1nce:A (ALA148) to (GLY251) CRYSTAL STRUCTURE OF A TERNARY COMPLEX OF E. COLI THYMIDYLATE SYNTHASE D169C WITH DUMP AND THE ANTIFOLATE CB3717 | BETA-SHEET INTERFACE, PROTEIN-DUMP-COFACTOR ANALOG COMPLEX, ASYMMETRIC DIMER, BIOSYNTHETIC PROTEIN
1nce:B (ALA148) to (GLY251) CRYSTAL STRUCTURE OF A TERNARY COMPLEX OF E. COLI THYMIDYLATE SYNTHASE D169C WITH DUMP AND THE ANTIFOLATE CB3717 | BETA-SHEET INTERFACE, PROTEIN-DUMP-COFACTOR ANALOG COMPLEX, ASYMMETRIC DIMER, BIOSYNTHETIC PROTEIN
2oip:A (VAL404) to (GLY508) CRYSTAL STRUCTURE OF THE S290G ACTIVE SITE MUTANT OF TS- DHFR FROM CRYPTOSPORIDIUM HOMINIS | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE
2oip:B (VAL404) to (GLY508) CRYSTAL STRUCTURE OF THE S290G ACTIVE SITE MUTANT OF TS- DHFR FROM CRYPTOSPORIDIUM HOMINIS | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE
2oip:C (VAL404) to (GLY508) CRYSTAL STRUCTURE OF THE S290G ACTIVE SITE MUTANT OF TS- DHFR FROM CRYPTOSPORIDIUM HOMINIS | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE
2oip:E (LEU405) to (GLY508) CRYSTAL STRUCTURE OF THE S290G ACTIVE SITE MUTANT OF TS- DHFR FROM CRYPTOSPORIDIUM HOMINIS | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE
3edw:X (HIS196) to (GLY300) REPLACEMENT OF VAL3 IN HUMAN THYMIDYLATE SYNTHASE AFFECTS ITS KINETIC PROPERTIES AND INTRACELLULAR STABILITY | TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS
1njc:A (LEU201) to (ASN303) THYMIDYLATE SYNTHASE, MUTATION, N229D WITH 2'-DEOXYCYTIDINE 5'- MONOPHOSPHATE (DCMP) | TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE (METHYLTRANSFERASE)
4h1i:B (LEU198) to (ILE298) STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE AT LOW SALT CONDITIONS | NUCLEOTIDE METABOLISM, CANCER CHEMOTHERAPY TARGET, METHYL TRANSFERASE, TRANSFERASE
4h1i:D (LEU198) to (HIS304) STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE AT LOW SALT CONDITIONS | NUCLEOTIDE METABOLISM, CANCER CHEMOTHERAPY TARGET, METHYL TRANSFERASE, TRANSFERASE
3ejl:A (LEU198) to (HIS304) REPLACEMENT OF VAL3 IN HUMAN THYMIDYLATE SYNTHASE AFFECTS ITS KINETIC PROPERTIES AND INTRACELLULAR STABILITY | TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS
3ejl:B (ALA197) to (GLY300) REPLACEMENT OF VAL3 IN HUMAN THYMIDYLATE SYNTHASE AFFECTS ITS KINETIC PROPERTIES AND INTRACELLULAR STABILITY | TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS
3ejl:C (ALA197) to (HIS304) REPLACEMENT OF VAL3 IN HUMAN THYMIDYLATE SYNTHASE AFFECTS ITS KINETIC PROPERTIES AND INTRACELLULAR STABILITY | TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS
3ejl:D (GLN200) to (GLY300) REPLACEMENT OF VAL3 IN HUMAN THYMIDYLATE SYNTHASE AFFECTS ITS KINETIC PROPERTIES AND INTRACELLULAR STABILITY | TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS
1b02:A (TYR163) to (ASN266) CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE A FROM BACILLUS SUBTILIS | TRANSFERASE, METHYLTRANSFERASE
2bbq:A (ALA148) to (GLY251) STRUCTURAL BASIS FOR RECOGNITION OF POLYGLUTAMYL FOLATES BY THYMIDYLATE SYNTHASE | TRANSFERASE(METHYLTRANSFERASE)
2bbq:B (ALA148) to (GLY251) STRUCTURAL BASIS FOR RECOGNITION OF POLYGLUTAMYL FOLATES BY THYMIDYLATE SYNTHASE | TRANSFERASE(METHYLTRANSFERASE)
1bdu:A (ALA148) to (GLY251) E. COLI THYMIDYLATE SYNTHASE COMPLEXED WITH DURD | TRANSFERASE (METHYLTRANSFERASE), SUBSTRATE MODULES, METHYLTRANSFERASE
1bjg:A (ALA148) to (GLY251) D221(169)N MUTANT DOES NOT PROMOTE OPENING OF THE COFACTOR IMIDAZOLIDINE RING | TRANSFERASE, ACTIVE SITE MUTANT, REACTION INTERMEDIATE METHYLTRANSFERASE
1bo8:A (LEU201) to (ASN303) THYMIDYLATE SYNTHASE R178T MUTANT | TRANSFERASE (METHYLTRANSFERASE), TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS
1bp6:A (LEU201) to (ASN303) THYMIDYLATE SYNTHASE R23I, R179T DOUBLE MUTANT | TRANSFERASE (METHYLTRANSFERASE), TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS
1bq1:B (PHE149) to (GLY251) E. COLI THYMIDYLATE SYNTHASE MUTANT N177A IN COMPLEX WITH CB3717 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) | TRANSFERASE, ACTIVE SITE MUTANT, REACTION INTERMEDIATE
1bq2:A (PHE149) to (GLY251) E. COLI THYMIDYLATE SYNTHASE MUTANT N177A | METHYLTRANSFERASE, TRANSFERASE, SUBSTRATE MODULES
1ci7:B (MET175) to (ASN284) TERNARY COMPLEX OF THYMIDYLATE SYNTHASE FROM PNEUMOCYSTIS CARINII | METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, HALF-SITES REACTIVITY
4xsc:B (LEU186) to (HIS292) COMPLEX STRUCTURE OF THYMIDYLATE SYNTHASE FROM VARICELLA ZOSTER VIRUS WITH A PHOSPHORYLATED BVDU | VZV, THYMIDYLATE SYNTHASE, HERPESVIRUS, TRANSFERASE
4xsc:D (THR185) to (GLY288) COMPLEX STRUCTURE OF THYMIDYLATE SYNTHASE FROM VARICELLA ZOSTER VIRUS WITH A PHOSPHORYLATED BVDU | VZV, THYMIDYLATE SYNTHASE, HERPESVIRUS, TRANSFERASE
4xsd:A (LEU186) to (GLY288) COMPLEX STRUCTURE OF THYMIDYLATE SYNTHASE FROM VARICELLA ZOSTER VIRUS WITH A DUMP | VZV, THYMIDYLATE SYNTHASE, HERPESVIRUS, VIRAL PROTEIN
4xsd:B (THR185) to (GLY288) COMPLEX STRUCTURE OF THYMIDYLATE SYNTHASE FROM VARICELLA ZOSTER VIRUS WITH A DUMP | VZV, THYMIDYLATE SYNTHASE, HERPESVIRUS, VIRAL PROTEIN
4xse:C (LEU186) to (GLY288) COMPLEX STRUCTURE OF THYMIDYLATE SYNTHASE FROM VARICELLA ZOSTER VIRUS | THYMIDYLATE SYNTHASE, HERPESVIRUS, VARICELLA ZOSTER VIRUS, VZV, VIRAL PROTEIN
4xse:D (CYS183) to (ASP287) COMPLEX STRUCTURE OF THYMIDYLATE SYNTHASE FROM VARICELLA ZOSTER VIRUS | THYMIDYLATE SYNTHASE, HERPESVIRUS, VARICELLA ZOSTER VIRUS, VZV, VIRAL PROTEIN
4xse:A (LEU186) to (GLY288) COMPLEX STRUCTURE OF THYMIDYLATE SYNTHASE FROM VARICELLA ZOSTER VIRUS | THYMIDYLATE SYNTHASE, HERPESVIRUS, VARICELLA ZOSTER VIRUS, VZV, VIRAL PROTEIN
4iqq:A (MET200) to (ASP302) CRYSTAL STRUCTURE OF C.ELEGANS THYMIDYLATE SYNTHASE IN COMPLEX WITH DUMP AND TOMUDEX | METHYLTRANSFERASE, INHIBITOR, ANTIFOLATE, PROTEIN DIMER, DEOXYNUCLEOTIDE BIOSYNTHESIS, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4iqq:C (MET200) to (ASP302) CRYSTAL STRUCTURE OF C.ELEGANS THYMIDYLATE SYNTHASE IN COMPLEX WITH DUMP AND TOMUDEX | METHYLTRANSFERASE, INHIBITOR, ANTIFOLATE, PROTEIN DIMER, DEOXYNUCLEOTIDE BIOSYNTHESIS, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
3gg5:C (LEU198) to (ILE298) REPLACEMENT OF VAL3 IN HUMAN THYMIDYLATE SYNTHASE AFFECTS ITS KINETIC PROPERTIES AND INTRACELLULAR STABILITY | METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE
3gh0:A (HIS196) to (GLY300) REPLACEMENT OF VAL3 IN HUMAN THYMIDYLATE SYNTHASE AFFECTS ITS KINETIC PROPERTIES AND INTRACELLULAR STABILITY | TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS
3gh2:X (HIS196) to (GLY300) REPLACEMENT OF VAL3 IN HUMAN THYMIDYLATE SYNTHASE AFFECTS ITS KINETIC PROPERTIES AND INTRACELLULAR STABILITY | TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS
3tms:A (ALA148) to (GLY251) PLASTIC ADAPTATION TOWARD MUTATIONS IN PROTEINS: STRUCTURAL COMPARISON OF THYMIDYLATE SYNTHASES | TRANSFERASE (METHYLTRANSFERASE)
