4wcu:A (ASN209) to (SER320) PDE4 COMPLEXED WITH INHIBITOR | INHIBITOR, COMPLEX, PDE4D, HYDROLASE
4wcu:B (ASN209) to (LEU319) PDE4 COMPLEXED WITH INHIBITOR | INHIBITOR, COMPLEX, PDE4D, HYDROLASE
4wcu:C (ASN209) to (LEU319) PDE4 COMPLEXED WITH INHIBITOR | INHIBITOR, COMPLEX, PDE4D, HYDROLASE
4wcu:D (ASN209) to (LEU319) PDE4 COMPLEXED WITH INHIBITOR | INHIBITOR, COMPLEX, PDE4D, HYDROLASE
3ecm:A (ASN605) to (LEU708) CRYSTAL STRUCTURE OF THE UNLIGANDED PDE8A CATALYTIC DOMAIN | PHOSPHODIESTERASE 8A PDE8A INHIBITOR SELECTIVITY, ALTERNATIVE SPLICING, CAMP, HYDROLASE, MAGNESIUM, MANGANESE, METAL-BINDING
4wn1:B (SER571) to (LYS680) CRYSTAL STRUCTURE OF PDE10A IN COMPLEX WITH 1-METHYL-5-(1-METHYL-3- {[4-(QUINOLIN-2-YL)PHENOXY]METHYL}-1H-PYRAZOL-4-YL)PYRIDIN-2(1H)-ONE | PHOSPHODIESTERASE, COMPLEX, INHIBITOR
2oun:B (SER571) to (CYS676) CRYSTAL STRUCTURE OF PDE10A2 IN COMPLEX WITH AMP | PDE, PRODUCT BINDING, HYDROLASE
2ouq:A (SER571) to (CYS676) CRYSTAL STRUCTURE OF PDE10A2 IN COMPLEX WITH GMP | PDE, GMP COMPLEX, HYDROLASE
2ouv:B (SER571) to (CYS676) CRYSTAL STRUCTURE OF PDE10A2 MUTANT OF D564N | PDE, HYDROLASE
4x0f:A (SER454) to (LEU565) CRYSTAL STRUCTURE OF CROSSLINK STABILIZED LONG-FORM PDE4B IN COMPLEX WITH (R)-(-)-ROLIPRAM | PHOSPHODIESTERASE, INHIBITOR, COMPLEX, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4x0f:B (SER454) to (LEU565) CRYSTAL STRUCTURE OF CROSSLINK STABILIZED LONG-FORM PDE4B IN COMPLEX WITH (R)-(-)-ROLIPRAM | PHOSPHODIESTERASE, INHIBITOR, COMPLEX, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4htx:A (ASN704) to (GLU785) CRYSTAL STRUCTURE OF PDE2 CATALYTIC DOMAIN IN COMPLEX WITH BAY60-7550 | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4htz:A (ASN704) to (GLU785) CRYSTAL STRUCTURE OF PDE2 CATALYTIC DOMAIN IN SPACE GROUP P1 | HYDROLASE
4htz:B (ASN704) to (GLU785) CRYSTAL STRUCTURE OF PDE2 CATALYTIC DOMAIN IN SPACE GROUP P1 | HYDROLASE
3sl3:A (SER208) to (LEU319) CRYSTAL STRUCTURE OF THE APO FORM OF THE CATALYTIC DOMAIN OF PDE4D2 | CATALYTIC MECHANISM, CAMP HYDROLYSIS, HYDROLASE
3sl3:B (ASN209) to (SER320) CRYSTAL STRUCTURE OF THE APO FORM OF THE CATALYTIC DOMAIN OF PDE4D2 | CATALYTIC MECHANISM, CAMP HYDROLYSIS, HYDROLASE
3sl3:C (SER208) to (LEU319) CRYSTAL STRUCTURE OF THE APO FORM OF THE CATALYTIC DOMAIN OF PDE4D2 | CATALYTIC MECHANISM, CAMP HYDROLYSIS, HYDROLASE
3sl3:D (ASN209) to (LEU319) CRYSTAL STRUCTURE OF THE APO FORM OF THE CATALYTIC DOMAIN OF PDE4D2 | CATALYTIC MECHANISM, CAMP HYDROLYSIS, HYDROLASE
3sl4:A (SER208) to (LEU319) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH COMPOUND 10D | CATALYTIC MECHANISM, CAMP HYDROLYSIS, HYDROLASE-INHIBITOR COMPLEX
3sl4:B (ASN209) to (LEU319) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH COMPOUND 10D | CATALYTIC MECHANISM, CAMP HYDROLYSIS, HYDROLASE-INHIBITOR COMPLEX
3sl4:C (ASN209) to (LEU319) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH COMPOUND 10D | CATALYTIC MECHANISM, CAMP HYDROLYSIS, HYDROLASE-INHIBITOR COMPLEX
3sl4:D (SER208) to (LEU319) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH COMPOUND 10D | CATALYTIC MECHANISM, CAMP HYDROLYSIS, HYDROLASE-INHIBITOR COMPLEX
3sl5:A (SER208) to (LEU319) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 COMPLEXED WITH COMPOUND 10D | CATALYTIC MECHANISM, CAMP HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3sl5:C (ASN209) to (LEU319) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 COMPLEXED WITH COMPOUND 10D | CATALYTIC MECHANISM, CAMP HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3sl5:D (SER208) to (LEU319) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 COMPLEXED WITH COMPOUND 10D | CATALYTIC MECHANISM, CAMP HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3sl6:A (SER208) to (LEU319) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH COMPOUND 12C | CATALYTIC DOMAIN, CAMP HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3sl6:B (SER208) to (LEU319) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH COMPOUND 12C | CATALYTIC DOMAIN, CAMP HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3sl6:C (SER208) to (LEU319) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH COMPOUND 12C | CATALYTIC DOMAIN, CAMP HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3sl6:D (SER208) to (LEU319) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH COMPOUND 12C | CATALYTIC DOMAIN, CAMP HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1oyn:B (ASN209) to (LEU319) CRYSTAL STRUCTURE OF PDE4D2 IN COMPLEX WITH (R,S)-ROLIPRAM | PDE, CAMP, ROLIPRAM, HYDROLASE
1oyn:C (ASN209) to (LEU319) CRYSTAL STRUCTURE OF PDE4D2 IN COMPLEX WITH (R,S)-ROLIPRAM | PDE, CAMP, ROLIPRAM, HYDROLASE
1oyn:D (ASN209) to (LEU319) CRYSTAL STRUCTURE OF PDE4D2 IN COMPLEX WITH (R,S)-ROLIPRAM | PDE, CAMP, ROLIPRAM, HYDROLASE
2chm:A (SER661) to (LYS770) CRYSTAL STRUCTURE OF N2 SUBSTITUTED PYRAZOLO PYRIMIDINONES- A FLIPPED BINDING MODE IN PDE5 | PHOSPHODIESTERASE 5, INHIBITOR, CHIMERA, ALLOSTERIC ENZYME, ALTERNATIVE SPLICING, CGMP, CGMP-BINDING, HYDROLASE, MAGNESIUM, METAL-BINDING, NUCLEOTIDE-BINDING, PHOSPHORYLATION, ZINC, CAMP
