2aid:B (LYS45) to (GLY94) STRUCTURE OF A NON-PEPTIDE INHIBITOR COMPLEXED WITH HIV-1 PROTEASE: DEVELOPING A CYCLE OF STRUCTURE-BASED DRUG DESIGN | ASPARTYL PROTEASE, HIV, NON-PEPTIDE INHIBITOR, DRUG DESIGN
1a30:A (LYS45) to (GLY94) HIV-1 PROTEASE COMPLEXED WITH A TRIPEPTIDE INHIBITOR | ASPARTIC PROTEASE, HIV PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1a8g:A (LYS45) to (GLY94) HIV-1 PROTEASE IN COMPLEX WITH SDZ283-910 | ACID PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1a8g:B (LYS45) to (GLY94) HIV-1 PROTEASE IN COMPLEX WITH SDZ283-910 | ACID PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1a8k:B (LYS45) to (GLY94) CRYSTALLOGRAPHIC ANALYSIS OF HUMAN IMMUNODEFICIENCY VIRUS 1 PROTEASE WITH AN ANALOG OF THE CONSERVED CA-P2 SUBSTRATE: INTERACTIONS WITH FREQUENTLY OCCURRING GLUTAMIC ACID RESIDUE AT P2' POSITION OF SUBSTRATES | HUMAN IMMUNODEFICIENCY VIRUS PROTEASE, PROTON-MEDIATED INTERACTION, VIRAL MATURATION, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1a8k:D (GLY52) to (GLY94) CRYSTALLOGRAPHIC ANALYSIS OF HUMAN IMMUNODEFICIENCY VIRUS 1 PROTEASE WITH AN ANALOG OF THE CONSERVED CA-P2 SUBSTRATE: INTERACTIONS WITH FREQUENTLY OCCURRING GLUTAMIC ACID RESIDUE AT P2' POSITION OF SUBSTRATES | HUMAN IMMUNODEFICIENCY VIRUS PROTEASE, PROTON-MEDIATED INTERACTION, VIRAL MATURATION, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1a94:B (LYS45) to (GLY94) STRUCTURAL BASIS FOR SPECIFICITY OF RETROVIRAL PROTEASES | HUMAN IMMUNODEFICIENCY VIRUS PROTEASE, ROUS SARCOMA VIRUS PROTEASE, PROTEIN-MEDIATED INTERACTION, VIRAL MATURATION, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2aoe:A (LYS45) to (GLY94) CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE MUTANT V82A WITH A SUBSTRATE ANALOG CA-P2 | HIV-1 PROTEASE, SUBSTRATE ANALOG, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2aog:A (LYS45) to (GLY94) CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE MUTANT V82A WITH A SUBSTRATE ANALOG P2-NC | HIV-1 PROTEASE, MUTANT, DIMER, SUBSTRATE ANALOG, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2aoi:A (LYS45) to (GLY94) CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE WITH A SUBSTRATE ANALOG P1-P6 | HIV-1 PROTEASE, MUTANT, DIMER, SUBSTRATE ANALOG, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1a9m:B (GLY52) to (ILE93) G48H MUTANT OF HIV-1 PROTEASE IN COMPLEX WITH A PEPTIDIC INHIBITOR U-89360E | ASPARTYL PROTEASE, DRUG RESISTANT, MUTATION
2aoj:A (LYS45) to (GLY94) CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE WITH A SUBSTRATE ANALOG P6-PR | HIV-1 PROTEASE, MUTANT, DIMER, SUBSTRATE ANALOG, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2aqu:A (LYS45) to (GLY94) STRUCTURE OF HIV-1 PROTEASE BOUND TO ATAZANAVIR | AIDS, ASPARTYL PROTEASE, HYDROLASE,, HYDROLASE
2aqu:B (LYS45) to (GLY94) STRUCTURE OF HIV-1 PROTEASE BOUND TO ATAZANAVIR | AIDS, ASPARTYL PROTEASE, HYDROLASE,, HYDROLASE
1aaq:A (GLY40) to (GLY94) HYDROXYETHYLENE ISOSTERE INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE: STRUCTURE-ACTIVITY ANALYSIS USING ENZYME KINETICS, X-RAY CRYSTALLOGRAPHY, AND INFECTED T-CELL ASSAYS | ACID PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1nh0:B (GLY52) to (GLY94) 1.03 A STRUCTURE OF HIV-1 PROTEASE: INHIBITOR BINDING INSIDE AND OUTSIDE THE ACTIVE SITE | ASPARTYL PROTEASE, HUMAN IMMUNODEFICIENCY VIRUS, INHIBITOR DESIGN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4gye:A (LYS45) to (GLY94) MDR 769 HIV-1 PROTEASE IN COMPLEX WITH REDUCED P1F | MULTI-DRUG RESISTANCE, PROTEASE INHIBITOR, DRUG RESISTANCE, SUBSTRATE PEPTIDE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4gye:B (LYS45) to (GLY94) MDR 769 HIV-1 PROTEASE IN COMPLEX WITH REDUCED P1F | MULTI-DRUG RESISTANCE, PROTEASE INHIBITOR, DRUG RESISTANCE, SUBSTRATE PEPTIDE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2avm:B (GLY52) to (GLY94) KINETICS, STABILITY, AND STRUCTURAL CHANGES IN HIGH RESOLUTION CRYSTAL STRUCTURES OF HIV-1 PROTEASE WITH DRUG RESISTANT MUTATIONS L24I, I50V, AND G73S | HIV-1 PROTEASE, DRUG RESISTANCE, SUBSTRATE ANALOG, NON-ACTIVE SITE MUTANTS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2avo:A (GLY52) to (GLY94) KINETICS, STABILITY, AND STRUCTURAL CHANGES IN HIGH RESOLUTION CRYSTAL STRUCTURES OF HIV-1 PROTEASE WITH DRUG RESISTANT MUTATIONS L24I, I50V, AND G73S | DRUG RESISTANCE; HIV-1 PROTEASE,INDINAVIR, SUBSTRATE ANALOG,NON- ACTIVE SITE MUTANTS., HYDROLASE
2avo:B (LYS45) to (GLY94) KINETICS, STABILITY, AND STRUCTURAL CHANGES IN HIGH RESOLUTION CRYSTAL STRUCTURES OF HIV-1 PROTEASE WITH DRUG RESISTANT MUTATIONS L24I, I50V, AND G73S | DRUG RESISTANCE; HIV-1 PROTEASE,INDINAVIR, SUBSTRATE ANALOG,NON- ACTIVE SITE MUTANTS., HYDROLASE
2avq:A (LYS45) to (GLY94) KINETICS, STABILITY, AND STRUCTURAL CHANGES IN HIGH RESOLUTION CRYSTAL STRUCTURES OF HIV-1 PROTEASE WITH DRUG RESISTANT MUTATIONS L24I, I50V, AND G73S | HIV-1 PROTEASE, DRUG RESISTANT, SUBSTRATE ANALOG, NON-ACTIVE SITE MUTANTS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2avv:D (LYS45) to (GLY94) KINETICS, STABILITY, AND STRUCTURAL CHANGES IN HIGH RESOLUTION CRYSTAL STRUCTURES OF HIV-1 PROTEASE WITH DRUG RESISTANT MUTATIONS L24I, I50V, AND G73S | DRUG RESISTANCE, HIV-1 PROTEASE,INDINAVIR, SUBSTRATE ANALOG, NON-ACTIVE SITE MUTANTS., HYDROLASE
4gzf:B (LYS45) to (GLY94) MULTI-DRUG RESISTANT HIV-1 PROTEASE 769 VARIANT WITH REDUCED LRF PEPTIDE | MULTI-DRUG RESISTANCE, PROTEASE INHIBITOR, DRUG RESISTANCE, SUBSTRATE PEPTIDES, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1aid:A (LYS45) to (GLY94) STRUCTURE OF A NON-PEPTIDE INHIBITOR COMPLEXED WITH HIV-1 PROTEASE: DEVELOPING A CYCLE OF STRUCTURE-BASED DRUG DESIGN | HYDROLASE, PROTEASE, HIV, NON-PEPTIDE INHIBITOR, DRUG DESIGN
2az9:A (GLY40) to (GLY94) HIV-1 PROTEASE NL4-3 1X MUTANT | HIV, PROTEASE, INHIBITOR, TL-3, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2azb:A (GLY40) to (GLY94) HIV-1 PROTEASE NL4-3 3X MUTANT IN COMPLEX WITH INHIBITOR, TL-3 | HIV-1, PROTEASE, INHIBITOR, TL-3, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1ajx:A (LYS45) to (GLY94) HIV-1 PROTEASE IN COMPLEX WITH THE CYCLIC UREA INHIBITOR AHA001 | PROTEASE, ASPARTYL PROTEASE, NON-PEPTIDE INHIBITOR, DRUG DESIGN, HIV-1
1npv:B (PRO244) to (GLY294) CRYSTAL STRUCTURE OF HIV-1 PROTEASE COMPLEXED WITH LDC271 | PROTEASE, HYDROLASE
3ekp:C (GLY40) to (GLY94) CRYSTAL STRUCTURE OF THE INHIBITOR AMPRENAVIR (APV) IN COMPLEX WITH A MULTI-DRUG RESISTANT HIV-1 PROTEASE VARIANT (L10I/G48V/I54V/V64I/V82A)REFER: FLAP+ IN CITATION | HIV-1, PROTEASE, MULTI-DRUG RESISTANCE, AMPRENAVIR, AIDS, HYDROLASE
3ekp:D (LYS45) to (GLY94) CRYSTAL STRUCTURE OF THE INHIBITOR AMPRENAVIR (APV) IN COMPLEX WITH A MULTI-DRUG RESISTANT HIV-1 PROTEASE VARIANT (L10I/G48V/I54V/V64I/V82A)REFER: FLAP+ IN CITATION | HIV-1, PROTEASE, MULTI-DRUG RESISTANCE, AMPRENAVIR, AIDS, HYDROLASE
3ekq:B (GLY52) to (GLY94) CRYSTAL STRUCTURE OF INHIBITOR SAQUINAVIR (SQV) IN COMPLEX WITH MULTI- DRUG RESISTANT HIV-1 PROTEASE (L63P/V82T/I84V) (REFERRED TO AS ACT IN PAPER) | PROTEASE INHIBITOR, DRUG RESISTANCE, ENTROPY ENTHALPY COMPENSATION, AIDS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, PROTEASE
3ekt:A (GLY40) to (GLY94) CRYSTAL STRUCTURE OF THE INHIBITOR DARUNAVIR (DRV) IN COMPLEX WITH A MULTI-DRUG RESISTANT HIV-1 PROTEASE VARIANT (L10F/G48V/I54V/V64I/V82A) (REFER: FLAP+ IN CITATION.) | HIV-1, PROTEASE, MULTI-DRUG RESISTANCE, DARUNAVIR, AIDS, HYDROLASE
3ekt:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF THE INHIBITOR DARUNAVIR (DRV) IN COMPLEX WITH A MULTI-DRUG RESISTANT HIV-1 PROTEASE VARIANT (L10F/G48V/I54V/V64I/V82A) (REFER: FLAP+ IN CITATION.) | HIV-1, PROTEASE, MULTI-DRUG RESISTANCE, DARUNAVIR, AIDS, HYDROLASE
3ekv:B (GLY40) to (GLY94) CRYSTAL STRUCTURE OF THE WILD TYPE HIV-1 PROTEASE WITH THE INHIBITOR, AMPRENAVIR | PROTEASE INHIBITOR, DRUG RESISTANCE, AMPRENAVIR, HIV PROTEASE, AIDS, PROTEASE, HYDROLASE
3ekw:B (GLY52) to (GLY94) CRYSTAL STRUCTURE OF THE INHIBITOR ATAZANAVIR (ATV) IN COMPLEX WITH A MULTI-DRUG RESISTANCE HIV-1 PROTEASE VARIANT (L10I/G48V/I54V/V64I/V82A) REFER: FLAP+ IN CITATION. | HIV-1, PROTEASE, MULTI-DRUG RESISTANCE, ATAZANAVIR, AIDS, HYDROLASE
3eky:B (GLY52) to (GLY94) CRYSTAL STRUCTURE OF WILD-TYPE HIV PROTEASE IN COMPLEX WITH THE INHIBITOR, ATAZANAVIR | HIV PROTEASE, PROTEASE INHIBITORS, DRUG RESISTANCE, ATAZANAVIR, AIDS, HYDROLASE, PROTEASE
3el0:A (LYS41) to (GLY94) CRYSTAL STRUCTURE OF THE INHIBITOR NELFINAVIR (NFV) IN COMPLEX WITH A MULTI-DRUG RESISTANT HIV-1 PROTEASE VARIANT (L10I/G48V/I54V/V64I/V82A) (REFER: FLAP+ IN CITATION) | HIV-1, PROTEASE, MULTI-DRUG RESISTANCE, NELFINAVIR, AIDS, HYDROLASE
3el0:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF THE INHIBITOR NELFINAVIR (NFV) IN COMPLEX WITH A MULTI-DRUG RESISTANT HIV-1 PROTEASE VARIANT (L10I/G48V/I54V/V64I/V82A) (REFER: FLAP+ IN CITATION) | HIV-1, PROTEASE, MULTI-DRUG RESISTANCE, NELFINAVIR, AIDS, HYDROLASE
3el1:B (GLY52) to (GLY94) CRYSTAL STRUCTURE OF WILD-TYPE HIV PROTEASE IN COMPLEX WITH THE INHIBITOR, ATAZANAVIR | HIV PROTEASE, PROTEASE INHIBITORS, DRUG RESISTANCE, ATAZANAVIR, AIDS, HYDROLASE, PROTEASE
3el5:A (GLY52) to (GLY94) CRYSTAL STRUCTURE OF NELFINAVIR (NFV) COMPLEXED WITH A MULTIDRUG VARIANT (ACT) (V82T/I84V) OF HIV-1 PROTEASE | PROTEASE INHIBITOR, DRUG RESISTANCE, NELFINAVIR, HIV-1 PROTEASE, ENTROPY-ENTHALPY COMPENSATION, HYDROLASE
3el5:B (GLY52) to (GLY94) CRYSTAL STRUCTURE OF NELFINAVIR (NFV) COMPLEXED WITH A MULTIDRUG VARIANT (ACT) (V82T/I84V) OF HIV-1 PROTEASE | PROTEASE INHIBITOR, DRUG RESISTANCE, NELFINAVIR, HIV-1 PROTEASE, ENTROPY-ENTHALPY COMPENSATION, HYDROLASE
3el9:A (GLY52) to (GLY94) CRYSTAL STRUCTURE OF ATAZANAVIR (ATV) IN COMPLEX WITH A MULTIDRUG HIV- 1 PROTEASE (V82T/I84V) | DRUG RESISTANCE, ENTROPY ENTHALPY COMPENSATION, HIV PROTEASE, ATAZANAVIR, AIDS, HYDROLASE
3el9:B (GLY52) to (GLY94) CRYSTAL STRUCTURE OF ATAZANAVIR (ATV) IN COMPLEX WITH A MULTIDRUG HIV- 1 PROTEASE (V82T/I84V) | DRUG RESISTANCE, ENTROPY ENTHALPY COMPENSATION, HIV PROTEASE, ATAZANAVIR, AIDS, HYDROLASE
3em3:B (GLY52) to (GLY94) CRYSTAL STRUCTURE OF AMPRENAVIR (APV) IN COMPLEX WITH A DRUG RESISTANT HIV-1 PROTEASE VARIANT (I50L/A71V). | PROTEASE INHIBITOR, HYPER SUSCEPTIBILITY, DRUG RESISTANCE, HIV, AMPRENAVIR, AIDS, HYDROLASE, PROTEASE
3em4:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF ATAZANAVIR (ATV) IN COMPLEX WITH I50L/A71V DRUG- RESISTANT HIV-1 PROTEASE | DRUG RESISTANCE, HYPERSUSCEPTIBILITY, PROTEASE INHIBITOR, HIV, ATAZANAVIR, AIDS, HYDROLASE, PROTEASE
3em4:U (LYS45) to (GLY94) CRYSTAL STRUCTURE OF ATAZANAVIR (ATV) IN COMPLEX WITH I50L/A71V DRUG- RESISTANT HIV-1 PROTEASE | DRUG RESISTANCE, HYPERSUSCEPTIBILITY, PROTEASE INHIBITOR, HIV, ATAZANAVIR, AIDS, HYDROLASE, PROTEASE
3em6:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF I50L/A71V MUTANT OF HIV-1 PROTEASE IN COMPLEX WITH INHIBITOR DARUNAVIR | PROTEASE INHIBITOR, HYPER SUSCEPTIBILITY, DRUG RESISTANCE, HIV, DARUNAVIR, AIDS, HYDROLASE, PROTEASE
1axa:B (LYS45) to (GLY94) ACTIVE-SITE MOBILITY IN HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE AS DEMONSTRATED BY CRYSTAL STRUCTURE OF A28S MUTANT | HIV PROTEASE, MUTANT, X-RAY, ASPARTIC PROTEASE, HYDROLASE, ACID PROTEINASE, ASPARTYL PROTEASE
2b7z:B (GLY40) to (ILE93) STRUCTURE OF HIV-1 PROTEASE MUTANT BOUND TO INDINAVIR | HIV-1, PROTEASE, INDINAVIR, DRUG RESISTANCE, ACTIVE SITE MUTATIONS, NON-ACTIVE SITE MUTATIONS,VIRAL PROTEIN, VIRAL PROTEIN
2bb9:A (GLY40) to (GLY94) STRUCTURE OF HIV1 PROTEASE AND AKC4P_133A COMPLEX. | PROTEASE, HYDROLASE
2bb9:B (PRO244) to (GLY294) STRUCTURE OF HIV1 PROTEASE AND AKC4P_133A COMPLEX. | PROTEASE, HYDROLASE
2bbb:B (PRO244) to (GLY294) STRUCTURE OF HIV1 PROTEASE AND HH1_173_3A COMPLEX. | PROTEASE, HYDROLASE
2p3b:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF THE SUBTYPE B WILD TYPE HIV PROTEASE COMPLEXED WITH TL-3 INHIBITOR | WILD TYPE SUBTYPE B HIV PROTEASE, TL-3 INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4hdb:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 PROTEASE MUTANTS D30N COMPLEXED WITH INHIBITOR GRL-0519 | ASPARTIC ACID PROTEASE, DRUG RESISTANCE, HIV-1 PROTEASE INHIBITOR GRL-0519, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4hdf:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 PROTEASE MUTANTS V82A COMPLEXED WITH INHIBITOR GRL-0519 | ASPARTIC ACID PROTEASE, DRUG RESISTANCE, HIV-1 PROTEASE INHIBITOR GRL-0519, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4hdp:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 PROTEASE MUTANTS I50V COMPLEXED WITH INHIBITOR GRL-0519 | ASPARTIC ACID PROTEASE, DRUG RESISTANCE, HIV-1 PROTEASE INHIBITOR GRL-0519, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4hdp:A (PRO44) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 PROTEASE MUTANTS I50V COMPLEXED WITH INHIBITOR GRL-0519 | ASPARTIC ACID PROTEASE, DRUG RESISTANCE, HIV-1 PROTEASE INHIBITOR GRL-0519, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4he9:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 PROTEASE MUTANTS I54M COMPLEXED WITH INHIBITOR GRL-0519 | ASPARTIC ACID PROTEASE, DRUG RESISTANCE, HIV-1 PROTEASE INHIBITOR GRL-0519, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4he9:B (PRO44) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 PROTEASE MUTANTS I54M COMPLEXED WITH INHIBITOR GRL-0519 | ASPARTIC ACID PROTEASE, DRUG RESISTANCE, HIV-1 PROTEASE INHIBITOR GRL-0519, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4heg:A (PRO44) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 PROTEASE MUTANTS R8Q COMPLEXED WITH INHIBITOR GRL-0519 | ASPARTIC ACID PROTEASE, DRUG RESISTANCE, HIV-1 PROTEASE INHIBITOR GRL-0519, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1b6j:B (GLY152) to (GLY194) HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 1 | COMPLEX (ACID PROTEINASE-PEPTIDE), HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1bdl:A (GLY52) to (GLY94) HIV-1 (2:31-37) PROTEASE COMPLEXED WITH INHIBITOR SB203386 | HYDROLASE, AIDS, POLYPROTEIN, ASPARTYL PROTEASE, ACID PROTEASE, HYDROXYETHYLENE ISOSTERE INHIBITOR, SUBSTRATE ANALOGUE INHIBITOR
1bdl:B (PRO44) to (GLY94) HIV-1 (2:31-37) PROTEASE COMPLEXED WITH INHIBITOR SB203386 | HYDROLASE, AIDS, POLYPROTEIN, ASPARTYL PROTEASE, ACID PROTEASE, HYDROXYETHYLENE ISOSTERE INHIBITOR, SUBSTRATE ANALOGUE INHIBITOR
3s43:A (GLY40) to (GLY94) HIV-1 PROTEASE TRIPLE MUTANTS V32I, I47V, V82I WITH ANTIVIRAL DRUG AMPRENAVIR | AMPRENAVIR, HIV/AIDS, DRUG RESISTANCE, ASPARTIC PROTEASE, MOLECULAR RECOGNITION, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4hla:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF WILD TYPE HIV-1 PROTEASE IN COMPLEX WITH DARUNAVIR | DARUNAVIR, PROTEASE, HYDROLASE, GAG, GAG-POL, TMC114, UIC-94017, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4hla:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF WILD TYPE HIV-1 PROTEASE IN COMPLEX WITH DARUNAVIR | DARUNAVIR, PROTEASE, HYDROLASE, GAG, GAG-POL, TMC114, UIC-94017, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3s54:A (LYS45) to (GLY94) HIV-1 PROTEASE TRIPLE MUTANTS V32I, I47V, V82I WITH ANTIVIRAL DRUG DARUNAVIR IN SPACE GROUP P21212 | DARUNAVIR,HIV/AIDS, DRUG RESISTANCE, ASPARTIC PROTEASE, MOLECULAR RECOGNITION, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3s56:A (LYS45) to (GLY94) HIV-1 PROTEASE TRIPLE MUTANTS V32I, I47V, V82I WITH ANTIVIRAL DRUG SAQUINAVIR | SAQUINAVIR,HIV/AIDS, DRUG RESISTANCE, ASPARTIC PROTEASE, MOLECULAR RECOGNITION, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3s56:B (LYS45) to (GLY94) HIV-1 PROTEASE TRIPLE MUTANTS V32I, I47V, V82I WITH ANTIVIRAL DRUG SAQUINAVIR | SAQUINAVIR,HIV/AIDS, DRUG RESISTANCE, ASPARTIC PROTEASE, MOLECULAR RECOGNITION, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2bpv:A (GLY52) to (GLY94) HIV-1 PROTEASE-INHIBITOR COMPLEX | ACID PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2bpw:A (GLY52) to (GLY94) HIV-1 PROTEASE-INHIBITOR COMPLEX | ACID PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2bpx:B (LYS45) to (GLY94) HIV-1 PROTEASE-INHIBITOR COMPLEX | ACID PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2bpy:A (GLY52) to (GLY94) HIV-1 PROTEASE-INHIBITOR COMPLEX | ACID PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2bpz:A (GLY52) to (GLY94) HIV-1 PROTEASE-INHIBITOR COMPLEX | ACID PROTEASE, HYDROLASE-HYDROLASE COMPLEX
2bqv:A (GLY52) to (GLY94) HIV-1 PROTEASE IN COMPLEX WITH INHIBITOR AHA455 | HYDROLASE/INHIBITOR, HYDROLASE/INHIBITOR COMPLEX, HIV-1 PROTEASE, INHIBITOR, DRUG DESIGN, HYDROLASE COMPLEX
3s85:A (LYS45) to (GLY94) DISCOVERY OF NEW HIV PROTEASE INHIBITORS WITH POTENTIAL FOR CONVENIENT DOSING AND REDUCED SIDE EFFECTS: A-790742 AND A-792611. | BETA BARREL, ACID PROTEASE, ASPARTIC-TYPE ENDOPEPIDASE ACTIVITY, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3s85:B (LYS45) to (GLY94) DISCOVERY OF NEW HIV PROTEASE INHIBITORS WITH POTENTIAL FOR CONVENIENT DOSING AND REDUCED SIDE EFFECTS: A-790742 AND A-792611. | BETA BARREL, ACID PROTEASE, ASPARTIC-TYPE ENDOPEPIDASE ACTIVITY, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3s85:C (GLY52) to (GLY94) DISCOVERY OF NEW HIV PROTEASE INHIBITORS WITH POTENTIAL FOR CONVENIENT DOSING AND REDUCED SIDE EFFECTS: A-790742 AND A-792611. | BETA BARREL, ACID PROTEASE, ASPARTIC-TYPE ENDOPEPIDASE ACTIVITY, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3s85:E (LYS45) to (GLY94) DISCOVERY OF NEW HIV PROTEASE INHIBITORS WITH POTENTIAL FOR CONVENIENT DOSING AND REDUCED SIDE EFFECTS: A-790742 AND A-792611. | BETA BARREL, ACID PROTEASE, ASPARTIC-TYPE ENDOPEPIDASE ACTIVITY, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3s85:G (LYS45) to (GLY94) DISCOVERY OF NEW HIV PROTEASE INHIBITORS WITH POTENTIAL FOR CONVENIENT DOSING AND REDUCED SIDE EFFECTS: A-790742 AND A-792611. | BETA BARREL, ACID PROTEASE, ASPARTIC-TYPE ENDOPEPIDASE ACTIVITY, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1bv7:A (LYS45) to (GLY94) COUNTERACTING HIV-1 PROTEASE DRUG RESISTANCE: STRUCTURAL ANALYSIS OF MUTANT PROTEASES COMPLEXED WITH XV638 AND SD146, CYCLIC UREA AMIDES WITH BROAD SPECIFICITIES | HYDROLASE(ACID PROTEINASE)