2rd8:A (LEU198) to (HIS304) HUMAN THYMIDYLATE SYNTHASE STABILIZED IN ACTIVE CONFORMATION BY R163K MUTATION: ASYMMETRY AND REACTIVITY OF CYS195 | METHYL TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS
2rd8:B (LEU198) to (GLY300) HUMAN THYMIDYLATE SYNTHASE STABILIZED IN ACTIVE CONFORMATION BY R163K MUTATION: ASYMMETRY AND REACTIVITY OF CYS195 | METHYL TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS
2rda:A (LEU198) to (HIS304) HUMAN THYMIDYLATE SYNTHASE STABILIZED IN ACTIVE CONFORMATION BY R163K MUTATION: ASYMMETRY AND REACTIVITY OF CYS195 | METHYL TRANSFERASE, ASYMMETRIC, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS
2rda:B (LEU198) to (HIS304) HUMAN THYMIDYLATE SYNTHASE STABILIZED IN ACTIVE CONFORMATION BY R163K MUTATION: ASYMMETRY AND REACTIVITY OF CYS195 | METHYL TRANSFERASE, ASYMMETRIC, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS
2rda:C (LEU198) to (HIS304) HUMAN THYMIDYLATE SYNTHASE STABILIZED IN ACTIVE CONFORMATION BY R163K MUTATION: ASYMMETRY AND REACTIVITY OF CYS195 | METHYL TRANSFERASE, ASYMMETRIC, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS
2rda:D (LEU198) to (GLY300) HUMAN THYMIDYLATE SYNTHASE STABILIZED IN ACTIVE CONFORMATION BY R163K MUTATION: ASYMMETRY AND REACTIVITY OF CYS195 | METHYL TRANSFERASE, ASYMMETRIC, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS
2rda:E (LEU198) to (GLY300) HUMAN THYMIDYLATE SYNTHASE STABILIZED IN ACTIVE CONFORMATION BY R163K MUTATION: ASYMMETRY AND REACTIVITY OF CYS195 | METHYL TRANSFERASE, ASYMMETRIC, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS
2tdd:A (THR200) to (ASN303) STRUCTURES OF THYMIDYLATE SYNTHASE WITH A C-TERMINAL DELETION: ROLE OF THE C-TERMINUS IN ALIGNMENT OF D/UMP AND CH2H4FOLATE | TRANSFERASE (METHYLTRANSFERASE)
2tdm:A (THR200) to (ASN303) STRUCTURE OF THYMIDYLATE SYNTHASE | TRANSFERASE, METHYLTRANSFERASE
2tsc:A (PHE149) to (GLY251) STRUCTURE, MULTIPLE SITE BINDING, AND SEGMENTAL ACCOMODATION IN THYMIDYLATE SYNTHASE ON BINDING D/UMP AND AN ANTI-FOLATE | TRANSFERASE (METHYLTRANSFERASE)
2tsc:B (PHE149) to (GLY251) STRUCTURE, MULTIPLE SITE BINDING, AND SEGMENTAL ACCOMODATION IN THYMIDYLATE SYNTHASE ON BINDING D/UMP AND AN ANTI-FOLATE | TRANSFERASE (METHYLTRANSFERASE)
2tsr:A (LEU192) to (GLY294) THYMIDYLATE SYNTHASE FROM RAT IN TERNARY COMPLEX WITH DUMP AND TOMUDEX | THYMIDYLATE SYNTHASE, METHYLTRANSFERASE, DUMP, TOMUDEX, ANTIFOLATE
2tsr:B (LEU192) to (GLY294) THYMIDYLATE SYNTHASE FROM RAT IN TERNARY COMPLEX WITH DUMP AND TOMUDEX | THYMIDYLATE SYNTHASE, METHYLTRANSFERASE, DUMP, TOMUDEX, ANTIFOLATE
2tsr:C (ALA191) to (GLY294) THYMIDYLATE SYNTHASE FROM RAT IN TERNARY COMPLEX WITH DUMP AND TOMUDEX | THYMIDYLATE SYNTHASE, METHYLTRANSFERASE, DUMP, TOMUDEX, ANTIFOLATE
2tsr:D (LEU192) to (HIS298) THYMIDYLATE SYNTHASE FROM RAT IN TERNARY COMPLEX WITH DUMP AND TOMUDEX | THYMIDYLATE SYNTHASE, METHYLTRANSFERASE, DUMP, TOMUDEX, ANTIFOLATE
1f28:A (MET175) to (ASN284) CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE FROM PNEUMOCYSTIS CARINII BOUND TO DUMP AND BW1843U89 | BETA-SHEET, PROTEIN-INHIBITOR COMPLEX, TRANSFERASE
1f28:C (MET175) to (ASN284) CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE FROM PNEUMOCYSTIS CARINII BOUND TO DUMP AND BW1843U89 | BETA-SHEET, PROTEIN-INHIBITOR COMPLEX, TRANSFERASE
1f4d:A (ALA148) to (GLY251) CRYSTAL STRUCTURE OF E. COLI THYMIDYLATE SYNTHASE C146S, L143C COVALENTLY MODIFIED AT C143 WITH N-[TOSYL-D-PROLINYL]AMINO- ETHANETHIOL | CRYSTAL STRUCTURE OF E. COLI THYMIDYLATE SYNTHASE C146S, L143C COVALENTLY MODIFIED AT C143 WITH N-[TOSYL-D-PROLINYL]AMINO- ETHANETHIOL, TRANSFERASE
3h9k:A (LEU198) to (HIS304) STRUCTURES OF THYMIDYLATE SYNTHASE R163K WITH SUBSTRATES AND INHIBITORS SHOW SUBUNIT ASYMMETRY | TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS
3h9k:B (LEU198) to (GLY300) STRUCTURES OF THYMIDYLATE SYNTHASE R163K WITH SUBSTRATES AND INHIBITORS SHOW SUBUNIT ASYMMETRY | TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS
3h9k:D (LEU198) to (HIS304) STRUCTURES OF THYMIDYLATE SYNTHASE R163K WITH SUBSTRATES AND INHIBITORS SHOW SUBUNIT ASYMMETRY | TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS
3h9k:E (LEU198) to (HIS304) STRUCTURES OF THYMIDYLATE SYNTHASE R163K WITH SUBSTRATES AND INHIBITORS SHOW SUBUNIT ASYMMETRY | TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS
3hb8:B (LEU198) to (GLY300) STRUCTURES OF THYMIDYLATE SYNTHASE R163K WITH SUBSTRATES AND INHIBITORS SHOW SUBUNIT ASYMMETRY | TRANSFERASE, METHYL TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS
3hb8:C (LEU198) to (HIS304) STRUCTURES OF THYMIDYLATE SYNTHASE R163K WITH SUBSTRATES AND INHIBITORS SHOW SUBUNIT ASYMMETRY | TRANSFERASE, METHYL TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS
3hb8:E (LEU198) to (GLY300) STRUCTURES OF THYMIDYLATE SYNTHASE R163K WITH SUBSTRATES AND INHIBITORS SHOW SUBUNIT ASYMMETRY | TRANSFERASE, METHYL TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS
3hbb:A (LEU405) to (ASP508) STRUCTURES OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE OF TRYPANOSOMA CRUZI IN THE FOLATE-FREE STATE AND IN COMPLEX WITH TWO ANTIFOLATE DRUGS, TRIMETREXATE AND METHOTREXATE | BIFUNCTIONAL ENZYME IN COMPLEX WITH NADP AND TMQ, OXIDOREDUCTASE, TRANSFERASE
3hbb:B (LEU405) to (TYR512) STRUCTURES OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE OF TRYPANOSOMA CRUZI IN THE FOLATE-FREE STATE AND IN COMPLEX WITH TWO ANTIFOLATE DRUGS, TRIMETREXATE AND METHOTREXATE | BIFUNCTIONAL ENZYME IN COMPLEX WITH NADP AND TMQ, OXIDOREDUCTASE, TRANSFERASE
3hbb:C (LEU405) to (PHE495) STRUCTURES OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE OF TRYPANOSOMA CRUZI IN THE FOLATE-FREE STATE AND IN COMPLEX WITH TWO ANTIFOLATE DRUGS, TRIMETREXATE AND METHOTREXATE | BIFUNCTIONAL ENZYME IN COMPLEX WITH NADP AND TMQ, OXIDOREDUCTASE, TRANSFERASE
3hbb:D (LEU405) to (TYR512) STRUCTURES OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE OF TRYPANOSOMA CRUZI IN THE FOLATE-FREE STATE AND IN COMPLEX WITH TWO ANTIFOLATE DRUGS, TRIMETREXATE AND METHOTREXATE | BIFUNCTIONAL ENZYME IN COMPLEX WITH NADP AND TMQ, OXIDOREDUCTASE, TRANSFERASE
3hj3:A (VAL404) to (GLY508) CRYSTAL STRUCTURE OF THE CHTS-DHFR F207A NON-ACTIVE SITE MUTANT | TS, DHFR, ENZYME, CROSSOVER, NON-ACTIVE SITE, OXIDOREDUCTASE
3um6:A (LEU493) to (HIS599) DOUBLE MUTANT (A16V+S108T) PLASMODIUM FALCIPARUM DHFR-TS (T9/94) COMPLEXED WITH CYCLOGUANIL, NADPH AND DUMP | MALARIAL DHFR-TS, CYCLOGUANIL, ANTIFOLATE, NAPDH, DUMP, OXIDOREDUCTASE, TRANSFERASE-INHIBITOR COMPLEX
3um8:A (LEU493) to (ASN595) WILD-TYPE PLASMODIUM FALCIPARUM DHFR-TS COMPLEXED WITH CYCLOGUANIL AND NADPH | MALARIAL DHFR-TS, CYCLOGUANIL, ANTIFOLATE, NADPH, OXIDOREDUCTASE, TRANSFERASE-INHIBITOR COMPLEX
3um8:B (LEU493) to (ASN595) WILD-TYPE PLASMODIUM FALCIPARUM DHFR-TS COMPLEXED WITH CYCLOGUANIL AND NADPH | MALARIAL DHFR-TS, CYCLOGUANIL, ANTIFOLATE, NADPH, OXIDOREDUCTASE, TRANSFERASE-INHIBITOR COMPLEX