3g4g:A (SER374) to (LEU485) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH REGULATORY DOMAIN AND D155871 | PHOSPHODIESTERASE, PDE4D, UCR2, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
3g4g:C (SER374) to (LEU485) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH REGULATORY DOMAIN AND D155871 | PHOSPHODIESTERASE, PDE4D, UCR2, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
3g4g:D (SER374) to (SER486) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH REGULATORY DOMAIN AND D155871 | PHOSPHODIESTERASE, PDE4D, UCR2, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
3g4i:A (ASN375) to (LEU485) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH D155871 | PHOSPHODIESTERASE, PDE4D, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
3g4i:B (ASN375) to (LEU485) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH D155871 | PHOSPHODIESTERASE, PDE4D, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
3g4i:C (ASN375) to (LEU485) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH D155871 | PHOSPHODIESTERASE, PDE4D, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
3g4i:D (ASN375) to (LEU485) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH D155871 | PHOSPHODIESTERASE, PDE4D, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
3g4k:A (ASN375) to (LEU485) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH ROLIPRAM | PHOSPHODIESTERASE, PDE4D, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
3g4k:B (ASN375) to (LEU485) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH ROLIPRAM | PHOSPHODIESTERASE, PDE4D, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
3g4k:C (ASN375) to (LEU485) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH ROLIPRAM | PHOSPHODIESTERASE, PDE4D, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
3g4k:D (ASN375) to (LEU485) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH ROLIPRAM | PHOSPHODIESTERASE, PDE4D, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
3g4l:A (SER374) to (SER486) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH ROFLUMILAST | PHOSPHODIESTERASE, PDE4D, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
3g4l:B (SER374) to (SER486) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH ROFLUMILAST | PHOSPHODIESTERASE, PDE4D, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
3g4l:C (SER374) to (LEU485) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH ROFLUMILAST | PHOSPHODIESTERASE, PDE4D, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
3g4l:D (ASN375) to (SER486) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH ROFLUMILAST | PHOSPHODIESTERASE, PDE4D, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
3g58:A (ASN375) to (SER486) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH D155988/PMNPQ | PHOSPHODIESTERASE, PDE4D, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
3g58:B (ASN375) to (LEU485) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH D155988/PMNPQ | PHOSPHODIESTERASE, PDE4D, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
3g58:D (ASN375) to (LEU485) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH D155988/PMNPQ | PHOSPHODIESTERASE, PDE4D, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL- BINDING, PHOSPHOPROTEIN
1ptw:C (ASN209) to (SER320) THE CRYSTAL STRUCTURE OF AMP-BOUND PDE4 SUGGESTS A MECHANISM FOR PHOSPHODIESTERASE CATALYSIS | CATALYTIC MECHANISM, CAMP HYDROLYSIS CRYSTAL STRUCTURE, BINUCLEAR CATALYSIS, HYDROLASE
1ptw:D (ASN209) to (SER320) THE CRYSTAL STRUCTURE OF AMP-BOUND PDE4 SUGGESTS A MECHANISM FOR PHOSPHODIESTERASE CATALYSIS | CATALYTIC MECHANISM, CAMP HYDROLYSIS CRYSTAL STRUCTURE, BINUCLEAR CATALYSIS, HYDROLASE
2qyk:A (ASN421) to (LEU531) CRYSTAL STRUCTURE OF PDE4A10 IN COMPLEX WITH INHIBITOR NPV | PDE4 INHIBITOR, SUBFAMILY INHIBITOR SELECTIVITY, HYDROLASE
2qyk:B (ASN421) to (LEU531) CRYSTAL STRUCTURE OF PDE4A10 IN COMPLEX WITH INHIBITOR NPV | PDE4 INHIBITOR, SUBFAMILY INHIBITOR SELECTIVITY, HYDROLASE
2qyl:A (ASN283) to (LEU393) CRYSTAL STRUCTURE OF PDE4B2B IN COMPLEX WITH INHIBITOR NPV | PDE4B STRUCTURE, SELECTIVE INHIBITOR NVP, HYDROLASE
2qyn:A (SER208) to (LEU319) CRYSTAL STRUCTURE OF PDE4D2 IN COMPLEX WITH INHIBITOR NPV | PDE4D SELECTIVE INHIBITOR NVP, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL-BINDING, PHOSPHORYLATION
2qyn:B (SER208) to (LEU319) CRYSTAL STRUCTURE OF PDE4D2 IN COMPLEX WITH INHIBITOR NPV | PDE4D SELECTIVE INHIBITOR NVP, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL-BINDING, PHOSPHORYLATION
4y86:B (ASN300) to (ASP402) CRYSTAL STRUCTURE OF PDE9 IN COMPLEX WITH RACEMIC INHIBITOR C33 | PHOSPHODIESTERASE 9A, INHIBITOR SELECTIVITY POCKET, PHARMACOKINETICS, ENANTIOMERIC DIFFERENTIATION, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4y87:B (ASN300) to (ASP402) CRYSTAL STRUCTURE OF PHOSPHODIESTERASE 9 IN COMPLEX WITH (R)-C33 (6- {[(1R)-1-(4-CHLOROPHENYL)ETHYL]AMINO}-1-CYCLOPENTYL-1,5-DIHYDRO-4H- PYRAZOLO[3,4-D]PYRIMIDIN-4-ONE) | PHOSPHODIESTERASE 9A, INHIBITOR SELECTIVITY POCKET, PHARMACOKINETICS, ENANTIOMERIC DIFFERENTIATION, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4y8c:A (ASN300) to (ASP402) CRYSTAL STRUCTURE OF PHOSPHODIESTERASE 9 IN COMPLEX WITH (S)-C33 | PHOSPHODIESTERASE 9A, INHIBITOR SELECTIVITY POCKET, PHARMACOKINETICS, ENANTIOMERIC DIFFERENTIATION, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4y8c:B (ASN300) to (ASP402) CRYSTAL STRUCTURE OF PHOSPHODIESTERASE 9 IN COMPLEX WITH (S)-C33 | PHOSPHODIESTERASE 9A, INHIBITOR SELECTIVITY POCKET, PHARMACOKINETICS, ENANTIOMERIC DIFFERENTIATION, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2r8q:A (ASN729) to (VAL836) STRUCTURE OF LMJPDEB1 IN COMPLEX WITH IBMX | LEISHIMANIASIS, PARASITE INHIBITOR SELECTIVITY, CAMP PHOSPHODIESTERASE, HYDROLASE
