4wcu:B (THR86) to (VAL202) PDE4 COMPLEXED WITH INHIBITOR | INHIBITOR, COMPLEX, PDE4D, HYDROLASE
4wcu:C (LEU92) to (VAL202) PDE4 COMPLEXED WITH INHIBITOR | INHIBITOR, COMPLEX, PDE4D, HYDROLASE
4wcu:D (ASP90) to (VAL202) PDE4 COMPLEXED WITH INHIBITOR | INHIBITOR, COMPLEX, PDE4D, HYDROLASE
4wzi:A (ASN334) to (ILE445) CRYSTAL STRUCTURE OF CROSSLINK STABILIZED LONG-FORM PDE4B | PHOSPHODIESTERASE, HYDROLASE
4wzi:B (THR332) to (ILE445) CRYSTAL STRUCTURE OF CROSSLINK STABILIZED LONG-FORM PDE4B | PHOSPHODIESTERASE, HYDROLASE
4x0f:A (GLU335) to (ILE445) CRYSTAL STRUCTURE OF CROSSLINK STABILIZED LONG-FORM PDE4B IN COMPLEX WITH (R)-(-)-ROLIPRAM | PHOSPHODIESTERASE, INHIBITOR, COMPLEX, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4x0f:B (THR332) to (ILE445) CRYSTAL STRUCTURE OF CROSSLINK STABILIZED LONG-FORM PDE4B IN COMPLEX WITH (R)-(-)-ROLIPRAM | PHOSPHODIESTERASE, INHIBITOR, COMPLEX, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4htx:A (ASP597) to (CYS695) CRYSTAL STRUCTURE OF PDE2 CATALYTIC DOMAIN IN COMPLEX WITH BAY60-7550 | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4htx:B (ASP597) to (CYS695) CRYSTAL STRUCTURE OF PDE2 CATALYTIC DOMAIN IN COMPLEX WITH BAY60-7550 | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4htz:B (ASP597) to (CYS695) CRYSTAL STRUCTURE OF PDE2 CATALYTIC DOMAIN IN SPACE GROUP P1 | HYDROLASE
4htz:D (ASP597) to (LEU698) CRYSTAL STRUCTURE OF PDE2 CATALYTIC DOMAIN IN SPACE GROUP P1 | HYDROLASE
3sl3:A (THR86) to (VAL202) CRYSTAL STRUCTURE OF THE APO FORM OF THE CATALYTIC DOMAIN OF PDE4D2 | CATALYTIC MECHANISM, CAMP HYDROLYSIS, HYDROLASE
3sl3:C (GLU87) to (VAL202) CRYSTAL STRUCTURE OF THE APO FORM OF THE CATALYTIC DOMAIN OF PDE4D2 | CATALYTIC MECHANISM, CAMP HYDROLYSIS, HYDROLASE
3sl3:D (GLU89) to (VAL202) CRYSTAL STRUCTURE OF THE APO FORM OF THE CATALYTIC DOMAIN OF PDE4D2 | CATALYTIC MECHANISM, CAMP HYDROLYSIS, HYDROLASE
3sl4:A (THR86) to (VAL202) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH COMPOUND 10D | CATALYTIC MECHANISM, CAMP HYDROLYSIS, HYDROLASE-INHIBITOR COMPLEX
3sl4:B (GLN88) to (ILE199) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH COMPOUND 10D | CATALYTIC MECHANISM, CAMP HYDROLYSIS, HYDROLASE-INHIBITOR COMPLEX
3sl4:C (GLU87) to (VAL202) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH COMPOUND 10D | CATALYTIC MECHANISM, CAMP HYDROLYSIS, HYDROLASE-INHIBITOR COMPLEX
3sl4:D (GLU89) to (VAL202) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH COMPOUND 10D | CATALYTIC MECHANISM, CAMP HYDROLYSIS, HYDROLASE-INHIBITOR COMPLEX
3sl5:A (THR86) to (VAL202) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 COMPLEXED WITH COMPOUND 10D | CATALYTIC MECHANISM, CAMP HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3sl5:B (GLN88) to (VAL202) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 COMPLEXED WITH COMPOUND 10D | CATALYTIC MECHANISM, CAMP HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3sl5:C (GLN88) to (VAL202) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 COMPLEXED WITH COMPOUND 10D | CATALYTIC MECHANISM, CAMP HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3sl5:D (GLU89) to (ILE199) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 COMPLEXED WITH COMPOUND 10D | CATALYTIC MECHANISM, CAMP HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3sl6:A (THR86) to (VAL202) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH COMPOUND 12C | CATALYTIC DOMAIN, CAMP HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3sl6:B (GLN88) to (ILE199) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH COMPOUND 12C | CATALYTIC DOMAIN, CAMP HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3sl6:C (THR86) to (VAL202) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH COMPOUND 12C | CATALYTIC DOMAIN, CAMP HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3sl6:D (GLU89) to (VAL202) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH COMPOUND 12C | CATALYTIC DOMAIN, CAMP HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1oyn:A (THR86) to (VAL202) CRYSTAL STRUCTURE OF PDE4D2 IN COMPLEX WITH (R,S)-ROLIPRAM | PDE, CAMP, ROLIPRAM, HYDROLASE
1oyn:B (GLU89) to (ILE199) CRYSTAL STRUCTURE OF PDE4D2 IN COMPLEX WITH (R,S)-ROLIPRAM | PDE, CAMP, ROLIPRAM, HYDROLASE
1oyn:C (THR86) to (ILE199) CRYSTAL STRUCTURE OF PDE4D2 IN COMPLEX WITH (R,S)-ROLIPRAM | PDE, CAMP, ROLIPRAM, HYDROLASE
