-ACID)
5e28:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH THE 4-(4-AMINOPHENYL)BENZENESULFONAMIDE INHIBITOR | LYASE
5e2k:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH THE 4-(3-AMINOPHENYL)BENZENESULFONAMIDE INHIBITOR | LYASE
5e2r:A (PRO46) to (TRP97) THE CRYSTAL STRUCTURE OF THE HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A 1,1'-BIPHENYL-4-SULFONAMIDE INHIBITOR | 1'-BIPHENYL-4-SULFONAMIDE, LYASE, COMPLEX, INHIBITOR
5e2s:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH THE 4-(2-ISO-PROPYLPHENYL)BENZENESULFONAMIDE INHIBITOR | LYASE
4q6d:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH 4-[(Z)- AZEPAN-1-YLDIAZENYL]BENZENESULFONAMIDE | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE,METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
4q6e:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH 4-{[3- (3,5-DIMETHYL-1H-PYRAZOL-1-YL)-3-OXOPROPYL]AMINO}BENZENE-1- SULFONAMIDE | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE,METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
5e5r:C (LEU102) to (TRP152) CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN CARBONIC ANHYDRASE-LIKE DOMAIN OF PTPRG AND IMMUNOGLOBULIN DOMAINS 2-3 OF CNTN3 | NEURAL CELL ADHESION MOLECULE, RECEPTOR-TYPE PROTEIN TYROSINE PHOSPHATASE, IMMUNOGLOBULIN DOMAINS, CARBONIC ANHYDRASE-LIKE DOMAIN, HYDROLASE-CELL ADHESION COMPLEX
4q7p:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF 1-HYDROXY-3-METHYLPYRIDINE-2(1H)-THIONE BOUND TO HCAII | LYASE
4q7s:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF 1-HYDROXY-4-METHYLPYRIDINE-2(1H)-THIONE BOUND TO HUMAN CARBONIC ANHYDRASE II | LYASE
4q7v:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF 1-HYDROXY-5-METHYLPYRIDINE-2(1H)-THIONE BOUND TO HUMAN CARBONIC ANHYDRASE II | LYASE
4q7w:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF 1-HYDROXY-6-METHYLPYRIDINE-2(1H)-THIONE BOUND TO HUMAN CARBONIC ANHYDRASE II | LYASE
4q81:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF 1-HYDROXY-4,6-DIMETHYLPYRIDINE-2(1H)-THIONE BOUND TO HUMAN CARBONIC ANHYDRASE II | LYASE
4q83:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF 1-HYDROXY-3-(TRIFLUOROMETHYL)PYRIDINE-2(1H)- THIONE BOUND TO HUMAN CARBONIC ANHYDRASE II | LYASE
4q87:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF 1-HYDROXY-4-(TRIFLUOROMETHYL)PYRIDINE-2(1H)- THIONE BOUND TO HUMAN CARBONIC ANHYDRASE II | LYASE
4q8x:A (LEU47) to (TRP97) CRYSTAL STRUCTURE OF 1-HYDROXY-5-(TRIFLUOROMETHYL)PYRIDINE-2(1H)- THIONE BOUND TO HUMAN CARBONIC ANHYDRASE II | LYASE
4q8y:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF 2-HYDROXYISOQUINOLINE-1(2H)-THIONE BOUND TO HUMAN CARBONIC ANHYDRASE II | LYASE
4q8z:A (LEU47) to (TRP97) CRYSTAL STRUCTURE OF 1-HYDROXY-4-METHYLPYRIDIN-2(1H)-ONE BOUND TO HUMAN CARBONIC ANHYDRASE II | LYASE
4q90:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF 4-METHYLPYRIDINE-2(1H)-THIONE BOUND TO HUMAN CARBONIC ANHYDRASE II | LYASE
4q99:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF 2-MERCAPTO-4-METHYLPHENOL BOUND TO HUMAN CARBONIC ANHYDRASE II | LYASE
4q9y:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF 3-METHYLTHIOPHENOL BOUND TO HUMAN CARBONIC ANHYDRASE II | LYASE
3m14:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II IN COMPLEX WITH NOVEL SULFONAMIDE INHIBITOR | 10 STRANDED TWISTED BETA-SHEETS, LYASE, DISEASE MUTATION, METAL- BINDING, LYASE-LYASE INHIBITOR COMPLEX
3m1j:A (PRO46) to (TRP97) THE CRYSTAL STRUCTURE OF A NAMI A-CARBONIC ANHYDRASE II ADDUCT DISCLOSES THE MODE OF ACTION OF THIS NOVEL ANTICANCER METALLODRUG | RUTHENIUM COMPLEXES, NAMI-A, ANTIMETASTATIC AGENTS, CARBONIC ANHYDRASE, LYASE
3m1k:A (PRO46) to (TRP97) CARBONIC ANHYDRASE IN COMPLEX WITH FRAGMENT | 10 STRANDED TWISTED BETA-SHEETS, LYASE, DISEASE MUTATION, METAL- BINDING
3m1q:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II MUTANT W5C-H64C WITH OPENED DISULFIDE BOND | 10 STRANDED TWISTED BETA-SHEETS, LYASE, DISEASE MUTATION, METAL- BINDING
3m1w:A (PRO46) to (TRP97) CARBONIC ANHYRDASE II MUTANT W5CH64C WITH CLOSED DISULFIDE BOND IN COMPLEX WITH SULFATE | 10 STRANDED TWISTED BETA-SHEETS, LYASE, DISEASE MUTATION, METAL- BINDING
3m2n:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH 4-{2-[N- (6-CHLORO-5-NITROPYRIMIDIN-4-YL)AMINO]ETHYL}BENZENESULFONAMIDE | DRUG DESIGN, CARBONIC ANHYDRASE, SULFONAMIDE, LYASE, METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
3m2y:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II IN COMPLEX WITH NOVEL SULFONAMIDE INHIBITOR | 10 STRANDED TWISTED BETA-SHEETS, LYASE, DISEASE MUTATION, METAL- BINDING, LYASE-LYASE INHIBITOR COMPLEX
4qef:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II V207I - CYANATE INHIBITOR COMPLEX | LYASE, PROTON TRANSFER, LYASE-LYASE INHIBITOR COMPLEX
3m3x:A (LEU47) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH 4-{2-[N- (6-METHOXY-5-NITROPYRIMIDIN-4-YL)AMINO]ETHYL}BENZENESULFONAMIDE | DRUG DESIGN, CARBONIC ANHYDRASE, SULFONAMIDE, METAL-BINDING, LYASE- LYASE INHIBITOR COMPLEX
3m40:A (LEU47) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH 4-[N-(6- CHLORO-5-NITROPYRIMIDIN-4-YL)AMINO]BENZENESULFONAMIDE | DRUG DESIGN, CARBONIC ANHYDRASE, SULFONAMIDE, METAL-BINDING, LYASE- LYASE INHIBITOR COMPLEX
3m5e:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH 4-{[N- (6-CHLORO-5-FORMYL-2-METHYLTHIOPYRIMIDIN-4-YL) AMINO]METHYL}BENZENESULFONAMIDE | DRUG DESIGN, CARBONIC ANHYDRASE, SULFONAMIDE, METAL-BINDING, LYASE- LYASE INHIBITOR COMPLEX
3m5s:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II MUTANT H64C IN COMPLEX WITH CARBONATE | STRANDED TWISTED BETA-SHEETS, LYASE, DISEASE MUTATION, METAL-BINDING
3m5t:A (PRO46) to (TRP97) FRAGMENT TETHERED TO CARBONIC ANHYDRASE II H64C MUTANT | STRANDED TWISTED BETA-SHEETS, LYASE, DISEASE MUTATION, METAL-BINDING
3m96:A (LEU47) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH 5-{[(5- BROMO-1H-BENZIMIDAZOL-2-YL)SULFANYL]ACETYL}-2- CHLOROBENZENESULFONAMIDE | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE, LYASE
3m98:A (LEU47) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH 5-(1H- BENZIMIDAZOL-1-YLACETYL)-2-CHLOROBENZENESULFONAMIDE | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE, LYASE
5eh5:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH LIGAND | HUMAN CARBONIC ANHYDRASE, LIGAND, LYASE
5eh7:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH LIGAND | HUMAN CARBONIC ANHYDRASE, LYASE