2r8q:B (ASN729) to (VAL836) STRUCTURE OF LMJPDEB1 IN COMPLEX WITH IBMX | LEISHIMANIASIS, PARASITE INHIBITOR SELECTIVITY, CAMP PHOSPHODIESTERASE, HYDROLASE
1q9m:A (ASN209) to (SER320) THREE DIMENSIONAL STRUCTURES OF PDE4D IN COMPLEX WITH ROLIPRAMS AND IMPLICATION ON INHIBITOR SELECTIVITY | PDE, ROLIPRAM, SPECIFIC INHIBITOR, HYDROLASE
1q9m:B (ASN209) to (THR289) THREE DIMENSIONAL STRUCTURES OF PDE4D IN COMPLEX WITH ROLIPRAMS AND IMPLICATION ON INHIBITOR SELECTIVITY | PDE, ROLIPRAM, SPECIFIC INHIBITOR, HYDROLASE
1q9m:C (ASN209) to (LEU319) THREE DIMENSIONAL STRUCTURES OF PDE4D IN COMPLEX WITH ROLIPRAMS AND IMPLICATION ON INHIBITOR SELECTIVITY | PDE, ROLIPRAM, SPECIFIC INHIBITOR, HYDROLASE
1q9m:D (ASN209) to (LEU319) THREE DIMENSIONAL STRUCTURES OF PDE4D IN COMPLEX WITH ROLIPRAMS AND IMPLICATION ON INHIBITOR SELECTIVITY | PDE, ROLIPRAM, SPECIFIC INHIBITOR, HYDROLASE
3tvx:B (GLN422) to (LEU531) THE STRUCTURE OF PDE4A WITH PENTOXIFYLLINE AT 2.84A RESOLUTION | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1ro6:B (ASN283) to (SER394) CRYSTAL STRUCTURE OF PDE4B2B COMPLEXED WITH ROLIPRAM (R & S) | PDE, ROLIPRAM, CRYSTAL, HYDROLASE
1ro9:A (ASN283) to (LEU393) CRYSTAL STRUCTURES OF THE CATALYTIC DOMAIN OF PHOSPHODIESTERASE 4B2B COMPLEXED WITH 8-BR-AMP | PDE, 8-BR-AMP, HYDROLASE
3hmv:B (SER282) to (LEU393) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B IN COMPLEX WITH A TETRAHYDROBENZOTHIOPHENE INHIBITOR | PDE, PHOSPHODIESTERASE, CAMP, ALTERNATIVE SPLICING, HYDROLASE, PHOSPHOPROTEIN, POLYMORPHISM
2fm0:A (ASN209) to (LEU319) CRYSTAL STRUCTURE OF PDE4D IN COMPLEX WITH L-869298 | PDE. ENANTIOMER BINDING, INHIBITOR SELECTIVITY, CAMP SIGNALLING, CRYSTAL STRUCTURE, HYDROLASE
2fm0:B (ASN209) to (LEU319) CRYSTAL STRUCTURE OF PDE4D IN COMPLEX WITH L-869298 | PDE. ENANTIOMER BINDING, INHIBITOR SELECTIVITY, CAMP SIGNALLING, CRYSTAL STRUCTURE, HYDROLASE
2fm0:C (ASN209) to (LEU319) CRYSTAL STRUCTURE OF PDE4D IN COMPLEX WITH L-869298 | PDE. ENANTIOMER BINDING, INHIBITOR SELECTIVITY, CAMP SIGNALLING, CRYSTAL STRUCTURE, HYDROLASE
2fm0:D (ASN209) to (LEU319) CRYSTAL STRUCTURE OF PDE4D IN COMPLEX WITH L-869298 | PDE. ENANTIOMER BINDING, INHIBITOR SELECTIVITY, CAMP SIGNALLING, CRYSTAL STRUCTURE, HYDROLASE
2fm5:A (ASN209) to (LEU319) CRYSTAL STRUCTURE OF PDE4D2 IN COMPLEX WITH INHIBITOR L- 869299 | PDE4, CRYSTAL STRUCTURE, INHIBITOR SELECTIVITY, L-869299, ENANTIOMER BINDING, CAMP SIGNAL, HYDROLASE
2fm5:B (ASN209) to (LYS290) CRYSTAL STRUCTURE OF PDE4D2 IN COMPLEX WITH INHIBITOR L- 869299 | PDE4, CRYSTAL STRUCTURE, INHIBITOR SELECTIVITY, L-869299, ENANTIOMER BINDING, CAMP SIGNAL, HYDROLASE
2fm5:C (ASN209) to (LEU319) CRYSTAL STRUCTURE OF PDE4D2 IN COMPLEX WITH INHIBITOR L- 869299 | PDE4, CRYSTAL STRUCTURE, INHIBITOR SELECTIVITY, L-869299, ENANTIOMER BINDING, CAMP SIGNAL, HYDROLASE
2fm5:D (ASN209) to (LEU319) CRYSTAL STRUCTURE OF PDE4D2 IN COMPLEX WITH INHIBITOR L- 869299 | PDE4, CRYSTAL STRUCTURE, INHIBITOR SELECTIVITY, L-869299, ENANTIOMER BINDING, CAMP SIGNAL, HYDROLASE
4kp6:A (SER282) to (LEU393) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4B (PDE4B) IN COMPLEX WITH A [1,3,5]TRIAZINE DERIVATIVE | PDE4 INHIBITOR, PHOSPHODIESTERASE, TRIAZINE, NEUTROPHILIA, COPD, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3v9b:A (SER208) to (LEU319) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH (S)-N-(3-{1- [1-(3-CYCLOPROPYLMETHOXY-4-DIFLUOROMETHOXYPHENYL)-2-(1-OXYPYRIDIN-4- YL)-ETHYL]-1H-PYRAZL-3-YL}PHENYL)ACETAMIDE | HYDROLASE, 3',5'-CYCLIC-AMP PHOSPHODIESTERASES, CYCLIC NUCLEOTIDE, PHOSPHODIESTERASES, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3v9b:B (ASN209) to (SER320) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH (S)-N-(3-{1- [1-(3-CYCLOPROPYLMETHOXY-4-DIFLUOROMETHOXYPHENYL)-2-(1-OXYPYRIDIN-4- YL)-ETHYL]-1H-PYRAZL-3-YL}PHENYL)ACETAMIDE | HYDROLASE, 3',5'-CYCLIC-AMP PHOSPHODIESTERASES, CYCLIC NUCLEOTIDE, PHOSPHODIESTERASES, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3v9b:C (ASN209) to (LEU319) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH (S)-N-(3-{1- [1-(3-CYCLOPROPYLMETHOXY-4-DIFLUOROMETHOXYPHENYL)-2-(1-OXYPYRIDIN-4- YL)-ETHYL]-1H-PYRAZL-3-YL}PHENYL)ACETAMIDE | HYDROLASE, 3',5'-CYCLIC-AMP PHOSPHODIESTERASES, CYCLIC NUCLEOTIDE, PHOSPHODIESTERASES, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3v9b:D (SER208) to (LEU319) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH (S)-N-(3-{1- [1-(3-CYCLOPROPYLMETHOXY-4-DIFLUOROMETHOXYPHENYL)-2-(1-OXYPYRIDIN-4- YL)-ETHYL]-1H-PYRAZL-3-YL}PHENYL)ACETAMIDE | HYDROLASE, 3',5'-CYCLIC-AMP PHOSPHODIESTERASES, CYCLIC NUCLEOTIDE, PHOSPHODIESTERASES, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1so2:A (THR829) to (ASN939) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 3B IN COMPLEX WITH A DIHYDROPYRIDAZINE INHIBITOR | PDE3B PHOSPHODIESTERASE, HYDROLASE