1oyn:D (ASP90) to (VAL202) CRYSTAL STRUCTURE OF PDE4D2 IN COMPLEX WITH (R,S)-ROLIPRAM | PDE, CAMP, ROLIPRAM, HYDROLASE
3g3n:A (ASP139) to (THR251) PDE7A CATALYTIC DOMAIN IN COMPLEX WITH 3-(2,6- DIFLUOROPHENYL)-2-(METHYLTHIO)QUINAZOLIN-4(3H)-ONE | PDE7, CRYSTAL, INHIBITOR COMPLEX, ALTERNATIVE SPLICING, CAMP, HYDROLASE, PHOSPHOPROTEIN
3g4g:A (ASP256) to (ILE365) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH REGULATORY DOMAIN AND D155871 | PHOSPHODIESTERASE, PDE4D, UCR2, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
3g4g:B (ASP256) to (VAL368) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH REGULATORY DOMAIN AND D155871 | PHOSPHODIESTERASE, PDE4D, UCR2, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
3g4g:C (GLU255) to (VAL368) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH REGULATORY DOMAIN AND D155871 | PHOSPHODIESTERASE, PDE4D, UCR2, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
3g4g:D (ASP256) to (VAL368) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH REGULATORY DOMAIN AND D155871 | PHOSPHODIESTERASE, PDE4D, UCR2, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
3g4i:A (THR252) to (VAL368) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH D155871 | PHOSPHODIESTERASE, PDE4D, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
3g4i:B (GLN254) to (VAL368) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH D155871 | PHOSPHODIESTERASE, PDE4D, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
3g4i:C (THR252) to (ILE365) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH D155871 | PHOSPHODIESTERASE, PDE4D, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
3g4i:D (GLN254) to (VAL368) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH D155871 | PHOSPHODIESTERASE, PDE4D, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
3g4k:A (THR252) to (VAL368) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH ROLIPRAM | PHOSPHODIESTERASE, PDE4D, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
3g4k:B (GLU255) to (VAL368) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH ROLIPRAM | PHOSPHODIESTERASE, PDE4D, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
3g4k:C (GLU253) to (VAL368) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH ROLIPRAM | PHOSPHODIESTERASE, PDE4D, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
3g4k:D (ASP256) to (VAL368) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH ROLIPRAM | PHOSPHODIESTERASE, PDE4D, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
3g4l:A (THR252) to (VAL368) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH ROFLUMILAST | PHOSPHODIESTERASE, PDE4D, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
3g4l:B (GLN254) to (VAL368) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH ROFLUMILAST | PHOSPHODIESTERASE, PDE4D, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
3g4l:C (GLU253) to (VAL368) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH ROFLUMILAST | PHOSPHODIESTERASE, PDE4D, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
3g4l:D (GLU255) to (VAL368) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH ROFLUMILAST | PHOSPHODIESTERASE, PDE4D, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
3g58:A (THR252) to (VAL368) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH D155988/PMNPQ | PHOSPHODIESTERASE, PDE4D, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
3g58:B (GLN254) to (VAL368) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH D155988/PMNPQ | PHOSPHODIESTERASE, PDE4D, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
3g58:C (THR252) to (VAL368) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH D155988/PMNPQ | PHOSPHODIESTERASE, PDE4D, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
3g58:D (GLU255) to (ILE365) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH D155988/PMNPQ | PHOSPHODIESTERASE, PDE4D, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
1ptw:A (THR86) to (VAL202) THE CRYSTAL STRUCTURE OF AMP-BOUND PDE4 SUGGESTS A MECHANISM FOR PHOSPHODIESTERASE CATALYSIS | CATALYTIC MECHANISM, CAMP HYDROLYSIS CRYSTAL STRUCTURE, BINUCLEAR CATALYSIS, HYDROLASE
1ptw:B (THR86) to (ILE199) THE CRYSTAL STRUCTURE OF AMP-BOUND PDE4 SUGGESTS A MECHANISM FOR PHOSPHODIESTERASE CATALYSIS | CATALYTIC MECHANISM, CAMP HYDROLYSIS CRYSTAL STRUCTURE, BINUCLEAR CATALYSIS, HYDROLASE