1bv7:B (GLY52) to (GLY94) COUNTERACTING HIV-1 PROTEASE DRUG RESISTANCE: STRUCTURAL ANALYSIS OF MUTANT PROTEASES COMPLEXED WITH XV638 AND SD146, CYCLIC UREA AMIDES WITH BROAD SPECIFICITIES | HYDROLASE(ACID PROTEINASE)
1bv9:B (LYS45) to (GLY94) HIV-1 PROTEASE (I84V) COMPLEXED WITH XV638 OF DUPONT PHARMACEUTICALS | HIV-1 PROTEASE (I84V) XV638, HYDROLASE
1bvg:A (LYS45) to (GLY94) HIV-1 PROTEASE-DMP323 COMPLEX IN SOLUTION, NMR MINIMIZED AVERAGE STRUCTURE | AIDS, POLYPROTEIN, HYDROLASE, ASPARTYL PROTEASE, ENDONUCLEASE, RNA-DIRECTED DNA POLYMERASE
1bvg:B (ARG41) to (GLY94) HIV-1 PROTEASE-DMP323 COMPLEX IN SOLUTION, NMR MINIMIZED AVERAGE STRUCTURE | AIDS, POLYPROTEIN, HYDROLASE, ASPARTYL PROTEASE, ENDONUCLEASE, RNA-DIRECTED DNA POLYMERASE
3sa4:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 PROTEASE IN COMPLEX WITH AF72 | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3sa5:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 PROTEASE IN COMPLEX WITH AF69 | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3sa6:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 PROTEASE IN COMPLEX WITH AF71 | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3sa7:A (GLY52) to (GLY94) CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 PROTEASE IN COMPLEX WITH AF55 | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3sa7:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 PROTEASE IN COMPLEX WITH AF55 | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3sa8:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 PROTEASE IN COMPLEX WITH KB83 | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3saa:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 PROTEASE IN COMPLEX WITH AF77 | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3sab:A (GLY52) to (GLY94) CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 PROTEASE IN COMPLEX WITH AF78 | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3sab:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 PROTEASE IN COMPLEX WITH AF78 | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3sac:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 PROTEASE IN COMPLEX WITH AF80 | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1odw:B (LYS45) to (GLY94) NATIVE HIV-1 PROTEINASE | PROTEINASE, RETROPEPSIN, RETROVIRUS, HIV, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1odx:B (GLY40) to (GLY94) HIV-1 PROTEINASE MUTANT A71T, V82A | PROTEINASE, RETROPEPSIN, RETROVIRUS, HIV, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1c6y:A (LYS45) to (GLY94) ALTERNATE BINDING SITE FOR THE P1-P3 GROUP OF A CLASS OF POTENT HIV-1 PROTEASE INHIBITORS AS A RESULT OF CONCERTED STRUCTURAL CHANGE IN 80'S LOOP. | HYDROLASE
1c6y:B (GLY252) to (GLY294) ALTERNATE BINDING SITE FOR THE P1-P3 GROUP OF A CLASS OF POTENT HIV-1 PROTEASE INHIBITORS AS A RESULT OF CONCERTED STRUCTURAL CHANGE IN 80'S LOOP. | HYDROLASE
1c6z:A (LYS45) to (GLY94) ALTERNATE BINDING SITE FOR THE P1-P3 GROUP OF A CLASS OF POTENT HIV-1 PROTEASE INHIBITORS AS A RESULT OF CONCERTED STRUCTURAL CHANGE IN 80'S LOOP. | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1c6z:B (ARG241) to (GLY294) ALTERNATE BINDING SITE FOR THE P1-P3 GROUP OF A CLASS OF POTENT HIV-1 PROTEASE INHIBITORS AS A RESULT OF CONCERTED STRUCTURAL CHANGE IN 80'S LOOP. | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1ohr:B (GLY52) to (GLY94) VIRACEPT (R) (NELFINAVIR MESYLATE, AG1343): A POTENT ORALLY BIOAVAILABLE INHIBITOR OF HIV-1 PROTEASE | ASPARTYL PROTEASE, HYDROLASE, HIV-I PROTEASE
2pqz:A (ARG41) to (GLY94) HIV-1 PROTEASE IN COMPLEX WITH A PYRROLIDINE-BASED INHIBITOR | PROTEIN-LIGAND COMPLEX, HYDROLASE
2pqz:B (PRO44) to (GLY94) HIV-1 PROTEASE IN COMPLEX WITH A PYRROLIDINE-BASED INHIBITOR | PROTEIN-LIGAND COMPLEX, HYDROLASE
2psu:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF WILD TYPE HIV-1 PROTEASE IN COMPLEX WITH CARB- AD37 | DRUG DESIGN, HIV-1 PROTEASE, PROTEASE INHIBITOR, HYDROLASE
2psv:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF WILD TYPE HIV-1 PROTEASE IN COMPLEX WITH CARB- KB45 | DRUG DESIGN, HIV-1 PROTEASE, PROTEASE INHIBITORS, HYDROLASE
2pwc:A (ARG41) to (GLY94) HIV-1 PROTEASE IN COMPLEX WITH A AMINO DECORATED PYRROLIDINE-BASED INHIBITOR | PROTEIN-LIGAND COMPLEX, HYDROLASE
2pym:A (LYS45) to (GLY94) HIV-1 PR MUTANT IN COMPLEX WITH NELFINAVIR | RESISTANCE; NELFINAVIR, HYDROLASE
2pym:B (LYS45) to (GLY94) HIV-1 PR MUTANT IN COMPLEX WITH NELFINAVIR | RESISTANCE; NELFINAVIR, HYDROLASE
2pyn:A (LYS45) to (GLY94) HIV-1 PR MUTANT IN COMPLEX WITH NELFINAVIR | RESISTANCE; NELFINAVIR, HYDROLASE
2pyn:B (LYS45) to (GLY94) HIV-1 PR MUTANT IN COMPLEX WITH NELFINAVIR | RESISTANCE; NELFINAVIR, HYDROLASE
3so9:A (PRO44) to (GLY94) DARUNAVIR IN COMPLEX WITH A HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE VARIANT | MULTI-DRUG RESISTANCE, HIV-1 PROTEASE, DARUNAVIR, PROTEASE INHIBITOR, HYDORLASE-HYDORLASE INHIBITOR COMPLEX
4i8w:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF WILD TYPE HIV-1 PROTEASE IN COMPLEX WITH NON- PEPTIDIC INHIBITOR, GRL007 | HIV-1 PROTEASE, HIV-1 PROTEASE-INHIBITOR COMPLEX, HYDROLASE, GRL007, PROTEASE INHIBITOR, NON-PEPTIDIC PROTEASE INHIBITOR, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
4i8z:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF WILD TYPE HIV-1 PROTEASE IN COMPLEX WITH NON- PEPTIDIC INHIBITOR, GRL008 | HIV-1 PROTEASE, HIV-1 PROTEASE-INHIBITOR COMPLEX, HYDROLASE, GRL008, NON-PEPTIDIC INHIBITOR, PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3spk:A (LYS45) to (GLY94) TIPRANAVIR IN COMPLEX WITH A HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE VARIANT | TIPRANAVIR, MULTI-DRUG RESISTANT HIV-1 PROTEASE, HYDORLASE-HYDORLASE INHIBITOR COMPLEX
1cpi:B (GLY40) to (GLY94) REGIOSELECTIVE STRUCTURAL AND FUNCTIONAL MIMICRY OF PEPTIDES. DESIGN OF HYDROLYTICALLY STABLE CYCLIC PEPTIDOMIMETIC INHIBITORS OF HIV-1 PROTEASE | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2q3k:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF LYSINE SULFONAMIDE INHIBITOR REVEALS THE DISPLACEMENT OF THE CONSERVED FLAP WATER MOLECULE IN HIV-1 PROTEASE | DRUG DESIGN, HIV-1 PROTEASE, PROTEASE INHIBITORS, VIRAL PROTEIN
2q54:A (GLY52) to (GLY94) CRYSTAL STRUCTURE OF KB73 BOUND TO HIV-1 PROTEASE | DRUG DESIGN, HIV-1 PROTEASE, PROTEASE INHIBITORS, HYDROLASE
2q54:B (GLY52) to (GLY94) CRYSTAL STRUCTURE OF KB73 BOUND TO HIV-1 PROTEASE | DRUG DESIGN, HIV-1 PROTEASE, PROTEASE INHIBITORS, HYDROLASE
2q55:A (GLY52) to (GLY94) CRYSTAL STRUCTURE OF KK44 BOUND TO HIV-1 PROTEASE | DRUG DESIGN, HIV-1 PROTEASE, PROTEASE INHIBITOR, HYDROLASE
2q55:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF KK44 BOUND TO HIV-1 PROTEASE | DRUG DESIGN, HIV-1 PROTEASE, PROTEASE INHIBITOR, HYDROLASE
2q5k:A (GLY52) to (GLY94) CRYSTAL STRUCTURE OF LOPINAVIR BOUND TO WILD TYPE HIV-1 PROTEASE | DRUG DESIGN, HIV-1 PROTEASE, PROTEASE INHIBITORS, HYDROLASE
2q5k:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF LOPINAVIR BOUND TO WILD TYPE HIV-1 PROTEASE | DRUG DESIGN, HIV-1 PROTEASE, PROTEASE INHIBITORS, HYDROLASE
2q63:A (LYS45) to (GLY94) HIV-1 PR MUTANT IN COMPLEX WITH NELFINAVIR | RESISTANCE; NELFINAVIR, HYDROLASE
2q63:B (LYS45) to (GLY94) HIV-1 PR MUTANT IN COMPLEX WITH NELFINAVIR | RESISTANCE; NELFINAVIR, HYDROLASE
3fx5:A (LYS45) to (GLY94) STRUCTURE OF HIV-1 PROTEASE IN COMPLEX WITH POTENT INHIBITOR KNI-272 DETERMINED BY HIGH RESOLUTION X-RAY CRYSTALLOGRAPHY | ACID PROTEASE, HOMODIMER, PROTEASE, HYDROLASE, NUCLEOTIDYLTRANSFERASE, TRANSFERASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3fx5:B (GLY152) to (GLY194) STRUCTURE OF HIV-1 PROTEASE IN COMPLEX WITH POTENT INHIBITOR KNI-272 DETERMINED BY HIGH RESOLUTION X-RAY CRYSTALLOGRAPHY | ACID PROTEASE, HOMODIMER, PROTEASE, HYDROLASE, NUCLEOTIDYLTRANSFERASE, TRANSFERASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2cej:B (PRO144) to (GLY194) P1' EXTENDED HIV-1 PROTEASE INHIBITORS ENCOMPASSING A TERTIARY ALCOHOL IN THE TRANSITION-STATE MIMICKING SCAFFOLD | HIV-1, PROTEASE, INHIBITOR, ASPARTYL PROTEASE, HYDROLASE
2qak:A (LYS45) to (GLY94) HIV-1 PR MUTANT IN COMPLEX WITH NELFINAVIR | HIV PROTEASE INHIBITORS; PROTEASE-INHIBITOR STRUCTURE; ISOTHERMAL CALORIMETRY; ANTIVIRAL RESISTANCE DEVELOPMENT, HYDROLASE
2qak:B (LYS45) to (GLY94) HIV-1 PR MUTANT IN COMPLEX WITH NELFINAVIR | HIV PROTEASE INHIBITORS; PROTEASE-INHIBITOR STRUCTURE; ISOTHERMAL CALORIMETRY; ANTIVIRAL RESISTANCE DEVELOPMENT, HYDROLASE
2cem:A (GLY52) to (GLY94) P1' EXTENDED HIV-1 PROTEASE INHIBITORS ENCOMPASSING A TERTIARY ALCOHOL IN THE TRANSITION-STATE MIMICKING SCAFFOLD | HIV-1, PROTEASE, INHIBITOR, ASPARTYL PROTEASE, HYDROLASE
2qci:A (LYS45) to (GLY94) HIV-1 PROTEASE MUTANT D30N WITH POTENT ANTIVIRAL INHIBITOR GRL-98065 | HIV-1, MUTANT D30N, PROTEASE INHIBITOR, HYDROLASE
1d4h:A (GLY52) to (GLY94) HIV-1 PROTEASE IN COMPLEX WITH THE INHIBITOR BEA435 | DIMER, HYDROLASE
1d4i:A (GLY52) to (GLY94) HIV-1 PROTEASE IN COMPLEX WITH THE INHIBITOR BEA425 | DIMER, HYDROLASE
1d4k:A (LYS45) to (GLY94) HIV-1 PROTEASE COMPLEXED WITH A MACROCYCLIC PEPTIDOMIMETIC INHIBITOR | HIV, PROTEASE, INHIBITOR, ANTIVIRAL, STRUCTURE, HYDROLASE
1d4l:B (GLY52) to (GLY94) HIV-1 PROTEASE COMPLEXED WITH A MACROCYCLIC PEPTIDOMIMETIC INHIBITOR | HIV, PROTEASE, INHIBITOR, ANTIVIRAL, STRUCTURE, HYDROLASE
1d4y:A (LYS45) to (GLY94) HIV-1 PROTEASE TRIPLE MUTANT/TIPRANAVIR COMPLEX | HYDROLASE, ACID PROTEASE, ASPARTYL PROTEASE
2qd6:A (LYS45) to (GLY94) HIV-1 PROTEASE MUTANT I50V WITH POTENT ANTIVIRAL INHIBITOR GRL-98065 | HIV-1 PROTEASE MUTANT I50V, PROTEASE INHIBITOR, HYDROLASE
2qd7:A (GLY40) to (GLY94) HIV-1 PROTEASE MUTANT V82A WITH POTENT ANTIVIRAL INHIBITOR GRL-98065 | HIV-1 PROTEASE MUTANT V82A, PROTEASE INHIBITOR, HYDROLASE
2qd8:A (LYS45) to (GLY94) HIV-1 PROTEASE MUTANT I84V WITH POTENT ANTIVIRAL INHIBITOR GRL-98065 | HIV-1 PROTEASE MUTANT I84V, PROTEASE INHIBITOR, HYDROLASE
2qhc:A (LYS45) to (GLY94) THE INFLUENCE OF I47A MUTATION ON REDUCED SUSCEPTIBILITY TO THE PROTEASE INHIBITOR LOPINAVIR | HIV PROTEASE INHIBITORS; PROTEASE-INHIBITOR STRUCTURE; ASPARTIC PROTEASE, RESISTANT STRAIN, HYDROLASE
2qhc:B (LYS45) to (GLY94) THE INFLUENCE OF I47A MUTATION ON REDUCED SUSCEPTIBILITY TO THE PROTEASE INHIBITOR LOPINAVIR | HIV PROTEASE INHIBITORS; PROTEASE-INHIBITOR STRUCTURE; ASPARTIC PROTEASE, RESISTANT STRAIN, HYDROLASE
2qhy:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF PROTEASE INHIBITOR, MIT-1-AC86 IN COMPLEX WITH WILD TYPE HIV-1 PROTEASE | DRUG DESIGN, HIV-1 PROTEASE, PROTEASE INHIBITORS, HYDROLASE
2qhz:B (GLY52) to (GLY94) CRYSTAL STRUCTURE OF PROTEASE INHIBITOR, MIT-1-AC87 IN COMPLEX WITH WILD TYPE HIV-1 PROTEASE | DRUG DESIGN, HIV-1 PROTEASE, PROTEASE INHIBITORS, HYDROLASE
2qi1:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF PROTEASE INHIBITOR, MIT-1-KK81 IN COMPLEX WITH WILD TYPE HIV-1 PROTEASE | DRUG DESIGN, HIV-1 PROTEASE, PROTEASE INHIBITORS, HYDROLASE
2qi3:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF PROTEASE INHIBITOR, MIT-2-AD94 IN COMPLEX WITH WILD TYPE HIV-1 PROTEASE | DRUG DESIGN, HIV-1 PROTEASE, PROTEASE INHIBITORS, HYDROLASE
2qi4:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF PROTEASE INHIBITOR, MIT-2-AD93 IN COMPLEX WITH WILD TYPE HIV-1 PROTEASE | DRUG DESIGN, HIV-1 PROTEASE, PROTEASE INHIBITORS, HYDROLASE
2qi5:A (GLY52) to (GLY94) CRYSTAL STRUCTURE OF PROTEASE INHIBITOR, MIT-2-KC08 IN COMPLEX WITH WILD TYPE HIV-1 PROTEASE | DRUG DESIGN, HIV-1 PROTEASE, PROTEASE INHIBITORS, HYDROLASE
2qi5:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF PROTEASE INHIBITOR, MIT-2-KC08 IN COMPLEX WITH WILD TYPE HIV-1 PROTEASE | DRUG DESIGN, HIV-1 PROTEASE, PROTEASE INHIBITORS, HYDROLASE
2qi6:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF PROTEASE INHIBITOR, MIT-2-KB98 IN COMPLEX WITH WILD TYPE HIV-1 PROTEASE | DRUG DESIGN, HIV-1 PROTEASE, PROTEASE INHIBITORS, HYDROLASE
2qi7:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF PROTEASE INHIBITOR, MIT-2-AD86 IN COMPLEX WITH WILD TYPE HIV-1 PROTEASE | DRUG DESIGN, HIV-1 PROTEASE, PROTEASE INHIBITORS, HYDROLASE
1dif:A (GLY52) to (GLY94) HIV-1 PROTEASE IN COMPLEX WITH A DIFLUOROKETONE CONTAINING INHIBITOR A79285 | ASPARTIC PROTEINASE
1dif:B (GLY52) to (GLY94) HIV-1 PROTEASE IN COMPLEX WITH A DIFLUOROKETONE CONTAINING INHIBITOR A79285 | ASPARTIC PROTEINASE
2qnn:A (GLY40) to (GLY94) HIV-1 PROTEASE IN COMPLEX WITH A MULTIPLE DECORATED PYRROLIDINE-BASED INHIBITOR | PROTEIN-LIGAND COMPLEX, AIDS, ASPARTYL PROTEASE, CAPSID MATURATION, CORE PROTEIN, DNA INTEGRATION, DNA RECOMBINATION, DNA-DIRECTED DNA POLYMERASE, ENDONUCLEASE, HYDROLASE, LIPOPROTEIN, MAGNESIUM, MEMBRANE, METAL-BINDING, MULTIFUNCTIONAL ENZYME, MYRISTATE, NUCLEASE, NUCLEOTIDYLTRANSFERASE, PHOSPHORYLATION, PROTEASE, RNA- BINDING, RNA-DIRECTED DNA POLYMERASE, TRANSFERASE, VIRAL NUCLEOPROTEIN, VIRION, ZINC-FINGER
2qnp:A (ARG41) to (GLY94) HIV-1 PROTEASE IN COMPLEX WITH A IODO DECORATED PYRROLIDINE- BASED INHIBITOR | PROTEIN-LIGAND COMPLEX, AIDS, ASPARTYL PROTEASE, CAPSID MATURATION, CORE PROTEIN, CYTOPLASM, DNA INTEGRATION, DNA RECOMBINATION, DNA-DIRECTED DNA POLYMERASE, ENDONUCLEASE, HYDROLASE, LIPOPROTEIN, MAGNESIUM, MEMBRANE, METAL-BINDING, MULTIFUNCTIONAL ENZYME, MYRISTATE, NUCLEASE, NUCLEOTIDYLTRANSFERASE, PHOSPHORYLATION, PROTEASE, RNA- BINDING, RNA-DIRECTED DNA POLYMERASE, TRANSFERASE, VIRAL NUCLEOPROTEIN, VIRION, ZINC, ZINC-FINGER
2qnq:A (GLY40) to (GLY94) HIV-1 PROTEASE IN COMPLEX WITH A CHLORO DECORATED PYRROLIDINE-BASED INHIBITOR | PROTEIN-LIGAND COMPLEX, AIDS, ASPARTYL PROTEASE, CAPSID MATURATION, CORE PROTEIN, CYTOPLASM, DNA INTEGRATION, DNA RECOMBINATION, DNA-DIRECTED DNA POLYMERASE, ENDONUCLEASE, HYDROLASE, LIPOPROTEIN, MAGNESIUM, MEMBRANE, METAL-BINDING, MULTIFUNCTIONAL ENZYME, MYRISTATE, NUCLEASE, NUCLEOTIDYLTRANSFERASE, PHOSPHORYLATION, PROTEASE, RNA- BINDING, RNA-DIRECTED DNA POLYMERASE, TRANSFERASE, VIRAL NUCLEOPROTEIN, VIRION, ZINC, ZINC-FINGER
3gga:G (GLY52) to (GLY94) HIV PROTEASE INHIBITORS WITH PSEUDO-SYMMETRIC CORES | PSEUDO-SYMMETRICAL HIV PROTEASE INHIBITORS, HYDROLASE, PROTEASE
3gga:H (PRO44) to (GLY94) HIV PROTEASE INHIBITORS WITH PSEUDO-SYMMETRIC CORES | PSEUDO-SYMMETRICAL HIV PROTEASE INHIBITORS, HYDROLASE, PROTEASE
3gga:B (GLY52) to (GLY94) HIV PROTEASE INHIBITORS WITH PSEUDO-SYMMETRIC CORES | PSEUDO-SYMMETRICAL HIV PROTEASE INHIBITORS, HYDROLASE, PROTEASE
3ggu:A (ARG45) to (GLY94) HIV PR DRUG RESISTANT PATIENT'S VARIANT IN COMPLEX WITH DARUNAVIR | DARUNVIR, RESISTANCE, MUTATION SCORE, HIV PROTEASE, TMC-114, HYDROLASE
3ggu:B (ARG45) to (GLY94) HIV PR DRUG RESISTANT PATIENT'S VARIANT IN COMPLEX WITH DARUNAVIR | DARUNVIR, RESISTANCE, MUTATION SCORE, HIV PROTEASE, TMC-114, HYDROLASE
3ggv:B (LYS45) to (GLY94) HIV PROTEASE, PSEUDO-SYMMETRIC INHIBITORS | HIV PROTEASE, PSEUDO-SYMMETRIC INHIBITORS, HYDROLASE, PROTEASE
3ggv:F (GLY52) to (GLY94) HIV PROTEASE, PSEUDO-SYMMETRIC INHIBITORS | HIV PROTEASE, PSEUDO-SYMMETRIC INHIBITORS, HYDROLASE, PROTEASE
3ggv:G (GLY52) to (GLY94) HIV PROTEASE, PSEUDO-SYMMETRIC INHIBITORS | HIV PROTEASE, PSEUDO-SYMMETRIC INHIBITORS, HYDROLASE, PROTEASE
3ggv:I (LYS45) to (GLY94) HIV PROTEASE, PSEUDO-SYMMETRIC INHIBITORS | HIV PROTEASE, PSEUDO-SYMMETRIC INHIBITORS, HYDROLASE, PROTEASE
3gi0:A (PRO148) to (GLY198) CRYSTAL STRUCTURE OF A CHEMICALLY SYNTHESIZED 203 AMINO ACID 'COVALENT DIMER' [L-ALA51,D-ALA51'] HIV-1 PROTEASE MOLECULE COMPLEXED WITH JG- 365 INHIBITOR | BETA-BARREL, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3gi0:B (GLY52) to (GLY94) CRYSTAL STRUCTURE OF A CHEMICALLY SYNTHESIZED 203 AMINO ACID 'COVALENT DIMER' [L-ALA51,D-ALA51'] HIV-1 PROTEASE MOLECULE COMPLEXED WITH JG- 365 INHIBITOR | BETA-BARREL, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3gi4:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF PROTEASE INHIBITOR, KB60 IN COMPLEX WITH WILD TYPE HIV-1 PROTEASE | DRUG DESIGN, PROTEASE INHIBITORS, HIV-1 PROTEASE, ASPARTYL PROTEASE, HYDROLASE, PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3gi5:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF PROTEASE INHIBITOR, KB62 IN COMPLEX WITH WILD TYPE HIV-1 PROTEASE | DRUG DESIGN, PROTEASE INHIBITORS, HIV-1 PROTEASE, ASPARTYL PROTEASE, HYDROLASE, PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3gi6:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF PROTEASE INHIBITOR, AD78 IN COMPLEX WITH WILD TYPE HIV-1 PROTEASE | DRUG DESIGN, PROTEASE INHIBITORS, HIV-1 PROTEASE, ASPARTYL PROTEASE, HYDROLASE, PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2r3t:B (LYS45) to (GLY94) I50V HIV-1 PROTEASE MUTANT IN COMPLEX WITH A CARBAMOYL DECORATED PYRROLIDINE-BASED INHIBITOR | PROTEIN-LIGAND COMPLEX, ASPARTYL PROTEASE, HYDROLASE, PROTEASE
2r43:A (ARG41) to (GLY94) I50V HIV-1 PROTEASE IN COMPLEX WITH AN AMINO DECORATED PYRROLIDINE- BASED INHIBITOR | PROTEIN-LIGAND COMPLEX, HYDROLASE