1rts:A (LEU192) to (HIS298) THYMIDYLATE SYNTHASE FROM RAT IN TERNARY COMPLEX WITH DUMP AND TOMUDEX | THYMIDYLATE SYNTHASE, METHYLTRANSFERASE, DUMP, TOMUDEX, ANTIFOLATE
1rts:B (LEU192) to (PRO299) THYMIDYLATE SYNTHASE FROM RAT IN TERNARY COMPLEX WITH DUMP AND TOMUDEX | THYMIDYLATE SYNTHASE, METHYLTRANSFERASE, DUMP, TOMUDEX, ANTIFOLATE
2vet:A (ALA148) to (GLY251) CRYSTAL STRUCTURE OF THE THYMIDYLATE SYNTHASE K48Q COMPLEXED WITH DUMP | REPRESSOR, CYTOPLASM, RNA-BINDING, TRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, DUMP SUBSTRATE, METHYLTRANSFERASE, THYMIDYLATE SYNTHASE, TRANSLATION REGULATION
2vf0:B (ALA148) to (GLY251) CRYSTAL STRUCTURE OF THE THYMIDYLATE SYNTHASE K48Q COMPLEXED WITH 5NO2DUMP AND BW1843U89 | NUCLEOTIDE BIOSYNTHESIS, SUBSTRATE ANOLOGUE, ANTIFOLATE BINDING, RNA-BINDING, TRANSFERASE, METHYLTRANSFERASE, REPRESSOR, BW1843U89, CYTOPLASM, 5-NO2-DUMP, THYMIDYLATE SYNTHASE, TRANSLATION REGULATION
3uwl:B (THR199) to (GLY302) CRYSTAL STRUCTURE OF ENTEROCCOCUS FAECALIS THYMIDYLATE SYNTHASE (EFTS) IN COMPLEX WITH 5-FORMYL TETRAHYDROFOLATE | METHYLTRANSFERASE, TRANSFERASE
3uwl:D (MET200) to (GLY302) CRYSTAL STRUCTURE OF ENTEROCCOCUS FAECALIS THYMIDYLATE SYNTHASE (EFTS) IN COMPLEX WITH 5-FORMYL TETRAHYDROFOLATE | METHYLTRANSFERASE, TRANSFERASE
1sej:A (VAL404) to (GLY508) CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE FROM CRYPTOSPORIDIUM HOMINIS BOUND TO 1843U89/NADPH/DUMP | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE
1sej:B (VAL404) to (GLY508) CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE FROM CRYPTOSPORIDIUM HOMINIS BOUND TO 1843U89/NADPH/DUMP | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE
1sej:C (VAL404) to (GLY508) CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE FROM CRYPTOSPORIDIUM HOMINIS BOUND TO 1843U89/NADPH/DUMP | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE
1sej:D (VAL404) to (GLY508) CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE FROM CRYPTOSPORIDIUM HOMINIS BOUND TO 1843U89/NADPH/DUMP | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE
1sej:E (VAL404) to (GLY508) CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE FROM CRYPTOSPORIDIUM HOMINIS BOUND TO 1843U89/NADPH/DUMP | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE
2g89:A (THR200) to (ASN303) L. CASEI THYMIDYLATE SYNTHASE Y261A IN COMPLEX WITH SUBSTRATE, DUMP | ALPHA/BETA PROTEIN, BETA SHEET, DUMP-BINDING RESIDUE, DUMP COMPLEX, ACTIVE SITE MUTATION, TRANSFERASE
2g8x:B (PHE149) to (GLY251) ESCHERICHIA COLI Y209W APOPROTEIN | BETA SHEET, ALPHA/BETA PROTEIN, DTT, TRANSFERASE
4ky4:A (LEU492) to (GLY597) CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 2 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR | SYNTHASE, BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE
4ky4:C (LEU492) to (GLY597) CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 2 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR | SYNTHASE, BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE
4ky4:H (LEU492) to (GLY597) CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 2 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR | SYNTHASE, BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE
4ky8:A (VAL404) to (GLY508) CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, METHOTREXATE, FDUMP AND 4-((2-AMINO-6-METHYL-4-OXO-4,7- DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)THIO)-2-CHLOROPHENYL)-L- GLUTAMIC ACID | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE,OXIDOREDUCTASE-INHIBITOR COMPLEX
4ky8:B (VAL404) to (GLY508) CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, METHOTREXATE, FDUMP AND 4-((2-AMINO-6-METHYL-4-OXO-4,7- DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)THIO)-2-CHLOROPHENYL)-L- GLUTAMIC ACID | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE,OXIDOREDUCTASE-INHIBITOR COMPLEX
4ky8:C (VAL404) to (GLY508) CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, METHOTREXATE, FDUMP AND 4-((2-AMINO-6-METHYL-4-OXO-4,7- DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)THIO)-2-CHLOROPHENYL)-L- GLUTAMIC ACID | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE,OXIDOREDUCTASE-INHIBITOR COMPLEX
4ky8:D (VAL404) to (GLY508) CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, METHOTREXATE, FDUMP AND 4-((2-AMINO-6-METHYL-4-OXO-4,7- DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)THIO)-2-CHLOROPHENYL)-L- GLUTAMIC ACID | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE,OXIDOREDUCTASE-INHIBITOR COMPLEX
4ky8:E (VAL404) to (GLY508) CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, METHOTREXATE, FDUMP AND 4-((2-AMINO-6-METHYL-4-OXO-4,7- DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)THIO)-2-CHLOROPHENYL)-L- GLUTAMIC ACID | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE,OXIDOREDUCTASE-INHIBITOR COMPLEX
4kya:B (LEU491) to (GLY597) CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 3 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR | SYNTHASE, BIFUNCTIONAL, CHIMERA PROTEIN, OXIDOREDUCTASE, TRANSFERASE- INHIBITOR COMPLEX
4kya:D (LEU491) to (GLY597) CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 3 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR | SYNTHASE, BIFUNCTIONAL, CHIMERA PROTEIN, OXIDOREDUCTASE, TRANSFERASE- INHIBITOR COMPLEX
4kya:F (LEU491) to (GLY597) CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 3 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR | SYNTHASE, BIFUNCTIONAL, CHIMERA PROTEIN, OXIDOREDUCTASE, TRANSFERASE- INHIBITOR COMPLEX
4kya:H (LEU491) to (GLY597) CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 3 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR | SYNTHASE, BIFUNCTIONAL, CHIMERA PROTEIN, OXIDOREDUCTASE, TRANSFERASE- INHIBITOR COMPLEX
1syn:B (PHE149) to (GLY251) E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH BW1843U89 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) | TRANSFERASE (METHYLTRANSFERASE)
1tda:A (THR200) to (ASN303) STRUCTURES OF THYMIDYLATE SYNTHASE WITH A C-TERMINAL DELETION: ROLE OF THE C-TERMINUS IN ALIGNMENT OF D/UMP AND CH2H4FOLATE | TRANSFERASE (METHYLTRANSFERASE)
1tdu:B (ALA148) to (GLY251) E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH CB3717 AND 2'- DEOXYURIDINE (DURD) | TRANSFERASE (METHYLTRANSFERASE), SUBSTRATE MODULES
1thy:A (LEU201) to (ASN303) REFINED STRUCTURES OF SUBSTRATE-BOUND AND PHOSPHATE-BOUND THYMIDYLATE SYNTHASE FROM LACTOBACILLUS CASEI | TRANSFERASE(METHYLTRANSFERASE)
1tjs:A (ALA148) to (GLY251) E. COLI THYMIDYLATE SYNTHASE | TRANSFERASE (METHYLTRANSFERASE), SUBSTRATE MODULES, METHYLTRANSFERASE
3irm:A (LEU405) to (TYR512) TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH CYCLOGUANIL | TRYPANOSOMA CRUZI, DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE
3irm:B (LEU405) to (ASP508) TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH CYCLOGUANIL | TRYPANOSOMA CRUZI, DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE
3irm:C (LEU405) to (ASP508) TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH CYCLOGUANIL | TRYPANOSOMA CRUZI, DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE
3irm:D (LEU405) to (TYR512) TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH CYCLOGUANIL | TRYPANOSOMA CRUZI, DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE
3irn:A (LEU405) to (TYR512) TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH NADPH AND CYCLOGUANIL | TRYPANOSOMA CRUZI,DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE
3irn:B (LEU405) to (ASP508) TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH NADPH AND CYCLOGUANIL | TRYPANOSOMA CRUZI,DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE
3irn:C (LEU405) to (ASP508) TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH NADPH AND CYCLOGUANIL | TRYPANOSOMA CRUZI,DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE
3irn:D (LEU405) to (ASP508) TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH NADPH AND CYCLOGUANIL | TRYPANOSOMA CRUZI,DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE
3iro:A (LEU405) to (PHE495) TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH NADPH AND Q-8 ANTIFOLATE | TRYPANOSOMA CRUZI, DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE
3iro:B (LEU406) to (ASP508) TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH NADPH AND Q-8 ANTIFOLATE | TRYPANOSOMA CRUZI, DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE
3iro:C (LEU405) to (ASP508) TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH NADPH AND Q-8 ANTIFOLATE | TRYPANOSOMA CRUZI, DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE
1tlc:A (ALA148) to (GLY251) THYMIDYLATE SYNTHASE COMPLEXED WITH DGMP AND FOLATE ANALOG 1843U89 | METHYLTRANSFERASE
1tlc:B (ALA148) to (GLY251) THYMIDYLATE SYNTHASE COMPLEXED WITH DGMP AND FOLATE ANALOG 1843U89 | METHYLTRANSFERASE
1trg:A (ALA148) to (GLY251) E. COLI THYMIDYLATE SYNTHASE IN SYMMETRIC COMPLEX WITH CB3717 AND 2'- DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) | METHYLTRANSFERASE, SYMMETRIC TERNARY COMPLEX
1tsd:A (ALA148) to (GLY251) THYMIDYLATE SYNTHASE COMPLEX WITH 2'-DEOXYURIDINE 5'- MONOPHOSPHATE (DUMP) AND FOLATE ANALOG 1843U89 | DUMP, 1843U89, TRANSFERASE (METHYLTRANSFERASE)
1tsd:B (ALA148) to (GLY251) THYMIDYLATE SYNTHASE COMPLEX WITH 2'-DEOXYURIDINE 5'- MONOPHOSPHATE (DUMP) AND FOLATE ANALOG 1843U89 | DUMP, 1843U89, TRANSFERASE (METHYLTRANSFERASE)
1tsl:A (THR200) to (ASN303) L. CASEI THYMIDYLATE SYNTHASE WITH SPECIES SPECIFIC INHIBITOR | METHYLTRANSFERASE, SPECIES SPECIFICITY, STRUCTURE-BASED DRUG DESIGN, ANTIBIOTIC
1tsm:A (LEU201) to (ASN303) L. CASEI THYMIDYLATE SYNTHASE WITH SPECIES SPECIFIC INHIBITOR | METHYLTRANSFERASE, SPECIES SPECIFICITY, STRUCTURE-BASED DRUG DESIGN, ANTIBIOTIC
1tsv:A (LEU201) to (ASN303) THYMIDYLATE SYNTHASE R179A MUTANT | TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS
1tsw:A (LEU201) to (ASN303) THYMIDYLATE SYNTHASE R179A MUTANT | TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS
1tsx:A (LEU201) to (ASN303) THYMIDYLATE SYNTHASE R179E MUTANT | TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS
1tsy:A (THR200) to (ASN303) THYMIDYLATE SYNTHASE R179K MUTANT | TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS
1tsz:A (LEU201) to (ASN303) THYMIDYLATE SYNTHASE R179K MUTANT | TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS
1tvu:A (LEU201) to (ASN303) CONTRIBUTIONS OF ORIENTATION AND HYDROGEN BONDING TO CATALYSIS IN ASN- 229 MUTANTS OF THYMIDYLATE SYNTHASE | TRANSFERASE, METHYLTRANSFERASE
1tvv:A (THR200) to (ASN303) CONTRIBUTIONS OF ORIENTATION AND HYDROGEN BONDING TO CATALYSIS IN ASN- 229 MUTANTS OF THYMIDYLATE SYNTHASE | TRANSFERASE, METHYLTRANSFERASE
1hvy:C (LEU198) to (GLY300) HUMAN THYMIDYLATE SYNTHASE COMPLEXED WITH DUMP AND RALTITREXED, AN ANTIFOLATE DRUG, IS IN THE CLOSED CONFORMATION | TOMUDEX, RALTITREXED, TRANSFERASE
1hvy:D (LEU198) to (GLY300) HUMAN THYMIDYLATE SYNTHASE COMPLEXED WITH DUMP AND RALTITREXED, AN ANTIFOLATE DRUG, IS IN THE CLOSED CONFORMATION | TOMUDEX, RALTITREXED, TRANSFERASE
1hw3:A (GLN200) to (GLY300) STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE SUGGESTS ADVANTAGES OF CHEMOTHERAPY WITH NONCOMPETITIVE INHIBITORS | THYMIDYLATE SYNTHASE, METHYLTRANSFERASE, TRANSFERASE
1hw4:A (GLN200) to (GLY300) STRUCTURE OF THYMIDYLATE SYNTHASE SUGGESTS ADVANTAGES OF CHEMOTHERAPY WITH NONCOMPETITIVE INHIBITORS | THYMIDYLATE SYNTHASE, METHYLTRANSFERASE, TRANSFERASE
1hzw:A (LEU198) to (HIS304) CRYSTAL STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE | THYMIDYLATE SYNTHASE, HUMAN, UNCOMPLEXED, OPEN CONFORMATION, DELTA(7-29) MUTANT, TRANSFERASE
1hzw:B (LEU198) to (HIS304) CRYSTAL STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE | THYMIDYLATE SYNTHASE, HUMAN, UNCOMPLEXED, OPEN CONFORMATION, DELTA(7-29) MUTANT, TRANSFERASE
1j3j:C (CYS490) to (HIS599) DOUBLE MUTANT (C59R+S108N) PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (PFDHFR-TS) COMPLEXED WITH PYRIMETHAMINE, NADPH, AND DUMP | BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE
1jmf:A (LEU201) to (ASN303) CONTRIBUTIONS OF ORIENTATION AND HYDROGEN BONDING TO CATALYSIS IN ASN- 229 MUTANTS OF THYMIDYLATE SYNTHASE | TRANSFERASE, METHYLTRANSFERASE
1jmg:A (LEU201) to (ASN303) CONTRIBUTIONS OF ORIENTATION AND HYDROGEN BONDING TO CATALYSIS IN ASN- 229 MUTANTS OF THYMIDYLATE SYNTHASE | TRANSFERASE, METHYLTRANSFERASE
1jmh:A (LEU201) to (ASN303) CONTRIBUTIONS OF ORIENTATION AND HYDROGEN BONDING TO CATALYSIS IN ASN- 229 MUTANTS OF THYMIDYLATE SYNTHASE | TRANSFERASE, METHYLTRANSFERASE
1jmi:A (LEU201) to (ASN303) CONTRIBUTIONS OF ORIENTATION AND HYDROGEN BONDING TO CATALYSIS IN ASN- 229 MUTANTS OF THYMIDYLATE SYNTHASE | TRANSFERASE, METHYLTRANSFERASE
1jtq:A (ALA148) to (GLY251) E. COLI TS COMPLEX WITH DUMP AND THE PYRROLO(2,3-D)PYRIMIDINE-BASED ANTIFOLATE LY341770 | ANTIFOLATE, CANCER, DRUG RESISTANCE, DTMP SYNTHESIS, TRANSFERASE
1jtq:B (ALA148) to (GLY251) E. COLI TS COMPLEX WITH DUMP AND THE PYRROLO(2,3-D)PYRIMIDINE-BASED ANTIFOLATE LY341770 | ANTIFOLATE, CANCER, DRUG RESISTANCE, DTMP SYNTHESIS, TRANSFERASE
1jtu:B (ALA148) to (GLY251) E. COLI THYMIDYLATE SYNTHASE IN A COMPLEX WITH DUMP AND LY338913, A POLYGLUTAMYLATED PYRROLO(2,3-D)PYRIMIDINE-BASED ANTIFOLATE | ANTIFOLATE, DTMP SYNTHESIS, CANCER, DRUG RESISTANCE, POLYGLUTAMYLATION, TRANSFERASE
1ju6:A (ALA197) to (GLY300) HUMAN THYMIDYLATE SYNTHASE COMPLEX WITH DUMP AND LY231514, A PYRROLO(2,3-D)PYRIMIDINE-BASED ANTIFOLATE | ANTIFOLATE, DTMP SYNTHESIS, DRUG RESISTANCE, CANCER, TRANSFERASE
1ju6:B (ALA197) to (GLY300) HUMAN THYMIDYLATE SYNTHASE COMPLEX WITH DUMP AND LY231514, A PYRROLO(2,3-D)PYRIMIDINE-BASED ANTIFOLATE | ANTIFOLATE, DTMP SYNTHESIS, DRUG RESISTANCE, CANCER, TRANSFERASE