5eh8:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH LIGAND | HUMAN CARBONIC ANHYDRASE, LYASE
5ehe:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH 3- (BENZYLAMINO)-2,5,6-TRIFLUORO-4-[(2-HYDROXYETHYL) SULFONYL]BENZENESULFONAMIDE | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE, METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX, LYASE
5ehv:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH LIGAND | HUMAN CARBONIC ANHYDRASE II, TRANSFERASE
2abe:A (PRO46) to (TRP97) CARBONIC ANHYDRASE ACTIVATORS: X-RAY CRYSTAL STRUCTURE OF THE ADDUCT OF HUMAN ISOZYME II WITH L-HISTIDINE AS A PLATFORM FOR THE DESIGN OF STRONGER ACTIVATORS | PROTEIN-ACTIVATOR COMPLEX, LYASE
5ehw:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH LIGAND | HUMAN CARBONIC ANHYDRASE II, TRANSFERASE
4qj0:A (PRO45) to (TRP94) CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF HUMAN CARBONIC ANHYDRASE ISOZYME XII WITH INHIBITOR | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE, METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
4qj0:C (TYR51) to (TRP94) CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF HUMAN CARBONIC ANHYDRASE ISOZYME XII WITH INHIBITOR | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE, METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
5eij:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II IN COMPLEX WITH SULFONAMIDE INHIBITOR | SULFONAMIDE, INHIBITOR, LYASE-LYASE INHIBITOR COMPLEX
4qjm:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH INHIBITOR | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE,METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
4qjw:A (PRO45) to (TRP94) CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF HUMAN CARBONIC ANHYDRASE ISOZYME XII WITH INHIBITOR | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE,METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
4qjw:B (PRO45) to (TRP94) CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF HUMAN CARBONIC ANHYDRASE ISOZYME XII WITH INHIBITOR | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE,METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
4qjw:C (PRO45) to (TRP94) CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF HUMAN CARBONIC ANHYDRASE ISOZYME XII WITH INHIBITOR | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE,METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
4qjw:D (PRO45) to (TRP94) CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF HUMAN CARBONIC ANHYDRASE ISOZYME XII WITH INHIBITOR | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE,METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
4qk1:A (PRO46) to (TRP97) STRUCTURAL AND CATALYTIC EFFECTS OF PROLINE SUBSTITUTION AND SURFACE LOOP DELETION IN THE EXTENDED ACTIVE SITE OF HUMAN CARBONIC ANHYDRASE II - K170P | LYASE
4qk2:A (PRO46) to (TRP97) STRUCTURAL AND CATALYTIC EFFECTS OF PROLINE SUBSTITUTION AND SURFACE LOOP DELETION IN THE EXTENDED ACTIVE SITE OF HUMAN CARBONIC ANHYDRASE II - E234P | LYASE
4qk3:A (PRO46) to (TRP97) STRUCTURAL AND CATALYTIC EFFECTS OF PROLINE SUBSTITUTION AND SURFACE LOOP DELETION IN THE EXTENDED ACTIVE SITE OF HUMAN CARBONIC ANHYDRASE II - [DELTA]230-240 | LYASE
4bcw:A (PRO46) to (TRP97) CARBONIC ANHYDRASE IX MIMIC IN COMPLEX WITH (E)-2-(5-BROMO- 2-HYDROXYPHENYL)ETHENESULFONIC ACID | LYASE, SULFOCOUMARIN
5ekh:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH A TWO-FACED GUEST | LYASE-LYASE INHIBITOR COMPLEX
5ekj:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH A TWO-FACED GUEST | LYASE-LYASE INHIBITOR COMPLEX
5ekm:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH A TWO-FACED GUEST | LYASE-LYASE INHIBITOR COMPLEX
3mhi:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH 4-{[(5- NITRO-6-OXO-1,6-DIHYDRO-4-PYRIMIDINYL)AMINO]METHYL}BENZENESULFONAMIDE | DRUG DESIGN, CARBONIC ANHYDRASE, SULFONAMIDE, LYASE-LYASE INHIBITOR COMPLEX
3mhm:A (LEU47) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH 4-{[N- (6-BENZYLAMINO-5-NITROPYRIMIDIN-4-YL)AMINO]METHYL}BENZENESULFONAMIDE | DRUG DESIGN, CARBONIC ANHYDRASE, SULFONAMIDE, LYASE-LYASE INHIBITOR COMPLEX
3mho:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH 4-[N-(6- CHLORO-5-FORMYL-2-METHYLTHIOPYRIMIDIN-4-YL)AMINO]BENZENESULFONAMIDE | DRUG DESIGN, CARBONIC ANHYDRASE, SULFONAMIDE, LYASE-LYASE INHIBITOR COMPLEX
4bf6:A (PRO46) to (TRP97) THREE DIMENSIONAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH 5-(1-(3-CYANOPHENYL)-1H-1,2,3-TRIAZOL-4-YL) THIOPHENE-2-SULFONAMIDE | LYASE
4qsb:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH 3-{[(4- METHYL-6-OXO-1,6-DIHYDROPYRIMIDIN-2-YL)THIO]ACETYL}BENZENESULFONAMIDE | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE, METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
3mmf:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A 1, 3,5-TRIAZINE-SUBSTITUTED BENZENESULFONAMIDE INHIBITOR | ZINC METALLOENZYME, INHIBITOR, SULFONAMIDE, METAL-BINDING, TRIAZINE, LYASE, LYASE-LYASE INHIBITOR COMPLEX
4qsi:A (LEU47) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH 5-{[(4- TERT-BUTHYL-6-OXO-1,6-DIHYDROPYRIMIDIN-2-YL)THIO]ACETYL}-2- CHLOROBENZENESULFONAMIDE | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE, METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
3mna:A (PRO46) to (TRP97) THE CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A 1,3,5-TRIAZINE-SUBSTITUTED BENZENESULFONAMIDE INHIBITOR | ZINC METALLOENZYME, INHIBITOR, SULFONAMIDE, LYASE, TRIAZINE, LYASE- LYASE INHIBITOR COMPLEX
3mni:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II MUTANT K170D | PROTON TRANSFER, METALLOENZYME, PROTON TRANSPORT
3mnj:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II MUTANT K170E | PROTON TRANSFER, METALLOENZYME, PROTON TRANSPORT
4qtl:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH INHIBITOR | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE, METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
3bl0:A (PRO46) to (TRP97) CARBONIC ANHYDRASE INHIBITORS. INTERACTION OF 2-N,N- DIMETHYLAMINO-1,3,4-THIADIAZOLE-5-METHANESULFONAMIDE WITH TWELVE MAMMALIAN ISOFORMS: KINETIC AND X-RAY CRYSTALLOGRAPHIC STUDIES | CARBONIC ANHYDRASE, INHIBITORS, CRYSTAL STRUCTURE, SULFONAMIDE, ACETYLATION, CYTOPLASM, DISEASE MUTATION, LYASE, METAL-BINDING, POLYMORPHISM, ZINC, LYASE(OXO-ACID)
3mwo:B (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II IN A DOUBLED MONOCLINIC CELL: A RE- DETERMINATION | DOUBLED UNIT CELL, LYASE, PSEUDOSYMMETRY, TRANSLATIONAL NCS