4j54:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF MULTIDRUG RESISTANT HIV-1 PROTEASE CLINICAL ISOLATE PR20 WITH THE POTENT ANTIVIRAL INHIBITOR GRL-0519A | MULTIDRUG RESISTANT HIV-1 PROTEASE CLINICAL ISOLATE PR20, CLINICAL INHIBITOR AMPRENAVIR, POTENT ANTIVIRAL INHIBITOR GRL-0519A, POTENT ANTIVIRAL INHIBITOR GRL-02031, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4j54:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF MULTIDRUG RESISTANT HIV-1 PROTEASE CLINICAL ISOLATE PR20 WITH THE POTENT ANTIVIRAL INHIBITOR GRL-0519A | MULTIDRUG RESISTANT HIV-1 PROTEASE CLINICAL ISOLATE PR20, CLINICAL INHIBITOR AMPRENAVIR, POTENT ANTIVIRAL INHIBITOR GRL-0519A, POTENT ANTIVIRAL INHIBITOR GRL-02031, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4j55:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF MULTIDRUG RESISTANT HIV-1 PROTEASE CLINICAL ISOLATE PR20 WITH THE POTENT ANTIVIRAL INHIBITOR GRL-02031 | MULTIDRUG RESISTANT HIV-1 PROTEASE CLINICAL ISOLATE PR20, CLINICAL INHIBITOR AMPRENAVIR, POTENT ANTIVIRAL INHIBITOR GRL-0519A, POTENT ANTIVIRAL INHIBITOR GRL-02031, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4j55:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF MULTIDRUG RESISTANT HIV-1 PROTEASE CLINICAL ISOLATE PR20 WITH THE POTENT ANTIVIRAL INHIBITOR GRL-02031 | MULTIDRUG RESISTANT HIV-1 PROTEASE CLINICAL ISOLATE PR20, CLINICAL INHIBITOR AMPRENAVIR, POTENT ANTIVIRAL INHIBITOR GRL-0519A, POTENT ANTIVIRAL INHIBITOR GRL-02031, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4j5j:B (GLY140) to (GLY194) CRYSTAL STRUCTURE OF MULTIDRUG RESISTANT HIV-1 PROTEASE CLINICAL ISOLATE PR20 IN COMPLEX WITH AMPRENAVIR | MULTIDRUG RESISTANT HIV-1 PROTEASE CLINICAL ISOLATE PR20, CLINICAL INHIBITOR AMPRENAVIR, POTENT ANTIVIRAL INHIBITOR GRL-0519A, POTENT ANTIVIRAL INHIBITOR GRL-02031, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2r5p:B (LYS45) to (GLY94) CRYSTAL STRUCTURE ANALYSIS OF HIV-1 SUBTYPE C PROTEASE COMPLEXED WITH INDINAVIR | HIV-1 SUBTYPE C, ASPARTYL PROTEASE, HYDROLASE, PROTEASE, VIRAL PROTEIN
2r5p:D (LYS45) to (GLY94) CRYSTAL STRUCTURE ANALYSIS OF HIV-1 SUBTYPE C PROTEASE COMPLEXED WITH INDINAVIR | HIV-1 SUBTYPE C, ASPARTYL PROTEASE, HYDROLASE, PROTEASE, VIRAL PROTEIN
3th9:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 PROTEASE MUTANT Q7K V32I L63I WITH A CYCLIC SULFONAMIDE INHIBITOR | ENZYME INHIBITION, ASPARTIC PROTEASE, HIV/AIDS, CONFORMATIONAL CHANGE, AMPRENAVIR, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3th9:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 PROTEASE MUTANT Q7K V32I L63I WITH A CYCLIC SULFONAMIDE INHIBITOR | ENZYME INHIBITION, ASPARTIC PROTEASE, HIV/AIDS, CONFORMATIONAL CHANGE, AMPRENAVIR, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1ebk:C (ARG41) to (GLY94) STRUCTURAL AND KINETIC ANALYSIS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE | HIV-1 PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1ebk:D (GLY152) to (ILE193) STRUCTURAL AND KINETIC ANALYSIS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE | HIV-1 PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1ebk:F (GLY152) to (GLY194) STRUCTURAL AND KINETIC ANALYSIS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE | HIV-1 PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1ebw:A (GLY52) to (GLY94) HIV-1 PROTEASE IN COMPLEX WITH THE INHIBITOR BEA322 | DIMER, PROTEIN-INHIBITOR COMPLEX, HYDROLASE/HYDROLASE INHIBITOR COMPLEX
1ec0:A (GLY52) to (GLY94) HIV-1 PROTEASE IN COMPLEX WITH THE INHIBITOR BEA403 | DIMER, PROTEIN-INHIBITOR COMPLEX, HYDROLASE/HYDROLASE INHIBITOR COMPLEX
1ec1:A (GLY52) to (GLY94) HIV-1 PROTEASE IN COMPLEX WITH THE INHIBITOR BEA409 | DIMER, PROTEIN-INHIBITOR COMPLEX, HYDROLASE/HYDROLASE INHIBITOR COMPLEX
1ec3:A (GLY52) to (GLY94) HIV-1 PROTEASE IN COMPLEX WITH THE INHIBITOR MSA367 | DIMER, PROTEIN-INHIBITOR COMPLEX, HYDROLASE/HYDROLASE INHIBITOR COMPLEX
3tkg:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV MODEL PROTEASE PRECURSOR/SAQUINAVIR COMPLEX | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3tkg:C (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV MODEL PROTEASE PRECURSOR/SAQUINAVIR COMPLEX | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3tl9:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV PROTEASE MODEL PRECURSOR/SAQUINAVIR COMPLEX | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3tlh:A (LYS45) to (GLY94) STRUCTURAL STUDIES OF HIV AND FIV PROTEASES COMPLEXED WITHAN EFFICIENT INHIBITOR OF FIV PR | HIV PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3tof:A (GLY40) to (GLY94) HIV-1 PROTEASE - EPOXYDIC INHIBITOR COMPLEX (PH 6 - ORTHOROMBIC CRYSTAL FORM P212121) | HIV PR, EPOXIDE, IN-CRYSTAL REACTION, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3tog:B (LYS45) to (GLY94) HIV-1 PROTEASE - EPOXYDIC INHIBITOR COMPLEX (PH 9 - MONOCLINIC CRYSTAL FORM P21) | HIV PR, EPOXIDE, IN-CRYSTAL REACTION, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3toh:A (GLY40) to (GLY94) HIV-1 PROTEASE - EPOXYDIC INHIBITOR COMPLEX (PH 9 - ORTHOROMBIC CRYSTAL FORM P212121) | HIV PR, EPOXIDE, IN-CRYSTAL REACTION, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1qbr:A (LYS45) to (GLY94) HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY | HYDROLASE (ACID PROTEINASE), ASPARTYL PROTEASE
1qbr:B (LYS45) to (GLY94) HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY | HYDROLASE (ACID PROTEINASE), ASPARTYL PROTEASE
1qbu:B (LYS45) to (GLY94) HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY | HYDROLASE (ACID PROTEINASE), ASPARTYL PROTEASE
4ye3:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF MULTIDRUG RESISTANT HIV-1 PROTEASE CLINICAL ISOLATE PR20 WITH INHIBITOR GRL-4410A | HIV-1 PROTEASE, DRUG RESISTANCE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4ye3:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF MULTIDRUG RESISTANT HIV-1 PROTEASE CLINICAL ISOLATE PR20 WITH INHIBITOR GRL-4410A | HIV-1 PROTEASE, DRUG RESISTANCE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3ttp:A (LYS45) to (GLY94) STRUCTURE OF MULTIRESISTANT HIV-1 PROTEASE IN COMPLEX WITH DARUNAVIR | HYDROLASE, VIRAL PRATICLE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2rkg:B (GLY53) to (GLY95) HIV-1 PR RESISTANT MUTANT + LPV | RESISTENCE, INSERTION, HYDROLASE
4yhq:B (GLY40) to (GLY94) CRYSTAL STRUCTURE OF MULTIDRUG RESISTANT CLINICAL ISOLATE PR20 WITH GRL-5010A | HIV PROTEASE, MUTANT, DRUG RESISTANT, INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3h5b:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF WILD TYPE HIV-1 PROTEASE WITH NOVEL P1'-LIGAND GRL-02031 | HIV-1, WILD TYPE PROTEASE, PROTEASE INHIBITOR, P1'-LIGAND, AIDS, HYDROLASE
3hau:B (GLY52) to (GLY94) CRYSTAL STRUCTURE OF CHEMICALLY SYNTHESIZED HIV-1 PROTEASE WITH REDUCED ISOSTERE MVT-101 INHIBITOR | BETA BARREL, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3haw:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF [L-ALA51/51']HIV-1 PROTEASE WITH REDUCED ISOSTERE MVT-101 INHIBITOR | BETA BARREL, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3hbo:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF CHEMICALLY SYNTHESIZED [D-ALA51/51']HIV-1 PROTEASE | BETA BARREL, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3u71:A (GLY40) to (GLY94) CRYSTAL STRUCTURE ANALYSIS OF SOUTH AFRICAN WILD TYPE HIV-1 SUBTYPE C PROTEASE | BETA SHEET, APO, PROTEASE, SOUTH AFRICAN, NON-B SUBTYPE, VIRAL POLYPROTEIN, HYDROLASE
3u7s:A (ARG41) to (GLY94) HIV PR DRUG RESISTANT PATIENT'S VARIANT IN COMPLEX WITH DARUNAVIR | DARUNVIR, RESISTANCE, MUTATION SCORE, HIV PROTEASE, TMC-114, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3u7s:B (LYS45) to (GLY94) HIV PR DRUG RESISTANT PATIENT'S VARIANT IN COMPLEX WITH DARUNAVIR | DARUNVIR, RESISTANCE, MUTATION SCORE, HIV PROTEASE, TMC-114, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3hdk:A (PRO44) to (GLY94) CRYSTAL STRUCTURE OF CHEMICALLY SYNTHESIZED [AIB51/51']HIV-1 PROTEASE | BETA BARREL, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2uy0:B (GLY152) to (GLY194) TWO-CARBON-ELONGATED HIV-1 PROTEASE INHIBITORS WITH A TERTIARY-ALCOHOL-CONTAINING TRANSITION-STATE MIMIC | HIV-1, PROTEASE, HYDROLASE, INHIBITOR, ASPARTYL PROTEASE
1fej:C (GLY40) to (GLY94) STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES | HIV-1 PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1ffi:C (GLY40) to (GLY94) STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES | HIV-1 PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1fg6:C (ARG41) to (GLY94) STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES | HIV-1 PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1fgc:C (GLY40) to (GLY94) STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES | HIV-1 PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3ucb:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF MULTIDRUG RESISTANT HIV-1 PROTEASE CLINICAL ISOLATE PR20 IN COMPLEX WITH DARUNAVIR | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3ucb:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF MULTIDRUG RESISTANT HIV-1 PROTEASE CLINICAL ISOLATE PR20 IN COMPLEX WITH DARUNAVIR | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3uf3:B (GLY40) to (GLY94) CRYSTAL STRUCTURE OF MULTIDRUG RESISTANT HIV-1 PROTEASE CLINICAL ISOLATE PR20 | HYDROLASE
3ufn:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF MULTIDRUG RESISTANT HIV-1 PROTEASE CLINICAL ISOLATE PR20 IN COMPLEX WITH SAQUINAVIR | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3ufn:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF MULTIDRUG RESISTANT HIV-1 PROTEASE CLINICAL ISOLATE PR20 IN COMPLEX WITH SAQUINAVIR | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4k4q:B (GLY40) to (GLY94) TL-3 INHIBITED TRP6ALA HIV PROTEASE WITH 3-BROMO-2,6-DIMETHOXYBENZOIC ACID BOUND IN FLAP SITE | FRAGMENT BINDING, EXOSITE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4k4r:B (LYS45) to (GLY94) TL-3 INHIBITED TRP6ALA HIV PROTEASE WITH 1-BROMO-2-NAPTHOIC ACID BOUND IN EXOSITE | FRAGMENT BINDING, EXOSITE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3hlo:A (LYS149) to (GLY198) CRYSTAL STRUCTURE OF CHEMICALLY SYNTHESIZED 'COVALENT DIMER' [GLY51/D- ALA51']HIV-1 PROTEASE | BETA BARREL, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3uhl:B (GLY40) to (GLY94) CRYSTAL STRUCTURE OF MULTIDRUG RESISTANT HIV-1 PROTEASE CLINICAL ISOLATE PR20 IN COMPLEX WITH P2-NC SUBSTRATE ANALOG | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3uhl:C (PRO44) to (GLY94) CRYSTAL STRUCTURE OF MULTIDRUG RESISTANT HIV-1 PROTEASE CLINICAL ISOLATE PR20 IN COMPLEX WITH P2-NC SUBSTRATE ANALOG | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3uhl:D (GLY40) to (GLY94) CRYSTAL STRUCTURE OF MULTIDRUG RESISTANT HIV-1 PROTEASE CLINICAL ISOLATE PR20 IN COMPLEX WITH P2-NC SUBSTRATE ANALOG | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2f3k:A (GLY52) to (GLY94) SUBSTRATE ENVELOPE AND DRUG RESISTANCE: CRYSTAL STRUCTURE OF R01 IN COMPLEX WITH WILD-TYPE HIV-1 PROTEASE | SUBSTRATE ENVELOPE, DRUG RESISTANCE, HIV PROTEASE, RO1, HYDROLASE
2f3k:B (GLY52) to (GLY94) SUBSTRATE ENVELOPE AND DRUG RESISTANCE: CRYSTAL STRUCTURE OF R01 IN COMPLEX WITH WILD-TYPE HIV-1 PROTEASE | SUBSTRATE ENVELOPE, DRUG RESISTANCE, HIV PROTEASE, RO1, HYDROLASE
1rl8:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF THE COMPLEX OF RESISTANT STRAIN OF HIV-1 PROTEASE(V82A MUTANT) WITH RITONAVIR | ASPARTIC PROTEASE, ASPARTIC PROTEASE-INHIBITOR COMPLEX, RESISTANT STRAIN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4kb9:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 PROTEASE WITH NOVEL TRICYCLIC P2- LIGANDS GRL-0739A | SPARTIC ACID PROTEASE, HIV-1 PROTEASE INHIBITOR GRL-0739A, A NOVEL TRICYCLIC P2-LIGAND,, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2f81:A (LYS45) to (GLY94) HIV-1 PROTEASE MUTANT L90M COMPLEXED WITH INHIBITOR TMC114 | HIV-1 PROTEASE-INHIBITOR COMPLEX, HYDROLASE
2f8g:A (LYS45) to (GLY94) HIV-1 PROTEASE MUTANT I50V COMPLEXED WITH INHIBITOR TMC114 | HIV-1 PROTEASE-INHIBITOR COMPLEX, HYDROLASE
1g2k:A (GLY52) to (GLY94) HIV-1 PROTEASE WITH CYCLIC SULFAMIDE INHIBITOR, AHA047 | HIV, PROTEASE INHIBITORS, HYDROLASE
1g35:A (GLY52) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 PROTEASE IN COMPLEX WITH INHIBITOR, AHA024 | PROTEIN-INHIBITOR COMPLEX, HYDROLASE
2fde:B (LYS45) to (ILE93) WILD TYPE HIV PROTEASE BOUND WITH GW0385 | HIV PROTEASE, INHIBITOR, GW0385, HYDROLASE
4z2z:B (GLY248) to (LEU298) NEW CRYSTAL STRUCTURE OF YEAST DDI1 ASPARTYL PROTEASE REVEALS SUBSTRATE ENGAGEMENT MODE | PROTEASE, DDI1, HYDROLASE
1g6l:A (LYS1045) to (GLY1094) 1.9A CRYSTAL STRUCTURE OF TETHERED HIV-1 PROTEASE | HYDROLASE
2fgu:B (GLY52) to (GLY94) X-RAY CRYSTAL STRUCTURE OF HIV-1 PROTEASE T80S VARIANT IN COMPLEX WITH THE INHIBITOR SAQUINAVIR USED TO EXPLORE THE ROLE OF INVARIANT THR80 IN HIV-1 PROTEASE STRUCTURE, FUNCTION, AND VIRAL INFECTIVITY. | HIV PROTEASE, DRUG RESISTANCE, ENZYME KINETICS, SEQUENCE CONSERVATION, PROTEIN STRUCTURE, HYDROLASE
2fgv:A (GLY52) to (GLY94) X-RAY CRYSTAL STRUCTURE OF HIV-1 PROTEASE T80N VARIANT IN COMPLEX WITH THE INHIBITOR SAQUINAVIR USED TO EXPLORE THE ROLE OF INVARIANT THR80 IN HIV-1 PROTEASE STRUCTURE, FUNCTION, AND VIRAL INFECTIVITY. | HIV PROTEASE, DRUG RESISTANCE, ENZYME KINETICS, SEQUENCE CONSERVATION, PROTEIN STRUCTURE, HYDROLASE
4z4x:B (GLY140) to (GLY194) CRYSTAL STRUCTURE OF MULTIDRUG RESISTANT HIV-1 PROTEASE CLINICAL ISOLATE PR20D25N WITH OPEN FLAP | HIV-1 PROTEASE, HYDROLASE
2fle:B (LYS45) to (GLY94) STRUCTURAL ANALYSIS OF ASYMMETRIC INHIBITOR BOUND TO THE HIV-1 PROTEASE V82A MUTANT | HIV-1 PROTEASE, INHIBITOR, RESISTANCE, INDUCED FIT, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
2fns:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF WILD-TYPE INACTIVE (D25N) HIV-1 PROTEASE COMPLEXED WITH WILD-TYPE HIV-1 NC-P1 SUBSTRATE. | STRUCTURAL INTERMEDIATE, SUBSTRATE RECOGNITION, HIV-1 PROTEASE, NC-P1 SUBSTRATE, DRUG RESISTANCE, FLAP CONFORMATION, HYDROLASE
2fnt:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF A DRUG-RESISTANT (V82A) INACTIVE (D25N) HIV-1 PROTEASE COMPLEXED WITH AP2V VARIANT OF HIV-1 NC-P1 SUBSTRATE. | STRUCTURAL INTERMEDIATE, SUBSTRATE RECOGNITION, HIV-1 PROTEASE, NC-P1 SUBSTRATE, DRUG RESISTANCE, FLAP CONFORMATION, HYDROLASE
1sbg:A (LYS45) to (GLY94) AN ORALLY-BIOAVAILABLE HIV-1 PROTEASE INHIBITOR CONTAINING AN IMIDAZOLE-DERIVED PEPTIDE BOND REPLACEMENT. CRYSTALLOGRAPHIC AND PHARMACOKINETIC ANALYSIS | HYDROLASE(ACID PROTEASE)
1sdv:B (PRO144) to (GLY194) CRYSTAL STRUCTURES OF HIV PROTEASE V82A AND L90M MUTANTS REVEAL CHANGES IN INDINAVIR BINDING SITE. | DRUG RESISTANCE; HIV-1 PROTEASE, HYDROLASE
2fxd:A (GLY52) to (GLY94) X-RAY CRYSTAL STRUCTURE OF HIV-1 PROTEASE IRM MUTANT COMPLEXED WITH ATAZANAVIR (BMS-232632) | HUMAN IMMUNODEFICIENCY VIRUS (HIV), HIV-1 PROTEASE, REYATAZ, ATAZANAVIR, BMS-232632, HYDROLASE
2fxd:B (GLY40) to (GLY94) X-RAY CRYSTAL STRUCTURE OF HIV-1 PROTEASE IRM MUTANT COMPLEXED WITH ATAZANAVIR (BMS-232632) | HUMAN IMMUNODEFICIENCY VIRUS (HIV), HIV-1 PROTEASE, REYATAZ, ATAZANAVIR, BMS-232632, HYDROLASE
1gnn:A (LYS45) to (GLY94) HIV-1 PROTEASE MUTANT WITH VAL 82 REPLACED BY ASN (V82N) COMPLEXED WITH U89360E (INHIBITOR) | ASPARTIC PROTEASE, HIV, MUTANT, INHIBITOR, U-89360E, HYDROLASE (ACID PROTEASE)
1gno:A (LYS45) to (GLY94) HIV-1 PROTEASE (WILD TYPE) COMPLEXED WITH U89360E (INHIBITOR) | ASPARTIC PROTEASE, HIV, MUTANT, INHIBITOR, U-89360E, HYDROLASE (ACID PROTEASE)
1sip:A (LYS45) to (GLY94) ALTERNATIVE NATIVE FLAP CONFORMATION REVEALED BY 2.3 ANGSTROMS RESOLUTION STRUCTURE OF SIV PROTEINASE | HYDROLASE(ACID PROTEINASE)
4zip:A (LYS45) to (GLY94) HIV-1 WILD TYPE PROTEASE WITH GRL-0648A (A ISOPHTHALAMIDE-DERIVED P2- LIGAND) | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1sp5:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 PROTEASE COMPLEXED WITH A PRODUCT OF AUTOPROTEOLYSIS | PRODUCT, PEPTIDE, AUTOPROTEOLYSIS, SELF-DIGESTION, AUTODIGESTION, ASPARTIC PROTEASE, HIV, PROTEASE, COMPLEX(ASPARTIC PROTEASE/PEPTIDE), HYDROLASE
3i7e:B (GLY40) to (GLY94) CO-CRYSTAL STRUCTURE OF HIV-1 PROTEASE BOUND TO A MUTANT RESISTANT INHIBITOR UIC-98038 | AIDS, HIV, HIV PRTEASE, HIV-PROTEASE INHIBITOR, DRUG DESIGN, ASPARTIC PROTEASE, ACID PROTEASE, STRUCTURE BASED DRUG DESIGN, ASPARTYL PROTEASE, HYDROLASE, PROTEASE
3ia9:B (PRO44) to (GLY94) CRYSTAL STRUCTURE OF A CHEMICALLY SYNTHESIZED [D25N]HIV-1 PROTEASE MOLECULE COMPLEXED WITH MVT-101 REDUCED ISOSTERE INHIBITOR | BETA-SHEET, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3vf5:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 PROTEASE MUTANT I47V WITH NOVEL P1'-LIGANDS GRL-02031 | PROTEASE INHIBITOR,P1'-LIGAND, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3vfb:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 PROTEASE MUTANT N88D WITH NOVEL P1'-LIGANDS GRL-02031 | PROTEASE INHIBITOR,P1'-LIGAND, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3iaw:A (LYS149) to (GLY198) CRYSTAL STRUCTURE OF A CHEMICALLY SYNTHESIZED 203 AMINO ACID 'COVALENT DIMER' [GLY51;AIB51']HIV-1 PROTEASE MOLECULE COMPLEXED WITH MVT-101 REDUCED ISOSTERE INHIBITOR AT 1.6 A RESOLUTION | ASYMMETRIC DIMER, COVALENT DIMER, BETA-SHEET, HYDROLASE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
1t3r:B (LYS45) to (GLY94) HIV PROTEASE WILD-TYPE IN COMPLEX WITH TMC114 INHIBITOR | HIV-1 PROTEASE; DRUG RESISTANCE; THERMODYNAMICS; SUBSTRATE ENVELOPE, HYDROLASE