1so2:B (THR829) to (ASP937) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 3B IN COMPLEX WITH A DIHYDROPYRIDAZINE INHIBITOR | PDE3B PHOSPHODIESTERASE, HYDROLASE
3i8v:A (ASN421) to (SER532) CRYSTAL STRUCTURE OF HUMAN PDE4A WITH 4-(3-BUTOXY-4-METHOXYPHENYL) METHYL-2-IMIDAZOLIDONE | CYCLIC-AMP SPECIFIC, CAMP, HYDROLASE, MEMBRANE, PHOSPHOPROTEIN
3i8v:B (ASN421) to (LEU531) CRYSTAL STRUCTURE OF HUMAN PDE4A WITH 4-(3-BUTOXY-4-METHOXYPHENYL) METHYL-2-IMIDAZOLIDONE | CYCLIC-AMP SPECIFIC, CAMP, HYDROLASE, MEMBRANE, PHOSPHOPROTEIN
3iad:A (SER374) to (SER486) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH BOUND ALLOSTERIC MODULATOR | PDE4D, ALLOSTERIC MODULATORY, INHIBITOR, UCR2, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL-BINDING, PHOSPHOPROTEIN
3iad:B (ASN375) to (SER486) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH BOUND ALLOSTERIC MODULATOR | PDE4D, ALLOSTERIC MODULATORY, INHIBITOR, UCR2, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL-BINDING, PHOSPHOPROTEIN
3iad:D (SER374) to (SER486) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D WITH BOUND ALLOSTERIC MODULATOR | PDE4D, ALLOSTERIC MODULATORY, INHIBITOR, UCR2, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL-BINDING, PHOSPHOPROTEIN
3iak:A (SER208) to (LEU319) CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D (PDE4D) WITH PAPAVERINE. | CAMP-SPECIFIC, ALTERNATIVE SPLICING, CAMP, CYTOPLASM, CYTOSKELETON, HYDROLASE, MEMBRANE, METAL-BINDING, PHOSPHOPROTEIN
1tb5:A (SER282) to (THR363) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH AMP | PDE4B, HYDROLASE
1tb5:B (SER282) to (LEU393) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH AMP | PDE4B, HYDROLASE
1tb7:A (SER208) to (LEU319) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH AMP | PDE4D, HYDROLASE
1tb7:B (SER208) to (THR289) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH AMP | PDE4D, HYDROLASE
1tbb:A (SER208) to (LEU319) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH ROLIPRAM | PDE4D, HYDROLASE
1tbb:B (SER208) to (LEU319) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH ROLIPRAM | PDE4D, HYDROLASE
3itu:C (ASN704) to (GLY787) HPDE2A CATALYTIC DOMAIN COMPLEXED WITH IBMX | ZN-BINDING, ALL-ALPHA-HELICAL, ALTERNATIVE SPLICING, CGMP, HYDROLASE, MEMBRANE, POLYMORPHISM
2hd1:A (ASN300) to (SER404) CRYSTAL STRUCTURE OF PDE9 IN COMPLEX WITH IBMX | CGMP, PDE9, IBMX, HYDROLASE
2hd1:B (ASN300) to (SER404) CRYSTAL STRUCTURE OF PDE9 IN COMPLEX WITH IBMX | CGMP, PDE9, IBMX, HYDROLASE
4lkq:B (SER571) to (CYS676) CRYSTAL STRUCTURE OF PDE10A2 WITH FRAGMENT ZT017 | FRAGMENT SCREENING, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4lm4:B (SER571) to (CYS676) CRYSTAL STRUCTURE OF PDE10A2 WITH FRAGMENT ZT902 | FRAGMENT SCREENING, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3w5e:A (ASN283) to (LEU393) CRYSTAL STRUCTURE OF PHOSPHODIESTERASE 4B IN COMPLEX WITH COMPOUND 31E | PHOSPHODIESTERASE, COPD, INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3w5e:B (ASN283) to (LEU393) CRYSTAL STRUCTURE OF PHOSPHODIESTERASE 4B IN COMPLEX WITH COMPOUND 31E | PHOSPHODIESTERASE, COPD, INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3wd9:A (ASN283) to (LEU393) CRYSTAL STRUCTURE OF PHOSPHODIESTERASE 4B IN COMPLEX WITH COMPOUND 10F | PHOSPHODIESTERASE, COPD, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3wd9:B (SER282) to (SER394) CRYSTAL STRUCTURE OF PHOSPHODIESTERASE 4B IN COMPLEX WITH COMPOUND 10F | PHOSPHODIESTERASE, COPD, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3wi2:A (SER571) to (CYS676) CRYSTAL STRUCTURE OF PDE10A IN COMPLEX WITH INHIBITOR | PHOSPHODIESTERASE, CGMP BINDING, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3wi2:B (SER571) to (CYS676) CRYSTAL STRUCTURE OF PDE10A IN COMPLEX WITH INHIBITOR | PHOSPHODIESTERASE, CGMP BINDING, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4mrz:B (SER571) to (CYS676) CRYSTAL STRUCTURE OF PDE10A2 WITH FRAGMENT ZT0429 (4-METHYL-3- NITROPYRIDIN-2-AMINE) | FRAGMENT SCREENING, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4msa:B (SER571) to (CYS676) CRYSTAL STRUCTURE OF PDE10A2 WITH FRAGMENT ZT0449 (5-NITRO-1H- BENZIMIDAZOLE) | FRAGMENT SCREENING, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4mse:B (ASN572) to (LEU675) CRYSTAL STRUCTURE OF PDE10A2 WITH FRAGMENT ZT1597 (2-({[(2S)-2-METHYL- 2,3-DIHYDRO-1,3-BENZOTHIAZOL-5-YL]OXY}METHYL)QUINOLINE) | FRAGMENT SCREENING, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4myq:A (SER454) to (LEU565) SELECTIVE INHIBITION OF THE CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B WITH A-33 | PHOSPHODIESTERASE, CATALYTIC, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5b25:B (THR271) to (SER372) CRYSTAL STRUCTURE OF HUMAN PDE1B WITH INHIBITOR 3 | HYDROLASE, INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5b25:D (THR271) to (SER372) CRYSTAL STRUCTURE OF HUMAN PDE1B WITH INHIBITOR 3 | HYDROLASE, INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4nw7:A (SER454) to (LEU565) PDE4 CATALYTIC DOMAIN | PHOSPHODIESTERASE, PDE4, CATALYTIC, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3jsi:A (ASN300) to (ASP402) HUMAN PHOSPHODIESTERASE 9 IN COMPLEX WITH INHIBITOR | PHOSPHODIESTERASE, INHIBITOR, ALTERNATIVE SPLICING, CGMP, HYDROLASE, MANGANESE, METAL-BINDING, PHOSPHOPROTEIN