3myq:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH 2- CHLORO-5-[(1H-IMIDAZO[4,5-C]QUINOLIN-2-YLSULFANYL) ACETYL]BENZENESULFONAMIDE | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE, LYASE
3mzc:A (PRO46) to (TRP97) HUMAN CARBONIC AHYDRASE II IN COMPLEX WITH A BENZENESULFONAMIDE INHIBITOR | LYASE, BENZENESULFONAMIDE INHIBITOR, ZINC METALLOENZYME, ZINC COORDINATION, LYASE-LYASE INHIBITOR COMPLEX
3n0n:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A BENZENESULFONAMIDE INHIBITOR | ZINC METALLOENZYME LYASE, BENZENESULFONAMIDE INHIBITOR, ZINC LIGANDS, , LYASE, LYASE-LYASE INHIBITOR COMPLEX
3n2p:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A BENZENESULFONAMIDE INHIBITOR | LYASE, ZINC METALLOENZYME, ZINC LIGANDS, BENZENESULFONAMIDE, INHIBITOR., LYASE-LYASE INHIBITOR COMPLEX
5fdc:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH THE ANTICONVULSANT SULFAMIDE JNJ-26990990 AND ITS S,S-DIOXIDE ANALOG. | SULFAMIDE INHIBITOR, PROTEIN-INHIBITOR COMPLEX, LYASE
4r5a:A (PRO46) to (TRP97) A CARBONIC ANHYDRASE IX MIMIC IN COMPLEX WITH A CARBOHYDRATE-BASED SULFAMATE | CARBONIC ANHYDRASE IX MIMIC, LYASE
4r5b:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A CARBOHYDRATE-BASED SULFAMATE | CYTOSOL, LYASE
3c7p:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH STX237 | PROTEIN-INHIBITOR COMPLEX, DISEASE MUTATION, LYASE, METAL-BINDING
3ca2:A (PRO46) to (TRP97) CRYSTALLOGRAPHIC STUDIES OF INHIBITOR BINDING SITES IN HUMAN CARBONIC ANHYDRASE II. A PENTACOORDINATED BINDING OF THE SCN-ION TO THE ZINC AT HIGH P*H | LYASE(OXO-ACID)
3caj:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF THE HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH ETHOXZOLAMIDE | PROTEIN-INHIBITOR COMPLEX, DISEASE MUTATION, LYASE, METAL-BINDING
5fl4:A (LEU48) to (TRP97) THREE DIMENSIONAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE IX IN COMPLEX WITH 5-(1-NAPHTHALEN-1-YL-1,2,3-TRIAZOL-4-YL) THIOPHENE-2-SULFONAMIDE | LYASE
5fl4:C (LEU48) to (TRP97) THREE DIMENSIONAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE IX IN COMPLEX WITH 5-(1-NAPHTHALEN-1-YL-1,2,3-TRIAZOL-4-YL) THIOPHENE-2-SULFONAMIDE | LYASE
5fl5:A (LEU48) to (TRP97) THREE DIMENSIONAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE IX IN COMPLEX WITH 5-(1-(4-METHOXYPHENYL)-1H-1,2,3-TRIAZOL-4- YL)THIOPHENE-2-SULFONAMIDE | LYASE, CARBONIC ANHYDRASE IX, CARBONIC ANHYDRASE 9, CA IX, CA 9
5fl5:D (LEU48) to (TRP97) THREE DIMENSIONAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE IX IN COMPLEX WITH 5-(1-(4-METHOXYPHENYL)-1H-1,2,3-TRIAZOL-4- YL)THIOPHENE-2-SULFONAMIDE | LYASE, CARBONIC ANHYDRASE IX, CARBONIC ANHYDRASE 9, CA IX, CA 9
5fl6:A (LEU48) to (TRP97) THREE DIMENSIONAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE IX IN COMPLEX WITH 5-(1-(4-METHYLPHENYL)-1H-1,2,3-TRIAZOL-4-YL) THIOPHENE-2-SULFONAMIDE | LYASE, CARBONIC ANHYDRASE IX, CARBONIC ANHYDRASE 9, CA IX, CA 9
5fl6:D (LEU48) to (TRP97) THREE DIMENSIONAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE IX IN COMPLEX WITH 5-(1-(4-METHYLPHENYL)-1H-1,2,3-TRIAZOL-4-YL) THIOPHENE-2-SULFONAMIDE | LYASE, CARBONIC ANHYDRASE IX, CARBONIC ANHYDRASE 9, CA IX, CA 9
4rfc:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH TERT-BUTYL 4-(4- SULFAMOYLPHENOXY)BUTYLCARBAMATE | SULFONAMIDE, CARBONIC ANHYDRASE, ANTIGLAUCOMA, O-(-AMINOALKYL)- BENZENESULFONAMIDES, LYASE
4rfd:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH 4-(4-SULFAMOYL-PHENOXY)- BUTYLAMMONIUM | SULFONAMIDE, CARBONIC ANHYDRASE, ANTIGLAUCOMA, O-(-AMINOALKYL)- BENZENESULFONAMIDESS, LYASE
5flo:A (PRO46) to (TRP97) NATIVE STATE MASS SPECTROMETRY, SURFACE PLASMON RESONANCE AND X-RAY CRYSTALLOGRAPHY CORRELATE STRONGLY AS A FRAGMENT SCREENING COMBINATION | LYASE, CARBONIC ANHYDRASE, METALLOPROTEIN
5flp:A (PRO46) to (TRP97) NATIVE STATE MASS SPECTROMETRY, SURFACE PLASMON RESONANCE AND X-RAY CRYSTALLOGRAPHY CORRELATE STRONGLY AS A FRAGMENT SCREENING COMBINATION | LYASE, CARBONIC ANHYDRASE, METALLOPROTEIN
5flq:A (PRO46) to (TRP97) NATIVE STATE MASS SPECTROMETRY, SURFACE PLASMON RESONANCE AND X-RAY CRYSTALLOGRAPHY CORRELATE STRONGLY AS A FRAGMENT SCREENING COMBINATION | LYASE, FRAGMENTS, CARBONIC ANHYDRASE, METALLOPROTEIN
4rh2:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH 2-(6- HYDROXY-3-OXO-3H-XANTHEN-9-YL)-5-{3-1-(4-SULFAMOYL-PHENYL)-1H-[1,2, 3]TRIAZOL-4-YLMETHYL-THIOUREIDO}-BENZOIC ACID | LYASE
3ni5:A (PRO46) to (TRP97) CARBONIC ANHYDRASE INHIBITOR: C1 FAMILY | CARBONIC ANHYDRASE, INHIBITORS, SULFONAMIDE, LYASE-LYASE INHIBITOR COMPLEX
5fng:A (PRO46) to (TRP97) NATIVE STATE MASS SPECTROMETRY, SURFACE PLASMON RESONANCE AND X-RAY CRYSTALLOGRAPHY CORRELATE STRONGLY AS A FRAGMENT SCREENING COMBINATION | LYASE, FRAGMENTS, CARBONIC ANHYDRASE, METALLOPROTEIN
5fnh:A (PRO46) to (TRP97) NATIVE STATE MASS SPECTROMETRY, SURFACE PLASMON RESONANCE AND X-RAY CRYSTALLOGRAPHY CORRELATE STRONGLY AS A FRAGMENT SCREENING COMBINATION | LYASE, FRAGMENTS, CARBONIC ANHYDRASE, METALLOPROTEIN
5fnj:A (PRO46) to (TRP97) NATIVE STATE MASS SPECTROMETRY, SURFACE PLASMON RESONANCE AND X-RAY CRYSTALLOGRAPHY CORRELATE STRONGLY AS A FRAGMENT SCREENING COMBINATION | LYASE, FRAGMENTS, CARBONIC ANHYDRASE, METALLOPROTEIN
5fnk:A (PRO46) to (TRP97) NATIVE STATE MASS SPECTROMETRY, SURFACE PLASMON RESONANCE AND X-RAY CRYSTALLOGRAPHY CORRELATE STRONGLY AS A FRAGMENT SCREENING COMBINATION | LYASE, FRAGMENTS, CARBONIC ANHYDRASE, METALLOPROTEIN
5fnl:A (PRO46) to (TRP97) NATIVE STATE MASS SPECTROMETRY, SURFACE PLASMON RESONANCE AND X-RAY CRYSTALLOGRAPHY CORRELATE STRONGLY AS A FRAGMENT SCREENING COMBINATION | LYASE, FRAGMENTS, CARBONIC ANHYDRASE, METALLOPROTEIN
5fnm:A (PRO46) to (TRP97) NATIVE STATE MASS SPECTROMETRY, SURFACE PLASMON RESONANCE AND X-RAY CRYSTALLOGRAPHY CORRELATE STRONGLY AS A FRAGMENT SCREENING COMBINATION | LYASE, FRAGMENTS, CARBONIC ANHYDRASE, METALLOPROTEIN
4riu:A (PRO46) to (TRP97) A CARBONIC ANHYDRASE IX MIMIC IN COMPLEX WITH A SACCHARIN-BASED INHIBITOR | CARBONIC ANHYDRASE FOLD, REVERSIBLE HYDRATION OF CO2, ACTIVE SITE POINT MUTATIONS, CYTOSOLIC, LYASE-LYASE INHIBITOR COMPLEX
4riv:A (PRO46) to (TRP97) A CARBONIC ANHYDRASE IX MIMIC IN COMPLEX WITH SACCHARIN | CARBONIC ANHYDRASE FOLD, REVERSIBLE HYDRATION OF CO2, ACTIVE SITE POINT MUTATIONS, CYTOSOLIC, LYASE
4cac:A (PRO46) to (TRP97) REFINED STRUCTURE OF HUMAN CARBONIC ANHYDRASE II AT 2.0 ANGSTROMS RESOLUTION | LYASE(OXO-ACID)