1ptw:C (GLU87) to (ILE199) THE CRYSTAL STRUCTURE OF AMP-BOUND PDE4 SUGGESTS A MECHANISM FOR PHOSPHODIESTERASE CATALYSIS | CATALYTIC MECHANISM, CAMP HYDROLYSIS CRYSTAL STRUCTURE, BINUCLEAR CATALYSIS, HYDROLASE
1ptw:D (GLU89) to (VAL202) THE CRYSTAL STRUCTURE OF AMP-BOUND PDE4 SUGGESTS A MECHANISM FOR PHOSPHODIESTERASE CATALYSIS | CATALYTIC MECHANISM, CAMP HYDROLYSIS CRYSTAL STRUCTURE, BINUCLEAR CATALYSIS, HYDROLASE
2qyk:A (GLU301) to (ILE411) CRYSTAL STRUCTURE OF PDE4A10 IN COMPLEX WITH INHIBITOR NPV | PDE4 INHIBITOR, SUBFAMILY INHIBITOR SELECTIVITY, HYDROLASE
2qyk:B (GLU301) to (ILE411) CRYSTAL STRUCTURE OF PDE4A10 IN COMPLEX WITH INHIBITOR NPV | PDE4 INHIBITOR, SUBFAMILY INHIBITOR SELECTIVITY, HYDROLASE
2qyl:A (GLU163) to (ILE273) CRYSTAL STRUCTURE OF PDE4B2B IN COMPLEX WITH INHIBITOR NPV | PDE4B STRUCTURE, SELECTIVE INHIBITOR NVP, HYDROLASE
2qym:A (GLU211) to (VAL324) CRYSTAL STRUCTURE OF UNLIGANDED PDE4C2 | PDE4C STRUCTURE, HYDROLASE
2qyn:A (THR86) to (VAL202) CRYSTAL STRUCTURE OF PDE4D2 IN COMPLEX WITH INHIBITOR NPV | PDE4D SELECTIVE INHIBITOR NVP, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL-BINDING, PHOSPHORYLATION
2qyn:B (GLN88) to (VAL202) CRYSTAL STRUCTURE OF PDE4D2 IN COMPLEX WITH INHIBITOR NPV | PDE4D SELECTIVE INHIBITOR NVP, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL-BINDING, PHOSPHORYLATION
1q9m:A (THR86) to (VAL202) THREE DIMENSIONAL STRUCTURES OF PDE4D IN COMPLEX WITH ROLIPRAMS AND IMPLICATION ON INHIBITOR SELECTIVITY | PDE, ROLIPRAM, SPECIFIC INHIBITOR, HYDROLASE
1q9m:B (THR86) to (ILE199) THREE DIMENSIONAL STRUCTURES OF PDE4D IN COMPLEX WITH ROLIPRAMS AND IMPLICATION ON INHIBITOR SELECTIVITY | PDE, ROLIPRAM, SPECIFIC INHIBITOR, HYDROLASE
1q9m:C (THR86) to (ILE199) THREE DIMENSIONAL STRUCTURES OF PDE4D IN COMPLEX WITH ROLIPRAMS AND IMPLICATION ON INHIBITOR SELECTIVITY | PDE, ROLIPRAM, SPECIFIC INHIBITOR, HYDROLASE
1q9m:D (GLN88) to (VAL202) THREE DIMENSIONAL STRUCTURES OF PDE4D IN COMPLEX WITH ROLIPRAMS AND IMPLICATION ON INHIBITOR SELECTIVITY | PDE, ROLIPRAM, SPECIFIC INHIBITOR, HYDROLASE
3gwt:A (ASN159) to (VAL276) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B IN COMPLEX WITH A QUINOLINE INHIBITOR | PDE, PHOSPHODIESTERASE, CAMP, HYDROLASE
3tvx:A (GLU301) to (VAL414) THE STRUCTURE OF PDE4A WITH PENTOXIFYLLINE AT 2.84A RESOLUTION | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3tvx:B (GLU301) to (VAL414) THE STRUCTURE OF PDE4A WITH PENTOXIFYLLINE AT 2.84A RESOLUTION | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1f0j:A (THR160) to (ILE273) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B | PDE PHOSPHODIESTERASE, HYDROLASE
1f0j:B (ASN159) to (ILE273) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B | PDE PHOSPHODIESTERASE, HYDROLASE
1ro6:A (ASN159) to (ILE273) CRYSTAL STRUCTURE OF PDE4B2B COMPLEXED WITH ROLIPRAM (R & S) | PDE, ROLIPRAM, CRYSTAL, HYDROLASE
1ro9:A (ASN159) to (ILE273) CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHODIESTERASE 4B2B COMPLEXED WITH 8-BR-AMP | PDE, 8-BR-AMP, HYDROLASE
1ro9:B (ASN159) to (ILE273) CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHODIESTERASE 4B2B COMPLEXED WITH 8-BR-AMP | PDE, 8-BR-AMP, HYDROLASE
1ror:A (ASN159) to (ILE273) CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHODIESTERASE 4B2B COMPLEXED WITH AMP | PDE, AMP, HYDROLASE
1ror:B (ASN159) to (ILE273) CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHODIESTERASE 4B2B COMPLEXED WITH AMP | PDE, AMP, HYDROLASE
3hmv:A (ASN162) to (ILE273) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B IN COMPLEX WITH A TETRAHYDROBENZOTHIOPHENE INHIBITOR | PDE, PHOSPHODIESTERASE, CAMP, ALTERNATIVE SPLICING, HYDROLASE, PHOSPHOPROTEIN, POLYMORPHISM
3hmv:B (ASN162) to (ILE273) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B IN COMPLEX WITH A TETRAHYDROBENZOTHIOPHENE INHIBITOR | PDE, PHOSPHODIESTERASE, CAMP, ALTERNATIVE SPLICING, HYDROLASE, PHOSPHOPROTEIN, POLYMORPHISM
2fm0:A (THR86) to (VAL202) CRYSTAL STRUCTURE OF PDE4D IN COMPLEX WITH L-869298 | PDE. ENANTIOMER BINDING, INHIBITOR SELECTIVITY, CAMP SIGNALLING, CRYSTAL STRUCTURE, HYDROLASE
2fm0:B (GLN88) to (VAL202) CRYSTAL STRUCTURE OF PDE4D IN COMPLEX WITH L-869298 | PDE. ENANTIOMER BINDING, INHIBITOR SELECTIVITY, CAMP SIGNALLING, CRYSTAL STRUCTURE, HYDROLASE
2fm0:C (GLU87) to (VAL202) CRYSTAL STRUCTURE OF PDE4D IN COMPLEX WITH L-869298 | PDE. ENANTIOMER BINDING, INHIBITOR SELECTIVITY, CAMP SIGNALLING, CRYSTAL STRUCTURE, HYDROLASE