3jsi:B (ASN300) to (ASP402) HUMAN PHOSPHODIESTERASE 9 IN COMPLEX WITH INHIBITOR | PHOSPHODIESTERASE, INHIBITOR, ALTERNATIVE SPLICING, CGMP, HYDROLASE, MANGANESE, METAL-BINDING, PHOSPHOPROTEIN
3jsw:A (ASN300) to (ASP402) HUMAN PDE9 IN COMPLEX WITH SELECTIVE INHIBITOR | PHOSPHODIESTERASE, CGMP, HYDROLASE, MANGANESE, METAL-BINDING, PHOSPHOPROTEIN
3jsw:B (ASN300) to (SER404) HUMAN PDE9 IN COMPLEX WITH SELECTIVE INHIBITOR | PHOSPHODIESTERASE, CGMP, HYDROLASE, MANGANESE, METAL-BINDING, PHOSPHOPROTEIN
4ogb:A (SER208) to (LEU319) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH COMPOUND 2 | CATALYTIC MECHANISM, CAMP HYDROLYSIS, HYDROLASE-INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4ogb:B (ASN209) to (SER320) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH COMPOUND 2 | CATALYTIC MECHANISM, CAMP HYDROLYSIS, HYDROLASE-INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4ogb:D (ASN209) to (LEU319) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH COMPOUND 2 | CATALYTIC MECHANISM, CAMP HYDROLYSIS, HYDROLASE-INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3k3e:B (ASN300) to (ASP402) CRYSTAL STRUCTURE OF THE PDE9A CATALYTIC DOMAIN IN COMPLEX WITH (R)- BAY73-6691 | PDE9, CATALYTIC DOMAIN, CGMP, HYDROLASE, MANGANESE, METAL-BINDING, PHOSPHOPROTEIN
3k3h:A (ASN301) to (GLU380) CRYSTAL STRUCTURE OF THE PDE9A CATALYTIC DOMAIN IN COMPLEX WITH (S)- BAY73-6691 | PDE9, CATALYTIC DOMAIN, CGMP, HYDROLASE, MANGANESE, METAL-BINDING, PHOSPHOPROTEIN
3k3h:B (ASN300) to (ILE403) CRYSTAL STRUCTURE OF THE PDE9A CATALYTIC DOMAIN IN COMPLEX WITH (S)- BAY73-6691 | PDE9, CATALYTIC DOMAIN, CGMP, HYDROLASE, MANGANESE, METAL-BINDING, PHOSPHOPROTEIN
1xlx:A (SER282) to (LEU393) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH CILOMILAST | PDE4B, CILOMILAST, HYDROLASE
1xlz:A (SER282) to (LEU393) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH FILAMINAST | PDE4B, FILAMINAST, HYDROLASE
1xm6:A (SER282) to (LEU393) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH (R)- MESOPRAM | PDE4B, (R)-MESOPRAM, HYDROLASE
1xn0:A (SER282) to (LEU393) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH (R,S)- ROLIPRAM | PHOSPHODIESTERASE, PDE, PDE4B, ROLIPRAM, (R,S)-ROLIPRAM, HYDROLASE
1xn0:B (SER282) to (LEU393) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH (R,S)- ROLIPRAM | PHOSPHODIESTERASE, PDE, PDE4B, ROLIPRAM, (R,S)-ROLIPRAM, HYDROLASE
1xom:A (SER208) to (LEU319) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH CILOMILAST | PHOSPHODIESTERASE, PDE, PDE4D, CILOMILAST, HYDROLASE
1xom:B (SER208) to (THR289) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH CILOMILAST | PHOSPHODIESTERASE, PDE, PDE4D, CILOMILAST, HYDROLASE
1xon:A (SER208) to (SER320) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH PICLAMILAST | PHOSPHODIESTERASE, PDE, PDE4D, PICLAMILAST, HYDROLASE
1xon:B (SER208) to (SER320) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH PICLAMILAST | PHOSPHODIESTERASE, PDE, PDE4D, PICLAMILAST, HYDROLASE
1xoq:A (SER208) to (LEU319) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH ROFLUMILAST | PHOSPHODIESTERASE, PDE, PDE4D, ROFLUMILAST, HYDROLASE
1xoq:B (SER208) to (SER320) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH ROFLUMILAST | PHOSPHODIESTERASE, PDE, PDE4D, ROFLUMILAST, HYDROLASE
3kkt:B (ASN283) to (LEU393) CRYSTAL STRUCTURE OF HUMAN PDE4B WITH 5-[3-[(1S,2S,4R)- BICYCLO[2.2.1]HEPT-2-YLOXY]-4-METHOXYP HENYL]TETRAHYDRO-2(1H)- PYRIMIDINONE REVEALS ORDERING OF THE C-TERMINAL HELIX RESIDUES 502- 509. | PHOSPHODIESTERASE, ALTERNATIVE SPLICING,HYDROLASE, PHOSPHOPROTEIN, HYDROLASE
1y2b:A (SER208) to (LEU319) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH 3,5- DIMETHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER | PHOSPHODIESTERASE, PDE, PDE4D, PYRAZOLE, HYDROLASE
1y2c:A (SER208) to (LEU319) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH 3,5- DIMETHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER | PHOSPHODIESTERASE, PDE, PDE4D, PYRAZOLE, HYDROLASE
1y2c:B (SER208) to (SER320) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH 3,5- DIMETHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER | PHOSPHODIESTERASE, PDE, PDE4D, PYRAZOLE, HYDROLASE
1y2d:A (SER208) to (LEU319) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH 1-(4- METHOXY-PHENYL)-3,5-DIMETHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER | PHOSPHODIESTERASE, PDE, PDE4D, PYRAZOLE, HYDROLASE
1y2d:B (SER208) to (LEU319) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH 1-(4- METHOXY-PHENYL)-3,5-DIMETHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER | PHOSPHODIESTERASE, PDE, PDE4D, PYRAZOLE, HYDROLASE