4rn4:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASES II IN COMPLEX WITH A ACETAZOLAMIDE DERIVATIVE COMPRISING ONE HYDROPHOBIC AND ONE HYDROPHILIC TAIL MOIETY | CARBONIC ANHYDRASE, ACETAZOLAMIDE, LYASE-LYASE INHIBITOR COMPLEX
4rux:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH 4- (ALLYLOXY)BENZENESULFONAMIDE | METALLOENZYME, ANALGESIC, LYASE
4ruy:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH 4- PROPOXYBENZENESULFONAMIDE | METALLOENZYME, ANALGESIC, LYASE
4ruz:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH 4- ETHOXYBENZENESULFONAMIDE | METALLOENZYME, ANALGESIC, LYASE
5g01:A (PRO46) to (TRP97) AN UNUSUAL NATURAL PRODUCT PRIMARY SULFONAMIDE: SYNTHESIS, CARBONIC ANHYDRASE INHIBITION AND PROTEIN X-RAY STRUCTURE OF PSAMMAPLIN C | LYASE, NATURAL PRODUCT INHIBITOR, ENGINEERED PROTEINS, CARBONIC ANHYDRASE
5g03:A (PRO46) to (TRP97) AN UNUSUAL NATURAL PRODUCT PRIMARY SULFONAMIDE: SYNTHESIS, CARBONIC ANHYDRASE INHIBITION AND PROTEIN X-RAY STRUCTURE OF PSAMMAPLIN C | LYASE, NATURAL PRODUCT INHIBITOR, PROTEIN ENGINEERING, CARBONIC ANHYDRASE
3d0n:B (SER48) to (GLY98) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE XIII | CARBONIC ANHYDRASE, LYASE, METAL-BINDING, METAL BINDING PROTEIN
4cq0:A (PRO46) to (TRP97) CYCLIC SECONDARY SULFONAMIDES: UNUSUALLY GOOD INHIBITORS OF CANCER-RELATED CARBONIC ANHYDRASE ENZYMES | LYASE, SACCHARIN, CLICK CHEMISTRY, DRUG DESIGN
3d8w:A (PRO46) to (TRP97) USE OF A CARBONIC ANHYDRASE II, IX ACTIVE-SITE MIMIC, FOR THE PURPOSE OF SCREENING INHIBITORS FOR POSSIBLE ANTI- CANCER PROPERTIES | CARBONIC ANHYDRASE II, ANTI-CANCER, BENZOLAMIDE, ACETYLATION, CYTOPLASM, DISEASE MUTATION, LYASE, METAL- BINDING, POLYMORPHISM, ZINC
3d92:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II BOUND WITH SUBSTRATE CARBON DIOXIDE | ZINC METALLOENZYME, SUBSTRATE-BOUND, DISEASE MUTATION, LYASE, METAL- BINDING
3d93:A (PRO46) to (TRP97) APO HUMAN CARBONIC ANHYDRASE II BOUND WITH SUBSTRATE CARBON DIOXIDE | ZINC METALLOENZYME, SUBSTRATE-BOUND, DISEASE MUTATION, LYASE, METAL- BINDING
3d9z:A (PRO46) to (TRP97) USE OF CARBONIC ANHYDRASE II, IX ACTIVE-SITE MIMIC, FOR THE PURPOSE OF SCREENING INHIBITORS FOR POSSIBLE ANTI-CANCER PROPERTIES | CARBONIC ANHYDRASE II COMPLEX, CAIX MIMIC INHIBITORS, ACETYLATION, CYTOPLASM, DISEASE MUTATION, LYASE, METAL- BINDING, POLYMORPHISM, ZINC
3da2:B (LEU48) to (GLY99) X-RAY STRUCTURE OF HUMAN CARBONIC ANHYDRASE 13 IN COMPLEX WITH INHIBITOR | CARBONIC ANHYDRASE, SULFONAMIDE, SGC, STRUCTURAL GENOMICS, STRUCTURAL GENOMICS CONSORTIUM, LYASE, METAL-BINDING
3daz:A (PRO46) to (TRP97) USE OF CARBONIC ANHYDRASE II, IX ACTIVE-SITE MIMIC, FOR THE PURPOSE OF SCREENING INHIBITORS FOR POSSIBLE ANTI-CANCER PROPERTIES | CARBONIC ANHYDRASE II COMPLEX, CAIX MIMIC INHIBITORS, DISEASE MUTATION, LYASE, METAL-BINDING
3dbu:A (PRO46) to (TRP97) USE OF CARBONIC ANHYDRASE II, IX ACTIVE-SITE MIMIC, FOR THE PURPOSE OF SCREENING INHIBITORS FOR POSSIBLE ANTI-CANCER PROPERTIES | CARBONIC ANHYDRASE II COMPLEX, CAIX MIMIC INHIBITORS, ACETYLATION, CYTOPLASM, DISEASE MUTATION, LYASE, METAL- BINDING, POLYMORPHISM, ZINC
3dc9:A (PRO46) to (TRP97) USE OF CARBONIC ANHYDRASE II, IX ACTIVE-SITE MIMIC, FOR THE PURPOSE OF SCREENING INHIBITORS FOR POSSIBLE ANTI-CANCER PROPERTIES | CARBONIC ANHYDRASE II COMPLEX, CAIX MIMIC INHIBITORS, ACETYLATION, CYTOPLASM, DISEASE MUTATION, LYASE, METAL- BINDING, POLYMORPHISM, ZINC
3dcc:A (PRO46) to (TRP97) USE OF CARBONIC ANHYDRASE II, IX ACTIVE-SITE MIMIC, FOR THE PURPOSE OF SCREENING INHIBITORS FOR POSSIBLE ANTI-CANCER PROPERTIES | CARBONIC ANHYDRASE II COMPLEX, CAIX MIMIC INHIBITORS, ACETYLATION, CYTOPLASM, DISEASE MUTATION, LYASE, METAL- BINDING, POLYMORPHISM, ZINC
3dcs:A (PRO46) to (TRP97) USE OF CARBONIC ANHYDRASE II, IX ACTIVE-SITE MIMIC, FOR THE PURPOSE OF SCREENING INHIBITORS FOR POSSIBLE ANTI-CANCER PROPERTIES | CARBONIC ANHYDRASE II COMPLEX, CAIX MIMIC INHIBITORS, DISEASE MUTATION, LYASE, METAL-BINDING
3dcw:A (PRO46) to (TRP97) USE OF CARBONIC ANHYDRASE II, IX ACTIVE-SITE MIMIC, FOR THE PURPOSE OF SCREENING INHIBITORS FOR POSSIBLE ANTI-CANCER PROPERTIES | CARBONIC ANHYDRASE II COMPLEX, CAIX MIMIC INHIBITORS, ACETYLATION, CYTOPLASM, DISEASE MUTATION, LYASE, METAL- BINDING, POLYMORPHISM, ZINC
3oik:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II MUTANT A65S, N67Q (CA IX MIMIC) BOUND BY 2-ETHYLESTRADIOL 3,17-O,O-BIS-SULFAMATE | 2-ETHYLESTRONE, ESTRADIOL, SULFAMATE, MIXED ALPHA-BETA, CARBON DIOXIDE/BICARBONATE CONVERSION, LYASE
3oil:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II MUTANT A65S, N67Q (CA IX MIMIC) BOUND BY 2-ETHYLESTRADIOL 3-O-SULFAMATE | 2-ETHYLESTRONE, ESTRADIOL, SULFAMATE, MIXED ALPHA-BETA, CARBON DIOXIDE/BICARBONATE CONVERSION, LYASE
3oim:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II BOUND BY 2-ETHYLESTRADIOL 3-O-SULFAMATE | 2-ETHYLESTRONE, ESTRADIOL, SULFAMATE, MIXED ALPHA-BETA, CARBON DIOXIDE/BICARBONATE CONVERSION, LYASE
3oku:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH 2-ETHYLESTRONE-3-O- SULFAMATE | MIXED ALPHA/BETA FOLD, REVERSIBLE HYDRATION OF CARBON DIOXIDE TO BICARBONATE, LYASE
3okv:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II A65S, N67Q (CA IX MIMIC) BOUND WITH 2- ETHYLESTRONE 3-O-SULFAMATE | MIXES ALPHA/BETA FOLD, REVERSIBLE HYDRATION OF CARBON DIOXIDE TO BICARBONATE, LYASE
3dvd:A (PRO46) to (TRP97) X-RAY CRYSTAL STRUCTURE OF MUTANT N62D OF HUMAN CARBONIC ANHYDRASE II | HUMAN CARBONIC ANHYDRASE II, ACETYLATION, CYTOPLASM, DISEASE MUTATION, LYASE, METAL-BINDING, POLYMORPHISM, ZINC
3oyq:A (PRO46) to (TRP97) STRUCTURE OF HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH 5,6-DIHYDRO- BENZO[H]CINNOLIN-3-YLAMINE | BENZENE SULPHONAMIDE INHIBITOR, DRUG INTERACTIONS, LYASE-LYASE INHIBITOR COMPLEX
3oys:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH 2-{[4-AMINO-3-(3- HYDROXYPROP-1-YN-1-YL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-1-YL]METHYL}-5- METHYL-3-(2-METHYLPHENYL)QUINAZOLIN-4(3H)-ONE | BENZENE SULPHONAMIDE INHIBITOR, DRUG INTERACTIONS, LYASE-LYASE INHIBITOR COMPLEX
3p3j:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH P-(5-RUTHENOCENYL-1H-1,2, 3-TRIAZOL-1-YL)BENZENESULFONAMIDE | CARBONIC ANHYDRASE ALPHA, LYASE, CYTOSOLIC
3p44:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH P-(4-RUTHENOCENYL-1H-1,2, 3-TRIAZOL-1-YL)BENZENESULFONAMIDE | CARBONIC ANHYDRASE ALPHA, LYASE, CYTOSOLIC
3p4v:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH (+)-XYLARIAMIDE A | CARBONIC ANHYDRASE, ALPHA TYPE, LYASE-LYASE INHIBITOR COMPLEX