2fm0:D (ASP90) to (VAL202) CRYSTAL STRUCTURE OF PDE4D IN COMPLEX WITH L-869298 | PDE. ENANTIOMER BINDING, INHIBITOR SELECTIVITY, CAMP SIGNALLING, CRYSTAL STRUCTURE, HYDROLASE
2fm5:A (THR86) to (VAL202) CRYSTAL STRUCTURE OF PDE4D2 IN COMPLEX WITH INHIBITOR L- 869299 | PDE4, CRYSTAL STRUCTURE, INHIBITOR SELECTIVITY, L-869299, ENANTIOMER BINDING, CAMP SIGNAL, HYDROLASE
2fm5:B (GLN88) to (VAL202) CRYSTAL STRUCTURE OF PDE4D2 IN COMPLEX WITH INHIBITOR L- 869299 | PDE4, CRYSTAL STRUCTURE, INHIBITOR SELECTIVITY, L-869299, ENANTIOMER BINDING, CAMP SIGNAL, HYDROLASE
2fm5:C (GLU87) to (VAL202) CRYSTAL STRUCTURE OF PDE4D2 IN COMPLEX WITH INHIBITOR L- 869299 | PDE4, CRYSTAL STRUCTURE, INHIBITOR SELECTIVITY, L-869299, ENANTIOMER BINDING, CAMP SIGNAL, HYDROLASE
2fm5:D (ASP90) to (VAL202) CRYSTAL STRUCTURE OF PDE4D2 IN COMPLEX WITH INHIBITOR L- 869299 | PDE4, CRYSTAL STRUCTURE, INHIBITOR SELECTIVITY, L-869299, ENANTIOMER BINDING, CAMP SIGNAL, HYDROLASE
3v9b:A (THR86) to (VAL202) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH (S)-N-(3-{1- [1-(3-CYCLOPROPYLMETHOXY-4-DIFLUOROMETHOXYPHENYL)-2-(1-OXYPYRIDIN-4- YL)-ETHYL]-1H-PYRAZL-3-YL}PHENYL)ACETAMIDE | HYDROLASE, 3',5'-CYCLIC-AMP PHOSPHODIESTERASES, CYCLIC NUCLEOTIDE, PHOSPHODIESTERASES, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3v9b:B (GLN88) to (VAL202) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH (S)-N-(3-{1- [1-(3-CYCLOPROPYLMETHOXY-4-DIFLUOROMETHOXYPHENYL)-2-(1-OXYPYRIDIN-4- YL)-ETHYL]-1H-PYRAZL-3-YL}PHENYL)ACETAMIDE | HYDROLASE, 3',5'-CYCLIC-AMP PHOSPHODIESTERASES, CYCLIC NUCLEOTIDE, PHOSPHODIESTERASES, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3v9b:C (GLU89) to (VAL202) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH (S)-N-(3-{1- [1-(3-CYCLOPROPYLMETHOXY-4-DIFLUOROMETHOXYPHENYL)-2-(1-OXYPYRIDIN-4- YL)-ETHYL]-1H-PYRAZL-3-YL}PHENYL)ACETAMIDE | HYDROLASE, 3',5'-CYCLIC-AMP PHOSPHODIESTERASES, CYCLIC NUCLEOTIDE, PHOSPHODIESTERASES, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3v9b:D (GLU89) to (VAL202) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH (S)-N-(3-{1- [1-(3-CYCLOPROPYLMETHOXY-4-DIFLUOROMETHOXYPHENYL)-2-(1-OXYPYRIDIN-4- YL)-ETHYL]-1H-PYRAZL-3-YL}PHENYL)ACETAMIDE | HYDROLASE, 3',5'-CYCLIC-AMP PHOSPHODIESTERASES, CYCLIC NUCLEOTIDE, PHOSPHODIESTERASES, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3i8v:A (GLU301) to (VAL414) CRYSTAL STRUCTURE OF HUMAN PDE4A WITH 4-(3-BUTOXY-4-METHOXYPHENYL) METHYL-2-IMIDAZOLIDONE | CYCLIC-AMP SPECIFIC, CAMP, HYDROLASE, MEMBRANE, PHOSPHOPROTEIN
3i8v:B (GLU302) to (ILE411) CRYSTAL STRUCTURE OF HUMAN PDE4A WITH 4-(3-BUTOXY-4-METHOXYPHENYL) METHYL-2-IMIDAZOLIDONE | CYCLIC-AMP SPECIFIC, CAMP, HYDROLASE, MEMBRANE, PHOSPHOPROTEIN
3iad:A (THR252) to (VAL368) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH BOUND ALLOSTERIC MODULATOR | PDE4D, ALLOSTERIC MODULATORY, INHIBITOR, UCR2, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL-BINDING, PHOSPHOPROTEIN
3iad:B (GLU255) to (VAL368) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH BOUND ALLOSTERIC MODULATOR | PDE4D, ALLOSTERIC MODULATORY, INHIBITOR, UCR2, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL-BINDING, PHOSPHOPROTEIN
3iad:C (THR252) to (VAL368) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH BOUND ALLOSTERIC MODULATOR | PDE4D, ALLOSTERIC MODULATORY, INHIBITOR, UCR2, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL-BINDING, PHOSPHOPROTEIN
3iad:D (GLU255) to (VAL368) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH BOUND ALLOSTERIC MODULATOR | PDE4D, ALLOSTERIC MODULATORY, INHIBITOR, UCR2, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL-BINDING, PHOSPHOPROTEIN
3iak:A (VAL91) to (VAL202) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D (PDE4D) WITH PAPAVERINE. | CAMP-SPECIFIC, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL-BINDING, PHOSPHOPROTEIN
1taz:A (SER151) to (ILE262) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 1B | PDE1B, HYDROLASE
1tb5:A (GLU163) to (VAL276) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH AMP | PDE4B, HYDROLASE
1tb5:B (GLU163) to (VAL276) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH AMP | PDE4B, HYDROLASE
1tb7:A (GLU87) to (VAL202) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH AMP | PDE4D, HYDROLASE