1ju6:C (ALA197) to (GLY300) HUMAN THYMIDYLATE SYNTHASE COMPLEX WITH DUMP AND LY231514, A PYRROLO(2,3-D)PYRIMIDINE-BASED ANTIFOLATE | ANTIFOLATE, DTMP SYNTHESIS, DRUG RESISTANCE, CANCER, TRANSFERASE
1ju6:D (ALA197) to (GLY300) HUMAN THYMIDYLATE SYNTHASE COMPLEX WITH DUMP AND LY231514, A PYRROLO(2,3-D)PYRIMIDINE-BASED ANTIFOLATE | ANTIFOLATE, DTMP SYNTHESIS, DRUG RESISTANCE, CANCER, TRANSFERASE
1vza:A (LEU201) to (ASN303) THYMIDYLATE SYNTHASE E60D MUTANT BINARY COMPLEX WITH 2'- DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) | METHYLTRANSFERASE, NUCLEOTIDE SYNTHASE
1vze:A (LEU201) to (ASN303) L. CASEI THYMIDYLATE SYNTHASE MUTANT E60Q TERNARY COMPLEX WITH DUMP AND CB3717 | METHYLTRANSFERASE, NUCLEOTIDE SYNTHASE
5by6:A (CYS191) to (ASN294) CRYSTAL STRUCTURE OF TRICHINELLA SPIRALIS THYMIDYLATE SYNTHASE COMPLEXED WITH DUMP | TRICHINELLA SPIRALIS, PARASITIC NEMATODE, PROTEIN-LIGAND COMPLEX, METHYLTRANSFERASE, TRANSFERASE
5by6:B (CYS191) to (ASN294) CRYSTAL STRUCTURE OF TRICHINELLA SPIRALIS THYMIDYLATE SYNTHASE COMPLEXED WITH DUMP | TRICHINELLA SPIRALIS, PARASITIC NEMATODE, PROTEIN-LIGAND COMPLEX, METHYLTRANSFERASE, TRANSFERASE
5by6:C (CYS191) to (ASN294) CRYSTAL STRUCTURE OF TRICHINELLA SPIRALIS THYMIDYLATE SYNTHASE COMPLEXED WITH DUMP | TRICHINELLA SPIRALIS, PARASITIC NEMATODE, PROTEIN-LIGAND COMPLEX, METHYLTRANSFERASE, TRANSFERASE
2kce:A (ALA148) to (GLY251) BINDING OF THE ANTICANCER DRUG ZD1694 TO E. COLI THYMIDYLATE SYNTHASE: ASSESSING SPECIFICITY AND AFFINITY | METHYLTRANSFERASE, REACTION INTERMEDIATE, ANTIFOLATE, DRUG DESIGN
2kce:B (ALA148) to (GLY251) BINDING OF THE ANTICANCER DRUG ZD1694 TO E. COLI THYMIDYLATE SYNTHASE: ASSESSING SPECIFICITY AND AFFINITY | METHYLTRANSFERASE, REACTION INTERMEDIATE, ANTIFOLATE, DRUG DESIGN
1kce:A (ALA148) to (GLY251) E. COLI THYMIDYLATE SYNTHASE MUTANT E58Q IN COMPLEX WITH CB3717 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) | TRANSFERASE, REACTION INTERMEDIATE
1kce:B (ALA148) to (GLY251) E. COLI THYMIDYLATE SYNTHASE MUTANT E58Q IN COMPLEX WITH CB3717 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) | TRANSFERASE, REACTION INTERMEDIATE
4o1x:D (SER195) to (ILE298) CRYSTAL STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE DOUBLE MUTANT C195S- Y202C | DIMER-DIMER INTERFACE MODIFICATION, ACTIVE CONFORMATION, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE
3jsu:A (GLN495) to (ASN595) QUADRUPLE MUTANT(N51I+C59R+S108N+I164L) PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE(PFDHFR-TS) COMPLEXED WITH QN254, NADPH, AND DUMP | ROSSMANN FOLD, OXIDOREDUCTASE, TRANSFERASE
4o7u:A (MET200) to (GLY302) ETHEROCOMPLEX OF ENTEROCCOCUS FAECALIS THYMIDYLATE SYNTHASE WITH 5- HYDROXYMETHILENE-6-HYDROFOLIC ACID AND THE PHTALIMIDIC INHIBITOR SS7 | TRANSFERASE, FOLATE BINDING, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4o7u:D (THR199) to (GLY302) ETHEROCOMPLEX OF ENTEROCCOCUS FAECALIS THYMIDYLATE SYNTHASE WITH 5- HYDROXYMETHILENE-6-HYDROFOLIC ACID AND THE PHTALIMIDIC INHIBITOR SS7 | TRANSFERASE, FOLATE BINDING, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
1lce:A (THR200) to (ASN303) LACTOBACILLUS CASEI THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH DUMP AND CH2THF | NUCLEOTIDE SYNTHASE, TRANSFERASE (METHYLTRANSFERASE)
3kgb:A (LEU177) to (HIS285) CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE 1/2 FROM ENCEPHALITOZOON CUNICULI AT 2.2 A RESOLUTION | SSGCID, NIH, NIAID, SBRI, UW, DECODE, ENCEPHALITOZOON CUNICULI, THYMIDYLATE SYNTHASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE, STRUCTURAL GENOMICS, SEATTLE STRUCTURAL GENOMICS CENTER FOR INFECTIOUS DISEASE
3kjs:A (LEU405) to (ASP508) CRYSTAL STRUCTURE OF T. CRUZI DHFR-TS WITH 3 HIGH AFFINITY DHFR INHIBITORS: DQ1 INHIBITOR COMPLEX | OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE,TRANSFERASE
3kjs:B (LEU405) to (TYR512) CRYSTAL STRUCTURE OF T. CRUZI DHFR-TS WITH 3 HIGH AFFINITY DHFR INHIBITORS: DQ1 INHIBITOR COMPLEX | OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE,TRANSFERASE
3kjs:C (LEU405) to (PHE495) CRYSTAL STRUCTURE OF T. CRUZI DHFR-TS WITH 3 HIGH AFFINITY DHFR INHIBITORS: DQ1 INHIBITOR COMPLEX | OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE,TRANSFERASE
3kjs:D (LEU405) to (TYR512) CRYSTAL STRUCTURE OF T. CRUZI DHFR-TS WITH 3 HIGH AFFINITY DHFR INHIBITORS: DQ1 INHIBITOR COMPLEX | OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE,TRANSFERASE
1ypv:A (GLN200) to (GLY300) STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE AT LOW SALT CONDITIONS | THYMIDYLATE SYNTHASE, METHYLTRANSFERASE, TRANSFERASE
4psg:B (MET200) to (ASP302) CRYSTAL STRUCTURE OF C.ELEGANS THYMIDYLATE SYNTHASE IN COMPLEX WITH AN INHIBITOR N(4)OHDCMP | ENZYME, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, PROTEIN DIMER, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4q0d:E (VAL404) to (GLY508) CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP, METHOTREXATE AND 2-AMINO-4-OXO-4,7-DIHYDRO- PYRROLO[2,3-D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID. | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4q0d:A (VAL404) to (GLY508) CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP, METHOTREXATE AND 2-AMINO-4-OXO-4,7-DIHYDRO- PYRROLO[2,3-D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID. | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4q0d:B (VAL404) to (GLY508) CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP, METHOTREXATE AND 2-AMINO-4-OXO-4,7-DIHYDRO- PYRROLO[2,3-D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID. | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4q0d:C (VAL404) to (GLY508) CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP, METHOTREXATE AND 2-AMINO-4-OXO-4,7-DIHYDRO- PYRROLO[2,3-D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID. | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4q0d:D (VAL404) to (GLY508) CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP, METHOTREXATE AND 2-AMINO-4-OXO-4,7-DIHYDRO- PYRROLO[2,3-D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID. | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
1zpr:A (ALA148) to (GLY251) E. COLI THYMIDYLATE SYNTHASE MUTANT E58Q IN COMPLEX WITH CB3717 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) | TRANSFERASE, ACTIVE SITE MUTANT, REACTION INTERMEDIATE
1zpr:B (PHE149) to (GLY251) E. COLI THYMIDYLATE SYNTHASE MUTANT E58Q IN COMPLEX WITH CB3717 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) | TRANSFERASE, ACTIVE SITE MUTANT, REACTION INTERMEDIATE
2a9w:B (ALA148) to (GLY251) E. COLI TS COMPLEXED WITH DUMP AND INHIBITOR GA9 | PROTEIN-INHIBITOR COMPLEX, TRANSFERASE
3b5b:A (ALA148) to (GLY251) CRYSTAL STRUCTURE OF THE THYMIDYLATE SYNTHASE K48Q | THYMIDYLATE SYNTHASE, 5-NO2-DUMP, SUBSTRATE ANOLOGUE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, REPRESSOR, RNA-BINDING, TRANSFERASE, TRANSLATION REGULATION