1y2e:A (SER208) to (SER320) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH 1-(4- AMINO-PHENYL)-3,5-DIMETHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER | PHOSPHODIESTERASE, PDE, PDE4D, PYRAZOLE, HYDROLASE
1y2e:B (SER208) to (SER320) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH 1-(4- AMINO-PHENYL)-3,5-DIMETHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER | PHOSPHODIESTERASE, PDE, PDE4D, PYRAZOLE, HYDROLASE
4phl:A (ASN718) to (ILE823) TBRPDEB1-INHIBITOR COMPLEX | PHOSPHODIESTERASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4phl:B (ASN718) to (ILE823) TBRPDEB1-INHIBITOR COMPLEX | PHOSPHODIESTERASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1z1l:A (ASN704) to (GLU785) THE CRYSTAL STRUCTURE OF THE PHOSPHODIESTERASE 2A CATALYTIC DOMAIN | PDE 2A, CRYSTAL STRUCTURE, PHOSPHODIESTERASE, HYDROLASE
1zkn:A (ASN209) to (LEU319) STRUCTURE OF PDE4D2-IBMX | PROTEIN-INHIBITOR COMPLEX, INHIBITOR SELECTIVITY, HYDROLASE
1zkn:C (ASN209) to (LEU319) STRUCTURE OF PDE4D2-IBMX | PROTEIN-INHIBITOR COMPLEX, INHIBITOR SELECTIVITY, HYDROLASE
1zkn:D (ASN209) to (SER320) STRUCTURE OF PDE4D2-IBMX | PROTEIN-INHIBITOR COMPLEX, INHIBITOR SELECTIVITY, HYDROLASE
3ly2:A (ASN283) to (LEU393) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH A COUMARIN-BASED INHIBITOR | PDE4B, COUMARIN, INHIBITOR, HYDROLASE, METAL-BINDING, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
3ly2:B (ASN283) to (GLU362) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH A COUMARIN-BASED INHIBITOR | PDE4B, COUMARIN, INHIBITOR, HYDROLASE, METAL-BINDING, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
4qge:A (ASN300) to (ASP402) PHOSPHODIESTERASE-9A IN COMPLEX WITH INHIBITOR WYQ-C36D | PDE9 CATALYTIC DOMAIN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4qge:B (ASN301) to (ILE403) PHOSPHODIESTERASE-9A IN COMPLEX WITH INHIBITOR WYQ-C36D | PDE9 CATALYTIC DOMAIN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3n3z:A (ASN301) to (ASP402) CRYSTAL STRUCTURE OF PDE9A (E406A) MUTANT IN COMPLEX WITH IBMX | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3n3z:B (ASN300) to (ASP402) CRYSTAL STRUCTURE OF PDE9A (E406A) MUTANT IN COMPLEX WITH IBMX | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3o0j:A (SER282) to (LEU393) PDE4B IN COMPLEX WITH LIGAND AN2898 | PHOSPHODIESTERASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3o57:A (SER282) to (LEU393) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B IN COMPLEX WITH A 5- HETEROCYCLE PYRAZOLOPYRIDINE INHIBITOR | PDE, HYDROLASE, PHOSPHODIESTERASE, CAMP BINDING, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4tpp:A (ASN562) to (CYS666) 2-(3-ALKOXY-1-AZETIDINYL) QUINOLINES AS NOVEL PDE10A INHIBITORS | PHOSPHODIESTERASE 10A, QUINOLINES, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3dy8:A (ASN300) to (SER404) HUMAN PHOSPHODIESTERASE 9 IN COMPLEX WITH PRODUCT 5'-GMP (E+P COMPLEX) | PHOSPHODIESTRASE, ENZYME MECHANISM, CGMP, HYDROLASE, MANGANESE, METAL-BINDING, PHOSPHOPROTEIN
3dy8:B (ASN300) to (SER404) HUMAN PHOSPHODIESTERASE 9 IN COMPLEX WITH PRODUCT 5'-GMP (E+P COMPLEX) | PHOSPHODIESTRASE, ENZYME MECHANISM, CGMP, HYDROLASE, MANGANESE, METAL-BINDING, PHOSPHOPROTEIN
3dyn:B (ASN300) to (SER404) HUMAN PHOSPHODIESTRASE 9 IN COMPLEX WITH CGMP (ZN INHIBITED) | PHOPHODIESTRASE, ENZYME MECHANISM, CGMP, HYDROLASE, MANGANESE, METAL- BINDING, PHOSPHOPROTEIN
3dyq:A (ASN300) to (SER404) HUMAN PHOSPHODIESTRASE 9 (INHIBITED BY OMITTING DIVALENT CATION) IN COMPLEX WITH CGMP | PHOSPHODIESTERASE, ENZYME MECHANISM, CGMP, HYDROLASE, MANGANESE, METAL-BINDING, PHOSPHOPROTEIN
3dyq:B (ASN300) to (SER404) HUMAN PHOSPHODIESTRASE 9 (INHIBITED BY OMITTING DIVALENT CATION) IN COMPLEX WITH CGMP | PHOSPHODIESTERASE, ENZYME MECHANISM, CGMP, HYDROLASE, MANGANESE, METAL-BINDING, PHOSPHOPROTEIN
3dys:A (ASN300) to (ASP402) HUMAN PHOSPHODIESTRASE-5'GMP COMPLEX (EP), PRODUCED BY SOAKING WITH 20MM CGMP+20 MM MNCL2+20 MM MGCL2 FOR 2 HOURS, AND FLASH-COOLED TO LIQUID NITROGEN TEMPERATURE WHEN SUBSTRATE WAS STILL ABUDANT. | PHOSPHODIESTRASE, ENZYME MECHANISM, CGMP, HYDROLASE, MANGANESE, METAL-BINDING, PHOSPHOPROTEIN
3dys:B (ASN300) to (SER404) HUMAN PHOSPHODIESTRASE-5'GMP COMPLEX (EP), PRODUCED BY SOAKING WITH 20MM CGMP+20 MM MNCL2+20 MM MGCL2 FOR 2 HOURS, AND FLASH-COOLED TO LIQUID NITROGEN TEMPERATURE WHEN SUBSTRATE WAS STILL ABUDANT. | PHOSPHODIESTRASE, ENZYME MECHANISM, CGMP, HYDROLASE, MANGANESE, METAL-BINDING, PHOSPHOPROTEIN
4e90:A (ASN300) to (ASP402) HUMAN PHOSPHODIESTERASE 9 IN COMPLEX WITH INHIBITORS | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4e90:B (ASN300) to (ASP402) HUMAN PHOSPHODIESTERASE 9 IN COMPLEX WITH INHIBITORS | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3qi3:B (ASN301) to (SER404) CRYSTAL STRUCTURE OF PDE9A(Q453E) IN COMPLEX WITH INHIBITOR BAY73-6691 | MUTATION, GLUTAMINE SWITCH, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3qi4:A (ASN301) to (ASP402) CRYSTAL STRUCTURE OF PDE9A(Q453E) IN COMPLEX WITH IBMX | PDE, HYDROLASE
3qi4:B (ASN301) to (ILE403) CRYSTAL STRUCTURE OF PDE9A(Q453E) IN COMPLEX WITH IBMX | PDE, HYDROLASE