1tb7:B (THR86) to (VAL202) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH AMP | PDE4D, HYDROLASE
1tbb:A (GLN88) to (VAL202) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH ROLIPRAM | PDE4D, HYDROLASE
1tbb:B (GLU87) to (VAL202) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH ROLIPRAM | PDE4D, HYDROLASE
3itm:A (ASP597) to (CYS695) CATALYTIC DOMAIN OF HPDE2A | ZN-BINDING, ALL-ALPHA HELICAL, CGMP, HYDROLASE, MEMBRANE
3itm:B (ASP597) to (CYS695) CATALYTIC DOMAIN OF HPDE2A | ZN-BINDING, ALL-ALPHA HELICAL, CGMP, HYDROLASE, MEMBRANE
3itm:C (ASP597) to (CYS695) CATALYTIC DOMAIN OF HPDE2A | ZN-BINDING, ALL-ALPHA HELICAL, CGMP, HYDROLASE, MEMBRANE
3itm:D (ASP597) to (CYS695) CATALYTIC DOMAIN OF HPDE2A | ZN-BINDING, ALL-ALPHA HELICAL, CGMP, HYDROLASE, MEMBRANE
3itu:A (ASP597) to (CYS695) HPDE2A CATALYTIC DOMAIN COMPLEXED WITH IBMX | ZN-BINDING, ALL-ALPHA-HELICAL, ALTERNATIVE SPLICING, CGMP, HYDROLASE, MEMBRANE, POLYMORPHISM
3itu:B (ASP597) to (CYS695) HPDE2A CATALYTIC DOMAIN COMPLEXED WITH IBMX | ZN-BINDING, ALL-ALPHA-HELICAL, ALTERNATIVE SPLICING, CGMP, HYDROLASE, MEMBRANE, POLYMORPHISM
3itu:C (ASP597) to (CYS695) HPDE2A CATALYTIC DOMAIN COMPLEXED WITH IBMX | ZN-BINDING, ALL-ALPHA-HELICAL, ALTERNATIVE SPLICING, CGMP, HYDROLASE, MEMBRANE, POLYMORPHISM
3itu:D (ASP597) to (LEU698) HPDE2A CATALYTIC DOMAIN COMPLEXED WITH IBMX | ZN-BINDING, ALL-ALPHA-HELICAL, ALTERNATIVE SPLICING, CGMP, HYDROLASE, MEMBRANE, POLYMORPHISM
3w5e:A (ASN162) to (VAL276) CRYSTAL STRUCTURE OF PHOSPHODIESTERASE 4B IN COMPLEX WITH COMPOUND 31E | PHOSPHODIESTERASE, COPD, INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3w5e:B (ASN159) to (VAL276) CRYSTAL STRUCTURE OF PHOSPHODIESTERASE 4B IN COMPLEX WITH COMPOUND 31E | PHOSPHODIESTERASE, COPD, INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3wd9:B (ASN159) to (VAL276) CRYSTAL STRUCTURE OF PHOSPHODIESTERASE 4B IN COMPLEX WITH COMPOUND 10F | PHOSPHODIESTERASE, COPD, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4myq:A (ASP336) to (ILE445) SELECTIVE INHIBITION OF THE CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B WITH A-33 | PHOSPHODIESTERASE, CATALYTIC, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5b25:A (THR152) to (ILE262) CRYSTAL STRUCTURE OF HUMAN PDE1B WITH INHIBITOR 3 | HYDROLASE, INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5b25:B (THR152) to (ILE262) CRYSTAL STRUCTURE OF HUMAN PDE1B WITH INHIBITOR 3 | HYDROLASE, INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5b25:C (SER151) to (ILE262) CRYSTAL STRUCTURE OF HUMAN PDE1B WITH INHIBITOR 3 | HYDROLASE, INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5b25:D (SER151) to (ILE262) CRYSTAL STRUCTURE OF HUMAN PDE1B WITH INHIBITOR 3 | HYDROLASE, INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4npv:A (SER151) to (ILE262) CRYSTAL STRUCTURE OF HUMAN PDE1B BOUND TO INHIBITOR 7A (6,7,8- TRIMETHOXY-N-(PENTAN-3-YL)QUINAZOLIN-4-AMINE) | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4npw:A (SER151) to (ILE262) CRYSTAL STRUCTURE OF HUMAN PDE1B BOUND TO INHIBITOR 19A (7,8- DIMETHOXY-N-[(2S)-1-(3-METHYL-1H-PYRAZOL-5-YL)PROPAN-2-YL]QUINAZOLIN- 4-AMINE) | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4nw7:A (ASP336) to (VAL448) PDE4 CATALYTIC DOMAIN | PHOSPHODIESTERASE, PDE4, CATALYTIC, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3jsw:B (SER189) to (PHE277) HUMAN PDE9 IN COMPLEX WITH SELECTIVE INHIBITOR | PHOSPHODIESTERASE, CGMP, HYDROLASE, MANGANESE, METAL-BINDING, PHOSPHOPROTEIN
4ogb:A (THR86) to (VAL202) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH COMPOUND 2 | CATALYTIC MECHANISM, CAMP HYDROLYSIS, HYDROLASE-INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4ogb:C (GLU87) to (VAL202) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH COMPOUND 2 | CATALYTIC MECHANISM, CAMP HYDROLYSIS, HYDROLASE-INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4ogb:D (GLU89) to (VAL202) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH COMPOUND 2 | CATALYTIC MECHANISM, CAMP HYDROLYSIS, HYDROLASE-INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3k4s:A (VAL91) to (VAL202) THE STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PDE4D WITH 4- (3-BUTOXY-4-METHOXYPHENYL)METHYL-2-IMIDAZOLIDONE | NUCLEOTIDE BINDING, PHOSPHODIESTERASE, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