3b5b:B (ALA148) to (GLY251) CRYSTAL STRUCTURE OF THE THYMIDYLATE SYNTHASE K48Q | THYMIDYLATE SYNTHASE, 5-NO2-DUMP, SUBSTRATE ANOLOGUE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, REPRESSOR, RNA-BINDING, TRANSFERASE, TRANSLATION REGULATION
2aaz:B (MET189) to (GLY304) CRYPTOCOCCUS NEOFORMANS THYMIDYLATE SYNTHASE COMPLEXED WITH SUBSTRATE AND AN ANTIFOLATE | METHYL TRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE
2aaz:C (MET189) to (GLY304) CRYPTOCOCCUS NEOFORMANS THYMIDYLATE SYNTHASE COMPLEXED WITH SUBSTRATE AND AN ANTIFOLATE | METHYL TRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE
2aaz:D (MET189) to (GLY304) CRYPTOCOCCUS NEOFORMANS THYMIDYLATE SYNTHASE COMPLEXED WITH SUBSTRATE AND AN ANTIFOLATE | METHYL TRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE
2aaz:E (MET189) to (GLY304) CRYPTOCOCCUS NEOFORMANS THYMIDYLATE SYNTHASE COMPLEXED WITH SUBSTRATE AND AN ANTIFOLATE | METHYL TRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE
2aaz:F (MET189) to (GLY304) CRYPTOCOCCUS NEOFORMANS THYMIDYLATE SYNTHASE COMPLEXED WITH SUBSTRATE AND AN ANTIFOLATE | METHYL TRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE
2aaz:G (MET189) to (GLY304) CRYPTOCOCCUS NEOFORMANS THYMIDYLATE SYNTHASE COMPLEXED WITH SUBSTRATE AND AN ANTIFOLATE | METHYL TRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE
2aaz:H (MET189) to (GLY304) CRYPTOCOCCUS NEOFORMANS THYMIDYLATE SYNTHASE COMPLEXED WITH SUBSTRATE AND AN ANTIFOLATE | METHYL TRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE
2aaz:I (MET189) to (GLY304) CRYPTOCOCCUS NEOFORMANS THYMIDYLATE SYNTHASE COMPLEXED WITH SUBSTRATE AND AN ANTIFOLATE | METHYL TRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE
2aaz:J (MET189) to (GLY304) CRYPTOCOCCUS NEOFORMANS THYMIDYLATE SYNTHASE COMPLEXED WITH SUBSTRATE AND AN ANTIFOLATE | METHYL TRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE
2aaz:K (MET189) to (GLY304) CRYPTOCOCCUS NEOFORMANS THYMIDYLATE SYNTHASE COMPLEXED WITH SUBSTRATE AND AN ANTIFOLATE | METHYL TRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE
2aaz:L (MET189) to (GLY304) CRYPTOCOCCUS NEOFORMANS THYMIDYLATE SYNTHASE COMPLEXED WITH SUBSTRATE AND AN ANTIFOLATE | METHYL TRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE
2aaz:M (MET189) to (GLY304) CRYPTOCOCCUS NEOFORMANS THYMIDYLATE SYNTHASE COMPLEXED WITH SUBSTRATE AND AN ANTIFOLATE | METHYL TRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE
2aaz:N (MET189) to (GLY304) CRYPTOCOCCUS NEOFORMANS THYMIDYLATE SYNTHASE COMPLEXED WITH SUBSTRATE AND AN ANTIFOLATE | METHYL TRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE
2aaz:O (MET189) to (GLY304) CRYPTOCOCCUS NEOFORMANS THYMIDYLATE SYNTHASE COMPLEXED WITH SUBSTRATE AND AN ANTIFOLATE | METHYL TRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE
2aaz:P (MET189) to (GLY304) CRYPTOCOCCUS NEOFORMANS THYMIDYLATE SYNTHASE COMPLEXED WITH SUBSTRATE AND AN ANTIFOLATE | METHYL TRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE
3b9h:A (ALA148) to (GLY251) E. COLI THYMIDYLATE SYNTHASE COMPLEXED WITH 5-NITRO-2'-DEOXY URIDINE | BINARY COMPLEX, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, REPRESSOR, RNA-BINDING, TRANSFERASE, TRANSLATION REGULATION, ----
3bgx:A (ALA148) to (GLY251) E. COLI THYMIDYLATE SYNTHASE C146S MUTANT COMPLEXED WITH DTMP AND MTF | METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, REPRESSOR, RNA-BINDING, TRANSLATION REGULATION, TRANSFERASE
3bnz:A (THR200) to (ASN303) CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH DUMP AND 8A INHIBITOR | THYMIDYLATE SYNTHASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE
3clb:A (LEU405) to (ASP508) STRUCTURE OF BIFUNCTIONAL TCDHFR-TS IN COMPLEX WITH TMQ | BIFUNCTIONAL ENZYME IN COMPLEX WITH NADP AND TMQ, OXIDOREDUCTASE- TRANSFERASE COMPLEX, OXIDOREDUCTASE, TRANSFERASE
3clb:B (LEU405) to (TYR512) STRUCTURE OF BIFUNCTIONAL TCDHFR-TS IN COMPLEX WITH TMQ | BIFUNCTIONAL ENZYME IN COMPLEX WITH NADP AND TMQ, OXIDOREDUCTASE- TRANSFERASE COMPLEX, OXIDOREDUCTASE, TRANSFERASE
3clb:C (LEU405) to (PHE495) STRUCTURE OF BIFUNCTIONAL TCDHFR-TS IN COMPLEX WITH TMQ | BIFUNCTIONAL ENZYME IN COMPLEX WITH NADP AND TMQ, OXIDOREDUCTASE- TRANSFERASE COMPLEX, OXIDOREDUCTASE, TRANSFERASE
3clb:D (LEU405) to (ASP508) STRUCTURE OF BIFUNCTIONAL TCDHFR-TS IN COMPLEX WITH TMQ | BIFUNCTIONAL ENZYME IN COMPLEX WITH NADP AND TMQ, OXIDOREDUCTASE- TRANSFERASE COMPLEX, OXIDOREDUCTASE, TRANSFERASE
3ob7:A (ALA197) to (HIS304) HUMAN THYMIDYLATE SYNTHASE R163K WITH CYS 195 COVALENTLY MODIFIED BY GLUTATHIONE | METHYLTRANSFERASE, TRANSFERASE
3ob7:B (LEU198) to (GLY300) HUMAN THYMIDYLATE SYNTHASE R163K WITH CYS 195 COVALENTLY MODIFIED BY GLUTATHIONE | METHYLTRANSFERASE, TRANSFERASE
3ob7:D (LEU198) to (HIS304) HUMAN THYMIDYLATE SYNTHASE R163K WITH CYS 195 COVALENTLY MODIFIED BY GLUTATHIONE | METHYLTRANSFERASE, TRANSFERASE
3dg8:C (CYS490) to (ILE593) QUADRUPLE MUTANT (N51I+C59R+S108N+I164L) PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (PFDHFR-TS) COMPLEXED WITH RJF670, NADPH, AND DUMP | ALPHA-BETA, METHYLTRANSFERASE, OXIDOREDUCTASE, TRANSFERASE
3dg8:D (LEU493) to (ASN595) QUADRUPLE MUTANT (N51I+C59R+S108N+I164L) PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (PFDHFR-TS) COMPLEXED WITH RJF670, NADPH, AND DUMP | ALPHA-BETA, METHYLTRANSFERASE, OXIDOREDUCTASE, TRANSFERASE
3dga:C (LEU493) to (HIS599) WILD-TYPE PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE- THYMIDYLATE SYNTHASE (PFDHFR-TS) COMPLEXED WITH RJF01302, NADPH, AND DUMP | ALPHA-BETA, METHYLTRANSFERASE, OXIDOREDUCTASE, TRANSFERASE
3dga:D (LEU493) to (ASN595) WILD-TYPE PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE- THYMIDYLATE SYNTHASE (PFDHFR-TS) COMPLEXED WITH RJF01302, NADPH, AND DUMP | ALPHA-BETA, METHYLTRANSFERASE, OXIDOREDUCTASE, TRANSFERASE
3dl5:B (VAL404) to (GLY508) CRYSTAL STRUCTURE OF THE A287F ACTIVE SITE MUTANT OF TS- DHFR FROM CRYPTOSPORIDIUM HOMINIS | ENZYME ACTIVE SITE MUTANT, ENZYME-LIGAND COMPLEX, , OXIDOREDUCTASE
3dl5:C (LEU405) to (GLY508) CRYSTAL STRUCTURE OF THE A287F ACTIVE SITE MUTANT OF TS- DHFR FROM CRYPTOSPORIDIUM HOMINIS | ENZYME ACTIVE SITE MUTANT, ENZYME-LIGAND COMPLEX, , OXIDOREDUCTASE
3dl5:D (VAL404) to (GLY508) CRYSTAL STRUCTURE OF THE A287F ACTIVE SITE MUTANT OF TS- DHFR FROM CRYPTOSPORIDIUM HOMINIS | ENZYME ACTIVE SITE MUTANT, ENZYME-LIGAND COMPLEX, , OXIDOREDUCTASE
3dl6:B (LEU405) to (GLY508) CRYSTAL STRUCTURE OF THE A287F/S290G ACTIVE SITE MUTANT OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS | ENZYME ACTIVE SITE MUTANT, ENZYME-LIGAND COMPLEX, OXIDOREDUCTASE
3dl6:C (VAL404) to (GLY508) CRYSTAL STRUCTURE OF THE A287F/S290G ACTIVE SITE MUTANT OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS | ENZYME ACTIVE SITE MUTANT, ENZYME-LIGAND COMPLEX, OXIDOREDUCTASE
4dp3:A (LEU493) to (ASN595) QUADRUPLE MUTANT (N51I+C59R+S108N+I164L) PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (PFDHFR-TS) COMPLEXED WITH P218 AND NADPH | ROSSMANN FOLD, REDUCTASE, OXIDOREDUCTASE, TRANSFERASE-INHIBITOR COMPLEX