4w1o:A (ASN209) to (LEU319) PDE4D COMPLEXED WITH INHIBITOR | INHIBITOR, COMPLEX, PDE4D, HYDROLASE
4w1o:B (ASN209) to (LEU319) PDE4D COMPLEXED WITH INHIBITOR | INHIBITOR, COMPLEX, PDE4D, HYDROLASE
4w1o:C (ASN209) to (LEU319) PDE4D COMPLEXED WITH INHIBITOR | INHIBITOR, COMPLEX, PDE4D, HYDROLASE
4w1o:D (ASN209) to (LEU319) PDE4D COMPLEXED WITH INHIBITOR | INHIBITOR, COMPLEX, PDE4D, HYDROLASE
4g2j:A (ASN300) to (ASP402) HUMAN PDE9 IN COMPLEX WITH SELECTIVE COMPOUND | PHOSPHODIESTERASE, INHIBITORS, CGMP->GMP, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4g2j:B (ASN300) to (ASP402) HUMAN PDE9 IN COMPLEX WITH SELECTIVE COMPOUND | PHOSPHODIESTERASE, INHIBITORS, CGMP->GMP, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4g2l:B (ASN300) to (SER404) HUMAN PDE9 IN COMPLEX WITH SELECTIVE COMPOUND | PHOSPHODIESTERASE, INHIBITOR COMPLEX, CGMP->GMP, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4gh6:B (ASN300) to (SER404) CRYSTAL STRUCTURE OF THE PDE9A CATALYTIC DOMAIN IN COMPLEX WITH INHIBITOR 28 | PDE9A,, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3ecn:A (ASN605) to (LEU708) CRYSTAL STRUCTURE OF PDE8A CATALYTIC DOMAIN IN COMPLEX WITH IBMX | IBMX, PDE8A CATALYTIC DOMAIN, REFOLDING, ALTERNATIVE SPLICING, CAMP, HYDROLASE, MAGNESIUM, MANGANESE, METAL- BINDING
3ecn:B (ASN605) to (LEU708) CRYSTAL STRUCTURE OF PDE8A CATALYTIC DOMAIN IN COMPLEX WITH IBMX | IBMX, PDE8A CATALYTIC DOMAIN, REFOLDING, ALTERNATIVE SPLICING, CAMP, HYDROLASE, MAGNESIUM, MANGANESE, METAL- BINDING
2oup:B (SER571) to (CYS676) CRYSTAL STRUCTURE OF PDE10A | PDE10, HYDROLASE
4i15:A (ASN718) to (ILE823) CRYSTAL STRUCTURE OF TBRPDEB1 | PARASITE PDE, SLEEPING SICKNESS, AFRICAN TRYPANOSOMIASIS, HYDROLASE
4i15:B (ASN718) to (ILE823) CRYSTAL STRUCTURE OF TBRPDEB1 | PARASITE PDE, SLEEPING SICKNESS, AFRICAN TRYPANOSOMIASIS, HYDROLASE
3sl8:B (ASN209) to (SER320) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH COMPOUND 10O | CATALYTIC MECHANISM, CAMP HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3sl8:C (SER208) to (LEU319) CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PDE4D2 WITH COMPOUND 10O | CATALYTIC MECHANISM, CAMP HYDROLYSIS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2pw3:A (SER208) to (LEU319) STRUCTURE OF THE PDE4D-CAMP COMPLEX | PDE4-CAMP COMPLEX, SUBSTRATE SPECIFICITY, CRYSTAL STRUCTURE., HYDROLASE
2pw3:B (SER208) to (LEU319) STRUCTURE OF THE PDE4D-CAMP COMPLEX | PDE4-CAMP COMPLEX, SUBSTRATE SPECIFICITY, CRYSTAL STRUCTURE., HYDROLASE
3frg:A (SER282) to (GLU362) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B IN COMPLEX WITH A QUINOLINE INHIBITOR | PDE, PHOSPHODIESTERASE, CAMP, ALTERNATIVE SPLICING, HYDROLASE, PHOSPHOPROTEIN, POLYMORPHISM, HYDROLASE/HYDROLASE INHIBITOR COMPLEX
3hdz:A (SER661) to (LYS770) IDENTIFICATION, SYNTHESIS, AND SAR OF AMINO SUBSTITUTED PYRIDO[3,2B]PRYAZIONES AS POTENT AND SELECTIVE PDE5 INHIBITORS | PDE5, PDE-5,INHIBITION, ALTERNATIVE SPLICING, CAMP, HYDROLASE, PHOSPHOPROTEIN, POLYMORPHISM ALLOSTERIC ENZYME, CGMP, CGMP-BINDING, MAGNESIUM, METAL-BINDING, NUCLEOTIDE- BINDING, ZINC
1soj:A (THR829) to (ASP937) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 3B IN COMPLEX WITH IBMX | PDE3B PHOSPHODIESTERASE, HYDROLASE
1soj:B (THR829) to (ASP937) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 3B IN COMPLEX WITH IBMX | PDE3B PHOSPHODIESTERASE, HYDROLASE
1soj:C (THR829) to (ASP937) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 3B IN COMPLEX WITH IBMX | PDE3B PHOSPHODIESTERASE, HYDROLASE
1soj:D (THR829) to (ASN939) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 3B IN COMPLEX WITH IBMX | PDE3B PHOSPHODIESTERASE, HYDROLASE
1soj:E (THR829) to (ASP937) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 3B IN COMPLEX WITH IBMX | PDE3B PHOSPHODIESTERASE, HYDROLASE
1soj:F (THR829) to (ASN939) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 3B IN COMPLEX WITH IBMX | PDE3B PHOSPHODIESTERASE, HYDROLASE
1soj:G (THR829) to (ASP937) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 3B IN COMPLEX WITH IBMX | PDE3B PHOSPHODIESTERASE, HYDROLASE
1soj:H (THR829) to (ASP937) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 3B IN COMPLEX WITH IBMX | PDE3B PHOSPHODIESTERASE, HYDROLASE
1soj:I (THR829) to (ASP937) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 3B IN COMPLEX WITH IBMX | PDE3B PHOSPHODIESTERASE, HYDROLASE
1soj:J (THR829) to (ASN939) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 3B IN COMPLEX WITH IBMX | PDE3B PHOSPHODIESTERASE, HYDROLASE
1soj:K (THR829) to (ASP937) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 3B IN COMPLEX WITH IBMX | PDE3B PHOSPHODIESTERASE, HYDROLASE
1soj:L (THR829) to (ASP937) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 3B IN COMPLEX WITH IBMX | PDE3B PHOSPHODIESTERASE, HYDROLASE