3p55:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH P-(4-FERROCENYL-1H-1,2,3- TRIAZOL-1-YL)BENZENESULFONAMIDE | CARBONIC ANHYDRASE ALPHA, LYASE, CYTOSOLIC
3p58:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE IN COMPLEX WITH BENZYL (METHYL) CARBAMODITHOIC ACID | CARBOTHIOATES, HCAII INHIBITORS, LYASE-INHIBITOR COMPLEX
3p5a:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE COMPLEXED WITH SODIUM MORPHOLINOCARBODITHIOATE | CARBOTHIOATES, HCAII INHIBITORS, LYASE-INHIBITOR COMPLEX
3p5l:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE COMPLEXED WITH SODIUM 4-CYANO-4- PHENYLPIPERIDINE-1-CARBODITHIOATE | CARBOTHIOATES, HCAII INHIBITORS, LYASE-INHIBITOR COMPLEX
4dz7:A (PRO46) to (TRP97) HCA II IN COMPLEX WITH NOVEL SULFONAMIDE INHIBITORS SET D | MIXED A/B GLOBULAR PROTEIN, INTERCONVERSION OF CO2 AND BICARBONATE, LYASE-LYASE INHIBITOR COMPLEX
4dz9:A (PRO46) to (TRP97) HCA II IN COMPLEX WITH NOVEL SULFONAMIDE INHIBITORS SET D | MIXED A/B GLOBULAR PROTEIN, INTERCONVERSION OF CO2 AND BICARBONATE, LYASE-LYASE INHIBITOR COMPLEX
4e3d:A (PRO46) to (TRP97) NUCLEOPHILE RECOGNITION AS AN ALTERNATIVE INHIBITION MODE FOR BENZOIC ACID BASED CARBONIC ANHYDRASE INHIBITORS | CARBONATE DEHYDRATASE, LYASE-LYASE INHIBITOR COMPLEX
4e3f:A (PRO46) to (TRP97) NUCLEOPHILE RECOGNITION AS AN ALTERNATIVE INHIBITION MODE FOR BENZOIC ACID BASED CARBONIC ANHYDRASE INHIBITORS | CARBONATE DEHYDRATASE, INHIBITOR BINDING, LYASE-LYASE INHIBITOR COMPLEX
4e3g:A (PRO46) to (TRP97) NUCLEOPHILE RECOGNITION AS AN ALTERNATIVE INHIBITION MODE FOR BENZOIC ACID BASED CARBONIC ANHYDRASE INHIBITORS | CARBONATE DEHYDRATASE, INHIBITOR, LYASE-LYASE INHIBITOR COMPLEX
4e3h:A (PRO46) to (TRP97) NUCLEOPHILE RECOGNITION AS AN ALTERNATIVE INHIBITION MODE FOR BENZOIC ACID BASED CARBONIC ANHYDRASE INHIBITORS | CARBONATE DEHYDRATASE, INHIBITOR, LYASE-LYASE INHIBITOR COMPLEX
4e49:A (PRO46) to (TRP97) NUCLEOPHILE RECOGNITION AS AN ALTERNATIVE INHIBITION MODE FOR BENZOIC ACID BASED CARBONIC ANHYDRASE INHIBITORS | CARBONATE DEHYDRATASE, INHIBITOR, LYASE-LYASE INHIBITOR COMPLEX
4e4a:A (PRO46) to (TRP97) NUCLEOPHILE RECOGNITION AS AN ALTERNATIVE INHIBITION MODE FOR BENZOIC ACID BASED CARBONIC ANHYDRASE INHIBITORS | CARBONATE DEHYDRATASE, INHIBITOR, LYASE-LYASE INHIBITOR COMPLEX
4e5q:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH CYANATE | MIXED ALPHA BETA PROTEIN, ENZYME PROTON TRANSFER, LYASE
4etq:C (PRO23) to (TRP70) VACCINIA VIRUS D8L IMV ENVELOPE PROTEIN IN COMPLEX WITH FAB OF MURINE IGG2A LA5 | VARIABLE DOMAIN, CONSTANT DOMAIN, IGG2A, IGG DOMAIN, CDR, HYPERVARIABLE REGION, NEUTRALIZING ANTIBODY, BETA SHEET, CARBONIC ANHYDRASE FOLD, LOOSE KNOT, CHONDROITIN-SULFATE BINDING SITE, DELTA 262, IMMUNE SYSTEM-VIRAL PROTEIN COMPLEX
3qyk:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH TRIPLE RING BENZENE SULFONAMIDE INHIBITOR | HYDRATION OF CO2, CO2, LYASE-LYASE INHIBITOR COMPLEX
4fik:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II H64A COMPLEXED WITH THIOXOLONE HYDROLYSIS PRODUCTS | CARBONIC ANHYDRASE II, HUMAN CARBONIC ANHYDRASE II, HCA II, HCA2, CA II, CA2, CARBONATE DEHYDRATASE II, CARBONIC ANHYDRASE C, THIOXOLONE, 4-MERCAPTOBENZENE-1,3-DIOL, 4-(2,4-DIHYDROXYPHENYL) DISULFANYLBENZENE-1,3-DIOL, DISEASE MUTATION, LYASE, METAL-BINDING
3r16:A (PRO46) to (TRP97) HUMAN CAII BOUND TO N-(4-SULFAMOYLPHENYL)-2-(THIOPHEN-2-YL) ACETAMIDE | REVERSIBLE HYDRATION OF CARBONDIOXIDE, LYASE
3r17:B (PRO46) to (TRP97) HCARBONIC ANHYDRASE II BOUND TO N-(2-FLUORO.4-SULFAMOYLPHENYL)-2- (THIOPHEN-2-YL) ACETAMIDE | REVERSIBLE HYDRATION OF CARBONDIOXIDE, LYASE
4fl7:A (PRO46) to (TRP97) THE CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH N-(HYDROXY)-BENZAMIDE | LYASE
4fpt:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II IN COMPLEX WITH ETHYL (2Z,4R)-2- (SULFAMOYLIMINO)-1,3-THIAZOLIDINE-4-CARBOXYLATE | 10 STRANDED TWISTED BETA-SHEETS, LYASE, LYASE-LYASE INHIBITOR COMPLEX
3rg3:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF THE W5E MUTANT OF HUMAN CARBONIC ANHYDRASE II | ZINC METALLOENZYME, W5E MUTATION, LYASE
3rg4:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF THE W5F MUTANT OF HUMAN CARBONIC ANHYDRASE II | ZINC METALLOENZYME, W5F MUTATION, LYASE
4frc:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II IN COMPLEX WITH N'-SULFAMOYLPYRROLIDINE-1- CARBOXIMIDAMIDE | 10 STRANDED TWISTED BETA-SHEETS, LYASE, LYASE-LYASE INHIBITOR COMPLEX
4fu5:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II IN COMPLEX WITH N-[(2Z)-1,3-OXAZOLIDIN-2- YLIDENE]SULFURIC DIAMIDE | 10 STRANDED TWISTED BETA-SHEETS, LYASE, LYASE-LYASE INHIBITOR COMPLEX
4fvo:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II IN COMPLEX WITH N-[(2E)-3,4-DIHYDROQUINAZOLIN- 2(1H)-YLIDENE]SULFURIC DIAMIDE | 10 STRANDED TWISTED BETA-SHEETS, LYASE, LYASE-LYASE INHIBITOR COMPLEX
3rj7:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH ITS INHIBITOR RHENIUM(I) TRISCARBONYL-CYCLOPENTADIENYL-CARBOXY-4-AMINOMETHYLBENZENE- SULFONAMIDE | INHIBITOR, TRANSITION METAL COMPLEX, ANHYDRASE, CARBON DIOXIDE, LYASE-LYASE INHIBITOR COMPLEX
5jq0:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH BENZOXABOROLE AT PH=8.7 | BENZOXABOROLE, LYASE, BORON, ZINC, CARBONATE DEHYDRATASE
5jqt:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH BENZOXABOROLE AT PH 7.4 | BENZOXABOROLE, LYASE, BORON, ZINC, CARBONATE DEHYDRATASE
4g0c:A (PRO46) to (TRP97) NEUTRON STRUCTURE OF ACETAZOLAMIDE-BOUND HUMAN CARBONIC ANHYDRASE II REVEAL MOLECULAR DETAILS OF DRUG BINDING. | CARBONIC ANHYDRASE, ACETAZOLAMIDE, HYDROGEN BONDING, LYASE-LYASE INHIBITOR COMPLEX
5k6z:A (PRO5) to (SER60) SIDEKICK CHIMERA CONTAINING SIDEKICK-2 IMMUNOGLOBULIN DOMAINS 1-2 AND SIDEKICK-1 IMMUNOGLOBULIN DOMAINS 3-4 | CELL ADHESION, IMMUNOGLOBULIN
5k70:A (PRO5) to (SER60) SIDEKICK-2 IMMUNOGLOBULIN DOMAINS 1-4 H18R/N22S MUTANT | CELL ADHESION, IMMUNOGLOBULIN
5k70:C (PRO5) to (SER60) SIDEKICK-2 IMMUNOGLOBULIN DOMAINS 1-4 H18R/N22S MUTANT | CELL ADHESION, IMMUNOGLOBULIN
4gl1:X (PRO46) to (TRP97) STRUCTURE OF H64A/N62L/N67L HUMAN CARBONIC ANHYDRASE II TRIPLE MUTANT | MIXED ALPA BETA, LYASE
5lmd:A (PRO46) to (TRP97) THE CRYSTAL STRUCTURE OF HCA II IN COMPLEX WITH A BENZOXABOROLE INHIBITOR | BENZOXABOROLE, ZINC ENZYME, INHIBITOR, LYASE
6ca2:A (PRO46) to (TRP97) ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II | LYASE(OXO-ACID)
7ca2:A (PRO46) to (TRP97) ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II | LYASE(OXO-ACID)