1t7k:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV PROTEASE COMPLEXED WITH ARYLSULFONAMIDE AZACYCLIC UREA | HIV PROTEASE, ARYLSULFONAMIDE AZACYCLIC UREA, HYDROLASE
1tcw:B (LYS45) to (GLY94) SIV PROTEASE COMPLEXED WITH INHIBITOR SB203386 | AIDS, POLYPROTEIN, HYDROLASE, ASPARTYL PROTEASE, ENDONUCLEASE, RNA-DIRECTED DNA POLYMERASE, ACID PROTEASE, HYDROLASE (ACID PROTEASE)
1tcx:A (GLY52) to (GLY94) HIV TRIPLE MUTANT PROTEASE COMPLEXED WITH INHIBITOR SB203386 | AIDS, POLYPROTEIN, HYDROLASE, ASPARTYL PROTEASE, ENDONUCLEASE, RNA-DIRECTED DNA POLYMERASE, ACID PROTEASE, HYDROLASE (ACID PROTEASE)
1tcx:B (LYS45) to (GLY94) HIV TRIPLE MUTANT PROTEASE COMPLEXED WITH INHIBITOR SB203386 | AIDS, POLYPROTEIN, HYDROLASE, ASPARTYL PROTEASE, ENDONUCLEASE, RNA-DIRECTED DNA POLYMERASE, ACID PROTEASE, HYDROLASE (ACID PROTEASE)
1hih:A (LYS45) to (GLY94) COMPARATIVE ANALYSIS OF THE X-RAY STRUCTURES OF HIV-1 AND HIV-2 PROTEASES IN COMPLEX WITH CGP 53820, A NOVEL PSEUDOSYMMETRIC INHIBITOR | ASPARTATE PROTEASE, INHIBITED, HIV, HYDROLASE (ASPARTIC PROTEINASE)
1hih:B (GLY52) to (GLY94) COMPARATIVE ANALYSIS OF THE X-RAY STRUCTURES OF HIV-1 AND HIV-2 PROTEASES IN COMPLEX WITH CGP 53820, A NOVEL PSEUDOSYMMETRIC INHIBITOR | ASPARTATE PROTEASE, INHIBITED, HIV, HYDROLASE (ASPARTIC PROTEINASE)
2hb3:A (LYS45) to (GLY94) WILD-TYPE HIV-1 PROTEASE IN COMPLEX WITH POTENT INHIBITOR GRL06579 | ACTIVE-SITE CAVITY PROTEASE INHIBITOR CATALYTIC ASPARTIC ACID, HYDROLASE
2hb4:A (GLY40) to (GLY94) STRUCTURE OF HIV PROTEASE NL4-3 IN AN UNLIGANDED STATE | HIV, PROTEASE, ASPARTYL, RETROVIRUS, HYDROLASE
1hos:A (LYS45) to (GLY94) INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE BY A C2- SYMMETRIC PHOSPHINATE SYNTHESIS AND CRYSTALLOGRAPHIC ANALYSIS | HYDROLASE(ACID PROTEINASE)
1hos:B (LYS45) to (GLY94) INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS-1 PROTEASE BY A C2- SYMMETRIC PHOSPHINATE SYNTHESIS AND CRYSTALLOGRAPHIC ANALYSIS | HYDROLASE(ACID PROTEINASE)
1hps:A (LYS45) to (GLY94) RATIONAL DESIGN, SYNTHESIS AND CRYSTALLOGRAPHIC ANALYSIS OF A HYDROXYETHYLENE-BASED HIV-1 PROTEASE INHIBITOR CONTAINING A HETEROCYCLIC P1'-P2' AMIDE BOND ISOSTERE | HYDROLASE(ACID PROTEINASE)
1hpv:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 PROTEASE IN COMPLEX WITH VX-478, A POTENT AND ORALLY BIOAVAILABLE INHIBITOR OF THE ENZYME | HYDROLASE (ACID PROTEINASE)
1hpx:A (GLY52) to (GLY94) HIV-1 PROTEASE COMPLEXED WITH THE INHIBITOR KNI-272 | ACID PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1tsq:A (GLY52) to (GLY94) CRYSTAL STRUCTURE OF AP2V SUBSTRATE VARIANT OF NC-P1 DECAMER PEPTIDE IN COMPLEX WITH V82A/D25N HIV-1 PROTEASE MUTANT | CO-EVOLUTION, NUCLEOCAPDIS, SUBSTRATE RECOGNITION, HIV-1 PROTEASE, HYDROLASE/VIRAL PROTEIN COMPLEX
1tsq:B (GLY52) to (GLY94) CRYSTAL STRUCTURE OF AP2V SUBSTRATE VARIANT OF NC-P1 DECAMER PEPTIDE IN COMPLEX WITH V82A/D25N HIV-1 PROTEASE MUTANT | CO-EVOLUTION, NUCLEOCAPDIS, SUBSTRATE RECOGNITION, HIV-1 PROTEASE, HYDROLASE/VIRAL PROTEIN COMPLEX
1tsu:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF DECAMER NCP1 SUBSTRATE PEPTIDE IN COMPLEX WITH WILD-TYPE D25N HIV-1 PROTEASE VARIANT | CO-EVOLUTION, NUCLEOCAPDIS, SUBSTRATE RECOGNITION, HIV-1 PROTEASE, VIRAL PROTEIN/HYDROLASE COMPLEX
1tsu:B (GLY52) to (GLY94) CRYSTAL STRUCTURE OF DECAMER NCP1 SUBSTRATE PEPTIDE IN COMPLEX WITH WILD-TYPE D25N HIV-1 PROTEASE VARIANT | CO-EVOLUTION, NUCLEOCAPDIS, SUBSTRATE RECOGNITION, HIV-1 PROTEASE, VIRAL PROTEIN/HYDROLASE COMPLEX
4ll3:A (LYS45) to (GLY94) STRUCTURE OF WILD-TYPE HIV PROTEASE IN COMPLEX WITH DARUNAVIR | HYDROLASE INHIBITOR-DARUNAVIR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, HIV-1 PROTEASE, TMC114
4ll3:B (LYS45) to (GLY94) STRUCTURE OF WILD-TYPE HIV PROTEASE IN COMPLEX WITH DARUNAVIR | HYDROLASE INHIBITOR-DARUNAVIR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, HIV-1 PROTEASE, TMC114
3ixo:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF UNCOMPLEXED HIV_1 PROTEASE SUBTYPE A | HIV-1 PROTEASE, SUBTYPE A, UNCOMPLEXED, ASPARTYL PROTEASE, HYDROLASE, MULTIFUNCTIONAL ENZYME, NUCLEOTIDYLTRANSFERASE, PROTEASE, RNA- DIRECTED DNA POLYMERASE, TRANSFERASE
3ixo:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF UNCOMPLEXED HIV_1 PROTEASE SUBTYPE A | HIV-1 PROTEASE, SUBTYPE A, UNCOMPLEXED, ASPARTYL PROTEASE, HYDROLASE, MULTIFUNCTIONAL ENZYME, NUCLEOTIDYLTRANSFERASE, PROTEASE, RNA- DIRECTED DNA POLYMERASE, TRANSFERASE
1hsg:B (PRO44) to (GLY94) CRYSTAL STRUCTURE AT 1.9 ANGSTROMS RESOLUTION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) II PROTEASE COMPLEXED WITH L- 735,524, AN ORALLY BIOAVAILABLE INHIBITOR OF THE HIV PROTEASES | HYDROLASE (ACID PROTEINASE)
1hsi:B (SER43) to (GLY94) CRYSTAL STRUCTURE AT 1.9 ANGSTROMS RESOLUTION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) II PROTEASE COMPLEXED WITH L- 735,524, AN ORALLY BIOAVAILABLE INHIBITOR OF THE HIV PROTEASES | HYDROLASE (ACID PROTEINASE)
1htf:B (LYS45) to (GLY94) X-RAY CRYSTALLOGRAPHIC STUDIES OF A SERIES OF PENICILLIN- DERIVED ASYMMETRIC INHIBITORS OF HIV-1 PROTEASE | HYDROLASE(ACID PROTEINASE)
1htg:A (GLY52) to (GLY94) X-RAY CRYSTALLOGRAPHIC STUDIES OF A SERIES OF PENICILLIN- DERIVED ASYMMETRIC INHIBITORS OF HIV-1 PROTEASE | HYDROLASE(ACID PROTEINASE)
2whh:A (LYS45) to (GLY94) HIV-1 PROTEASE TETHERED DIMER Q-PRODUCT COMPLEX ALONG WITH NUCLEOPHILIC WATER MOLECULE | PROTEASE, HYDROLASE, DRUG DESIGN, TRANSFERASE, NUCLEOTIDYLTRANSFERASE, RNA-DIRECTED DNA POLYMERASE, CATALYTIC MECHANISM, MULTIFUNCTIONAL ENZYME, TRANSITION STATE, ASPARTYL PROTEASE
2whh:A (LYS1045) to (GLY1094) HIV-1 PROTEASE TETHERED DIMER Q-PRODUCT COMPLEX ALONG WITH NUCLEOPHILIC WATER MOLECULE | PROTEASE, HYDROLASE, DRUG DESIGN, TRANSFERASE, NUCLEOTIDYLTRANSFERASE, RNA-DIRECTED DNA POLYMERASE, CATALYTIC MECHANISM, MULTIFUNCTIONAL ENZYME, TRANSITION STATE, ASPARTYL PROTEASE
1hvc:A (GLY52) to (GLY94) CRYSTAL STRUCTURE OF A TETHERED DIMER OF HIV-1 PROTEASE COMPLEXED WITH AN INHIBITOR | HYDROLASE(ACID PROTEASE)
1hvi:B (GLY52) to (GLY94) INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C2 SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE | HYDROLASE(ACID PROTEASE)
1hvj:B (GLY52) to (GLY94) INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C2 SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE | HYDROLASE(ACID PROTEASE)
1hvk:B (GLY52) to (GLY94) INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C2 SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE | HYDROLASE(ACID PROTEASE)
1hvr:B (LYS45) to (GLY94) RATIONAL DESIGN OF POTENT, BIOAVAILABLE, NONPEPTIDE CYCLIC UREAS AS HIV PROTEASE INHIBITORS | HYDROLASE, ACID PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1hxw:B (LYS45) to (GLY94) HIV-1 PROTEASE DIMER COMPLEXED WITH A-84538 | ASPARTYL PROTEASE, HYDROLASE, ASPARTIC PROTEINASE, HIV, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
2hpe:B (ASN41) to (GLY94) COMPARISON OF THE STRUCTURES OF HIV-2 PROTEASE COMPLEXES IN THREE CRYSTAL SPACE GROUPS WITH AN HIV-1 PROTEASE COMPLEX STRUCTURE | HYDROLASE(ACID PROTEASE)
2hpf:A (LYS45) to (GLY94) COMPARISON OF THE STRUCTURES OF HIV-2 PROTEASE COMPLEXES IN THREE CRYSTAL SPACE GROUPS WITH AN HIV-1 PROTEASE COMPLEX STRUCTURE | HYDROLASE(ACID PROTEASE)
2hpf:B (ASN41) to (GLY94) COMPARISON OF THE STRUCTURES OF HIV-2 PROTEASE COMPLEXES IN THREE CRYSTAL SPACE GROUPS WITH AN HIV-1 PROTEASE COMPLEX STRUCTURE | HYDROLASE(ACID PROTEASE)
2wl0:B (GLY152) to (GLY194) HIV-1 PROTEASE INHIBITORS CONTAINING A TERTIARY ALCOHOL IN THE TRANSITION-STATE MIMIC WITH IMPROVED CELL-BASED ANTIVIRAL ACTIVITY | TRANSITION-STATE MIMIC, INHIBITOR, HYDROLASE
2hs1:A (LYS45) to (GLY94) ULTRA-HIGH RESOLUTION X-RAY CRYSTAL STRUCTURE OF HIV-1 PROTEASE V32I MUTANT WITH TMC114 (DARUNAVIR) INHIBITOR | ULTRA-HIGH RESOLUTION ACTIVE SITE SURFACE BINDING SITE, HYDROLASE
2hs1:B (GLY152) to (GLY194) ULTRA-HIGH RESOLUTION X-RAY CRYSTAL STRUCTURE OF HIV-1 PROTEASE V32I MUTANT WITH TMC114 (DARUNAVIR) INHIBITOR | ULTRA-HIGH RESOLUTION ACTIVE SITE SURFACE BINDING SITE, HYDROLASE
2hs2:B (GLY152) to (GLY194) CRYSTAL STRUCTURE OF M46L MUTANT OF HIV-1 PROTEASE COMPLEXED WITH TMC114 (DARUNAVIR) | ASPARTIC PROTEASE ACTIVE SITE SURFACE BINDING SITE, HYDROLASE
1u8g:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF A HIV-1 PROTEASE IN COMPLEX WITH PEPTIDOMIMETIC INHIBITOR KI2-PHE-GLU-GLU-NH2 | ASPARTYL PROTEASE, HUMAN IMMUNODEFICIENCY VIRUS, INHIBITOR DESIGN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1u8g:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF A HIV-1 PROTEASE IN COMPLEX WITH PEPTIDOMIMETIC INHIBITOR KI2-PHE-GLU-GLU-NH2 | ASPARTYL PROTEASE, HUMAN IMMUNODEFICIENCY VIRUS, INHIBITOR DESIGN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2i0a:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF KB-19 COMPLEXED WITH WILD TYPE HIV-1 PROTEASE | DRUG DESIGN, HIV-1 PROTEASE, PROTEASE INHIBITORS, HYDROLASE
2i0d:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF AD-81 COMPLEXED WITH WILD TYPE HIV-1 PROTEASE | DRUG DESIGN, HIV-1 PROTEASE, PROTEASE INHIBITORS, HYDROLASE
1idb:A (GLY52) to (GLY94) CRYSTAL STRUCTURES OF HIV-2 PROTEASE IN COMPLEX WITH INHIBITORS CONTAINING THE HYDROXYETHYLAMINE DIPEPTIDE ISOSTERE | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2i4u:A (LYS45) to (GLY94) HIV-1 PROTEASE WITH TMC-126 | PROTEIN INHIBITOR COMPLEX, HYDROLASE
2i4w:A (LYS45) to (GLY94) HIV-1 PROTEASE WT WITH GS-8374 | HIV-1 PROTEASE INHIBITOR, HYDROLASE
2i4x:A (GLY52) to (ILE93) HIV-1 PROTEASE I84V, L90M WITH GS-8374 | HIV-1 PROTEASE I84VL90M INHIBITOR, HYDROLASE
2idw:A (LYS45) to (GLY94) CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE MUTANT V82A WITH A POTENT NON-PEPTIDE INHIBITOR (UIC-94017) | HIV-1 PROTEASE, MUTANT, DIMER, INHIBITOR, UIC-94017, HYDROLASE
4m8x:A (GLY40) to (GLY94) GS-8374, A NOVEL PHOSPHONATE-CONTAINING INHIBITOR OF HIV-1 PROTEASE, EFFECTIVELY INHIBITS HIV PR MUTANTS WITH AMINO ACID INSERTIONS | HIV PROTEASE, ASPARTIC PROTEASE, GS8374, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4m8x:B (GLY40) to (GLY94) GS-8374, A NOVEL PHOSPHONATE-CONTAINING INHIBITOR OF HIV-1 PROTEASE, EFFECTIVELY INHIBITS HIV PR MUTANTS WITH AMINO ACID INSERTIONS | HIV PROTEASE, ASPARTIC PROTEASE, GS8374, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2ieo:A (LYS45) to (GLY94) CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE MUTANT I84V WITH A POTENT NON-PEPTIDE INHIBITOR (UIC-94017) | HIV-1 PROTEASE, MUTANT, I84V, DIMER, INHIBITOR, UIC-94017, TMC114, DARUNAVIR, HYDROLASE
1ivp:A (ASN41) to (GLY94) THE CRYSTALLOGRAPHIC STRUCTURE OF THE PROTEASE FROM HUMAN IMMUNODEFICIENCY VIRUS TYPE 2 WITH TWO SYNTHETIC PEPTIDIC TRANSITION STATE ANALOG INHIBITORS | ACID PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1ivp:B (LYS45) to (GLY94) THE CRYSTALLOGRAPHIC STRUCTURE OF THE PROTEASE FROM HUMAN IMMUNODEFICIENCY VIRUS TYPE 2 WITH TWO SYNTHETIC PEPTIDIC TRANSITION STATE ANALOG INHIBITORS | ACID PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1ivq:B (ASN41) to (GLY94) THE CRYSTALLOGRAPHIC STRUCTURE OF THE PROTEASE FROM HUMAN IMMUNODEFICIENCY VIRUS TYPE 2 WITH TWO SYNTHETIC PEPTIDIC TRANSITION STATE ANALOG INHIBITORS | ACID PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4mc1:A (LYS45) to (GLY94) HIV PROTEASE IN COMPLEX WITH SA526P | CARBAMATES, DRUG DESIGN, HIV PROTEASE INHIBITORS, PROTEIN BINDING, STEREOISOMERISM, STRUCTURE-ACTIVITY RELATIONSHIP, THIAZEPINES, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4mc1:B (PRO44) to (GLY94) HIV PROTEASE IN COMPLEX WITH SA526P | CARBAMATES, DRUG DESIGN, HIV PROTEASE INHIBITORS, PROTEIN BINDING, STEREOISOMERISM, STRUCTURE-ACTIVITY RELATIONSHIP, THIAZEPINES, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4mc2:A (LYS45) to (GLY94) HIV PROTEASE IN COMPLEX WITH SA525P | CARBAMATES, DRUG DESIGN, HIV PROTEASE INHIBITORS, PROTEIN BINDING, STEREOISOMERISM, STRUCTURE-ACTIVITY RELATIONSHIP, THIAZEPINES, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4mc2:B (PRO44) to (GLY94) HIV PROTEASE IN COMPLEX WITH SA525P | CARBAMATES, DRUG DESIGN, HIV PROTEASE INHIBITORS, PROTEIN BINDING, STEREOISOMERISM, STRUCTURE-ACTIVITY RELATIONSHIP, THIAZEPINES, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4mc6:A (LYS45) to (GLY94) HIV PROTEASE IN COMPLEX WITH SA499 | CARBAMATES, DRUG DESIGN, HIV PROTEASE INHIBITORS, PROTEIN BINDING, STEREOISOMERISM, STRUCTURE-ACTIVITY RELATIONSHIP, THIAZEPINES, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4mc6:B (PRO44) to (GLY94) HIV PROTEASE IN COMPLEX WITH SA499 | CARBAMATES, DRUG DESIGN, HIV PROTEASE INHIBITORS, PROTEIN BINDING, STEREOISOMERISM, STRUCTURE-ACTIVITY RELATIONSHIP, THIAZEPINES, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4mc9:A (LYS45) to (GLY94) HIV PROTEASE IN COMPLEX WITH AA74 | CARBAMATES, DRUG DESIGN, HIV PROTEASE INHIBITORS, PROTEIN BINDING, STEREOISOMERISM, STRUCTURE-ACTIVITY RELATIONSHIP, THIAZEPINES, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4mc9:B (PRO44) to (GLY94) HIV PROTEASE IN COMPLEX WITH AA74 | CARBAMATES, DRUG DESIGN, HIV PROTEASE INHIBITORS, PROTEIN BINDING, STEREOISOMERISM, STRUCTURE-ACTIVITY RELATIONSHIP, THIAZEPINES, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1izh:A (LYS45) to (GLY94) INHIBITOR OF HIV PROTEASE WITH UNUSUAL BINDING MODE POTENTLY INHIBITING MULTI-RESISTANT PROTEASE MUTANTS | HIV-1 PROTEINASE, POTENT INHIBITOR, SUBSITE BINDING, HYDROLASE
1izi:B (LYS45) to (GLY94) INHIBITOR OF HIV PROTEASE WITH UNUSUAL BINDING MODE POTENTLY INHIBITING MULTI-RESISTANT PROTEASE MUTANTS | HIV-1 PROTEINASE, TRIPLE MUTANT, POTENT INHIBITOR, SUBSITE BINDING, HYDROLASE
5agz:A (LYS45) to (GLY94) DISUBSTITUTED BIS-THF MOIETIES AS NEW P2 LIGANDS IN NON- PEPTIDAL HIV-1 PROTEASE INHIBITORS (II) | HYDROLASE, INHIBITOR, RATIONAL DRUG DESIGN, BIS-THF BIS-DIOL
5ah6:A (LYS45) to (GLY94) DISUBSTITUTED BIS-THF MOIETIES AS NEW P2 LIGANDS IN NON- PEPTIDAL HIV-1 PROTEASE INHIBITORS (II) | HYDROLASE, INHIBITOR, RATIONAL DRUG DESIGN, BIS-THF BIS-DIOL
5ah6:B (PRO144) to (GLY194) DISUBSTITUTED BIS-THF MOIETIES AS NEW P2 LIGANDS IN NON- PEPTIDAL HIV-1 PROTEASE INHIBITORS (II) | HYDROLASE, INHIBITOR, RATIONAL DRUG DESIGN, BIS-THF BIS-DIOL
5ah7:A (LYS45) to (GLY94) DISUBSTITUTED BIS-THF MOIETIES AS NEW P2 LIGANDS IN NON-PEPTIDAL HIV-1 PROTEASE INHIBITORS (II) | HYDROLASE, RATIONAL DRUG DESIGN, BIS-THF BIS-DIOL
5ah8:B (PRO144) to (GLY194) DISUBSTITUTED BIS-THF MOIETIES AS NEW P2 LIGANDS IN NON-PEPTIDAL HIV-1 PROTEASE INHIBITORS (II) | HYDROLASE, RATIONAL DRUG DESIGN, BIS-THF BIS-DIOL
5ah9:A (LYS45) to (GLY94) DISUBSTITUTED BIS-THF MOIETIES AS NEW P2 LIGANDS IN NON- PEPTIDAL HIV-1 PROTEASE INHIBITORS (II) | HYDROLASE, INHIBITOR, RATIONAL DRUG DESIGN, BIS-THF BIS-DIOL
5aha:B (PRO144) to (GLY194) DISUBSTITUTED BIS-THF MOIETIES AS NEW P2 LIGANDS IN NON- PEPTIDAL HIV-1 PROTEASE INHIBITORS (II) | HYDROLASE, INHIBITOR, RATIONAL DRUG DESIGN, BIS-THF BIS-DIOL
5ahb:B (PRO144) to (GLY194) DISUBSTITUTED BIS-THF MOIETIES AS NEW P2 LIGANDS IN NON-PEPTIDAL HIV-1 PROTEASE INHIBITORS (II) | HYDROLASE, INHIBITOR, RATIONAL DRUG DESIGN, BIS-THF BIS-DIOL
1vij:B (LYS45) to (GLY94) HIV-1 PROTEASE COMPLEXED WITH THE INHIBITOR HOE/BAY 793 HEXAGONAL FORM | ASPARTYL PROTEASE, HUMAN IMMUNODEFICIENCY VIRUS, HOE/BAY 793: INHIBITOR DESIGN
1vik:A (GLY52) to (GLY94) HIV-1 PROTEASE COMPLEXED WITH THE INHIBITOR HOE/BAY 793 ORTHORHOMBIC FORM | ASPARTYL PROTEASE, HUMAN IMMUNODEFICIENCY VIRUS, HOE/BAY 793: INHIBITOR DESIGN
2j9j:B (GLY52) to (GLY94) ATOMIC-RESOLUTION CRYSTAL STRUCTURE OF CHEMICALLY-SYNTHESIZED HIV-1 PROTEASE COMPLEXED WITH INHIBITOR JG-365 | HYDROLASE-HYDROLASE INHIBITOR COMPLEX, PROTEASE, HYDROLASE, HIGH RESOLUTION, RNA-DIRECTED DNA POLYMERASE, ASPARTYL PROTEASE, HUMAN IMMUNODEFICIENCY VIRUS 1, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
2j9k:B (GLY52) to (GLY94) ATOMIC-RESOLUTION CRYSTAL STRUCTURE OF CHEMICALLY-SYNTHESIZED HIV-1 PROTEASE COMPLEXED WITH INHIBITOR MVT-101 | PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, ASPARTYL PROTEASE, HUMAN IMMUNODEFICIENCY VIRUS 1
5b18:A (GLY40) to (GLY94) CRYSTAL STRUCTURE OF A DARUNAVIR RESISTANT HIV-1 PROTEASE | HIV-1 PROTEASE, DRUG RESISTANCE, DARUNAVIR, FLAP, HYDROLASE
5b18:D (GLY52) to (GLY94) CRYSTAL STRUCTURE OF A DARUNAVIR RESISTANT HIV-1 PROTEASE | HIV-1 PROTEASE, DRUG RESISTANCE, DARUNAVIR, FLAP, HYDROLASE
2je4:B (GLY52) to (GLY94) ATOMIC-RESOLUTION CRYSTAL STRUCTURE OF CHEMICALLY-SYNTHESIZED HIV-1 PROTEASE IN COMPLEX WITH JG-365 | PROTEASE, HYDROLASE, HIGH RESOLUTION, ASPARTYL PROTEASE, HUMAN IMMUNODEFICIENCY VIRUS 1, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1w5w:A (GLY52) to (GLY94) HIV-1 PROTEASE IN COMPLEX WITH FLUORO SUBSTITUTED DIOL- BASED C2-SYMMETRIC INHIBITOR | HYDROLASE/HYDROLASE INHIBITOR, HYDROLASE, DIMER, PROTEIN-INHIBITOR COMPLEX
1w5x:A (GLY52) to (GLY94) HIV-1 PROTEASE IN COMPLEX WITH FLUORO SUBSTITUTED DIOL- BASED C2-SYMMETRIC INHIBITOR | HYDROLASE/HYDROLASE INHIBITOR, HYDROLASE, DIMER, PROTEIN-INHIBITOR COMPLEX
1w5y:A (GLY52) to (GLY94) HIV-1 PROTEASE IN COMPLEX WITH FLUORO SUBSTITUTED DIOL- BASED C2-SYMMETRIC INHIBITOR | HYDROLASE/HYDROLASE INHIBITOR, HYDROLASE, DIMER, PROTEIN-INHIBITOR COMPLEX