4llk:B (SER571) to (CYS676) CRYSTAL STRUCTURE OF PDE10A2 WITH FRAGMENT ZT217 | FRAGMENT SCREENING, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4llx:B (SER571) to (CYS676) CRYSTAL STRUCTURE OF PDE10A2 WITH FRAGMENT ZT434 | FRAGMENT SCREENING, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4lm0:B (SER571) to (CYS676) CRYSTAL STRUCTURE OF PDE10A2 WITH FRAGMENT ZT448 | FRAGMENT SCREENING, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4lm2:B (SER571) to (CYS676) CRYSTAL STRUCTURE OF PDE10A2 WITH FRAGMENT ZT462 | FRAGMENT SCREENING, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4lm3:B (SER571) to (CYS676) CRYSTAL STRUCTURE OF PDE10A2 WITH FRAGMENT ZT464 | FRAGMENT SCREENING, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2y0j:B (ASN562) to (CYS666) TRIAZOLOQUINAZOLINES AS A NOVEL CLASS OF PHOSPHODIESTERASE 10A (PDE10A) INHIBITORS, PART 2, LEAD-OPTIMISATION. | HYDROLASE
2yy2:A (ASN300) to (ASP402) CRYSTAL STRUCTURE OF THE HUMAN PHOSPHODIESTERASE 9A CATALYTIC DOMAIN COMPLEXED WITH IBMX | CATALYTIC DOMAIN, PHOSPHODIESTERASE, STRUCTURAL GENOMICS, NPPSFA, NATIONAL PROJECT ON PROTEIN STRUCTURAL AND FUNCTIONAL ANALYSES, RIKEN STRUCTURAL GENOMICS/PROTEOMICS INITIATIVE, RSGI, HYDROLASE
2yy2:B (ASN301) to (SER404) CRYSTAL STRUCTURE OF THE HUMAN PHOSPHODIESTERASE 9A CATALYTIC DOMAIN COMPLEXED WITH IBMX | CATALYTIC DOMAIN, PHOSPHODIESTERASE, STRUCTURAL GENOMICS, NPPSFA, NATIONAL PROJECT ON PROTEIN STRUCTURAL AND FUNCTIONAL ANALYSES, RIKEN STRUCTURAL GENOMICS/PROTEOMICS INITIATIVE, RSGI, HYDROLASE
1xmu:B (SER282) to (LEU393) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH ROFLUMILAST | PHOSPHODIESTERASE, PDE, PDE4B, ROFLUMILAST, HYDROLASE
1xmy:A (SER282) to (LEU393) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH (R)- ROLIPRAM | PHOSPHODIESTERASE, PDE, PDE4B, ROLIPRAM, (R)-ROLIPRAM, HYDROLASE
1xor:B (SER208) to (LEU319) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH ZARDAVERINE | PHOSPHODIESTERASE, PDE, PDE4D, ZARDAVERINE, HYDROLASE
1xot:B (SER282) to (SER394) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH VARDENAFIL | PHOSPHODIESTERASE, PDE, PDE4B, VARDENAFIL, LEVITRA, HYDROLASE
1xot:A (SER282) to (LEU393) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH VARDENAFIL | PHOSPHODIESTERASE, PDE, PDE4B, VARDENAFIL, LEVITRA, HYDROLASE
1y2h:A (SER282) to (LEU393) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH 1-(2- CHLORO-PHENYL)-3,5-DIMETHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER | PHOSPHODIESTERASE, PDE, PDE4B, PYRAZOLE, HYDROLASE
1y2j:A (SER282) to (LEU393) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH 3,5- DIMETHYL-1-(3-NITRO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER | PHOSPHODIESTERASE, PDE, PDE4B, PYRAZOLE, HYDROLASE
1y2j:B (ASN283) to (LEU393) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B IN COMPLEX WITH 3,5- DIMETHYL-1-(3-NITRO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER | PHOSPHODIESTERASE, PDE, PDE4B, PYRAZOLE, HYDROLASE
1y2k:A (SER208) to (LEU319) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH 3,5- DIMETHYL-1-(3-NITRO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER | PHOSPHODIESTERASE, PDE, PDE4D, PYRAZOLE, HYDROLASE
1y2k:B (SER208) to (LEU319) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH 3,5- DIMETHYL-1-(3-NITRO-PHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER | PHOSPHODIESTERASE, PDE, PDE4D, PYRAZOLE, HYDROLASE
1mkd:A (SER305) to (LEU416) CRYSTAL STRUCTURE OF PDE4D CATALYTIC DOMAIN AND ZARDAVERINE COMPLEX | PDE, ZARDAVERINE, HYDROLASE
1mkd:B (SER305) to (LEU416) CRYSTAL STRUCTURE OF PDE4D CATALYTIC DOMAIN AND ZARDAVERINE COMPLEX | PDE, ZARDAVERINE, HYDROLASE
1mkd:C (SER305) to (LEU416) CRYSTAL STRUCTURE OF PDE4D CATALYTIC DOMAIN AND ZARDAVERINE COMPLEX | PDE, ZARDAVERINE, HYDROLASE
1mkd:D (SER305) to (LEU416) CRYSTAL STRUCTURE OF PDE4D CATALYTIC DOMAIN AND ZARDAVERINE COMPLEX | PDE, ZARDAVERINE, HYDROLASE
1mkd:E (SER305) to (LEU416) CRYSTAL STRUCTURE OF PDE4D CATALYTIC DOMAIN AND ZARDAVERINE COMPLEX | PDE, ZARDAVERINE, HYDROLASE
1mkd:F (SER305) to (LEU416) CRYSTAL STRUCTURE OF PDE4D CATALYTIC DOMAIN AND ZARDAVERINE COMPLEX | PDE, ZARDAVERINE, HYDROLASE
1mkd:G (SER305) to (LEU416) CRYSTAL STRUCTURE OF PDE4D CATALYTIC DOMAIN AND ZARDAVERINE COMPLEX | PDE, ZARDAVERINE, HYDROLASE
1mkd:H (SER305) to (LEU416) CRYSTAL STRUCTURE OF PDE4D CATALYTIC DOMAIN AND ZARDAVERINE COMPLEX | PDE, ZARDAVERINE, HYDROLASE
1mkd:I (SER305) to (LEU416) CRYSTAL STRUCTURE OF PDE4D CATALYTIC DOMAIN AND ZARDAVERINE COMPLEX | PDE, ZARDAVERINE, HYDROLASE
1mkd:J (SER305) to (LEU416) CRYSTAL STRUCTURE OF PDE4D CATALYTIC DOMAIN AND ZARDAVERINE COMPLEX | PDE, ZARDAVERINE, HYDROLASE
1mkd:K (SER305) to (LEU416) CRYSTAL STRUCTURE OF PDE4D CATALYTIC DOMAIN AND ZARDAVERINE COMPLEX | PDE, ZARDAVERINE, HYDROLASE
3o56:A (SER282) to (LEU393) CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4B2B IN COMPLEX WITH A 5- HETEROCYCLE PYRAZOLOPYRIDINE INHIBITOR | PDE, HYDROLASE, PHOSPHODIESTERASE, CAMP BINDING, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3dyl:A (ASN300) to (ASP402) HUMAN PHOSPHDIESTERASE 9 SUBSTRATE COMPLEX (ES COMPLEX) | PHOSPHODIESTERASE, ENZYME MECHANISM, CGMP, HYDROLASE, MANGANESE, METAL-BINDING, PHOSPHOPROTEIN
3dyl:B (ASN300) to (SER404) HUMAN PHOSPHDIESTERASE 9 SUBSTRATE COMPLEX (ES COMPLEX) | PHOSPHODIESTERASE, ENZYME MECHANISM, CGMP, HYDROLASE, MANGANESE, METAL-BINDING, PHOSPHOPROTEIN