1xlx:B (ASP164) to (VAL276) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH CILOMILAST | PDE4B, CILOMILAST, HYDROLASE
1xlz:A (GLU163) to (VAL276) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH FILAMINAST | PDE4B, FILAMINAST, HYDROLASE
1xm6:A (GLU163) to (VAL276) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH (R)- MESOPRAM | PDE4B, (R)-MESOPRAM, HYDROLASE
1xm6:B (ASP164) to (ILE273) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH (R)- MESOPRAM | PDE4B, (R)-MESOPRAM, HYDROLASE
1xom:A (THR86) to (VAL202) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH CILOMILAST | PHOSPHODIESTERASE, PDE, PDE4D, CILOMILAST, HYDROLASE
1xom:B (GLN88) to (VAL202) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH CILOMILAST | PHOSPHODIESTERASE, PDE, PDE4D, CILOMILAST, HYDROLASE
1xon:A (THR86) to (VAL202) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH PICLAMILAST | PHOSPHODIESTERASE, PDE, PDE4D, PICLAMILAST, HYDROLASE
1xon:B (THR86) to (VAL202) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH PICLAMILAST | PHOSPHODIESTERASE, PDE, PDE4D, PICLAMILAST, HYDROLASE
1xoq:A (GLU87) to (VAL202) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH ROFLUMILAST | PHOSPHODIESTERASE, PDE, PDE4D, ROFLUMILAST, HYDROLASE
1xoq:B (THR86) to (VAL202) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH ROFLUMILAST | PHOSPHODIESTERASE, PDE, PDE4D, ROFLUMILAST, HYDROLASE
3kkt:A (HIS165) to (VAL276) CRYSTAL STRUCTURE OF HUMAN PDE4B WITH 5-[3-[(1S,2S,4R)- BICYCLO[2.2.1]HEPT-2-YLOXY]-4-METHOXYP HENYL]TETRAHYDRO-2(1H)- PYRIMIDINONE REVEALS ORDERING OF THE C-TERMINAL HELIX RESIDUES 502- 509. | PHOSPHODIESTERASE, ALTERNATIVE SPLICING,HYDROLASE, PHOSPHOPROTEIN, HYDROLASE
3kkt:B (ASN159) to (VAL276) CRYSTAL STRUCTURE OF HUMAN PDE4B WITH 5-[3-[(1S,2S,4R)- BICYCLO[2.2.1]HEPT-2-YLOXY]-4-METHOXYP HENYL]TETRAHYDRO-2(1H)- PYRIMIDINONE REVEALS ORDERING OF THE C-TERMINAL HELIX RESIDUES 502- 509. | PHOSPHODIESTERASE, ALTERNATIVE SPLICING,HYDROLASE, PHOSPHOPROTEIN, HYDROLASE
1y2b:A (THR86) to (VAL202) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH 3,5- DIMETHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER | PHOSPHODIESTERASE, PDE, PDE4D, PYRAZOLE, HYDROLASE
1y2b:B (THR86) to (VAL202) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH 3,5- DIMETHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER | PHOSPHODIESTERASE, PDE, PDE4D, PYRAZOLE, HYDROLASE
1y2c:A (THR86) to (VAL202) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH 3,5- DIMETHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER | PHOSPHODIESTERASE, PDE, PDE4D, PYRAZOLE, HYDROLASE
1y2c:B (THR86) to (VAL202) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH 3,5- DIMETHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER | PHOSPHODIESTERASE, PDE, PDE4D, PYRAZOLE, HYDROLASE
1y2d:A (THR86) to (VAL202) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH 1-(4- METHOXY-PHENYL)-3,5-DIMETHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER | PHOSPHODIESTERASE, PDE, PDE4D, PYRAZOLE, HYDROLASE
1y2d:B (THR86) to (VAL202) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH 1-(4- METHOXY-PHENYL)-3,5-DIMETHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER | PHOSPHODIESTERASE, PDE, PDE4D, PYRAZOLE, HYDROLASE
1y2e:A (THR86) to (VAL202) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH 1-(4- AMINO-PHENYL)-3,5-DIMETHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER | PHOSPHODIESTERASE, PDE, PDE4D, PYRAZOLE, HYDROLASE
1y2e:B (GLN88) to (VAL202) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH 1-(4- AMINO-PHENYL)-3,5-DIMETHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER | PHOSPHODIESTERASE, PDE, PDE4D, PYRAZOLE, HYDROLASE
1z1l:A (PRO592) to (LEU698) THE CRYSTAL STRUCTURE OF THE PHOSPHODIESTERASE 2A CATALYTIC DOMAIN | PDE 2A, CRYSTAL STRUCTURE, PHOSPHODIESTERASE, HYDROLASE
1zkl:A (TYR140) to (THR251) MULTIPLE DETERMINANTS FOR INHIBITOR SELECTIVITY OF CYCLIC NUCLEOTIDE PHOSPHODIESTERASES | PDE, HYDROLASE
1zkn:A (THR86) to (VAL202) STRUCTURE OF PDE4D2-IBMX | PROTEIN-INHIBITOR COMPLEX, INHIBITOR SELECTIVITY, HYDROLASE
1zkn:B (GLU89) to (VAL202) STRUCTURE OF PDE4D2-IBMX | PROTEIN-INHIBITOR COMPLEX, INHIBITOR SELECTIVITY, HYDROLASE
1zkn:C (GLU87) to (VAL202) STRUCTURE OF PDE4D2-IBMX | PROTEIN-INHIBITOR COMPLEX, INHIBITOR SELECTIVITY, HYDROLASE