1k1t:A (GLY40) to (GLY94) COMBINING MUTATIONS IN HIV-1 PROTEASE TO UNDERSTAND MECHANISMS OF RESISTANCE | HIV-1 PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5bry:A (LYS45) to (GLY94) HIV-1 WILD TYPE PROTEASE WITH GRL-011-11A (A METHYLAMINE BIS- TETRAHYDROFURAN P2-LIGAND, SULFONAMIDE ISOSTERE DERIVATE) | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1k2b:A (LYS45) to (GLY94) COMBINING MUTATIONS IN HIV-1 PROTEASE TO UNDERSTAND MECHANISMS OF RESISTANCE | HIV-1 PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5bs4:A (LYS45) to (GLY94) HIV-1 WILD TYPE PROTEASE WITH GRL-047-11A (A METHYLAMINE BIS- TETRAHYDROFURAN P2-LIGAND, 4-AMINO SULFONAMIDE DERIVATIVE) | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1wbk:A (GLY52) to (GLY94) HIV-1 PROTEASE IN COMPLEX WITH ASYMMETRIC INHIBITOR, BEA568 | HYDROLASE/INHIBITOR, HYDROLASE/INHIBITOR COMPLEX, AIDS, ASPARTYL PROTEASE, DIMER, HYDROLASE, HYDROLASE/HYDROLASE INHIBITOR, PROTEIN-INHIBITOR COMPLEX
1wbm:A (GLY52) to (GLY94) HIV-1 PROTEASE IN COMPLEX WITH SYMMETRIC INHIBITOR, BEA450 | HYDROLASE/INHIBITOR, HYDROLASE/INHIBITOR COMPLEX, AIDS, ASPARTYL PROTEASE, DIMER, HYDROLASE, HYDROLASE/HYDROLASE INHIBITOR, PROTEIN-INHIBITOR COMPLEX
2xyf:B (GLY152) to (GLY194) HIV-1 INHIBITORS WITH A TERTIARY-ALCOHOL-CONTAINING TRANSITION-STATE MIMIC AND VARIOUS P2 AND P1 PRIME SUBSTITUENTS | HYDROLASE, AIDS
4njt:A (ARG45) to (GLY94) CRYSTAL STRUCTURE OF MULTIDRUG-RESISTANT CLINICAL ISOLATE A02 HIV-1 PROTEASE IN COMPLEX WITH DARUNAVIR | MULTIDRUG-RESISTANCE, HIV-1 PROTEASE, DARUNAVIR, NON-PEPTIDIC INHIBITOR, PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4njt:C (ARG41) to (GLY94) CRYSTAL STRUCTURE OF MULTIDRUG-RESISTANT CLINICAL ISOLATE A02 HIV-1 PROTEASE IN COMPLEX WITH DARUNAVIR | MULTIDRUG-RESISTANCE, HIV-1 PROTEASE, DARUNAVIR, NON-PEPTIDIC INHIBITOR, PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4nju:A (ARG45) to (GLY94) CRYSTAL STRUCTURE OF MULTIDRUG-RESISTANT CLINICAL ISOLATE A02 HIV-1 PROTEASE IN COMPLEX WITH TIPRANAVIR | MULTIDRUG-RESISTANCE, HIV-1 PROTEASE, TIPRANAVIR, TPV, PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4nju:C (ARG45) to (GLY94) CRYSTAL STRUCTURE OF MULTIDRUG-RESISTANT CLINICAL ISOLATE A02 HIV-1 PROTEASE IN COMPLEX WITH TIPRANAVIR | MULTIDRUG-RESISTANCE, HIV-1 PROTEASE, TIPRANAVIR, TPV, PROTEASE INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4njv:C (GLY52) to (GLY94) CRYSTAL STRUCTURE OF MULTIDRUG-RESISTANT CLINICAL ISOLATE A02 HIV-1 PROTEASE IN COMPLEX WITH RITONAVIR | MULTIDRUG-RESISTANCE, HIV-1 PROTEASE, RITONAVIR, RIT, PROTEASE INHIBITOR, KALETRA, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3zps:A (LYS45) to (GLY94) DESIGN AND SYNTHESIS OF P1-P3 MACROCYCLIC TERTIARY ALCOHOL COMPRISING HIV-1 PROTEASE INHIBITORS | HYDROLASE, PROTEASE INHIBITOR, RATIONAL DRUG DESIGN,
3zpt:A (LYS45) to (GLY94) DESIGN AND SYNTHESIS OF P1-P3 MACROCYCLIC TERTIARY ALCOHOL COMPRISING HIV-1 PROTEASE INHIBITORS | HYDROLASE, RATIONAL DRUG DESIGN, MACROCYCLIC TERTIARY ALCOHOL
3zpu:A (LYS45) to (GLY94) DESIGN AND SYNTHESIS OF P1-P3 MACROCYCLIC TERTIARY ALCOHOL COMPRISING HIV-1 PROTEASE INHIBITORS | HYDROLASE, PROTEASE INHIBITOR, RATIONAL DRUG DESIGN
2nmz:A (GLY52) to (GLY94) CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE MUTANT V82A WITH A INHIBITOR SAQUINAVIR | HIV-1 PROTEASE, MUTANT, V82A, DIMER, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2nmy:A (LYS45) to (GLY94) CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE MUTANT V82A WITH A INHIBITOR SAQUINAVIR | HIV-1 PROTEASE, MUTANT, V82A, DIMER, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2nmy:B (PRO144) to (GLY194) CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE MUTANT V82A WITH A INHIBITOR SAQUINAVIR | HIV-1 PROTEASE, MUTANT, V82A, DIMER, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5c9b:A (THR166) to (LYS218) CRYSTAL STRUCTURE OF A RETROPEPSIN-LIKE ASPARTIC PROTEASE FROM RICKETTSIA CONORII | PEPSIN, APRICK, HYDROLASE
5c9d:B (THR166) to (LYS218) CRYSTAL STRUCTURE OF A RETROPEPSIN-LIKE ASPARTIC PROTEASE FROM RICKETTSIA CONORII | PEPSIN, APRICK, HYDROLASE
5c9f:A (THR166) to (LYS218) CRYSTAL STRUCTURE OF A RETROPEPSIN-LIKE ASPARTIC PROTEASE FROM RICKETTSIA CONORII | PEPSIN, APRICK, HYDROLASE
5c9f:D (LEU163) to (LYS218) CRYSTAL STRUCTURE OF A RETROPEPSIN-LIKE ASPARTIC PROTEASE FROM RICKETTSIA CONORII | PEPSIN, APRICK, HYDROLASE
2nnp:A (GLY40) to (GLY94) CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE MUTANT I84V WITH A INHIBITOR SAQUINAVIR | HIV-1 PROTEASE, MUTANT, I84V, DIMER, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1kzk:A (GLY52) to (GLY94) JE-2147-HIV PROTEASE COMPLEX | HIV PROTEASE COMPLEX, ANISOTROPIC DISPLACEMENT PARAMETERS, VIRAL PROTEIN, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1kzk:B (GLY40) to (GLY94) JE-2147-HIV PROTEASE COMPLEX | HIV PROTEASE COMPLEX, ANISOTROPIC DISPLACEMENT PARAMETERS, VIRAL PROTEIN, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3jw2:A (LYS45) to (ILE93) HIV-1 PROTEASE MUTANT G86S WITH DARUNAVIR | HIV-1 PROTEASE, MUTANT G86S, INHIBITOR, DARUNAVIR, AIDS, ASPARTYL PROTEASE, METAL-BINDING, HYDROLASE
4obd:A (GLY40) to (GLY94) CRYSTAL STRUCTURE OF NELFINAVIR-RESISTANT, INACTIVE HIV-1 PROTEASE (D30N/N88D) IN COMPLEX WITH THE P1-P6 SUBSTRATE VARIANT (L449F/S451N) | CO-EVOLUTION, RESISTANCE, HYDROLASES, HYDROLASE
4obd:B (GLY52) to (GLY94) CRYSTAL STRUCTURE OF NELFINAVIR-RESISTANT, INACTIVE HIV-1 PROTEASE (D30N/N88D) IN COMPLEX WITH THE P1-P6 SUBSTRATE VARIANT (L449F/S451N) | CO-EVOLUTION, RESISTANCE, HYDROLASES, HYDROLASE
4obd:C (LYS45) to (GLY94) CRYSTAL STRUCTURE OF NELFINAVIR-RESISTANT, INACTIVE HIV-1 PROTEASE (D30N/N88D) IN COMPLEX WITH THE P1-P6 SUBSTRATE VARIANT (L449F/S451N) | CO-EVOLUTION, RESISTANCE, HYDROLASES, HYDROLASE
4obf:A (GLY40) to (GLY94) CRYSTAL STRUCTURE OF NELFINAVIR-RESISTANT, INACTIVE HIV-1 PROTEASE VARIANT (D30N/N88D) IN COMPLEX WITH THE P1-P6 SUBSTRATE VARIANT (S451N) | CO-EVOLUTION, RESISTANCE, HYDROLASE
4obf:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF NELFINAVIR-RESISTANT, INACTIVE HIV-1 PROTEASE VARIANT (D30N/N88D) IN COMPLEX WITH THE P1-P6 SUBSTRATE VARIANT (S451N) | CO-EVOLUTION, RESISTANCE, HYDROLASE
4obf:D (LYS45) to (GLY94) CRYSTAL STRUCTURE OF NELFINAVIR-RESISTANT, INACTIVE HIV-1 PROTEASE VARIANT (D30N/N88D) IN COMPLEX WITH THE P1-P6 SUBSTRATE VARIANT (S451N) | CO-EVOLUTION, RESISTANCE, HYDROLASE
4obg:A (GLY40) to (GLY94) CRYSTAL STRUCTURE OF NELFINAVIR-RESISTANT, INACTIVE HIV-1 PROTEASE (D30N/N88D) IN COMPLEX WITH THE P1-P6 SUBSTRATE. | CO-EVOLUTION, RESISTANCE, HYDROLASE
4obg:C (LYS45) to (GLY94) CRYSTAL STRUCTURE OF NELFINAVIR-RESISTANT, INACTIVE HIV-1 PROTEASE (D30N/N88D) IN COMPLEX WITH THE P1-P6 SUBSTRATE. | CO-EVOLUTION, RESISTANCE, HYDROLASE
4obh:B (GLY40) to (GLY94) CRYSTAL STRUCTURE OF INACTIVE HIV-1 PROTEASE IN COMPLEX WITH THE P1-P6 SUBSTRATE VARIANT (L449F) | CO-EVOLUTION, RESISTANCE, HYDROLASE
4obj:A (GLY52) to (GLY94) CRYSTAL STRUCTURE OF INACTIVE HIV-1 PROTEASE IN COMPLEX WITH THE P1-P6 SUBSTRATE VARIANT (S451N) | CO-EVOLUTION, RESISTANCE, HYDROLASE
4obj:B (GLY40) to (GLY94) CRYSTAL STRUCTURE OF INACTIVE HIV-1 PROTEASE IN COMPLEX WITH THE P1-P6 SUBSTRATE VARIANT (S451N) | CO-EVOLUTION, RESISTANCE, HYDROLASE
4obk:A (GLY52) to (GLY94) CRYSTAL STRUCTURE OF INACTIVE HIV-1 PROTEASE IN COMPLEX WITH THE P1-P6 SUBSTRATE VARIANT (L449F/S451N) | CO-EVOLUTION, RESISTANCE, HYDROLASE
2nxd:B (LYS45) to (ILE93) STRUCTURE OF HIV-1 PROTEASE D25N COMPLEXED WITH RT-RH ANALOGUE PEPTIDE GLY-ALA-ASP-ILE-PHE*TYR-LEU-ASP-GLY-ALA | PEPTIDE DESIGN; MOLECULAR DYNAMICS; HIV PROTEASE; SUBSTRATE RECOGNITION; CALORIMETRY, HYDROLASE/HYDROLASE SUBSTRATE COMPLEX
2nxl:A (GLY52) to (GLY94) STRUCTURE OF HIV-1 PROTEASE D25N COMPLEXED WITH THE RT-RH ANALOGUE PEPTIDE GLY-ALA-GLU-VAL-PHE*TYR-VAL-ASP-GLY-ALA | PEPTIDE DESIGN; MOLECULAR DYNAMICS; HIV PROTEASE; SUBSTRATE RECOGNITION; CALORIMETRY, HYDROLASE/HYDROLASE SUBSTRATE COMPLEX
2nxm:B (LYS45) to (GLY94) STRUCTURE OF HIV-1 PROTEASE D25N COMPLEXED WITH THE RT-RH ANALOGUE PEPTIDE GLY-ALA-GLN-THR-PHE*TYR-VAL-ASP-GLY-ALA | PEPTIDE DESIGN; MOLECULAR DYNAMICS; HIV PROTEASE; SUBSTRATE RECOGNITION; CALORIMETRY, HYDROLASE/HYDROLASE SUBSTRATE COMPLEX
2z4o:A (LYS45) to (GLY94) WILD TYPE HIV-1 PROTEASE WITH POTENT ANTIVIRAL INHIBITOR GRL-98065 | HIV-1, WILD TYPE PROTEASE, PROTEASE INHIBITOR, HYDROLASE
3k4v:A (LYS45) to (GLY94) NEW CRYSTAL FORM OF HIV-1 PROTEASE/SAQUINAVIR STRUCTURE REVEALS CARBAMYLATION OF N-TERMINAL PROLINE | HYDROLASE-HYDROLASE INHIBITOR COMPLEX, CARBAMYLATION, AIDS, ASPARTYL PROTEASE, CAPSID MATURATION, CAPSID PROTEIN,
5cok:A (LYS45) to (GLY94) X-RAY CRYSTAL STRUCTURE OF WILD TYPE HIV-1 PROTEASE IN COMPLEX WITH GRL-0476 | GRL-0476, HIV-1 PROTEASE, PROTEASE-INHIBITOR, DARUNAVIR, TP-THF, NONPEPTIDIC, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5cok:B (LYS45) to (GLY94) X-RAY CRYSTAL STRUCTURE OF WILD TYPE HIV-1 PROTEASE IN COMPLEX WITH GRL-0476 | GRL-0476, HIV-1 PROTEASE, PROTEASE-INHIBITOR, DARUNAVIR, TP-THF, NONPEPTIDIC, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5con:A (LYS45) to (GLY94) X-RAY CRYSTAL STRUCTURE OF WILD TYPE HIV-1 PROTEASE IN COMPLEX WITH GRL-015 | GRL-015, HIV-1 PROTEASE, PROTEASE-INHIBITOR, DARUNAVIR, TP-THF, NONPEPTIDIC, HYDROXYL, O-METHOXY., HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5con:B (LYS45) to (GLY94) X-RAY CRYSTAL STRUCTURE OF WILD TYPE HIV-1 PROTEASE IN COMPLEX WITH GRL-015 | GRL-015, HIV-1 PROTEASE, PROTEASE-INHIBITOR, DARUNAVIR, TP-THF, NONPEPTIDIC, HYDROXYL, O-METHOXY., HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5coo:A (LYS45) to (GLY94) X-RAY CRYSTAL STRUCTURE OF WILD TYPE HIV-1 PROTEASE IN COMPLEX WITH GRL-085 | GRL-085, HIV-1 PROTEASE, PROTEASE-INHIBITOR, DARUNAVIR, TP-THF, NONPEPTIDIC, HYDROXYL, O-METHOXY., HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5coo:B (LYS45) to (GLY94) X-RAY CRYSTAL STRUCTURE OF WILD TYPE HIV-1 PROTEASE IN COMPLEX WITH GRL-085 | GRL-085, HIV-1 PROTEASE, PROTEASE-INHIBITOR, DARUNAVIR, TP-THF, NONPEPTIDIC, HYDROXYL, O-METHOXY., HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5cop:A (LYS45) to (GLY94) X-RAY CRYSTAL STRUCTURE OF WILD TYPE HIV-1 PROTEASE IN COMPLEX WITH GRL-097 | GRL-097, HIV-1 PROTEASE, PROTEASE-INHIBITOR, DARUNAVIR, TP-THF, NONPEPTIDIC, HYDROXYL, O-METHOXY., HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5cop:B (LYS45) to (GLY94) X-RAY CRYSTAL STRUCTURE OF WILD TYPE HIV-1 PROTEASE IN COMPLEX WITH GRL-097 | GRL-097, HIV-1 PROTEASE, PROTEASE-INHIBITOR, DARUNAVIR, TP-THF, NONPEPTIDIC, HYDROXYL, O-METHOXY., HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2o40:A (PRO148) to (GLY198) CRYSTAL STRUCTURE OF A CHEMICALLY SYNTHESIZED 203 AMINO ACID 'COVALENT DIMER' HIV-1 PROTEASE MOLECULE | BETA-TURN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2o4k:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 PROTEASE (Q7K) IN COMPLEX WITH ATAZANAVIR | PROTEASE COMPLEX, VIRAL PROTEIN
2o4p:A (GLY52) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 PROTEASE (Q7K) IN COMPLEX WITH TIPRANAVIR | PROTEASE, VIRAL PROTEIN
2o4s:A (GLY52) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 PROTEASE (Q7K) IN COMPLEX WITH LOPINAVIR | PROTEASE, VIRAL PROTEIN
1lv1:A (LYS45) to (GLY94) CRYSTAL STRUCTURE ANALYSIS OF THE NON-ACTIVE SITE MUTANT OF TETHERED HIV-1 PROTEASE TO 2.1A RESOLUTION | BETA-RIBBON FLAP, HYDROLASE
1xl5:A (ARG41) to (GLY94) HIV-1 PROTEASE IN COMPLEX WITH AMIDHYROXYSULFONE | ASPARTYL PROTEASE, HIV PROTEASE, AMIDHYDROXYSULFONE INHIBITOR, HYDROLASE
4a6b:B (GLY152) to (GLY194) STEREOSELECTIVE SYNTHESIS, X-RAY ANALYSIS, AND BIOLOGICAL EVALUATION OF A NEW CLASS OF LACTAM BASED HIV-1 PROTEASE INHIBITORS | HYDROLASE, GAMMA-BUTYROL-LACTAM
1m0b:B (LYS145) to (GLY194) HIV-1 PROTEASE IN COMPLEX WITH AN ETHYLENEAMINE INHIBITOR | HIV PROTEASE, PEPTIDOMIMETICS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2zga:A (LYS45) to (GLY94) HIV-1 PROTEASE IN COMPLEX WITH A DIMETHYLALLYL DECORATED PYRROLIDINE BASED INHIBITOR (HEXAGONAL SPACE GROUP) | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3kdb:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 PROTEASE (Q7K, L33I, L63I) IN COMPLEX WITH KNI-10006 | VIRAL PROTEIN, HYDROLASE, PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3kf0:A (LYS45) to (GLY94) HIV PROTEASE WITH FRAGMENT 4D9 BOUND | PROTEASE, TL-3 INHIBITOR, FRAGMENT HIT, ASPARTYL PROTEASE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
3kfr:B (GLY52) to (GLY94) HIV PROTEASE (PR) DIMER WITH INHIBITOR TL-3 BOUND AND FRAGMENT 1F1 IN THE OUTSIDE/TOP OF FLAP | HIV-1, PROTEASE, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1met:A (LYS45) to (GLY94) HIV-1 MUTANT (V82F) PROTEASE COMPLEXED WITH DMP323 | HYDROLASE, ACID PROTEINASE, ASPARTYL PROTEASE
1met:B (LYS45) to (GLY94) HIV-1 MUTANT (V82F) PROTEASE COMPLEXED WITH DMP323 | HYDROLASE, ACID PROTEINASE, ASPARTYL PROTEASE
2zye:A (GLY52) to (GLY94) STRUCTURE OF HIV-1 PROTEASE IN COMPLEX WITH POTENT INHIBITOR KNI-272 DETERMINED BY NEUTRON CRYSTALLOGRAPHY | HIV-1 PROTEASE, ACID PROTEASE, HOMODIMER, HYDROLASE, MULTIFUNCTIONAL ENZYME, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2zye:B (GLY152) to (GLY194) STRUCTURE OF HIV-1 PROTEASE IN COMPLEX WITH POTENT INHIBITOR KNI-272 DETERMINED BY NEUTRON CRYSTALLOGRAPHY | HIV-1 PROTEASE, ACID PROTEASE, HOMODIMER, HYDROLASE, MULTIFUNCTIONAL ENZYME, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1mrw:B (PRO44) to (GLY94) STRUCTURE OF HIV PROTEASE (MUTANT Q7K L33I L63I) COMPLEXED WITH KNI- 577 | HIV, KNI-577, PROTEASE, DRUG TARGET, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1msn:A (LYS45) to (GLY94) THE HIV PROTEASE (MUTANT Q7K L33I L63I V82F I84V) COMPLEXED WITH KNI- 764 (AN INHIBITOR) | HIV, KNI-764, PROTEASE, DRUG TARGET, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1msm:A (GLY40) to (GLY94) THE HIV PROTEASE (MUTANT Q7K L33I L63I) COMPLEXED WITH KNI-764 (AN INHIBITOR) | HIV, KNI-764, PROTEASE, DRUG TARGET, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1mt7:B (GLY52) to (GLY94) VIABILITY OF A DRUG-RESISTANT HIV-1 PROTEASE MUTANT: STRUCTURAL INSIGHTS FOR BETTER ANTIVIRAL THERAPY | MATRIX, CAPSID, GAG CLEAVAGE, DRUG RESISTANCE, SUBSTRATE RECOGNITION, HYDROLASE/HYDROLASE INHIBITOR COMPLEX
3kt2:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF N88D MUTANT HIV-1 PROTEASE | DRUG RESISTANT MUTATION, N88D, NELFINAVIR, HIV-1 PROTEASE, HYDROLASE, PROTEASE
3kt2:A (GLY1052) to (GLY1094) CRYSTAL STRUCTURE OF N88D MUTANT HIV-1 PROTEASE | DRUG RESISTANT MUTATION, N88D, NELFINAVIR, HIV-1 PROTEASE, HYDROLASE, PROTEASE
3kt5:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF N88S MUTANT HIV-1 PROTEASE | DRUG RESISTANT, MUTATION, HIV-1 PROTEASE, N88S, NELFINAVIR, HYDROLASE, PROTEASE
1n49:A (GLY40) to (GLY94) VIABILITY OF A DRUG-RESISTANT HIV-1 PROTEASE VARIANT: STRUCTURAL INSIGHTS FOR BETTER ANTI-VIRAL THERAPY | HIV-1 PROTEASE, DRUG RESISTANCE, SUBSTRATE RECOGNITION, INHIBITOR BINDING, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1n49:C (GLY40) to (GLY94) VIABILITY OF A DRUG-RESISTANT HIV-1 PROTEASE VARIANT: STRUCTURAL INSIGHTS FOR BETTER ANTI-VIRAL THERAPY | HIV-1 PROTEASE, DRUG RESISTANCE, SUBSTRATE RECOGNITION, INHIBITOR BINDING, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4phv:A (LYS45) to (GLY94) X-RAY CRYSTAL STRUCTURE OF THE HIV PROTEASE COMPLEX WITH L- 700,417, AN INHIBITOR WITH PSEUDO C2 SYMMETRY | HYDROLASE(ASPARTIC PROTEINASE)
5dgu:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 PROTEASE INHIBITORS CONTAINING SUBSTITUTED FUSED-TETRAHYDROPYRANYL TETRAHYDROFURAN AS P2-LIGAND GRL-004-11A | HIV-1 PROTEASE, ENZYME, HYDROLASE, HYDROLASE INHIBITOR
1yt9:A (LYS45) to (ILE93) HIV PROTEASE WITH OXIMINOARYLSULFONAMIDE BOUND | HIV PROTEASE, OXIMINOARYLSULFONAMIDES, HYDROLASE
1yth:B (GLY40) to (GLY94) SIV PROTEASE CRYSTALLIZED WITH PEPTIDE PRODUCT | AIDS, POLYPROTEIN, HYDROLASE, ASPARTYL PROTEASE, ENDONUCLEASE, RNA- DIRECTED DNA POLYMERASE, HYDROLASE-PEPTIDE COMPLEX
1z1h:B (GLY152) to (GLY194) HIV-1 PROTEASE COMPLEXED WITH MACROCYCLIC PEPTIDOMIMETIC INHIBITOR 3 | MACROCYCLIC INHIBITORS, PEPTIDOMIMETIC INHIBITORS, HIV1 PROTEASE, HYDROLASE
3aid:B (GLY52) to (GLY94) A NEW CLASS OF HIV-1 PROTEASE INHIBITOR: THE CRYSTALLOGRAPHIC STRUCTURE, INHIBITION AND CHEMICAL SYNTHESIS OF AN AMINIMIDE PEPTIDE ISOSTERE | ASPARTYL PROTEASE, PROTEASE, HIV, PEPTIDE ISOSTERE INHIBITOR, DRUG DESIGN
1zj7:A (GLY52) to (GLY94) CRYSTAL STRUCTURE OF A COMPLEX OF MUTANT HIV-1 PROTEASE (A71V, V82T, I84V) WITH A HYDROXYETHYLAMINE PEPTIDOMIMETIC INHIBITOR BOC-PHE- PSI[S-CH(OH)CH2NH]-PHE-GLU-PHE-NH2 | HIV, PROTEASE, PEPTIDOMIMETIC INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1zlf:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF A COMPLEX OF MUTANT HIV-1 PROTEASE (A71V, V82T, I84V) WITH A HYDROXYETHYLAMINE PEPTIDOMIMETIC INHIBITOR | HIV, PROTEASE, PEPTIDOMIMETIC INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1zlf:B (LYS145) to (GLY194) CRYSTAL STRUCTURE OF A COMPLEX OF MUTANT HIV-1 PROTEASE (A71V, V82T, I84V) WITH A HYDROXYETHYLAMINE PEPTIDOMIMETIC INHIBITOR | HIV, PROTEASE, PEPTIDOMIMETIC INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4q1w:A (GLY52) to (GLY94) MUTATIONS OUTSIDE THE ACTIVE SITE OF HIV-1 PROTEASE ALTER ENZYME STRUCTURE AND DYNAMIC ENSEMBLE OF THE ACTIVE SITE TO CONFER DRUG RESISTANCE | HIV-1 PROTEASE, AIDS, INHIBITOR COMPLEX, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4q1x:B (LYS45) to (GLY94) MUTATIONS OUTSIDE THE ACTIVE SITE OF HIV-1 PROTEASE ALTER ENZYME STRUCTURE AND DYNAMIC ENSEMBLE OF THE ACTIVE SITE TO CONFER DRUG RESISTANCE | HIV-1 PROTEASE, AIDS, INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1zpa:A (LYS45) to (GLY94) HIV PROTEASE WITH SCRIPPS AB-3 INHIBITOR | PROTEASE, RETROVIRAL, HYDROLASE