9ca2:A (PRO46) to (TRP97) ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II | LYASE(OXO-ACID)
3ryy:A (PRO46) to (TRP97) FLUOROALKYL AND ALKYL CHAINS HAVE SIMILAR HYDROPHOBICITIES IN BINDING TO THE HYDROPHOBIC WALL OF CARBONIC ANHYDRASE | ALPHA BETA, LYASE
1bic:A (PRO46) to (TRP97) CRYSTALLOGRAPHIC ANALYSIS OF THR-200-> HIS HUMAN CARBONIC ANHYDRASE II AND ITS COMPLEX WITH THE SUBSTRATE, HCO3- | LYASE(OXO-ACID)
3f4x:A (PRO46) to (TRP97) CARBONIC ANHYDRASE INHIBITORS. COMPARISON OF CHLORTHALIDONE AND INDAPAMIDE X-RAY CRYSTAL STRUCTURES IN ADDUCTS WITH ISOZYME II: WHEN THREE WATER MOLECULES MAKE THE DIFFERENCE | CARBONIC ANHYDRASE, INHIBITORS, CRYSTAL STRUCTURE, DIURETICS, ACETYLATION, CYTOPLASM, DISEASE MUTATION, LYASE, METAL-BINDING, POLYMORPHISM, ZINC
3s71:B (PRO46) to (TRP97) THE ORIGIN OF THE HYDROPHOBIC EFFECT IN THE MOLECULAR RECOGNITION OF ARYLSULFONAMIDES BY CARBONIC ANHYDRASE | ALPHA BETA, LYASE
3s77:B (PRO46) to (TRP97) THE ORIGIN OF THE HYDROPHOBIC EFFECT IN THE MOLECULAR RECOGNITION OF ARYLSULFONAMIDES BY CARBONIC ANHYDRASE | ALPHA BETA, LYASE
4xam:F (GLU1624) to (ARG1670) COMPLEMENT COMPONENT C4B | COMPLEMENT COMPONENT C4, ALPHA-2-MACROGLOBULIN FAMILY, IMMUNE SYSTEM
3ffp:X (PRO46) to (TRP97) X RAY STRUCTURE OF THE COMPLEX BETWEEN CARBONIC ANHYDRASE II AND LC INHIBITORS | CARBONIC ANHYDRASE, INHIBITORS, CRYSTAL STRUCTURE, ACETYLATION, CYTOPLASM, DISEASE MUTATION, LYASE, METAL- BINDING, POLYMORPHISM, ZINC
1ca2:A (PRO46) to (TRP97) REFINED STRUCTURE OF HUMAN CARBONIC ANHYDRASE II AT 2.0 ANGSTROMS RESOLUTION | LYASE(OXO-ACID)
1cay:A (PRO46) to (TRP97) WILD-TYPE AND E106Q MUTANT CARBONIC ANHYDRASE COMPLEXED WITH ACETATE | LYASE(OXO-ACID)
2q38:A (LEU47) to (TRP97) CARBONIC ANHYDRASE II IN COMPLEX WITH SACCHARIN AT 1.95 ANGSTROM | TEN STRANDED TWISTED BETA SHEET, LYASE
1cva:A (PRO46) to (TRP97) STRUCTURAL AND FUNCTIONAL IMPORTANCE OF A CONSERVED HYDROGEN BOND NETWORK IN HUMAN CARBONIC ANHYDRASE II | LYASE(OXO-ACID)
4ilx:A (PRO46) to (TRP97) STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH AN ADAMANTYL SULFONAMIDE INHIBITOR | LYASE, REVERSIBLE HYDRATION OF CARBON DIOXIDE, CYTOSOLIC, LYASE-LYASE INHIBITOR COMPLEX
3t84:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH ACETYLATED CARBOHYDRATE SULFAMATES | ALPHA CARBONIC ANHYDRASE, LYASE-LYASE INHIBITOR COMPLEX
3u7c:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF THE V143I MUTANT OF HUMAN CARBONIC ANHYDRASE II | LYASE, CARBONIC ANYDRASE C, CAC, SUBSTRATE BOUND, PRODUCT BOUND, CO2 PRESSURIZED, PRIMARILY BETA
1fsq:A (PRO46) to (MET97) X-RAY CRYSTAL STRUCTURE OF COBALT-BOUND F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT | CARBONIC ANHYDRASE, METAL BINDING, METAL SPECIFICITY, COBALT, LYASE
1fsq:B (PRO46) to (MET97) X-RAY CRYSTAL STRUCTURE OF COBALT-BOUND F93S/F95L/W97M CARBONIC ANHYDRASE (CAII) VARIANT | CARBONIC ANHYDRASE, METAL BINDING, METAL SPECIFICITY, COBALT, LYASE
4z0q:A (PRO46) to (TRP97) CARBONIC ANHYDRASE INHIBITORS: DESIGN AND SYNTHESIS OF NEW HETEROARYL- N-CARBONYLBENZENESULFONAMIDES TARGETING DRUGGABLE HUMAN CARBONIC ANHYDRASE ISOFORMS (HCA VII, HCA IX, AND HCA XIV) | CARBONATE DEHYDRATASE II, CARBONIC ANHYDRASE C, CARBONIC ANHYDRASE II, CA-II, CARBONATE DEHYDRATASE II- INHIBITOR COMPLEX, LYASE
1g1d:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N- [(2-FLUOROPHENYL)METHYL]-BENZAMIDE | CARBONIC ANHYDRASE II, 4-(AMINOSULFONYL)-N-[(2- FLUOROPHENYL)METHYL]-BENZAMIDE, LYASE
4z1j:A (PRO46) to (TRP97) CARBONIC ANHYDRASE INHIBITORS: DESIGN AND SYNTHESIS OF NEW HETEROARYL- N-CARBONYLBENZENESULFONAMIDES TARGETING DRUGGABLE HUMAN CARBONIC ANHYDRASE ISOFORMS (HCA VII, HCA IX, AND HCA XIV) | CARBONATE DEHYDRATASE II, CARBONIC ANHYDRASE C, CARBONIC ANHYDRASE II, CA-II, CARBONATE DEHYDRATASE II- INHIBITOR COMPLEX, LYASE
1g46:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4- (AMINOSULFONYL)-N-[(2,3-DIFLUOROPHENYL)METHYL]-BENZAMIDE | CARBONIC ANHYDRASE II, F131V, 4-(AMINOSULFONYL)-N-[(2,3- DIFLUOROPHENYL)METHYL]-BENZAMIDE, LYASE
1g48:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4- (AMINOSULFONYL)-N-[(2,6-DIFLUOROPHENYL)METHYL]-BENZAMIDE | CARBONIC ANHYDRASE II, F131V, 4-(AMINOSULFONYL)-N-[(2,6- DIFLUOROPHENYL)METHYL]-BENZAMIDE, LYASE
1g4j:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4- (AMINOSULFONYL)-N-[(2,3,4,5,6-PENTAFLUOROPHENYL)METHYL]- BENZAMIDE | CARBONIC ANHYDRASE II, F131V, 4-(AMINOSULFONYL)-N-[(2,3,4,5, 6-PENTAFLUOROPHENYL)METHYL]-BENZAMIDE, LYASE
1rza:A (PRO46) to (TRP97) X-RAY ANALYSIS OF METAL SUBSTITUTED HUMAN CARBONIC ANHYDRASE II DERIVATIVES | LYASE(OXO-ACID)
4knj:A (LEU47) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH 2- CHLORO-4-[(PYRIMIDIN-2-YLSULFANYL)ACETYL]BENZENESULFONAMIDE | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE, METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
4kp5:A (PRO45) to (TRP94) CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF HUMAN CARBONIC ANHYDRASE ISOZYME XII WITH 2-CHLORO-4-[(PYRIMIDIN-2-YLSULFANYL) ACETYL]BENZENESULFONAMIDE | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE, METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
4kp5:C (PRO45) to (TRP94) CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF HUMAN CARBONIC ANHYDRASE ISOZYME XII WITH 2-CHLORO-4-[(PYRIMIDIN-2-YLSULFANYL) ACETYL]BENZENESULFONAMIDE | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE, METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
4kuy:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH THE 5-(3-(O-TOLYLSULFONYL)UREIDO)PYRIDINE-2-SULFONAMIDE INHIBITOR | LYASE, LYASE-LYASE INHIBITOR COMPLEX
3ibl:A (PRO46) to (TRP97) THE CRYSTAL STRUCTURE OF THE HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH AN ALIPHATIC BIS-SULFAMATE INHIBITOR | CARBONIC ANHYDRASE II, PROTEIN-INHIBITOR COMPLEX, ALIPHATIC BIS- SULFAMATE INHIBITOR, DISEASE MUTATION, METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
4l5w:A (PRO46) to (TRP97) STRUCTURAL IMPLICATIONS OF THE SECONDARY CO2 BINDING POCKET IN HUMAN CARBONIC ANHYDRASE II | ALLOSTERIC REGULATION, THERMOSTABILITY, LYASE
1tg3:A (PRO46) to (TRP97) EFFECT OF SHUTTLE LOCATION AND PH ENVIRONMENT ON H+ TRANSFER IN HUMAN CARBONIC ANHYDRASE II | PROTON SHUTTLE CARBONIC ANHYDRASE METALLOENZYME, LYASE
1hea:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II (CARBONATE DEHYDRATASE) (HCA II) (E.C.4.2.1.1) MUTANT WITH LEU 198 REPLACED BY ARG (L198R) | LYASE(OXO-ACID)