4dp3:B (LEU493) to (ASN595) QUADRUPLE MUTANT (N51I+C59R+S108N+I164L) PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (PFDHFR-TS) COMPLEXED WITH P218 AND NADPH | ROSSMANN FOLD, REDUCTASE, OXIDOREDUCTASE, TRANSFERASE-INHIBITOR COMPLEX
5hs3:A (LEU198) to (GLY300) HUMAN THYMIDYLATE SYNTHASE COMPLEXED WITH DUMP AND 3-AMINO-2-BENZOYL- 4-METHYLTHIENO[2,3-B]PYRIDIN-6-OL | NHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5hs3:D (LEU198) to (GLY300) HUMAN THYMIDYLATE SYNTHASE COMPLEXED WITH DUMP AND 3-AMINO-2-BENZOYL- 4-METHYLTHIENO[2,3-B]PYRIDIN-6-OL | NHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
5hs3:E (LEU198) to (GLY300) HUMAN THYMIDYLATE SYNTHASE COMPLEXED WITH DUMP AND 3-AMINO-2-BENZOYL- 4-METHYLTHIENO[2,3-B]PYRIDIN-6-OL | NHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4up1:A (ALA197) to (HIS304) CRYSTAL STRUCTURE OF NATIVE HUMAN THYMIDYLATE SYNTHASE IN ACTIVE FORM | TRANSFERASE, LOW-SALT CONDITIONS
4up1:B (LEU198) to (GLY300) CRYSTAL STRUCTURE OF NATIVE HUMAN THYMIDYLATE SYNTHASE IN ACTIVE FORM | TRANSFERASE, LOW-SALT CONDITIONS
4up1:C (ALA197) to (GLY300) CRYSTAL STRUCTURE OF NATIVE HUMAN THYMIDYLATE SYNTHASE IN ACTIVE FORM | TRANSFERASE, LOW-SALT CONDITIONS
4up1:D (CYS195) to (GLY300) CRYSTAL STRUCTURE OF NATIVE HUMAN THYMIDYLATE SYNTHASE IN ACTIVE FORM | TRANSFERASE, LOW-SALT CONDITIONS
4e5o:E (LEU192) to (GLY294) CRYSTAL STRUCTURE OF MOUSE THYMIDYLATE SYNTHASE IN COMPLEX WITH DUMP | PROTEIN-LIGAND COMPLEX, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE
4ein:A (LEU192) to (HIS298) CRYSTAL STRUCTURE OF MOUSE THYMIDYLATE SYNTHASE IN BINARY COMPLEX WITH A SUBSTRATE ANALOGUE AND STRONG INHIBITOR, N(4)-HYDROXY-2'- DEOXYCYTIDINE-5'-MONOPHOSPHATE | METHYLTRANSFERASE, BINDING SITE, CATALYSIS, DIMERIZATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4f2v:B (PHE149) to (GLY251) CRYSTAL STRUCTURE OF DE NOVO DESIGNED SERINE HYDROLASE, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR165 | STRUCTURAL GENOMICS, PSI-BIOLOGY, PROTEIN STRUCTURE INITIATIVE, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM, NESG, DE NOVO DESIGN, DE NOVO PROTEIN
3qj7:C (ALA148) to (ASN250) CRYSTAL STRUCTURE OF THE MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE SYNTHASE (THYA) BOUND TO DUMP | THYMIDILATE SYNTHASE, STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, TRANSFERASE
5j7w:C (THR199) to (GLY302) ENTEROCOCCUS FAECALIS THYMIDYLATE SYNTHASE COMPLEX WITH METHOTREXATE | ENTEROCOCCUS FAECALIS, THYMIDYLATE SYNTHASE, METHOTREXATE, COMPLEX, TRANSFERASE
5j7w:D (THR199) to (GLY302) ENTEROCOCCUS FAECALIS THYMIDYLATE SYNTHASE COMPLEX WITH METHOTREXATE | ENTEROCOCCUS FAECALIS, THYMIDYLATE SYNTHASE, METHOTREXATE, COMPLEX, TRANSFERASE
4foa:A (PHE149) to (VAL248) CRYSTAL STRUCTURE OF THE MTB THYA IN COMPLEX WITH 5-FLUORO-DUMP | STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, TRANSFERASE, THYMIDYLATE SYNTHASE
4foa:B (ALA148) to (ASN250) CRYSTAL STRUCTURE OF THE MTB THYA IN COMPLEX WITH 5-FLUORO-DUMP | STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, TRANSFERASE, THYMIDYLATE SYNTHASE
4foa:C (ALA148) to (ASN250) CRYSTAL STRUCTURE OF THE MTB THYA IN COMPLEX WITH 5-FLUORO-DUMP | STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, TRANSFERASE, THYMIDYLATE SYNTHASE
4foa:D (ALA148) to (ASN250) CRYSTAL STRUCTURE OF THE MTB THYA IN COMPLEX WITH 5-FLUORO-DUMP | STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, TRANSFERASE, THYMIDYLATE SYNTHASE
4fog:D (ALA148) to (ASN250) CRYSTAL STRUCTURE OF MTB THYA IN COMPLEX WITH 5-FLUORO-DUMP AND 5- METHYLTETRAHYDROFOLIC ACID | STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, TRANSFERASE, THYMIDYLATE SYNTHASE
4fox:A (ALA148) to (ASN250) CRYSTAL STRUCTURE OF MTB THYA IN COMPLEX WITH DUMP AND RALTITREXED | STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, TRANSFERASE, THYMIDYLATE SYNTHASE
4fox:B (ALA148) to (ASN250) CRYSTAL STRUCTURE OF MTB THYA IN COMPLEX WITH DUMP AND RALTITREXED | STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, TRANSFERASE, THYMIDYLATE SYNTHASE
4fox:D (ALA148) to (ASN250) CRYSTAL STRUCTURE OF MTB THYA IN COMPLEX WITH DUMP AND RALTITREXED | STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, TRANSFERASE, THYMIDYLATE SYNTHASE
4fox:E (ALA148) to (VAL248) CRYSTAL STRUCTURE OF MTB THYA IN COMPLEX WITH DUMP AND RALTITREXED | STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, TRANSFERASE, THYMIDYLATE SYNTHASE
4fox:F (ALA148) to (ASN250) CRYSTAL STRUCTURE OF MTB THYA IN COMPLEX WITH DUMP AND RALTITREXED | STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, TRANSFERASE, THYMIDYLATE SYNTHASE
4fox:G (ALA148) to (ASN250) CRYSTAL STRUCTURE OF MTB THYA IN COMPLEX WITH DUMP AND RALTITREXED | STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, TRANSFERASE, THYMIDYLATE SYNTHASE
4fox:H (ALA148) to (ASN250) CRYSTAL STRUCTURE OF MTB THYA IN COMPLEX WITH DUMP AND RALTITREXED | STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, TRANSFERASE, THYMIDYLATE SYNTHASE
4fqs:A (ALA148) to (ASN250) CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYA IN COMPLEX WITH UMP AND PEMETREXED | TRANSFERASE, FOLATE BINDING, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4fqs:B (ALA148) to (ASN250) CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYA IN COMPLEX WITH UMP AND PEMETREXED | TRANSFERASE, FOLATE BINDING, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4g2o:X (HIS196) to (GLY300) HUMAN THYMIDYLATE SYNTHASE M190K WITH BOUND PURPUROGALLIN | METHYLTRANSFERASE, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4g6w:X (HIS196) to (GLY300) HUMAN THYMIDYLATE SYNTHASE M190K WITH BOUND 4-BROMOBENZENE-1,2,3-TRIOL | METHYLTRANSFERASE, TRANSFERASE
3ed7:A (HIS196) to (GLY300) REPLACEMENT OF VAL3 IN HUMAN THYMIDYLATE SYNTHASE AFFECTS ITS KINETIC PROPERTIES AND INTRACELLULAR STABILITY | TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS
1nja:A (THR200) to (ASN303) THYMIDYLATE SYNTHASE, MUTATION, N229C WITH 2'-DEOXYCYTIDINE 5'- MONOPHOSPHATE (DCMP) | TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE (METHYLTRANSFERASE)
1njb:A (LEU201) to (LEU301) THYMIDYLATE SYNTHASE | TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE (METHYLTRANSFERASE)
2onb:A (GLN200) to (GLY300) HUMAN THYMIDYLATE SYNTHASE AT LOW SALT CONDITIONS WITH PDPA BOUND | DIPHOSPHONIC ACID, FDUMP, ZD9331, HETEROINHIBITION, TRANSFERASE
3egy:X (GLN200) to (GLY300) CRYSTAL STRUCTURE OF HUMAN THYMIDYALTE SYNTHASE A191K WITH LOOP 181- 197 STABILIZED IN THE INACTIVE CONFORMATION | METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE
1aiq:B (ALA148) to (GLY251) CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE R126E MUTANT | TRANSFERASE, METHYLTRANSFERASE
1an5:B (ALA148) to (GLY251) E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH CB3717 | TRANSFERASE (METHYLTRANSFERASE), SUBSTRATE MODULES