4q5m:A (LYS45) to (GLY94) D30N TETHERED HIV-1 PROTEASE DIMER/SAQUINAVIR COMPLEX | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4q5m:A (LYS1045) to (GLY1094) D30N TETHERED HIV-1 PROTEASE DIMER/SAQUINAVIR COMPLEX | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1zsf:B (LYS145) to (GLY194) CRYSTAL STRUCTURE OF COMPLEX OF A HYDROXYETHYLAMINE INHIBITOR WITH HIV-1 PROTEASE AT 2.0A RESOLUTION | HIV, PROTEASE, PEPTIDOMIMETIC INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1zsr:B (LYS145) to (GLY194) CRYSTAL STRUCTURE OF WILD TYPE HIV-1 PROTEASE (BRU ISOLATE) WITH A HYDROXYETHYLAMINE PEPTIDOMIMETIC INHIBITOR BOC-PHE-PSI[S-CH(OH) CH2NH]-PHE-GLU-PHE-NH2 | HIV, PROTEASE, PEPTIDOMIMETIC INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1ztz:A (PRO44) to (GLY94) CRYSTAL STRUCTURE OF HIV PROTEASE- METALLACARBORANE COMPLEX | RATIONAL DRUG DESIGN; HIV PROTEASE INHIBITORS; ASPARTIC PROTEASES; CARBORANES; METALLACARBORANES, HYDROLASE
2a1e:A (GLY40) to (GLY94) HIGH RESOLUTION STRUCTURE OF HIV-1 PR WITH TS-126 | HIV PR, PEPTIDOMIMETIC INHIBITOR, STEREOISOMER, SCREENING A MIXTURE, HYDROLASE
3lzu:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF A NELFINAVIR RESISTANT HIV-1 CRF01_AE PROTEASE VARIANT (N88S) IN COMPLEX WITH THE PROTEASE INHIBITOR DARUNAVIR. | HIV-1 PROTEASE, NON-B CLADES, CRF01_AE, INHIBITOR RESISTANCE, AIDS, ASPARTYL PROTEASE, HYDROLASE
3lzu:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF A NELFINAVIR RESISTANT HIV-1 CRF01_AE PROTEASE VARIANT (N88S) IN COMPLEX WITH THE PROTEASE INHIBITOR DARUNAVIR. | HIV-1 PROTEASE, NON-B CLADES, CRF01_AE, INHIBITOR RESISTANCE, AIDS, ASPARTYL PROTEASE, HYDROLASE
2a4f:A (ARG41) to (GLY94) SYNTHESIS AND ACTIVITY OF N-AXYL AZACYCLIC UREA HIV-1 PROTEASE INHIBITORS WITH HIGH POTENCY AGAINST MULTIPLE DRUG RESISTANT VIRAL STRAINS. | HIV PROTEASE, AZA-CYCLIC UREA, HYDROLASE
2a4f:B (PRO44) to (GLY94) SYNTHESIS AND ACTIVITY OF N-AXYL AZACYCLIC UREA HIV-1 PROTEASE INHIBITORS WITH HIGH POTENCY AGAINST MULTIPLE DRUG RESISTANT VIRAL STRAINS. | HIV PROTEASE, AZA-CYCLIC UREA, HYDROLASE
4qgi:A (LYS45) to (GLY94) X-RAY CRYSTAL STRUCTURE OF HIV-1 PROTEASE VARIANT G48T/L89M IN COMPLEX WITH SAQUINAVIR | SAQUINAVIR, HIV PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3m9f:A (ARG41) to (GLY94) HIV PROTEASE COMPLEXED WITH COMPOUND 10B | HIV, PROTEASE, TRANSFERASE
4qj6:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF INACTIVE HIV-1 PROTEASE VARIANT (I50V/A71V) IN COMPLEX WITH P1-P6 SUBSTRATE VARIANT (L449F) | CO-EVOLUTION, PROTEASE, HYDROLASE
4qj6:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF INACTIVE HIV-1 PROTEASE VARIANT (I50V/A71V) IN COMPLEX WITH P1-P6 SUBSTRATE VARIANT (L449F) | CO-EVOLUTION, PROTEASE, HYDROLASE
4qj6:C (LYS45) to (GLY94) CRYSTAL STRUCTURE OF INACTIVE HIV-1 PROTEASE VARIANT (I50V/A71V) IN COMPLEX WITH P1-P6 SUBSTRATE VARIANT (L449F) | CO-EVOLUTION, PROTEASE, HYDROLASE
4qj6:D (LYS45) to (GLY94) CRYSTAL STRUCTURE OF INACTIVE HIV-1 PROTEASE VARIANT (I50V/A71V) IN COMPLEX WITH P1-P6 SUBSTRATE VARIANT (L449F) | CO-EVOLUTION, PROTEASE, HYDROLASE
4qj7:B (GLY52) to (GLY94) CRYSTAL STRUCTURE OF INACTIVE HIV-1 PROTEASE VARIANT (I50V/A71V) IN COMPLEX WITH P1-P6 SUBSTRATE VARIANT (R452S) | CO-EVOLUTION, PROTEASE, HYDROLASE
4qja:A (GLY52) to (GLY94) CRYSTAL STRUCTURE OF INACTIVE HIV-1 PROTEASE IN COMPLEX WITH P1-P6 SUBSTRATE VARIANT (P453L) | CO-EVOLUTION, PROTEASE, HYDROLASE
3mim:A (LYS45) to (GLY94) X-RAY SNAPSHOT OF HIV-1 PROTEASE IN ACTION: OBSERVATION OF TETRAHEDRAL INTERMEDIATE AND ITS SIHB WITH CATALYTIC ASPARTATE | HIV-1 PROTEASE, SHORT IONIC HYDROGEN BOND, TETHERED DIMER, TETRAHEDRAL INTERMEDIATE, REVERSE TRANSCRIPTASE-RNASEH OLIGOPEPTIDE SUBSTRATE, REACTION MECHANISM, HYDROLASE
3mim:B (LYS1045) to (GLY1094) X-RAY SNAPSHOT OF HIV-1 PROTEASE IN ACTION: OBSERVATION OF TETRAHEDRAL INTERMEDIATE AND ITS SIHB WITH CATALYTIC ASPARTATE | HIV-1 PROTEASE, SHORT IONIC HYDROGEN BOND, TETHERED DIMER, TETRAHEDRAL INTERMEDIATE, REVERSE TRANSCRIPTASE-RNASEH OLIGOPEPTIDE SUBSTRATE, REACTION MECHANISM, HYDROLASE
3bgb:A (GLY40) to (GLY94) HIV-1 PROTEASE IN COMPLEX WITH A ISOBUTYL DECORATED OLIGOAMINE | PROTEIN-LIGAND COMPLEX, AIDS, ASPARTYL PROTEASE, CAPSID MATURATION, CORE PROTEIN, CYTOPLASM, DNA INTEGRATION, DNA RECOMBINATION, DNA-DIRECTED DNA POLYMERASE, ENDONUCLEASE, HYDROLASE, LIPOPROTEIN, MAGNESIUM, MEMBRANE, METAL-BINDING, MULTIFUNCTIONAL ENZYME, MYRISTATE, NUCLEASE, NUCLEOTIDYLTRANSFERASE, NUCLEUS, PHOSPHOPROTEIN, PROTEASE, RNA-BINDING, RNA-DIRECTED DNA POLYMERASE, TRANSFERASE, VIRAL NUCLEOPROTEIN, VIRION, ZINC, ZINC-FINGER
3bgc:A (GLY40) to (GLY94) HIV-1 PROTEASE IN COMPLEX WITH A BENZYL DECORATED OLIGOAMINE | PROTEIN-LIGAND COMPLEX, AIDS, ASPARTYL PROTEASE, CAPSID MATURATION, CORE PROTEIN, CYTOPLASM, DNA INTEGRATION, DNA RECOMBINATION, DNA-DIRECTED DNA POLYMERASE, ENDONUCLEASE, HYDROLASE, LIPOPROTEIN, MAGNESIUM, MEMBRANE, METAL-BINDING, MULTIFUNCTIONAL ENZYME, MYRISTATE, NUCLEASE, NUCLEOTIDYLTRANSFERASE, NUCLEUS, PHOSPHOPROTEIN, PROTEASE, RNA-BINDING, RNA-DIRECTED DNA POLYMERASE, TRANSFERASE, VIRAL NUCLEOPROTEIN, VIRION, ZINC, ZINC-FINGER
3bhe:B (GLY40) to (GLY94) HIV-1 PROTEASE IN COMPLEX WITH A THREE ARMED PYRROLIDINE DERIVATIVE | PROTEIN-LIGAND COMPLEX, HYDROLASE
3mws:B (GLY152) to (GLY194) CRYSTAL STRUCTURE OF GROUP N HIV-1 PROTEASE | HIV-1, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3mxe:A (GLY52) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 PROTEASE INHIBITOR, KC32 COMPLEXED WITH WILD-TYPE PROTEASE | DRUG DESIGN, PROTEASE INHIBITORS, HIV PROTEASE, HYDROLASE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
3mxe:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 PROTEASE INHIBITOR, KC32 COMPLEXED WITH WILD-TYPE PROTEASE | DRUG DESIGN, PROTEASE INHIBITORS, HIV PROTEASE, HYDROLASE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
3bvb:A (LYS45) to (GLY94) CYSTAL STRUCTURE OF HIV-1 ACTIVE SITE MUTANT D25N AND INHIBITOR DARUNAVIR | DRUG RESISTANCE; HIV-1; D25N, MUTANT, AIDS, ASPARTYL PROTEASE, CAPSID MATURATION, CORE PROTEIN, DNA INTEGRATION, DNA RECOMBINATION, DNA- DIRECTED DNA POLYMERASE, ENDONUCLEASE, HYDROLASE, LIPOPROTEIN, MAGNESIUM, MEMBRANE, METAL-BINDING, MULTIFUNCTIONAL ENZYME, MYRISTATE, NUCLEASE, NUCLEOTIDYLTRANSFERASE, NUCLEUS, PHOSPHOPROTEIN, PROTEASE, RNA-BINDING, RNA-DIRECTED DNA POLYMERASE, TRANSFERASE, VIRAL NUCLEOPROTEIN, VIRION, ZINC-FINGER
3bxr:B (GLY152) to (GLY194) CRYSTAL STRUCTURES OF HIGHLY CONSTRAINED SUBSTRATE AND HYDROLYSIS PRODUCTS BOUND TO HIV-1 PROTEASE. IMPLICATIONS FOR CATALYTIC MECHANISM | HIV PROTEASE, HIVPR, SUBSTRATE, PRODUCT, MECHANISM, AIDS, ASPARTYL PROTEASE, CAPSID MATURATION, CORE PROTEIN, CYTOPLASM, DNA INTEGRATION, DNA RECOMBINATION, DNA-DIRECTED DNA POLYMERASE, ENDONUCLEASE, HYDROLASE, LIPOPROTEIN, MAGNESIUM, MEMBRANE, METAL-BINDING, MULTIFUNCTIONAL ENZYME, MYRISTATE, NUCLEASE, NUCLEOTIDYLTRANSFERASE, NUCLEUS, PHOSPHOPROTEIN, RNA-BINDING, RNA-DIRECTED DNA POLYMERASE, TRANSFERASE, VIRAL NUCLEOPROTEIN, VIRION, ZINC, ZINC-FINGER
3bxs:B (GLY152) to (GLY194) CRYSTAL STRUCTURES OF HIGHLY CONSTRAINED SUBSTRATE AND HYDROLYSIS PRODUCTS BOUND TO HIV-1 PROTEASE. IMPLICATIONS FOR CATALYTIC MECHANISM | HIV PROTEASE, HIVPR, SUBSTRATE, PRODUCT, MECHANISM, AIDS, ASPARTYL PROTEASE, CAPSID MATURATION, CORE PROTEIN, CYTOPLASM, DNA INTEGRATION, DNA RECOMBINATION, DNA-DIRECTED DNA POLYMERASE, ENDONUCLEASE, HYDROLASE, LIPOPROTEIN, MAGNESIUM, MEMBRANE, METAL-BINDING, MULTIFUNCTIONAL ENZYME, MYRISTATE, NUCLEASE, NUCLEOTIDYLTRANSFERASE, NUCLEUS, PHOSPHOPROTEIN, RNA-BINDING, RNA-DIRECTED DNA POLYMERASE, TRANSFERASE, VIRAL NUCLEOPROTEIN, VIRION, ZINC, ZINC-FINGER
3n3i:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF G48V/C95F TETHERED HIV-1 PROTEASE/SAQUINAVIR COMPLEX | HIV-1 PROTEASE, SAQUINAVIR, DRUG RESISTANCE, TETHERED-DIMER, FUSION PROTEIN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5fiv:A (GLY52) to (ASN111) STRUCTURAL STUDIES OF HIV AND FIV PROTEASES COMPLEXED WITH AN EFFICIENT INHIBITOR OF FIV PR | FIV PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3ndt:A (LYS46) to (GLY95) HIV-1 PROTEASE SAQUINAVIR:RITONAVIR 1:1 COMPLEX STRUCTURE | HYDROLASE, AIDS, ASPARTYL PROTEASE, CARBAMYLATION, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
3ndt:B (LYS46) to (GLY95) HIV-1 PROTEASE SAQUINAVIR:RITONAVIR 1:1 COMPLEX STRUCTURE | HYDROLASE, AIDS, ASPARTYL PROTEASE, CARBAMYLATION, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
3ndt:D (LYS45) to (GLY94) HIV-1 PROTEASE SAQUINAVIR:RITONAVIR 1:1 COMPLEX STRUCTURE | HYDROLASE, AIDS, ASPARTYL PROTEASE, CARBAMYLATION, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
3ndx:A (GLY52) to (GLY94) HIV-1 PROTEASE SAQUINAVIR:RITONAVIR 1:50 COMPLEX STRUCTURE | HIV-1 PROTEASE, HYDROLASE, AIDS, ASPARTYL PROTEASE, SAQUINAVIR, CARBAMYLATION, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3ckt:A (GLY52) to (GLY94) HIV-1 PROTEASE IN COMPLEX WITH A DIMETHYLALLYL DECORATED PYRROLIDINE BASED INHIBITOR (ORTHOROMBIC SPACE GROUP) | HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3nu5:A (ARG41) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 PROTEASE MUTANT I50V WITH ANTIVIRAL DRUG AMPRENAVIR | ENZYME INHIBITION, ASPARTIC PROTEASE, HIV/AIDS, CONFORMATIONAL CHANGE, AMPRENAVIR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3nu5:B (LYS145) to (GLY194) CRYSTAL STRUCTURE OF HIV-1 PROTEASE MUTANT I50V WITH ANTIVIRAL DRUG AMPRENAVIR | ENZYME INHIBITION, ASPARTIC PROTEASE, HIV/AIDS, CONFORMATIONAL CHANGE, AMPRENAVIR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3nu6:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 PROTEASE MUTANT I54M WITH ANTIVIRAL DRUG AMPRENAVIR | ENZYME INHIBITION, ASPARTIC PROTEASE, HIV/AIDS, AMPRENAVIR, CONFORMATIONAL CHANGE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3nu9:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 PROTEASE MUTANT I84V WITH ANTIVIRAL DRUG AMPRENAVIR | ENZYME INHIBITION, ASPARTIC PROTEASE, HIV/AIDS, CONFORMATIONAL CHANGE, AMPRENAVIR, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3nuj:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 PROTEASE MUTANT I54V WITH ANTIVIRAL DRUG AMPRENAVIR | ENZYME INHIBITION, ASPARTIC PROTEASE, HIV/AIDS, CONFORMATIONAL CHANGE, AMPRENAVIR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3nuj:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 PROTEASE MUTANT I54V WITH ANTIVIRAL DRUG AMPRENAVIR | ENZYME INHIBITION, ASPARTIC PROTEASE, HIV/AIDS, CONFORMATIONAL CHANGE, AMPRENAVIR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3nwq:A (LYS45) to (GLY94) X-RAY STRUCTURE OF ESTER CHEMICAL ANALOGUE [O-ILE50,O-ILE50']HIV-1 PROTEASE COMPLEXED WITH MVT-101 | BETA-BARREL, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3nwx:A (PRO44) to (GLY94) X-RAY STRUCTURE OF ESTER CHEMICAL ANALOGUE [O-ILE50,O-ILE50']HIV-1 PROTEASE COMPLEXED WITH KVS-1 INHIBITOR | BETA-BARREL, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3nwx:B (GLY52) to (GLY94) X-RAY STRUCTURE OF ESTER CHEMICAL ANALOGUE [O-ILE50,O-ILE50']HIV-1 PROTEASE COMPLEXED WITH KVS-1 INHIBITOR | BETA-BARREL, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3nxe:A (LYS149) to (GLY198) X-RAY STRUCTURE OF ESTER CHEMICAL ANALOGUE 'COVALENT DIMER' [ILE50,O- ILE50']HIV-1 PROTEASE COMPLEXED WITH MVT-101 INHIBITOR | BETA-BARREL, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3nxn:A (PRO44) to (GLY94) X-RAY STRUCTURE OF ESTER CHEMICAL ANALOGUE 'COVALENT DIMER' [ILE50,O- ILE50']HIV-1 PROTEASE COMPLEXED WITH KVS-1 INHIBITOR | BETA-BARREL, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3nxn:A (GLY156) to (GLY198) X-RAY STRUCTURE OF ESTER CHEMICAL ANALOGUE 'COVALENT DIMER' [ILE50,O- ILE50']HIV-1 PROTEASE COMPLEXED WITH KVS-1 INHIBITOR | BETA-BARREL, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4rvx:A (GLY52) to (GLY94) CRYSTAL STRUCTURE OF MULTIDRUG-RESISTANT CLINICAL ISOLATE A02 HIV-1 PROTEASE IN COMPLEX WITH NON-PEPTIDIC INHIBITOR, GRL079 | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, HIV-1 PROTEASE- INHIBITOR COMPLEX, GRL079, NON-PEPTIDIC PROTEASE INHIBITOR
4rvx:C (GLY52) to (GLY94) CRYSTAL STRUCTURE OF MULTIDRUG-RESISTANT CLINICAL ISOLATE A02 HIV-1 PROTEASE IN COMPLEX WITH NON-PEPTIDIC INHIBITOR, GRL079 | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, HIV-1 PROTEASE- INHIBITOR COMPLEX, GRL079, NON-PEPTIDIC PROTEASE INHIBITOR
4rvx:D (GLY52) to (GLY94) CRYSTAL STRUCTURE OF MULTIDRUG-RESISTANT CLINICAL ISOLATE A02 HIV-1 PROTEASE IN COMPLEX WITH NON-PEPTIDIC INHIBITOR, GRL079 | HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, HIV-1 PROTEASE- INHIBITOR COMPLEX, GRL079, NON-PEPTIDIC PROTEASE INHIBITOR
3cyw:A (LYS45) to (GLY94) EFFECT OF FLAP MUTATIONS ON STRUCTURE OF HIV-1 PROTEASE AND INHIBITION BY SAQUINAVIR AND DARUNAVIR | DRUG RESISTANCE; HIV-1, AIDS, ASPARTYL PROTEASE, CAPSID MATURATION, CAPSID PROTEIN, DNA INTEGRATION, DNA RECOMBINATION, DNA-DIRECTED DNA POLYMERASE, ENDONUCLEASE, HYDROLASE, LIPOPROTEIN, MAGNESIUM, MEMBRANE, METAL-BINDING, MULTIFUNCTIONAL ENZYME, MYRISTATE, NUCLEASE, NUCLEOTIDYLTRANSFERASE, NUCLEUS, PHOSPHOPROTEIN, PROTEASE, RNA-BINDING, RNA-DIRECTED DNA POLYMERASE, TRANSFERASE, VIRAL NUCLEOPROTEIN, VIRION, ZINC-FINGER
3cyx:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 MUTANT I50V AND INHIBITOR SAQUINAVIRA | DRUG RESISTANCE; HIV-1, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4coe:A (LYS45) to (GLY94) MACROCYCLIC TRANSITION-STATE MIMICKING HIV-1 PROTEASE INHIBITORS ENCOMPASSING A TERTIARY ALCOHOL | HYDROLASE, INHIBITOR, RATIONAL DRUG DESIGN, ENZYME
3d1x:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 MUTANT I54M AND INHIBITOR SAQUINAVIR | DRUG RESISTANCE, HIV-1, I54M, FLAP MUTANT, AIDS, ASPARTYL PROTEASE, CAPSID MATURATION, CAPSID PROTEIN, HYDROLASE-HYDROLASE INHIBITOR COMPLEX, VIRAL NUCLEOPROTEIN
3d1z:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 MUTANT I54M AND INHIBITOR DARUNAVIR | DRUG RESISTANCE; HIV-1, FLAP MUTANT, I54M, DARUNAVIR, HYDROLASE
4cpr:A (LYS45) to (GLY94) MACROCYCLIC TRANSITION-STATE MIMICKING HIV-1 PROTEASE INHIBITORS ENCOMPASSING A TERTIARY ALCOHOL | HYDROLASE, INHIBITOR, RATIONAL DRUG DESIGN
4cps:A (LYS45) to (GLY94) MACROCYCLIC TRANSITION-STATE MIMICKING HIV-1 PROTEASE INHIBITORS ENCOMPASSING A TERTIARY ALCOHOL | HYDROLASE, INHIBITOR, RATIONAL DRUG DESIGN
4cpt:A (LYS45) to (GLY94) MACROCYCLIC TRANSITION-STATE MIMICKING HIV-1 PROTEASE INHIBITORS ENCOMPASSING A TERTIARY ALCOHOL | HYDROLASE, HIV-1 PROTEASE, INHIBITOR, RATIONAL DRUG DESIGN, ENZYME
4cpu:A (LYS45) to (GLY94) MACROCYCLIC TRANSITION-STATE MIMICKING HIV-1 PROTEASE INHIBITORS ENCOMPASSING A TERTIARY ALCOHOL | HYDROLASE, HIV-1 PROTEASE, INHIBITOR, RATIONAL DRUG DESIGN
4cpw:A (LYS45) to (GLY94) MACROCYCLIC TRANSITION-STATE MIMICKING HIV-1 PROTEASE INHIBITORS ENCOMPASSING A TERTIARY ALCOHOL | HYDROLASE, INHIBITOR, RATIONAL DRUG DESIGN
3o99:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 PROTEASE IN COMPLEX WITH KD13 | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3o9a:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 PROTEASE IN COMPLEX WITH KD14 | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3o9b:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 PROTEASE IN COMPLEX WITH KD25 | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3o9d:A (GLY52) to (GLY94) CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 PROTEASE IN COMPLEX WITH KD19 | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3o9f:A (GLY52) to (GLY94) CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 PROTEASE IN COMPLEX WITH KD27 | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3o9f:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 PROTEASE IN COMPLEX WITH KD27 | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3o9g:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 PROTEASE IN COMPLEX WITH AF53 | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3o9i:A (GLY52) to (GLY94) CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 PROTEASE IN COMPLEX WITH AF61 | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3o9i:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 PROTEASE IN COMPLEX WITH AF61 | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3dcr:A (GLY52) to (GLY94) X-RAY STRUCTURE OF HIV-1 PROTEASE AND HYDRATED FORM OF KETOMETHYLENE ISOSTERE INHIBITOR | HIV-1 PROTEASE, HOMODIMER, BETA-TURN, BETA-STRAND, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3djk:A (LYS45) to (GLY94) WILD TYPE HIV-1 PROTEASE WITH POTENT ANTIVIRAL INHIBITOR GRL-0255A | HIV-1, WILD TYPE PROTEASE, PROTEASE INHIBITOR, HYDROLASE, AIDS, ASPARTYL PROTEASE, CAPSID MATURATION, CAPSID PROTEIN, CYTOPLASM, DNA INTEGRATION, DNA RECOMBINATION, DNA-DIRECTED DNA POLYMERASE, ENDONUCLEASE, LIPOPROTEIN, MAGNESIUM, METAL- BINDING, MULTIFUNCTIONAL ENZYME, MYRISTATE, NUCLEASE, NUCLEOTIDYLTRANSFERASE, NUCLEUS, PHOSPHOPROTEIN, PROTEASE, RIBOSOMAL FRAMESHIFTING, RNA-BINDING, RNA-DIRECTED DNA POLYMERASE, TRANSFERASE, VIRAL NUCLEOPROTEIN, VIRION, ZINC, ZINC-FINGER
3dk1:A (LYS45) to (GLY94) WILD TYPE HIV-1 PROTEASE WITH POTENT ANTIVIRAL INHIBITOR GRL-0105A | HIV-1, WILD TYPE PROTEASE, PROTEASE INHIBITOR, HYDROLASE, AIDS, ASPARTYL PROTEASE, CAPSID MATURATION, CAPSID PROTEIN, CYTOPLASM, DNA INTEGRATION, DNA RECOMBINATION, DNA-DIRECTED DNA POLYMERASE, ENDONUCLEASE, LIPOPROTEIN, MAGNESIUM, METAL- BINDING, MULTIFUNCTIONAL ENZYME, MYRISTATE, NUCLEASE, NUCLEOTIDYLTRANSFERASE, NUCLEUS, PHOSPHOPROTEIN, PROTEASE, RIBOSOMAL FRAMESHIFTING, RNA-BINDING, RNA-DIRECTED DNA POLYMERASE, TRANSFERASE, VIRAL NUCLEOPROTEIN, VIRION, ZINC, ZINC-FINGER