4zwi:A (PRO46) to (TRP97) SURFACE LYSINE ACETYLATED HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A SULFAMATE-BASED INHIBITOR | ACETYLATED LYSINES, SULFAMATE-BASED INHIBITOR, LYASE-LYASE INHIBITOR COMPLEX
4zx1:A (PRO46) to (TRP97) ENGINEERED CARBONIC ANHYDRASE IX MIMIC IN COMPLEX WITH A GLUCOSYL SULFAMATE INHIBITOR | CARBONIC ANHYDRASE IX MIMIC, GLUCOSYL SULFAMATE, INHIBITOR COMPLEX., LYASE-LYASE INHIBITOR COMPLEX
2hnc:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF THE HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH THE 5-AMINO-1,3,4-THIADIAZOLE-2-SULFONAMIDE INHIBITOR. | PROTEIN-INHIBITOR COMPLEX, LYASE
4m2u:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II IN COMPLEX WITH DORZOLAMIDE | LYASE-LYASE INHIBITOR COMPLEX
4mdl:A (PRO46) to (TRP97) META CARBORANE CARBONIC ANHYDRASE INHIBITOR | CARBONIC ANHYDRASE INHIBITOR COMPLEX, LYASE-LYASE INHIBITOR COMPLEX
1j9w:B (ILE47) to (GLY98) SOLUTION STRUCTURE OF THE CAI MICHIGAN 1 VARIANT | 10-STRANDED-BETA-SHEET, LYASE
1jd0:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN CARBONIC ANHYDRASE XII COMPLEXED WITH ACETAZOLAMIDE | EXTRACELLULAR DOMAIN, HUMAN CARBONIC ANHYDRASE XII, BITOPIC MEMBRANE PROTEIN, TYPE I MEMBRANE PROTEIN, LYASE
1jd0:B (PRO46) to (TRP97) CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN CARBONIC ANHYDRASE XII COMPLEXED WITH ACETAZOLAMIDE | EXTRACELLULAR DOMAIN, HUMAN CARBONIC ANHYDRASE XII, BITOPIC MEMBRANE PROTEIN, TYPE I MEMBRANE PROTEIN, LYASE
2nnv:A (PRO46) to (TRP97) STRUCTURE OF INHIBITOR BINDING TO CARBONIC ANHYDRASE II | ZINC METALLOENZYME, SULFONAMIDE, LYASE
3jxg:A (ASP108) to (TRP152) CA-LIKE DOMAIN OF MOUSE PTPRG | CA-LIKE DOMAIN, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PHOSPHOPROTEIN, PROTEIN PHOSPHATASE, TRANSMEMBRANE, CELL ADHESION
3jxg:B (LEU102) to (TRP152) CA-LIKE DOMAIN OF MOUSE PTPRG | CA-LIKE DOMAIN, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PHOSPHOPROTEIN, PROTEIN PHOSPHATASE, TRANSMEMBRANE, CELL ADHESION
3jxg:C (ASP108) to (TRP152) CA-LIKE DOMAIN OF MOUSE PTPRG | CA-LIKE DOMAIN, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PHOSPHOPROTEIN, PROTEIN PHOSPHATASE, TRANSMEMBRANE, CELL ADHESION
3jxg:D (LEU102) to (TRP152) CA-LIKE DOMAIN OF MOUSE PTPRG | CA-LIKE DOMAIN, GLYCOPROTEIN, HYDROLASE, MEMBRANE, PHOSPHOPROTEIN, PROTEIN PHOSPHATASE, TRANSMEMBRANE, CELL ADHESION
3jxf:A (LEU80) to (GLY131) CA-LIKE DOMAIN OF HUMAN PTPRZ | CA-LIKE DOMAIN, ALTERNATIVE SPLICING, GLYCOPROTEIN, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEIN PHOSPHATASE, TRANSMEMBRANE, CELL ADHESION
3jxf:B (LYS79) to (GLY131) CA-LIKE DOMAIN OF HUMAN PTPRZ | CA-LIKE DOMAIN, ALTERNATIVE SPLICING, GLYCOPROTEIN, HYDROLASE, MEMBRANE, POLYMORPHISM, PROTEIN PHOSPHATASE, TRANSMEMBRANE, CELL ADHESION
3k34:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II WITH A SULFONAMIDE INHIBITOR | CARBONIC ANHYDRASE, ATOMIC RESOLUTION, SULFONAMIDE INHIBITOR, DISEASE MUTATION, LYASE, METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
3k7k:A (LEU47) to (TRP97) CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN CARBONIC ANHYDRASE II AND ANIONS | INORGANIC ANION, TRITHIOCARBONATE, X RAY, CARBONIC ANHYDRASE II
3kld:B (LEU102) to (TRP152) PTPRG CNTN4 COMPLEX | CELL ADHESION, PROTEIN COMPLEX, RECEPTOR PROTEIN TYROSINE PHOSPHATASE, NEURAL RECOGNITION MOLECULE, GLYCOPROTEIN, MEMBRANE, PHOSPHOPROTEIN, PROTEIN PHOSPHATASE, TRANSMEMBRANE
1yo0:A (PRO46) to (TRP97) PROTON TRANSFER FROM HIS200 IN HUMAN CARBONIC ANHYDRASE II | PROTON TRANSFER, HUMAN CARBONIC ANHYDRASE, LYASE
1yo1:A (PRO46) to (TRP97) PROTON TRANSFER FROM HIS200 IN HUMAN CARBONIC ANHYDRASE II | PROTON TRANSFER HUMAN CARBONIC ANHYDRASE, LYASE
3l14:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH ALTHIAZIDE | LYASE, CARBONIC ANHYDRASE II, ALTHIAZIDE, 6-CHLORO-3, 4-DIHYDRO-3- ((2-PROPENYLTHIO)METHYL)-2H-1, 2, 4-BENZOTHIADIAZINE-7-SULFONAMIDE, DISEASE MUTATION, METAL-BINDING
5dsj:A (PRO46) to (TRP97) STRUCTURE OF CO2 RELEASED HOLO-FORM OF HUMAN CARBONIC ANHYDRASE II WITH 50 SEC WARMING | CARBONIC ANHYDRASE II, CO2 RELEASE, INTERMEDIATE STATES, LYASE
1ze8:A (LEU47) to (TRP97) CARBONIC ANHYDRASE II IN COMPLEX WITH A MEMBRANE-IMPERMEANT SULFONAMIDE INHIBITOR | TWISTED BETA-SHEET, LYASE
4q0l:B (PRO45) to (TRP94) CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF HUMAN CARBONIC ANHYDRASE ISOZYME XII WITH INHIBITOR | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE,METAL-BINDING, LYASE-LYASE INHIBITOR COMPLE, LYASE-LYASE INHIBITOR COMPLEX
4q0l:C (PRO45) to (TRP94) CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF HUMAN CARBONIC ANHYDRASE ISOZYME XII WITH INHIBITOR | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE,METAL-BINDING, LYASE-LYASE INHIBITOR COMPLE, LYASE-LYASE INHIBITOR COMPLEX
4q0l:D (PRO45) to (TRP94) CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF HUMAN CARBONIC ANHYDRASE ISOZYME XII WITH INHIBITOR | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE,METAL-BINDING, LYASE-LYASE INHIBITOR COMPLE, LYASE-LYASE INHIBITOR COMPLEX
4q78:A (PRO46) to (TRP97) STRUCTURE-ASSISTED DESIGN OF CARBORANE-BASED INHIBITORS OF CARBONIC ANHYDRASE | CARBONIC ANHYDRASE, LYASE-LYASE INHIBITOR COMPLEX
4qiy:B (LEU47) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH INHIBITOR | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE, METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
4qiy:C (LEU47) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH INHIBITOR | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE, METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
4qjo:A (PRO45) to (TRP94) CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF HUMAN CARBONIC ANHYDRASE ISOZYME XII WITH INHIBITOR | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE,METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
4qjo:B (PRO45) to (TRP94) CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF HUMAN CARBONIC ANHYDRASE ISOZYME XII WITH INHIBITOR | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE,METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
4qjo:C (PRO45) to (TRP94) CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF HUMAN CARBONIC ANHYDRASE ISOZYME XII WITH INHIBITOR | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE,METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