1axw:A (ALA148) to (GLY251) E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH METHOTREXATE (MTX) AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) | METHYLTRANSFERASE, TRANSFERASE, INHIBITOR
1axw:B (ALA148) to (GLY251) E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH METHOTREXATE (MTX) AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) | METHYLTRANSFERASE, TRANSFERASE, INHIBITOR
1bpj:A (THR200) to (ASN303) THYMIDYLATE SYNTHASE R178T, R179T DOUBLE MUTANT | TRANSFERASE (METHYLTRANSFERASE), TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS
4irr:A (MET200) to (HIS306) CRYSTAL STRUCTURE OF C.ELEGANS THYMIDYLATE SYNTHASE IN COMPLEX WITH DUMP | PROTEIN DIMER, DEOXYNUCLEOTIDE BIOSYNTHESIS, TRANSFERASE
4irr:B (MET200) to (ASP302) CRYSTAL STRUCTURE OF C.ELEGANS THYMIDYLATE SYNTHASE IN COMPLEX WITH DUMP | PROTEIN DIMER, DEOXYNUCLEOTIDE BIOSYNTHESIS, TRANSFERASE
1dna:A (ALA148) to (GLY251) D221(169)N MUTANT DOES NOT PROMOTE OPENING OF THE COFACTOR IMIDAZOLIDINE RING | TRANSFERASE, ACTIVE SITE MUTANT, REACTION INTERMEDIATE, METHYLTRANSFERASE
1dna:B (ALA148) to (GLY251) D221(169)N MUTANT DOES NOT PROMOTE OPENING OF THE COFACTOR IMIDAZOLIDINE RING | TRANSFERASE, ACTIVE SITE MUTANT, REACTION INTERMEDIATE, METHYLTRANSFERASE
4isk:B (ALA148) to (GLY251) CRYSTAL STRUCTURE OF E.COLI THYMIDYLATE SYNTHASE WITH DUMP AND THE BGC 945 INHIBITOR | ALPHA/BETA PROTEIN, METHYLASE, METHYLTRANSFERASE, DUMP SUBTRATE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4isk:C (ALA148) to (GLY251) CRYSTAL STRUCTURE OF E.COLI THYMIDYLATE SYNTHASE WITH DUMP AND THE BGC 945 INHIBITOR | ALPHA/BETA PROTEIN, METHYLASE, METHYLTRANSFERASE, DUMP SUBTRATE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4isk:G (ALA148) to (GLY251) CRYSTAL STRUCTURE OF E.COLI THYMIDYLATE SYNTHASE WITH DUMP AND THE BGC 945 INHIBITOR | ALPHA/BETA PROTEIN, METHYLASE, METHYLTRANSFERASE, DUMP SUBTRATE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
4isw:A (MET200) to (HIS306) CRYSTAL STRUCTURE OF PHOSPHORYLATED C.ELEGANS THYMIDYLATE SYNTHASE IN COMPLEX WITH DUMP | PHOSPHOPROTEIN, PROTEIN HOMODIMER, DEOXYNUCLEOTIDE BIOSYNTHESIS, PHOSPHORYLATION, TRANSFERASE
4isw:B (THR199) to (ASP302) CRYSTAL STRUCTURE OF PHOSPHORYLATED C.ELEGANS THYMIDYLATE SYNTHASE IN COMPLEX WITH DUMP | PHOSPHOPROTEIN, PROTEIN HOMODIMER, DEOXYNUCLEOTIDE BIOSYNTHESIS, PHOSPHORYLATION, TRANSFERASE
1fwm:A (ALA148) to (GLY251) CRYSTAL STRUCTURE OF THE THYMIDYLATE SYNTHASE R166Q MUTANT | METHYLTRANSFERASE, TRANSFERASE
1fwm:B (ALA448) to (GLY551) CRYSTAL STRUCTURE OF THE THYMIDYLATE SYNTHASE R166Q MUTANT | METHYLTRANSFERASE, TRANSFERASE
2h2q:A (LEU406) to (PHE495) CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE- THYMIDYLATE SYNTHASE | BIFUNCTIONAL ENZYME IN COMPLEX WITH NADP AND DUMP, OXIDOREDUCTASE, TRANSFERASE
3ix6:A (LEU149) to (ASP250) CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE THYA FROM BRUCELLA MELITENSIS | NIAID, SSGCID, SEATTLE STRUCTURAL CENTER FOR INFECTIOUS DISEASE, BRUCELLOSIS, ORCHITIS, EPIDIDYMITIS, MASTITIS, THYMIDYLATE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE, STRUCTURAL GENOMICS, SEATTLE STRUCTURAL GENOMICS CENTER FOR INFECTIOUS DISEASE
1jut:A (ALA148) to (GLY251) E. COLI THYMIDYLATE SYNTHASE BOUND TO DUMP AND LY338529, A PYRROLO(2, 3-D)PYRIMIDINE-BASED ANTIFOLATE | ANTIFOLATE, DTMP SYNTHESIS, CANCER, DRUG RESISTANCE, TRANSFERASE
1jut:B (ALA148) to (GLY251) E. COLI THYMIDYLATE SYNTHASE BOUND TO DUMP AND LY338529, A PYRROLO(2, 3-D)PYRIMIDINE-BASED ANTIFOLATE | ANTIFOLATE, DTMP SYNTHESIS, CANCER, DRUG RESISTANCE, TRANSFERASE
1kzj:C (ALA148) to (GLY251) CRYSTAL STRUCTURE OF ECTS W80G/DUMP/CB3717 COMPLEX | ENZYME SUBSTRATE COFACTOR ANALOG COMPLEX, TRANSFERASE
1kzj:E (ALA148) to (GLY251) CRYSTAL STRUCTURE OF ECTS W80G/DUMP/CB3717 COMPLEX | ENZYME SUBSTRATE COFACTOR ANALOG COMPLEX, TRANSFERASE
1lca:A (LEU201) to (ASN303) LACTOBACILLUS CASEI THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH DUMP AND CB3717 | NUCLEOTIDE SYNTHASE, TRANSFERASE (METHYLTRANSFERASE)
4q0e:A (VAL404) to (GLY508) CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP AND 2-AMINO-4-OXO-4,7-DIHYDRO-PYRROLO[2,3- D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID. | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4q0e:B (VAL404) to (GLY508) CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP AND 2-AMINO-4-OXO-4,7-DIHYDRO-PYRROLO[2,3- D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID. | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4q0e:C (VAL404) to (GLY508) CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP AND 2-AMINO-4-OXO-4,7-DIHYDRO-PYRROLO[2,3- D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID. | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4q0e:D (VAL404) to (GLY508) CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP AND 2-AMINO-4-OXO-4,7-DIHYDRO-PYRROLO[2,3- D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID. | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4q0e:E (VAL404) to (GLY508) CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP AND 2-AMINO-4-OXO-4,7-DIHYDRO-PYRROLO[2,3- D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID. | BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX
4tms:A (LEU201) to (ASN303) PLASTIC ADAPTATION TOWARD MUTATIONS IN PROTEINS: STRUCTURAL COMPARISON OF THYMIDYLATE SYNTHASES | TRANSFERASE (METHYLTRANSFERASE)
4dph:B (CYS490) to (ASN595) QUADRUPLE MUTANT (N51I+C59R+S108N+I164L) PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (PFDHFR-TS) COMPLEXED WITH P65 AND NADPH | PLASMODIUM FALCIPARUM, ANTIFOLATE, ROSSMANN FOLD, REDUCTASE, NADPH BINDING, OXIDOREDUCTASE, TRANSFERASE
4eil:A (LEU492) to (GLY597) CRYSTAL STRUCTURE OF THE LOOP TRUNCATED TOXOPLASMA GONDII TS-DHFR | BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE
4eil:B (LEU492) to (GLY597) CRYSTAL STRUCTURE OF THE LOOP TRUNCATED TOXOPLASMA GONDII TS-DHFR | BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE
4eil:C (LEU492) to (GLY597) CRYSTAL STRUCTURE OF THE LOOP TRUNCATED TOXOPLASMA GONDII TS-DHFR | BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE
4eil:D (LEU491) to (GLY597) CRYSTAL STRUCTURE OF THE LOOP TRUNCATED TOXOPLASMA GONDII TS-DHFR | BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE
4eil:F (LEU491) to (GLY597) CRYSTAL STRUCTURE OF THE LOOP TRUNCATED TOXOPLASMA GONDII TS-DHFR | BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE
4eil:H (LEU491) to (GLY597) CRYSTAL STRUCTURE OF THE LOOP TRUNCATED TOXOPLASMA GONDII TS-DHFR | BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE
3qg2:A (LEU493) to (ILE593) PLASMODIUM FALCIPARUM DHFR-TS QRADRUPLE MUTANT (N51I+C59R+S108N+I164L, V1/S) PYRIMETHAMINE COMPLEX | PYRIMETHAMINE, ANTIFOLATE RESISTANCE, PLASMODIUM FALCIPARUM, DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE, TRANSFERASE, TRANSFERASE- INHIBITOR COMPLEX