1zkn:D (GLU89) to (VAL202) STRUCTURE OF PDE4D2-IBMX | PROTEIN-INHIBITOR COMPLEX, INHIBITOR SELECTIVITY, HYDROLASE
3ly2:A (ASP164) to (VAL276) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH A COUMARIN-BASED INHIBITOR | PDE4B, COUMARIN, INHIBITOR, HYDROLASE, METAL-BINDING, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
3ly2:B (ASP164) to (ILE273) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH A COUMARIN-BASED INHIBITOR | PDE4B, COUMARIN, INHIBITOR, HYDROLASE, METAL-BINDING, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
3ly2:C (GLU163) to (ILE273) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH A COUMARIN-BASED INHIBITOR | PDE4B, COUMARIN, INHIBITOR, HYDROLASE, METAL-BINDING, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
3ly2:D (ASN159) to (VAL276) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH A COUMARIN-BASED INHIBITOR | PDE4B, COUMARIN, INHIBITOR, HYDROLASE, METAL-BINDING, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
3ly2:E (GLU163) to (ILE273) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH A COUMARIN-BASED INHIBITOR | PDE4B, COUMARIN, INHIBITOR, HYDROLASE, METAL-BINDING, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
3ly2:F (ASN159) to (VAL276) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH A COUMARIN-BASED INHIBITOR | PDE4B, COUMARIN, INHIBITOR, HYDROLASE, METAL-BINDING, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
3ly2:G (ASN159) to (ILE273) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH A COUMARIN-BASED INHIBITOR | PDE4B, COUMARIN, INHIBITOR, HYDROLASE, METAL-BINDING, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
3ly2:H (ASN159) to (ILE273) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH A COUMARIN-BASED INHIBITOR | PDE4B, COUMARIN, INHIBITOR, HYDROLASE, METAL-BINDING, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
4c1i:A (ASP597) to (CYS695) SELECTIVE INHIBITORS OF PDE2, PDE9, AND PDE10: MODULATORS OF ACTIVITY OF THE CENTRAL NERVOUS SYSTEM | HYDROLASE, HYDROLASE INHIBITOR COMPLEX
4c1i:D (PRO592) to (CYS695) SELECTIVE INHIBITORS OF PDE2, PDE9, AND PDE10: MODULATORS OF ACTIVITY OF THE CENTRAL NERVOUS SYSTEM | HYDROLASE, HYDROLASE INHIBITOR COMPLEX
3o0j:A (ASN162) to (VAL276) PDE4B IN COMPLEX WITH LIGAND AN2898 | PHOSPHODIESTERASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3o57:A (ASN159) to (VAL276) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B IN COMPLEX WITH A 5- HETEROCYCLE PYRAZOLOPYRIDINE INHIBITOR | PDE, HYDROLASE, PHOSPHODIESTERASE, CAMP BINDING, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3d3p:A (ASN159) to (VAL276) CRYSTAL STRUCTURE OF PDE4B CATALYTIC DOMAIN IN COMPLEX WITH A PYRAZOLOPYRIDINE INHIBITOR | PDE, PHOSPHODIESTERASE, CAMP, ALTERNATIVE SPLICING, HYDROLASE, PHOSPHOPROTEIN, POLYMORPHISM
4d08:B (ASP597) to (CYS695) PDE2A CATALYTIC DOMAIN IN COMPLEX WITH A BRAIN PENETRANT INHIBITOR | HYDROLASE, BINDING SITES, CATALYTIC DOMAIN, CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 2, TYPE 4, DISEASE MODELS, ANIMAL, DRUG EVALUATION, PRECLINICAL, PHOSPHODIESTERASE 2 INHIBITORS, PHOSPHODIESTERASE INHIBITORS, PROTEIN BINDING, STRUCTURE-ACTIVITY RELATIONSHIP
4d09:B (ASP597) to (LEU698) PDE2A CATALYTIC DOMAIN IN COMPLEX WITH A BRAIN PENETRANT INHIBITOR | HYDROLASE, CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 2, TYPE 4, DISEASE MODELS, ANIMAL, DRUG EVALUATION, PRECLINICAL, PHOSPHODIESTERASE 2 INHIBITORS, PHOSPHODIESTERASE INHIBITORS, PROTEIN BINDING, STRUCTURE-ACTIVITY RELATIONSHIP
4w1o:A (VAL91) to (VAL202) PDE4D COMPLEXED WITH INHIBITOR | INHIBITOR, COMPLEX, PDE4D, HYDROLASE
4w1o:B (THR86) to (VAL202) PDE4D COMPLEXED WITH INHIBITOR | INHIBITOR, COMPLEX, PDE4D, HYDROLASE
4w1o:C (GLU87) to (ILE199) PDE4D COMPLEXED WITH INHIBITOR | INHIBITOR, COMPLEX, PDE4D, HYDROLASE
4w1o:D (VAL91) to (VAL202) PDE4D COMPLEXED WITH INHIBITOR | INHIBITOR, COMPLEX, PDE4D, HYDROLASE
3sl8:A (THR86) to (ILE199) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH COMPOUND 10O | CATALYTIC MECHANISM, CAMP HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3sl8:B (GLU89) to (ILE199) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH COMPOUND 10O | CATALYTIC MECHANISM, CAMP HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3sl8:C (GLU89) to (ILE199) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH COMPOUND 10O | CATALYTIC MECHANISM, CAMP HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3sl8:D (GLU89) to (ILE199) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH COMPOUND 10O | CATALYTIC MECHANISM, CAMP HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2pw3:A (GLN88) to (VAL202) STRUCTURE OF THE PDE4D-CAMP COMPLEX | PDE4-CAMP COMPLEX, SUBSTRATE SPECIFICITY, CRYSTAL STRUCTURE., HYDROLASE