4tvg:A (LYS45) to (GLY94) HIV PROTEASE (PR) DIMER IN CLOSED FORM WITH PEPSTATIN IN ACTIVE SITE AND FRAGMENT AK-2097 IN THE OUTSIDE/TOP OF FLAP | APO PROTEASE, ALLOSTERY, FRAGMENT BINDING
3dox:A (LYS45) to (GLY94) X-RAY STRUCTURE OF HIV-1 PROTEASE IN SITU PRODUCT COMPLEX | HIV-1 PROTEASE; TRANSITION STATE; REACTION INTERMEDIATE; CATALYSIS; INHIBITOR; X-RAY CRYSTALLOGRAPHY, AIDS, ASPARTYL PROTEASE, CAPSID MATURATION, CAPSID PROTEIN, CYTOPLASM, DNA INTEGRATION, DNA RECOMBINATION, DNA-DIRECTED DNA POLYMERASE, ENDONUCLEASE, HOST-VIRUS INTERACTION, HYDROLASE, LIPOPROTEIN, MAGNESIUM, METAL-BINDING, MULTIFUNCTIONAL ENZYME, MYRISTATE, NUCLEASE, NUCLEOTIDYLTRANSFERASE, NUCLEUS, PHOSPHOPROTEIN, PROTEASE, RIBOSOMAL FRAMESHIFTING, RNA-BINDING, RNA-DIRECTED DNA POLYMERASE, TRANSFERASE, VIRAL NUCLEOPROTEIN, VIRION, ZINC, ZINC-FINGER
3dox:A (LYS1045) to (GLY1094) X-RAY STRUCTURE OF HIV-1 PROTEASE IN SITU PRODUCT COMPLEX | HIV-1 PROTEASE; TRANSITION STATE; REACTION INTERMEDIATE; CATALYSIS; INHIBITOR; X-RAY CRYSTALLOGRAPHY, AIDS, ASPARTYL PROTEASE, CAPSID MATURATION, CAPSID PROTEIN, CYTOPLASM, DNA INTEGRATION, DNA RECOMBINATION, DNA-DIRECTED DNA POLYMERASE, ENDONUCLEASE, HOST-VIRUS INTERACTION, HYDROLASE, LIPOPROTEIN, MAGNESIUM, METAL-BINDING, MULTIFUNCTIONAL ENZYME, MYRISTATE, NUCLEASE, NUCLEOTIDYLTRANSFERASE, NUCLEUS, PHOSPHOPROTEIN, PROTEASE, RIBOSOMAL FRAMESHIFTING, RNA-BINDING, RNA-DIRECTED DNA POLYMERASE, TRANSFERASE, VIRAL NUCLEOPROTEIN, VIRION, ZINC, ZINC-FINGER
3oxv:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 I50V, A71 PROTEASE IN COMPLEX WITH THE PROTEASE INHIBITOR AMPRENAVIR. | HIV-1 PROTEASE, INHIBITOR RESISTANCE, AIDS, ASPARTYL PROTEASE, DRUG RESISTANCE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3oxv:D (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 I50V, A71 PROTEASE IN COMPLEX WITH THE PROTEASE INHIBITOR AMPRENAVIR. | HIV-1 PROTEASE, INHIBITOR RESISTANCE, AIDS, ASPARTYL PROTEASE, DRUG RESISTANCE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3oxv:C (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 I50V, A71 PROTEASE IN COMPLEX WITH THE PROTEASE INHIBITOR AMPRENAVIR. | HIV-1 PROTEASE, INHIBITOR RESISTANCE, AIDS, ASPARTYL PROTEASE, DRUG RESISTANCE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3oxw:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 I50V, A71V PROTEASE IN COMPLEX WITH THE PROTEASE INHIBITOR DARUNAVIR | HIV-1 PROTEASE, INHIBITOR RESISTANCE, AIDS, ASPARTYL PROTEASE, DRUG RESISTANCE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3oxw:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 I50V, A71V PROTEASE IN COMPLEX WITH THE PROTEASE INHIBITOR DARUNAVIR | HIV-1 PROTEASE, INHIBITOR RESISTANCE, AIDS, ASPARTYL PROTEASE, DRUG RESISTANCE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3oxx:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 I50V, A71V PROTEASE IN COMPLEX WITH THE PROTEASE INHIBITOR ATAZANAVIR | HIV-1 PROTEASE, INHIBITOR RESISTANCE, AIDS, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3oxx:C (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 I50V, A71V PROTEASE IN COMPLEX WITH THE PROTEASE INHIBITOR ATAZANAVIR | HIV-1 PROTEASE, INHIBITOR RESISTANCE, AIDS, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3oy4:A (GLY40) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 L76V PROTEASE IN COMPLEX WITH THE PROTEASE INHIBITOR DARUNAVIR. | HIV-1 PROTEASE, INHIBITOR RESISTANCE, AIDS, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4djp:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 PROTEASE IN COMPLEX WITH MKP73 | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4djq:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 PROTEASE IN COMPLEX WITH MKP86 | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4djr:A (GLY52) to (GLY94) CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 PROTEASE IN COMPLEX WITH MKP97 | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4djr:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 PROTEASE IN COMPLEX WITH MKP97 | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4u7q:A (PRO44) to (GLY94) STRUCTURE OF WILD-TYPE HIV PROTEASE IN COMPLEX WITH PHOTOSENSITIVE INHIBITOR PDI-6 | HIV-1, VIRAL PROTEASE, ASPARTIC PROTEASE, INHIBITION, HYDROLASE
4u7q:B (PRO44) to (GLY94) STRUCTURE OF WILD-TYPE HIV PROTEASE IN COMPLEX WITH PHOTOSENSITIVE INHIBITOR PDI-6 | HIV-1, VIRAL PROTEASE, ASPARTIC PROTEASE, INHIBITION, HYDROLASE
4u8w:A (LYS45) to (GLY94) HIV-1 WILD TYPE PROTEASE WITH GRL-050-10A (A GEM-DIFLUORO-BIS- TETRAHYDROFURAN AS P2-LIGAND) | HIV-1 PROTEASE INHIBITOR, MULTIDRUG-RESISTANT HIV-1 STRAINS, BLOOD- BRAIN-BARRIER, FLUORO-BIS-THF, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4dqb:A (GLY40) to (GLY94) CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 PROTEASE IN COMPLEX WITH DRV | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4dqe:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF (G16C/L38C) HIV-1 PROTEASE IN COMPLEX WITH DRV | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4dqe:B (GLY52) to (GLY94) CRYSTAL STRUCTURE OF (G16C/L38C) HIV-1 PROTEASE IN COMPLEX WITH DRV | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4dqg:B (GLY52) to (GLY94) CRYSTAL STRUCTURE OF APO(G16C/L38C) HIV-1 PROTEASE | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5hvp:A (LYS45) to (GLY94) CRYSTALLOGRAPHIC ANALYSIS OF A COMPLEX BETWEEN HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE AND ACETYL-PEPSTATIN AT 2.0-ANGSTROMS RESOLUTION | ACID PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4upj:B (ASN41) to (GLY94) HUMAN IMMUNODEFICIENCY VIRUS TYPE 2 PROTEASE MUTANT WITH LYS 57 REPLACED BY LEU (K57L) COMPLEX WITH U097410 [4-HYDROXY-3-[1-[3- [[[[(TERT-BUTYLOXYCARBONYL) AMINOMETHYL]CARBONYL]AMINO]PHENYL]PROPYL]COUMARIN | HYDROLASE (ACID PROTEASE)
3psu:A (LYS45) to (GLY94) HIV-1 PROTEASE IN COMPLEX WITH AN ISOBUTYL DECORATED OLIGOAMINE (SYMMETRIC BINDING MODE) | ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3pwr:A (LYS45) to (GLY94) HIV-1 PROTEASE MUTANT L76V COMPLEXED WITH SAQUINAVIR | HIV-1, PROTEASE, MUTATION L76V, SAQUINAVIR, HYDROLASE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
4ej8:A (PRO44) to (GLY94) APO HIV PROTEASE (PR) DIMER IN CLOSED FORM WITH FRAGMENT 1F1 IN THE OUTSIDE/TOP OF FLAP | APO PROTEASE, ALLOSTERY, FRAGMENT BINDING, CLOSED FORM, HYDROLASE
4ej8:B (GLY52) to (GLY94) APO HIV PROTEASE (PR) DIMER IN CLOSED FORM WITH FRAGMENT 1F1 IN THE OUTSIDE/TOP OF FLAP | APO PROTEASE, ALLOSTERY, FRAGMENT BINDING, CLOSED FORM, HYDROLASE
4ejd:A (LYS45) to (GLY94) HIV PROTEASE (PR) DIMER IN CLOSED FORM WITH PEPSTATIN IN ACTIVE SITE AND FRAGMENT 1F1 IN THE OUTSIDE/TOP OF FLAP | APO PROTEASE, ALLOSTERY, FRAGMENT BINDING, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4ejd:B (LYS45) to (GLY94) HIV PROTEASE (PR) DIMER IN CLOSED FORM WITH PEPSTATIN IN ACTIVE SITE AND FRAGMENT 1F1 IN THE OUTSIDE/TOP OF FLAP | APO PROTEASE, ALLOSTERY, FRAGMENT BINDING, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4ejk:A (LYS45) to (GLY94) HIV PROTEASE (PR) DIMER IN CLOSED FORM WITH PEPSTATIN IN ACTIVE SITE AND FRAGMENT 1F1-N IN THE OUTSIDE/TOP OF FLAP | APO PROTEASE, ALLOSTERY, FRAGMENT BINDING, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4ep2:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF INACTIVE SINGLE CHAIN WILD-TYPE HIV-1 PROTEASE IN COMPLEX WITH THE SUBSTRATE RT-RH | HIV-1 PROTEASE, SPECIFICITY DESIGN, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE SUBSTRATE COMPLEX
5ivr:A (GLY40) to (GLY94) CRYSTAL STRUCTURE OF HIV PROTEASE COMPLEXED WITH METHYL N-[(1S)-1-[[2- [(3S)-3-[(4-AMINOPHENYL)METHYLAMINO]-4-HYDROXY- BUTYL]PHENYL]CARBAMOYL]-2,2-DIPHENYL-ETHYL]CARBAMATE | HIV, PROTEASE, HYDROLASE-INHIBITOR COMPLEX
5ivs:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV PROTEASE COMPLEXED WITH METHYL N-[(1S)-1- BENZHYDRYL-2-[2-[2-[(2R,5S)-5-(BENZYLCARBAMOYLOXYMETHYL)MORPHOLIN-2- YL]ETHYL]ANILINO]-2-OXO-ETHYL]CARBAMATE | HIV, PROTEASE, HYDROLASE-INHIBITOR COMPLEX
5ivt:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV PROTEASE COMPLEXED WITH [(1S)-1-[(S)-(4- CHLOROPHENYL)-(3,5-DIFLUOROPHENYL)METHYL]-2-[[5-FLUORO-4-[2-[(2R,5S)- 5-(2,2,2-TRIFLUOROETHYLCARBAMOYLOXYMETHYL)MORPHOLIN-4-IUM-2- YL]ETHYL]PYRIDIN-1-IUM-3-YL]AMINO]-2-OXO-ETHYL]AMMONIUM | HIV, PROTEASE, HYDROLASE-INHIBITOR COMPLEX
3qbf:B (PRO44) to (GLY94) HIV-1 PROTEASE (MUTANT Q7K L33I L63I) IN COMPLEX WITH A THREE-ARMED PYRROLIDINE-BASED INHIBITOR | ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3qih:B (PRO44) to (GLY94) HIV-1 PROTEASE (MUTANT Q7K L33I L63I) IN COMPLEX WITH A NOVEL INHIBITOR | ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4f74:A (GLY52) to (GLY94) CRYSTAL STRUCTURE OF ACTIVE HIV-1 PROTEASE IN COMPLEX WITH THE N TERMINAL PRODUCT OF THE SUBSTRATE MA-CA. | HIV-1 PROTEASE, SUBSTRATE COMPLEX, AIDS, PRODUCT COMPLEX, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE PRODUCT COMPLEX
4f75:A (GLY52) to (GLY94) CRYSTAL STRUCTURE OF ACTIVE HIV-1 PROTEASE IN COMPLEX WITH THE N TERMINAL PRODUCT OF THE SUBSTRATE RH-IN | HIV-1 PROTEASE, SUBSTRATE COMPLEX, AIDS, PRODUCT COMPLEX, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE PRODUCT COMPLEX
4f75:B (GLY52) to (GLY94) CRYSTAL STRUCTURE OF ACTIVE HIV-1 PROTEASE IN COMPLEX WITH THE N TERMINAL PRODUCT OF THE SUBSTRATE RH-IN | HIV-1 PROTEASE, SUBSTRATE COMPLEX, AIDS, PRODUCT COMPLEX, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE PRODUCT COMPLEX
4f76:A (GLY52) to (GLY94) CRYSTAL STRUCTURE OF THE ACTIVE HIV-1 PROTEASE IN COMPLEX WITH THE PRODUCTS OF P1-P6 SUBSTRATE | HIV-1 PROTEASE, SUBSTRATE COMPLEX, AIDS, PRODUCT COMPLEX, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE PRODUCT COMPLEX
4f76:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF THE ACTIVE HIV-1 PROTEASE IN COMPLEX WITH THE PRODUCTS OF P1-P6 SUBSTRATE | HIV-1 PROTEASE, SUBSTRATE COMPLEX, AIDS, PRODUCT COMPLEX, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE PRODUCT COMPLEX
4faf:A (LYS45) to (GLY94) SUBSTRATE CA/P2 IN COMPLEX WITH A HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE VARIANT | PROTEASE, VIRAL PROTEIN
3qn8:A (LYS45) to (GLY94) HIV-1 PROTEASE (MUTANT Q7K L33I L63I) IN COMPLEX WITH A NOVEL INHIBITOR | ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3qn8:B (PRO44) to (GLY94) HIV-1 PROTEASE (MUTANT Q7K L33I L63I) IN COMPLEX WITH A NOVEL INHIBITOR | ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3qp0:A (LYS45) to (GLY94) HIV-1 PROTEASE (MUTANT Q7K L33I L63I) IN COMPLEX WITH A NOVEL INHIBITOR | ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3qrm:A (ARG41) to (GLY94) HIV-1 PROTEASE (MUTANT Q7K L33I L63I) IN COMPLEX WITH A THREE-ARMED PYRROLIDINE-BASED INHIBITOR | ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3qro:A (ARG41) to (GLY94) HIV-1 PROTEASE (MUTANT Q7K L33I L63I) IN COMPLEX WITH A THREE-ARMED PYRROLIDINE-BASED INHIBITOR | ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4fe6:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 PROTEASE IN COMPLEX WITH AN ENAMINO- OXINDOLE INHIBITOR | HYDROLASE-INHIBITOR COMPLEX
4fiv:A (GLY52) to (ASN111) FIV PROTEASE COMPLEXED WITH AN INHIBITOR LP-130 | ASPARTIC PROTEASE, FIV, RETROPEPSIN, RETROVIRUS, CAT
5jfp:A (LYS45) to (GLY94) HIV-1 WILD TYPE PROTEASE WITH GRL-097-13A (A ADAMANTANE P1-LIGAND WITH BIS-THF IN P2 AND ISOBUTYLAMINE IN P1') | ADAMANTANE, HIV-1 PROTEASE INHIBITOR GRL-097-13A, DARUNAVIR, MULTIDRUG-RESISTANT, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5jfu:A (LYS45) to (GLY94) HIV-1 WILD TYPE PROTEASE WITH GRL-007-14A (A ADAMANTANE P1-LIGAND WITH BIS-THF IN P2 AND BENZYLAMINE IN P1') | ADAMANTANE, HIV-1 PROTEASE INHIBITOR GRL-007-14A, DARUNAVIR, MULTIDRUG-RESISTANT, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5jg1:A (LYS45) to (GLY94) HIV-1 WILD TYPE PROTEASE WITH GRL-031-14A (A ADAMANTANE P1-LIGAND WITH TETRAHYDROPYRANO-TETRAHYDROFURAN IN P2 AND ISOBUTYLAMINE IN P1') | ADAMANTANE, HIV-1 PROTEASE INHIBITOR GRL-031-14A, DARUNAVIR, MULTIDRUG-RESISTANT, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5jg1:B (PRO44) to (GLY94) HIV-1 WILD TYPE PROTEASE WITH GRL-031-14A (A ADAMANTANE P1-LIGAND WITH TETRAHYDROPYRANO-TETRAHYDROFURAN IN P2 AND ISOBUTYLAMINE IN P1') | ADAMANTANE, HIV-1 PROTEASE INHIBITOR GRL-031-14A, DARUNAVIR, MULTIDRUG-RESISTANT, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5kqx:A (LYS45) to (GLY94) PROTEASE E35D-SQV | HIV-1 PROTEASE, E35D, SALT-BRIDGE INTERACTION, NATURAL POLYMORPHISM, HYDROLASE-HUDROLASE INHIBITOR COMPLEX
5kqy:A (LYS45) to (GLY94) PROTEASE E35D-DRV | HIV-1 PROTEASE, E35D, SALT-BRIDGE INTERACTION, NATURAL POLYMORPHISM, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5kqy:B (PRO44) to (GLY94) PROTEASE E35D-DRV | HIV-1 PROTEASE, E35D, SALT-BRIDGE INTERACTION, NATURAL POLYMORPHISM, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5kr0:A (LYS45) to (GLY94) PROTEASE E35D-APV | HIV-1 PROTEASE, E35D, SALT-BRIDGE INTERACTION, NATURAL POLYMORPHISM, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5kr1:A (GLY40) to (GLY94) PROTEASE PR5-DRV | HIV-1 PROTEASE, E35D, SALT-BRIDGE INTERACTION, NATURAL POLYMORPHISM, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5kr2:A (PRO44) to (GLY94) PROTEASE PR5-SQV | HIV-1 PROTEASE, E35D, SALT-BRIDGE INTERACTION, NATURAL POLYMORPHISM, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5kr2:B (GLY52) to (GLY94) PROTEASE PR5-SQV | HIV-1 PROTEASE, E35D, SALT-BRIDGE INTERACTION, NATURAL POLYMORPHISM, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5kr2:C (LYS45) to (GLY94) PROTEASE PR5-SQV | HIV-1 PROTEASE, E35D, SALT-BRIDGE INTERACTION, NATURAL POLYMORPHISM, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5kr2:D (LYS45) to (GLY94) PROTEASE PR5-SQV | HIV-1 PROTEASE, E35D, SALT-BRIDGE INTERACTION, NATURAL POLYMORPHISM, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
9hvp:B (LYS45) to (GLY94) DESIGN, ACTIVITY AND 2.8 ANGSTROMS CRYSTAL STRUCTURE OF A C2 SYMMETRIC INHIBITOR COMPLEXED TO HIV-1 PROTEASE | ACID PROTEINASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2p3a:A (ARG45) to (GLY94) CRYSTAL STRUCTURE OF THE MULTI-DRUG RESISTANT MUTANT SUBTYPE B HIV PROTEASE COMPLEXED WITH TL-3 INHIBITOR | MULTI-DRUG RESISTANT MUTANT SUBTYPE B HIV PROTEASE, TL-3 INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2p3a:B (ARG45) to (GLY94) CRYSTAL STRUCTURE OF THE MULTI-DRUG RESISTANT MUTANT SUBTYPE B HIV PROTEASE COMPLEXED WITH TL-3 INHIBITOR | MULTI-DRUG RESISTANT MUTANT SUBTYPE B HIV PROTEASE, TL-3 INHIBITOR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1bdr:A (LYS45) to (GLY94) HIV-1 (2: 31, 33-37) PROTEASE COMPLEXED WITH INHIBITOR SB203386 | HYDROLASE, AIDS, POLYPROTEIN, ASPARTYL PROTEASE, ACID PROTEASE, HYDROXYETHYLENE ISOSTERE INHIBITOR, SUBSTRATE ANALOGUE INHIBITOR
3s53:B (GLY52) to (GLY94) HIV-1 PROTEASE TRIPLE MUTANTS V32I, I47V, V82I WITH ANTIVIRAL DRUG DARUNAVIR IN SPACE GROUP P212121 | DARUNAVIR,HIV/AIDS, DRUG RESISTANCE, ASPARTIC PROTEASE, MOLECULAR RECOGNITION, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1bve:B (GLY40) to (GLY94) HIV-1 PROTEASE-DMP323 COMPLEX IN SOLUTION, NMR, 28 STRUCTURES | AIDS, POLYPROTEIN, HYDROLASE, ASPARTYL PROTEASE, ENDONUCLEASE, RNA-DIRECTED DNA POLYMERASE
1bwa:A (LYS45) to (GLY94) HIV-1 PROTEASE (V82F/I84V) DOUBLE MUTANT COMPLEXED WITH XV638 OF DUPONT PHARMACEUTICALS | HIV-1 PROTEASE, HYDROLASE
3sa3:A (GLY52) to (GLY94) CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 PROTEASE IN COMPLEX WITH AG23 | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3sa3:B (GLY52) to (GLY94) CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 PROTEASE IN COMPLEX WITH AG23 | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3sa9:A (GLY52) to (GLY94) CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 PROTEASE IN COMPLEX WITH AF68 | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3sa9:B (GLY52) to (GLY94) CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 PROTEASE IN COMPLEX WITH AF68 | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1c6x:A (ILE47) to (GLY94) ALTERNATE BINDING SITE FOR THE P1-P3 GROUP OF A CLASS OF POTENT HIV-1 PROTEASE INHIBITORS AS A RESULT OF CONCERTED STRUCTURAL CHANGE IN 80'S LOOP. | HYDROLASE
1c6x:B (LYS245) to (GLY294) ALTERNATE BINDING SITE FOR THE P1-P3 GROUP OF A CLASS OF POTENT HIV-1 PROTEASE INHIBITORS AS A RESULT OF CONCERTED STRUCTURAL CHANGE IN 80'S LOOP. | HYDROLASE
1c70:A (GLY52) to (GLY94) ALTERNATE BINDING SITE FOR THE P1-P3 GROUP OF A CLASS OF POTENT HIV-1 PROTEASE INHIBITORS AS A RESULT OF CONCERTED STRUCTURAL CHANGE IN 80'S LOOP. | HYDROLASE
3fsm:A (LYS149) to (GLY198) CRYSTAL STRUCTURE OF A CHEMICALLY SYNTHESIZED 203 AMINO ACID 'COVALENT DIMER' [L-ALA51,D-ALA51'] HIV-1 PROTEASE MOLECULE | ASYMMETRIC DIMER, COVALENT DIMER, BETA-SHEET, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3st5:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 PROTEASE WITH C3-SUBSTITUTED HEXAHYDROCYCLOPENTAFURANYL URETHANE AS P2-LIGAND, GRL-0489A | ASPARTIC ACID PROTEASE, HIV-1 PROTEASE INHIBITOR GRL-0489A, C3- SUBSTITUTED HEXAHYDROCYCLOPENTAFURANYL URETHANE AS P2-LIGANDS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1dmp:A (GLY40) to (GLY94) STRUCTURE OF HIV-1 PROTEASE COMPLEX | AIDS, POLYPROTEIN, HYDROLASE, ASPARTYL PROTEASE, ACID PROTEASE, RNA-DIRECTED DNA POLYMERASE, ENDONUCLEASE, ASPARTYL PROTEINASE