4qjo:D (PRO45) to (TRP94) CRYSTAL STRUCTURE OF CATALYTIC DOMAIN OF HUMAN CARBONIC ANHYDRASE ISOZYME XII WITH INHIBITOR | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE,METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
3mhc:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CABONIC ANHYDRASE II IN ADDUCT WITH AN ADAMANTYL ANALOGUE OF ACETAZOLAMIDE IN A NOVEL HYDROPHOBIC BINDING POCKET | CARBONIC ANHYDRASE INHIBITORS, ADAMANTYL, ACETAZOLAMIDE, LYASE
3ml2:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDSASE II IN COMPLEX WITH AN ARYL SULFONAMIDE INHIBITOR | ZINC METALLOENZYME, METAL-BINDING, LYASE,SULFONAMIDE, ZINC LIGANDS, INHIBITOR, LYASE, LYASE-LYASE INHIBITOR COMPLEX
3bet:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF THE HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH STX 641 AT 1.85 ANGSTROMS RESOLUTION | PROTEIN-INHIBITOR COMPLEX, DISEASE MUTATION, LYASE, METAL-BINDING
4bf1:A (PRO46) to (TRP97) THREE DIMENSIONAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH 5-(1-NAPHTHALEN-1-YL-1,2,3-TRIAZOL-4-YL) THIOPHENE-2-SULFONAMIDE | LYASE
4qsa:A (LEU47) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE ISOZYME II WITH 2- CHLORO-4-{[(4-METHYL-6-OXO-1,6-DIHYDROPYRIMIDIN-2-YL) THIO]ACETYL}BENZENESULFONAMIDE | DRUG DESIGN, CARBONIC ANHYDRASE, BENZENESULFONAMIDE, METAL-BINDING, LYASE-LYASE INHIBITOR COMPLEX
3mnh:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II MUTANT K170A | PROTON TRANSFER, METALLOENZYME, PROTON TRANSPORT
3mnu:A (PRO46) to (TRP97) CARBONIC ANHYDRASE INHIBITORS: CRYSTALLOGRAPHIC AND SOLUTION BINDING STUDIES FOR THE INTERACTION OF A BORON CONTAINING AROMATIC SULFAMIDE WITH MAMMALIAN ISOFORMS I-XV | PROTEIN-INHIBITOR COMPLEX, LYASE
4qy3:A (PRO46) to (TRP97) THE CRYSTAL STRUCTURE OF THE COMPLEX OF HCAII WITH AN ORTHO- SUBSTITUTED BENZOIC ACID | CARBONIC ANHYDRASE II, LYASE, LYASE-LYASE INHIBITOR COMPLEX
3n3j:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A BENZENESULFONAMIDE INHIBITOR | LYASE, METALLOENZYME, ZINC LIGANDS, BENZENESULFONAMIDE, INHIBITOR, GLYCEROL, LYASE-LYASE INHIBITOR COMPLEX
3n4b:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH A BENZENESULFONAMIDE INHIBITOR | LYASE, ZINC METALLOENZYME, ZINC LIGANDS, BENZENESULFONAMIDE, INHIBITOR, LYASE-LYASE INHIBITOR COMPLEX
5fdi:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II WITH THE ANTICONVULSANT SULFAMIDE JNJ-26990990 AND ITS S,S-DIOXIDE ANALOG. | SULFAMIDE INHIBITOR, PROTEIN-INHIBITOR COMPLEX, LYASE
4r59:A (PRO46) to (TRP97) A CARBONIC ANHYDRASE IX MIMIC IN COMPLEX WITH A CARBOHYDRATE-BASED SULFAMATE | CARBONIC ANHYDRASE IX MIMIC, LYASE
3nb5:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH 2-(3-CHLORO-4- HYDROXYPHENYL)-N-(4-SULFAMOYLPHENETHYL)ACETAMIDE | DRUG DESIGN, NATURAL PRODUCT, SULFAMATE, LYASE-LYASE INHIBITOR COMPLEX
5flr:A (PRO46) to (TRP97) NATIVE STATE MASS SPECTROMETRY, SURFACE PLASMON RESONANCE AND X-RAY CRYSTALLOGRAPHY CORRELATE STRONGLY AS A FRAGMENT SCREENING COMBINATION | LYASE, FRAGMENTS, METALLOPROTEIN
5fls:A (PRO46) to (TRP97) NATIVE STATE MASS SPECTROMETRY, SURFACE PLASMON RESONANCE AND X-RAY CRYSTALLOGRAPHY CORRELATE STRONGLY AS A FRAGMENT SCREENING COMBINATION | LYASE, FRAGMENTS, METALLOPROTEIN
5flt:A (PRO46) to (TRP97) NATIVE STATE MASS SPECTROMETRY, SURFACE PLASMON RESONANCE AND X-RAY CRYSTALLOGRAPHY CORRELATE STRONGLY AS A FRAGMENT SCREENING COMBINATION | LYASE, FRAGMENTS, CARBONIC ANHYDRASE, METALLOPROTEIN
5fni:A (PRO46) to (TRP97) NATIVE STATE MASS SPECTROMETRY, SURFACE PLASMON RESONANCE AND X-RAY CRYSTALLOGRAPHY CORRELATE STRONGLY AS A FRAGMENT SCREENING COMBINATION | LYASE, FRAGMENTS, CARBONIC ANHYDRASE, METALLOPROTEIN
5g0b:A (LEU47) to (TRP97) AN UNUSUAL NATURAL PRODUCT PRIMARY SULFONAMIDE: SYNTHESIS, CARBONIC ANHYDRASE INHIBITION AND PROTEIN X-RAY STRUCTURE OF PSAMMAPLIN C | LYASE, PROTEIN ENGINEERING, NATURAL PRODUCT INHIBITOR, CARBONIC ANHYDRASE
3dc3:A (PRO46) to (TRP97) USE OF CARBONIC ANHYDRASE II, IX ACTIVE-SITE MIMIC, FOR THE PURPOSE OF SCREENING INHIBITORS FOR POSSIBLE ANTI-CANCER PROPERTIES | CARBONIC ANHYDRASE II COMPLEX, CAIX MIMIC INHIBITORS, ACETYLATION, CYTOPLASM, DISEASE MUTATION, LYASE, METAL- BINDING, POLYMORPHISM, ZINC
3dd0:A (PRO46) to (TRP97) USE OF CARBONIC ANHYDRASE II, IX ACTIVE-SITE MIMIC, FOR THE PURPOSE OF SCREENING INHIBITORS FOR POSSIBLE ANTI-CANCER PROPERTIES | CARBONIC ANHYDRASE II COMPLEX, CAIX MIMIC INHIBITORS, ACETYLATION, CYTOPLASM, DISEASE MUTATION, LYASE, METAL- BINDING, POLYMORPHISM, ZINC
3dd8:A (PRO46) to (TRP97) CARBONIC ANHYDRASE INHIBITORS. INTERACTION OF THE ANTITUMOR SULFAMATE EMD-486019 WITH TWELVE MAMMALIAN ISOFORMS: KINETIC AND X-RAY CRYSTALLOGRAPHIC STUDIES | CARBONIC ANHYDRASE, INHIBITORS, CRYSTAL STRUCTURE, ANTIGLAUCOMA, OAO-ACID, ACETYLATION, CYTOPLASM, DISEASE MUTATION, LYASE, METAL-BINDING, POLYMORPHISM, ZINC
3dv7:A (PRO46) to (TRP97) ROLE OF HYDROPHILIC RESIDUES IN PROTON TRANSFER DURING CATALYSIS BY HUMAN CARBONIC ANHYDRASE II (N62A) | HCA II, ACETYLATION, CYTOPLASM, DISEASE MUTATION, LYASE, METAL-BINDING, POLYMORPHISM, ZINC
3dvb:A (PRO46) to (TRP97) X-RAY CRYSTAL STRUCTURE OF MUTANT N62V HUMAN CARBONIC ANHYDRASE II | HUMAN CARBONIC ANHYDRASE II, ACETYLATION, CYTOPLASM, DISEASE MUTATION, LYASE, METAL-BINDING, POLYMORPHISM, ZINC
3dvc:A (PRO46) to (TRP97) X-RAY CRYSTAL STRUCTURE OF MUTANT N62T OF HUMAN CARBONIC ANHYDRASE II | HUMAN CARBONIC ANHYDRASE, ACETYLATION, CYTOPLASM, DISEASE MUTATION, LYASE, METAL-BINDING, POLYMORPHISM, ZINC
3oy0:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH 1-(4-(4-(2- (ISOPROPYLSULFONYL)PHENYLAMINO)-1H-PYRROLO[2,3-B]PYRIDIN-6-YLAMINO)- 3-METHOXYPHENYL)PIPERIDIN-4-OL | BENZENE SULFONAMIDE, DRUG INTERACTION, LYASE-LYASE INHIBITOR COMPLEX
3p3h:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH P-(5-FERROCENYL-1H-1,2,3- TRIAZOL-1-YL)BENZENESULFONAMIDE | CARBONIC ANHYDRASE ALPHA, LYASE, CYTOSOLIC
3po6:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II WITH 6,7-DIMETHOXY-1- METHYL-3,4-DIHYDROISOQUINOLINE-2(1H)-SULFONAMIDE | CARBONIC ANHYDRASE, LYASE-LYASE INHIBITOR COMPLEX
5j8z:A (PRO46) to (TRP97) HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH LIGAND | CYTOPLASM, LYASE, 2-THIO-6-OXO-1, 6-DIHYDROPYRIMIDINES, SULFONAMIDES
3rge:A (PRO46) to (TRP97) CRYSTAL STRUCTURE OF THE W5H MUTANT OF HUMAN CARBONIC ANHYDRASE II | ZINC METALLOENZYME, W5H MUTATION, LYASE
4fvn:A (PRO46) to (TRP97) CARBONIC ANHYDRASE II IN COMPLEX WITH N-(TETRAHYDROPYRIMIDIN-2(1H)- YLIDENE)SULFURIC DIAMIDE | 10 STRANDED TWISTED BETA-SHEETS, LYASE, LYASE-LYASE INHIBITOR COMPLEX