2pw3:B (GLN88) to (VAL202) STRUCTURE OF THE PDE4D-CAMP COMPLEX | PDE4-CAMP COMPLEX, SUBSTRATE SPECIFICITY, CRYSTAL STRUCTURE., HYDROLASE
3frg:A (ASN159) to (VAL276) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B IN COMPLEX WITH A QUINOLINE INHIBITOR | PDE, PHOSPHODIESTERASE, CAMP, ALTERNATIVE SPLICING, HYDROLASE, PHOSPHOPROTEIN, POLYMORPHISM, HYDROLASE/HYDROLASE INHIBITOR COMPLEX
4jib:A (ASP597) to (CYS695) CRYSTAL STRUCTURE OF OF PDE2-INHIBITOR COMPLEX | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4jib:B (ASP597) to (CYS695) CRYSTAL STRUCTURE OF OF PDE2-INHIBITOR COMPLEX | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1xmu:A (ASP164) to (VAL276) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH ROFLUMILAST | PHOSPHODIESTERASE, PDE, PDE4B, ROFLUMILAST, HYDROLASE
1xor:A (GLN88) to (VAL202) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH ZARDAVERINE | PHOSPHODIESTERASE, PDE, PDE4D, ZARDAVERINE, HYDROLASE
1xor:B (GLU87) to (VAL202) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH ZARDAVERINE | PHOSPHODIESTERASE, PDE, PDE4D, ZARDAVERINE, HYDROLASE
1xot:B (ASP164) to (VAL276) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH VARDENAFIL | PHOSPHODIESTERASE, PDE, PDE4B, VARDENAFIL, LEVITRA, HYDROLASE
1xot:A (GLU163) to (VAL276) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH VARDENAFIL | PHOSPHODIESTERASE, PDE, PDE4B, VARDENAFIL, LEVITRA, HYDROLASE
1y2h:B (GLU163) to (ILE273) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH 1-(2- CHLORO-PHENYL)-3,5-DIMETHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER | PHOSPHODIESTERASE, PDE, PDE4B, PYRAZOLE, HYDROLASE
1y2j:B (GLU163) to (ILE273) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH 3,5- DIMETHYL-1-(3-NITRO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER | PHOSPHODIESTERASE, PDE, PDE4B, PYRAZOLE, HYDROLASE
1y2k:A (THR86) to (VAL202) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH 3,5- DIMETHYL-1-(3-NITRO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER | PHOSPHODIESTERASE, PDE, PDE4D, PYRAZOLE, HYDROLASE
1y2k:B (THR86) to (VAL202) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH 3,5- DIMETHYL-1-(3-NITRO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER | PHOSPHODIESTERASE, PDE, PDE4D, PYRAZOLE, HYDROLASE
1mkd:A (GLU186) to (ILE296) CRYSTAL STRUCTURE OF PDE4D CATALYTIC DOMAIN AND ZARDAVERINE COMPLEX | PDE, ZARDAVERINE, HYDROLASE
1mkd:B (GLU186) to (ILE296) CRYSTAL STRUCTURE OF PDE4D CATALYTIC DOMAIN AND ZARDAVERINE COMPLEX | PDE, ZARDAVERINE, HYDROLASE
1mkd:C (GLU186) to (ILE296) CRYSTAL STRUCTURE OF PDE4D CATALYTIC DOMAIN AND ZARDAVERINE COMPLEX | PDE, ZARDAVERINE, HYDROLASE
1mkd:D (GLU186) to (ILE296) CRYSTAL STRUCTURE OF PDE4D CATALYTIC DOMAIN AND ZARDAVERINE COMPLEX | PDE, ZARDAVERINE, HYDROLASE
1mkd:E (GLU186) to (ILE296) CRYSTAL STRUCTURE OF PDE4D CATALYTIC DOMAIN AND ZARDAVERINE COMPLEX | PDE, ZARDAVERINE, HYDROLASE
1mkd:F (GLU186) to (ILE296) CRYSTAL STRUCTURE OF PDE4D CATALYTIC DOMAIN AND ZARDAVERINE COMPLEX | PDE, ZARDAVERINE, HYDROLASE
1mkd:G (GLU186) to (ILE296) CRYSTAL STRUCTURE OF PDE4D CATALYTIC DOMAIN AND ZARDAVERINE COMPLEX | PDE, ZARDAVERINE, HYDROLASE
1mkd:H (GLU186) to (ILE296) CRYSTAL STRUCTURE OF PDE4D CATALYTIC DOMAIN AND ZARDAVERINE COMPLEX | PDE, ZARDAVERINE, HYDROLASE
1mkd:I (GLU186) to (ILE296) CRYSTAL STRUCTURE OF PDE4D CATALYTIC DOMAIN AND ZARDAVERINE COMPLEX | PDE, ZARDAVERINE, HYDROLASE
1mkd:J (GLU186) to (ILE296) CRYSTAL STRUCTURE OF PDE4D CATALYTIC DOMAIN AND ZARDAVERINE COMPLEX | PDE, ZARDAVERINE, HYDROLASE
1mkd:K (GLU186) to (ILE296) CRYSTAL STRUCTURE OF PDE4D CATALYTIC DOMAIN AND ZARDAVERINE COMPLEX | PDE, ZARDAVERINE, HYDROLASE
1mkd:L (GLU186) to (ILE296) CRYSTAL STRUCTURE OF PDE4D CATALYTIC DOMAIN AND ZARDAVERINE COMPLEX | PDE, ZARDAVERINE, HYDROLASE
3o56:A (ASN159) to (VAL276) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B IN COMPLEX WITH A 5- HETEROCYCLE PYRAZOLOPYRIDINE INHIBITOR | PDE, HYDROLASE, PHOSPHODIESTERASE, CAMP BINDING, HYDROLASE-HYDROLASE INHIBITOR COMPLEX