1dmp:B (LYS45) to (GLY94) STRUCTURE OF HIV-1 PROTEASE COMPLEX | AIDS, POLYPROTEIN, HYDROLASE, ASPARTYL PROTEASE, ACID PROTEASE, RNA-DIRECTED DNA POLYMERASE, ENDONUCLEASE, ASPARTYL PROTEINASE
3ggx:C (LYS45) to (GLY94) HIV PROTEASE, PSEUDO-SYMMETRIC INHIBITORS | HIV PROTEASE, PSEUDO-SYMMETRIC INHIBITORS, HYDROLASE, PROTEASE
3ggx:D (LYS45) to (GLY94) HIV PROTEASE, PSEUDO-SYMMETRIC INHIBITORS | HIV PROTEASE, PSEUDO-SYMMETRIC INHIBITORS, HYDROLASE, PROTEASE
3ggx:F (GLY52) to (GLY94) HIV PROTEASE, PSEUDO-SYMMETRIC INHIBITORS | HIV PROTEASE, PSEUDO-SYMMETRIC INHIBITORS, HYDROLASE, PROTEASE
1ebz:A (GLY52) to (GLY94) HIV-1 PROTEASE IN COMPLEX WITH THE INHIBITOR BEA388 | DIMER, PROTEIN-INHIBITOR COMPLEX, HYDROLASE/HYDROLASE INHIBITOR COMPLEX
1ec2:A (GLY52) to (GLY94) HIV-1 PROTEASE IN COMPLEX WITH THE INHIBITOR BEA428 | DIMER, PROTEIN-INHIBITOR COMPLEX, HYDROLASE/HYDROLASE INHIBITOR COMPLEX
4jec:A (GLY52) to (GLY94) JOINT NEUTRON AND X-RAY STRUCTURE OF PER-DEUTERATED HIV-1 PROTEASE IN COMPLEX WITH CLINICAL INHIBITOR AMPRENAVIR | PROTEASE, HYDROLYSIS, POLYPEPTIDES, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4jec:B (GLY140) to (GLY194) JOINT NEUTRON AND X-RAY STRUCTURE OF PER-DEUTERATED HIV-1 PROTEASE IN COMPLEX WITH CLINICAL INHIBITOR AMPRENAVIR | PROTEASE, HYDROLYSIS, POLYPEPTIDES, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1qbs:B (GLY52) to (GLY94) HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY | HYDROLASE (ACID PROTEINASE), ASPARTYL PROTEASE
1fg8:C (LYS45) to (GLY94) STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES | HIV-1 PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1fqx:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF THE COMPLEX OF HIV-1 PROTEASE WITH A PEPTIDOMIMETIC INHIBITOR | ASPARTYL PROTEASE, PROTEASE, HIV, PEPTIDOMIMETIC, INHIBITOR, DRUG DESIGN, HYDROXYETHYLAMINE ISOSTERE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1fqx:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF THE COMPLEX OF HIV-1 PROTEASE WITH A PEPTIDOMIMETIC INHIBITOR | ASPARTYL PROTEASE, PROTEASE, HIV, PEPTIDOMIMETIC, INHIBITOR, DRUG DESIGN, HYDROXYETHYLAMINE ISOSTERE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
2f80:A (LYS45) to (GLY94) HIV-1 PROTEASE MUTANT D30N COMPLEXED WITH INHIBITOR TMC114 | PROTEIN-INHIBITOR COMPLEX, HYDROLASE
4z50:C (GLY52) to (GLY94) CRYSTAL STRUCTURE OF MULTIDRUG RESISTANT HIV-1 PROTEASE CLINICAL ISOLATE PR20D25N WITH TUCKED FLAP | HIV-1 PROTEASE, HYDROLASE
3hzc:A (LYS149) to (GLY198) CRYSTAL STRUCTURE OF A CHEMICALLY SYNTHESIZED 203 AMINO ACID 'COVALENT DIMER' [GLY51;AIB51']HIV-1 PROTEASE MOLECULE COMPLEXED WITH MVT-101 REDUCED ISOSTERE INHIBITOR | ASYMMETRIC DIMER, COVALENT DIMER, BETA-SHEET, HYDROLASE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
1gnm:A (LYS45) to (GLY94) HIV-1 PROTEASE MUTANT WITH VAL 82 REPLACED BY ASP (V82D) COMPLEXED WITH U89360E (INHIBITOR) | ASPARTIC PROTEASE, HIV, MUTANT, INHIBITOR, U-89360E, HYDROLASE (ACID PROTEASE)
1sgu:A (GLY40) to (GLY94) COMPARING THE ACCUMULATION OF ACTIVE SITE AND NON-ACTIVE SITE MUTATIONS IN THE HIV-1 PROTEASE | ACTIVE SITE MUTATIONS, NON-ACTIVE SITE MUTATIONS, INDINAVIR, HIV-1 PROTEASE, HYDROLASE
1sh9:A (LYS45) to (GLY94) COMPARING THE ACCUMULATION OF ACTIVE SITE AND NON-ACTIVE SITE MUTATIONS IN THE HIV-1 PROTEASE | HIV-1 PROTEASE, NON-ACTIVE SITE MUTATIONS, ACTIVE SITE MUTATIONS, RITONAVIR, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3i2l:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF A CHEMICALLY SYNTHESIZED [ALLO-ILE50/50']HIV-1 PROTEASE MOLECULE COMPLEXED WITH MVT-101 REDUCED ISOSTERE INHIBITOR | BETA-SHEET, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3i8w:A (GLY40) to (GLY94) CRYSTAL STRUCTURE OF A METALLACARBORANE INHIBITOR BOUND TO HIV PROTEASE | INHIBITOR, COBALT BIS(1,2-DICARBOLLIDE), VIRAL RESISTANCE, ASPARTIC PROTEASE, AIDS, ASPARTYL PROTEASE, CAPSID MATURATION, CAPSID PROTEIN, CELL MEMBRANE, DNA INTEGRATION, DNA RECOMBINATION, DNA- DIRECTED DNA POLYMERASE, ENDONUCLEASE, HYDROLASE, LIPOPROTEIN, MAGNESIUM, MEMBRANE, METAL-BINDING, MULTIFUNCTIONAL ENZYME, MYRISTATE, NUCLEASE, NUCLEOTIDYLTRANSFERASE, NUCLEUS, PHOSPHOPROTEIN, PROTEASE, RNA-BINDING, RNA-DIRECTED DNA POLYMERASE, TRANSFERASE, VIRAL NUCLEOPROTEIN, VIRION, ZINC-FINGER, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
3vf7:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 PROTEASE MUTANT L76V WITH NOVEL P1'-LIGANDS GRL-02031 | PROTEASE INHIBITOR,P1'-LIGAND, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1t7j:A (GLY52) to (GLY94) CRYSTAL STRUCTURE OF INHIBITOR AMPRENAVIR IN COMPLEX WITH A MULTI-DRUG RESISTANT VARIANT OF HIV-1 PROTEASE (L63P/V82T/I84V) | HIV-1 PROTEASE, DRUG RESITANCE, THERMODYNAMICS, SUBSTRATE ENVELOPE, HYDROLASE
1heg:E (LYS45) to (GLY94) THE CRYSTAL STRUCTURES AT 2.2 ANGSTROMS RESOLUTION OF HYDROXYETHYLENE- BASED INHIBITORS BOUND TO HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE SHOW THAT THE INHIBITORS ARE PRESENT IN TWO DISTINCT ORIENTATIONS | HYDROLASE-HYDROLASE INHIBITOR COMPLEX, ACID PROTEINASE
2hb2:A (LYS43) to (GLY94) STRUCTURE OF HIV PROTEASE 6X MUTANT IN APO FORM | HIV, PROTEASE, RETROVIRUS, ASPARTYL, HYDROLASE
1hxb:A (LYS45) to (GLY94) HIV-1 PROTEINASE COMPLEXED WITH RO 31-8959 | HYDROLASE-HYDROLASE INHIBITOR COMPLEX, ASPARTYL PROTEASE
2i4d:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF WT HIV-1 PROTEASE WITH GS-8373 | HIV-1 PROTEASE, HYDROLASE
1iiq:A (GLY52) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 PROTEASE COMPLEXED WITH A HYDROXYETHYLAMINE PEPTIDOMIMETIC INHIBITOR | HIV PROTEASE, PEPTIDOMIMETICS, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4m8y:A (PRO45) to (GLY95) GS-8374, A NOVEL PHOSPHONATE-CONTAINING INHIBITOR OF HIV-1 PROTEASE, EFFECTIVELY INHIBITS HIV PR MUTANTS WITH AMINO ACID INSERTIONS | HIV-1 PROTEASE, ASPARTIC PROTEASE, AMINO ACID INSERTION, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
2ien:A (LYS45) to (GLY94) CRYSTAL STRUCTURE ANALYSIS OF HIV-1 PROTEASE WITH A POTENT NON-PEPTIDE INHIBITOR (UIC-94017) | HIV-1 PROTEASE, DIMER, INHIBITOR, UIC-94017, TMC114, DARUNAVIR, HYDROLASE
1w5v:A (GLY52) to (GLY94) HIV-1 PROTEASE IN COMPLEX WITH FLUORO SUBSTITUTED DIOL- BASED C2-SYMMETRIC INHIBITOR | HYDROLASE/HYDROLASE INHIBITOR, HYDROLASE, DIMER, PROTEIN-INHIBITOR COMPLEX
4njs:A (ARG45) to (GLY94) CRYSTAL STRUCTURE OF MULTIDRUG-RESISTANT CLINICAL ISOLATE A02 HIV-1 PROTEASE IN COMPLEX WITH NON-PEPTIDIC INHIBITOR, GRL008 | MULTIDRUG-RESISTANCE, HIV-1 PROTEASE, NON-PEPTIDIC INHIBITOR, PROTEASE INHIBITOR, DARUNAVIR ANALOG, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4njs:C (ARG45) to (GLY94) CRYSTAL STRUCTURE OF MULTIDRUG-RESISTANT CLINICAL ISOLATE A02 HIV-1 PROTEASE IN COMPLEX WITH NON-PEPTIDIC INHIBITOR, GRL008 | MULTIDRUG-RESISTANCE, HIV-1 PROTEASE, NON-PEPTIDIC INHIBITOR, PROTEASE INHIBITOR, DARUNAVIR ANALOG, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1kj4:D (LYS45) to (GLY94) SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES | MARIX-CAPSID, SUBSTRATE RECOGNITION, HYDROLASE
1kjf:A (GLY40) to (GLY94) SUBSTRATE SHAPE DETERMINES SPECIFICITY OF RECOGNITION RECOGNITION FOR HIV-1 PROTEASE: ANALYSIS OF CRYSTAL STRUCTURES OF SIX SUBSTRATE COMPLEXES | P1-P6, SUBSTRATE RECOGNITION, HYDROLASE
2nph:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV1 PROTEASE IN SITU PRODUCT COMPLEX | ANTI-PARALLEL BETA SHEET, HYDROLASE
2nph:B (GLY1052) to (GLY1094) CRYSTAL STRUCTURE OF HIV1 PROTEASE IN SITU PRODUCT COMPLEX | ANTI-PARALLEL BETA SHEET, HYDROLASE
2z54:A (LYS45) to (GLY94) THE INFLUENCE OF I47A MUTATION ON REDUCED SUSCEPTIBILITY TO THE PROTEASE INHIBITOR LOPINAVIR | COMPLEX (ASPARTIC PROTEASE/INHIBITOR), ASPARTIC PROTEASE, RESISTANT STRAIN, HYDROLASE
2z54:B (LYS45) to (GLY94) THE INFLUENCE OF I47A MUTATION ON REDUCED SUSCEPTIBILITY TO THE PROTEASE INHIBITOR LOPINAVIR | COMPLEX (ASPARTIC PROTEASE/INHIBITOR), ASPARTIC PROTEASE, RESISTANT STRAIN, HYDROLASE
1lzq:A (GLY52) to (GLY94) CRYSTAL STRUCTURE OF THE COMPLEX OF MUTANT HIV-1 PROTEASE (A71V, V82T, I84V) WITH AN ETHYLENAMINE PEPTIDOMIMETIC INHIBITOR BOC-PHE- PSI[CH2CH2NH]-PHE-GLU-PHE-NH2 | HIV, PEPTIDOMIMETIC, ETHYLENAMINE ISOSTERE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3ka2:A (PRO148) to (GLY198) CRYSTAL STRUCTURE OF CHEMICALLY SYNTHESIZED 203 AMINO ACID 'COVALENT DIMER' [L-ALA;GLY51']HIV-1 PROTEASE MOLECULE COMPLEXED WITH MVT-101 REDUCED ISOSTERE INHIBITOR AT 1.4 A RESOLUTION | BETA-BARREL, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3kfs:B (GLY52) to (GLY94) HIV PROTEASE (PR) DIMER WITH INHIBITOR TL-3 BOUND AND FRAGMENT 2F4 IN THE OUTSIDE/TOP OF FLAP | HIV-1, PROTEASE, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1mer:A (LYS45) to (GLY94) HIV-1 MUTANT (I84V) PROTEASE COMPLEXED WITH DMP450 | HYDROLASE, ACID PROTEINASE, ASPARTYL PROTEASE
3a2o:A (ARG41) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 PROTEASE COMPLEXED WITH KNI-1689 | HIV-1 PROTEASE, INHIBITOR, ASPARTYL PROTEASE, HYDROLASE, PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3a2o:B (GLY152) to (GLY194) CRYSTAL STRUCTURE OF HIV-1 PROTEASE COMPLEXED WITH KNI-1689 | HIV-1 PROTEASE, INHIBITOR, ASPARTYL PROTEASE, HYDROLASE, PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
1ytg:B (LYS45) to (GLY94) SIV PROTEASE CRYSTALLIZED WITH PEPTIDE PRODUCT | AIDS, POLYPROTEIN, HYDROLASE, ASPARTYL PROTEASE, ENDONUCLEASE, RNA- DIRECTED DNA POLYMERASE, HYDROLASE-PEPTIDE COMPLEX
5e5j:A (GLY52) to (GLY94) JOINT X-RAY/NEUTRON STRUCTURE OF HIV-1 PROTEASE TRIPLE MUTANT (V32I, I47V,V82I) WITH DARUNAVIR AT PH 6.0 | PROTEASE HIV-1 DRUG RESISTANT MUTANT INHIBITOR COMPLEX, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
5e5j:B (LYS45) to (GLY94) JOINT X-RAY/NEUTRON STRUCTURE OF HIV-1 PROTEASE TRIPLE MUTANT (V32I, I47V,V82I) WITH DARUNAVIR AT PH 6.0 | PROTEASE HIV-1 DRUG RESISTANT MUTANT INHIBITOR COMPLEX, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
5e5k:A (GLY52) to (GLY94) JOINT X-RAY/NEUTRON STRUCTURE OF HIV-1 PROTEASE TRIPLE MUTANT (V32I, I47V,V82I) WITH DARUNAVIR AT PH 4.3 | PROTEASE DRUG RESISTANT MUTANT INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5e5k:B (GLY52) to (GLY94) JOINT X-RAY/NEUTRON STRUCTURE OF HIV-1 PROTEASE TRIPLE MUTANT (V32I, I47V,V82I) WITH DARUNAVIR AT PH 4.3 | PROTEASE DRUG RESISTANT MUTANT INHIBITOR COMPLEX, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4qj2:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF INACTIVE HIV-1 PROTEASE VARIANT (I50V/A71V) IN COMPLEX WITH WT P1-P6 SUBSTRATE | CO-EVOLUTION, PROTEASE, HYDROLASE
4qj2:C (LYS45) to (GLY94) CRYSTAL STRUCTURE OF INACTIVE HIV-1 PROTEASE VARIANT (I50V/A71V) IN COMPLEX WITH WT P1-P6 SUBSTRATE | CO-EVOLUTION, PROTEASE, HYDROLASE
4qj2:D (GLY52) to (GLY94) CRYSTAL STRUCTURE OF INACTIVE HIV-1 PROTEASE VARIANT (I50V/A71V) IN COMPLEX WITH WT P1-P6 SUBSTRATE | CO-EVOLUTION, PROTEASE, HYDROLASE
4qlh:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF DRUG RESISTANT V82S/V1082S HIV-1 PROTEASE | TETHERED HIV-1 PROTEASE DIMER, PEPTIDE BOND HYDROLYSIS, HYDROLASE
4qlh:A (LYS1045) to (GLY1094) CRYSTAL STRUCTURE OF DRUG RESISTANT V82S/V1082S HIV-1 PROTEASE | TETHERED HIV-1 PROTEASE DIMER, PEPTIDE BOND HYDROLYSIS, HYDROLASE
3nyg:A (LYS45) to (GLY94) X-RAY STRUCTURE OF ESTER CHEMICAL ANALOGUE [O-GLY51,O-GLY51']HIV-1 PROTEASE COMPLEXED WITH MVT-101 INHIBITOR | BETA-BARREL, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4rvi:A (GLY52) to (GLY94) CRYSTAL STRUCTURE OF MULTIDRUG-RESISTANT CLINICAL ISOLATE A02 HIV-1 PROTEASE IN COMPLEX WITH NON-PEPTIDIC INHIBITOR, GRL0519 | HIV-1 PROTEASE-INHIBITOR COMPLEX, GRL0519, G52, PROTEASE INHIBITOR, NON-PEPTIDIC PROTEASE INHIBITOR, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4rvi:B (GLY52) to (GLY94) CRYSTAL STRUCTURE OF MULTIDRUG-RESISTANT CLINICAL ISOLATE A02 HIV-1 PROTEASE IN COMPLEX WITH NON-PEPTIDIC INHIBITOR, GRL0519 | HIV-1 PROTEASE-INHIBITOR COMPLEX, GRL0519, G52, PROTEASE INHIBITOR, NON-PEPTIDIC PROTEASE INHIBITOR, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4rvi:C (GLY52) to (GLY94) CRYSTAL STRUCTURE OF MULTIDRUG-RESISTANT CLINICAL ISOLATE A02 HIV-1 PROTEASE IN COMPLEX WITH NON-PEPTIDIC INHIBITOR, GRL0519 | HIV-1 PROTEASE-INHIBITOR COMPLEX, GRL0519, G52, PROTEASE INHIBITOR, NON-PEPTIDIC PROTEASE INHIBITOR, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4rvi:D (GLY52) to (GLY94) CRYSTAL STRUCTURE OF MULTIDRUG-RESISTANT CLINICAL ISOLATE A02 HIV-1 PROTEASE IN COMPLEX WITH NON-PEPTIDIC INHIBITOR, GRL0519 | HIV-1 PROTEASE-INHIBITOR COMPLEX, GRL0519, G52, PROTEASE INHIBITOR, NON-PEPTIDIC PROTEASE INHIBITOR, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4rvj:B (GLY40) to (GLY94) CRYSTAL STRUCTURE OF MULTIDRUG-RESISTANT CLINICAL ISOLATE A02 HIV-1 PROTEASE IN COMPLEX WITH AMPRENAVIR | HIV-1 PROTEASE-INHIBITOR COMPLEX, AMPRENAVIR, NON-PEPTIDIC PROTEASE INHIBITOR, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4rvj:D (GLY40) to (GLY94) CRYSTAL STRUCTURE OF MULTIDRUG-RESISTANT CLINICAL ISOLATE A02 HIV-1 PROTEASE IN COMPLEX WITH AMPRENAVIR | HIV-1 PROTEASE-INHIBITOR COMPLEX, AMPRENAVIR, NON-PEPTIDIC PROTEASE INHIBITOR, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4cp7:A (LYS45) to (GLY94) MACROCYCLIC TRANSITION-STATE MIMICKING HIV-1 PROTEASE INHIBITORS ENCOMPASSING A TERTIARY ALCOHOL | HYDROLASE, INHIBITOR, RATIONAL DRUG DESIGN, ENZYME
3d1y:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV-1 MUTANT I54V AND INHIBITOR SAQUINA | DRUG RESISTANCE, HIV-1, I54V, FLAP MUTANT, AIDS, ASPARTYL PROTEASE, CAPSID MATURATION, CAPSID PROTEIN, PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4cpq:A (LYS45) to (GLY94) MACROCYCLIC TRANSITION-STATE MIMICKING HIV-1 PROTEASE INHIBITORS ENCOMPASSING A TERTIARY ALCOHOL | HYDROLASE, INHIBITOR, RATIONAL DRUG DESIGN
3o9c:A (GLY52) to (GLY94) CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 PROTEASE IN COMPLEX WITH KD20 | HIV-1 PROTEASE, DRUG RESISTANCE, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, ASPARTYL PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3dck:A (PRO44) to (GLY94) X-RAY STRUCTURE OF D25N CHEMICAL ANALOGUE OF HIV-1 PROTEASE COMPLEXED WITH KETOMETHYLENE ISOSTERE INHIBITOR | HIV-1 PROTEASE, HOMODIMER, BETA-TURNS, BETA-STRAND, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3ogq:B (GLY52) to (ASN111) CRYSTAL STRUCTURE OF 6S-98S FIV PROTEASE WITH LOPINAVIR BOUND | ASPARTYL PROTEASE, HIV-LIKE FIV CHIMERA, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3ok9:B (LYS145) to (GLY194) CRYSTAL STRUCTURE OF WILD-TYPE HIV-1 PROTEASE WITH NEW OXATRICYCLIC DESIGNED INHIBITOR GRL-0519A | ASPARTIC ACID PROTEASE, HIV-1 PROTEASE INHIBITOR GRL-0519A, OXATRICYCLIC LIGANDS, MULTIDRUG-RESISTANT HIV STRAINS, WILD-TYPE HIV-1 PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
3oxc:A (LYS45) to (GLY94) WILD TYPE HIV-1 PROTEASE WITH ANTIVIRAL DRUG SAQUINAVIR | ENZYME INHIBITION, ASPARTIC PROTEASE, HIV/AIDS, SAQUINAVIR, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4e43:A (LYS45) to (GLY94) HIV PROTEASE (PR) DIMER WITH ACETATE IN EXO SITE AND PEPTIDE IN ACTIVE SITE | HIV-1 PROTEASE, EXO SITE, ASPARTYL PROTEASE, FRAGMENT SCREEN, HYDROLASE
3pwm:A (LYS45) to (GLY94) HIV-1 PROTEASE MUTANT L76V WITH DARUNAVIR | HIV-1, PROTEASE, MUTATION L76V, DARUNAVIR, HYDROLASE, HYDROLASE- HYDROLASE INHIBITOR COMPLEX
4ejl:B (LYS45) to (GLY94) APO HIV PROTEASE (PR) DIMER IN CLOSED FORM WITH FRAGMENT 1F1-N IN THE OUTSIDE/TOP OF FLAP | APO PROTEASE, ALLOSTERY, FRAGMENT BINDING, HYDROLASE
4ep3:A (GLY152) to (GLY194) CRYSTAL STRUCTURE OF INACTIVE SINGLE CHAIN WILD-TYPE HIV-1 PROTEASE IN COMPLEX WITH THE SUBSTRATE CA-P2 | HIV-1 PROTEASE, SPECIFICITY DESIGN, DRUG DESIGN, PROTEASE INHIBITORS, AIDS, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE SUBSTRATE COMPLEX
5ivq:A (LYS45) to (GLY94) CRYSTAL STRUCTURE OF HIV PROTEASE COMPLEXED WITH METHYL N-[(1S)-1- BENZHYDRYL-2-(3-MORPHOLIN-4-IUM-2-YLPROPYLAMINO)-2-OXO- ETHYL]CARBAMATE | HIV, PROTEASE, HYDROLASE-INHIBITOR COMPLEX
3qaa:A (LYS45) to (GLY94) HIV-1 WILD TYPE PROTEASE WITH A SUBSTITUTED BIS-TETRAHYDROFURAN INHIBITOR, GRL-044-10A | ASPARTIC ACID PROTEASE, HIV-1 PROTEASE INHIBITOR GRL-044-10A, SUBSTITUTED BIS-TETRAHYDROFURAN INHIBITOR, WILD-TYPE HIV-1 PROTEASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
4f73:A (GLY52) to (GLY94) CRYSTAL STRUCTURE OF ACTIVE HIV-1 PROTEASE IN COMPLEX WITH THE N TERMINAL PRODUCT OF CA-P2 CLEAVAGE SITE | HIV-1 PROTEASE, SUBSTRATE COMPLEX, AIDS, PRODUCT COMPLEX, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE PRODUCT COMPLEX
4f73:B (LYS45) to (GLY94) CRYSTAL STRUCTURE OF ACTIVE HIV-1 PROTEASE IN COMPLEX WITH THE N TERMINAL PRODUCT OF CA-P2 CLEAVAGE SITE | HIV-1 PROTEASE, SUBSTRATE COMPLEX, AIDS, PRODUCT COMPLEX, ASPARTYL PROTEASE, HYDROLASE, HYDROLASE-HYDROLASE PRODUCT COMPLEX
5kao:A (GLY52) to (GLY94) CRYSTAL STRUCTURE OF WILD TYPE HIV-1 PROTEASE IN COMPLEX WITH GRL- 10413 | GRL-10413, HIV-1 PROTEASE, PROTEASE-INHIBITOR, DARUNAVIR, 2- CHLOROANISOLE, NONPEPTIDIC, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5kao:B (GLY40) to (GLY94) CRYSTAL STRUCTURE OF WILD TYPE HIV-1 PROTEASE IN COMPLEX WITH GRL- 10413 | GRL-10413, HIV-1 PROTEASE, PROTEASE-INHIBITOR, DARUNAVIR, 2- CHLOROANISOLE, NONPEPTIDIC, HYDROLASE-HYDROLASE INHIBITOR COMPLEX
5kqz:A (LYS45) to (GLY94) PROTEASE E35D-CAP2 | HIV-1 PROTEASE, E35D, SALT-BRIDGE INTERACTION, NATURAL POLYMORPHISM, HYDROLASE, HYDROLASE-HYDROLASE INHIBITOR COMPLEX