Usages in wwPDB of concept: c_0287
nUsages: 281; SSE string: EEEHEEHEE
1nce:A   (ALA148) to   (GLY251)  CRYSTAL STRUCTURE OF A TERNARY COMPLEX OF E. COLI THYMIDYLATE SYNTHASE D169C WITH DUMP AND THE ANTIFOLATE CB3717  |   BETA-SHEET INTERFACE, PROTEIN-DUMP-COFACTOR ANALOG COMPLEX, ASYMMETRIC DIMER, BIOSYNTHETIC PROTEIN 
1nce:B   (ALA148) to   (GLY251)  CRYSTAL STRUCTURE OF A TERNARY COMPLEX OF E. COLI THYMIDYLATE SYNTHASE D169C WITH DUMP AND THE ANTIFOLATE CB3717  |   BETA-SHEET INTERFACE, PROTEIN-DUMP-COFACTOR ANALOG COMPLEX, ASYMMETRIC DIMER, BIOSYNTHETIC PROTEIN 
2oip:A   (VAL404) to   (GLY508)  CRYSTAL STRUCTURE OF THE S290G ACTIVE SITE MUTANT OF TS- DHFR FROM CRYPTOSPORIDIUM HOMINIS  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE 
2oip:B   (VAL404) to   (GLY508)  CRYSTAL STRUCTURE OF THE S290G ACTIVE SITE MUTANT OF TS- DHFR FROM CRYPTOSPORIDIUM HOMINIS  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE 
2oip:C   (VAL404) to   (GLY508)  CRYSTAL STRUCTURE OF THE S290G ACTIVE SITE MUTANT OF TS- DHFR FROM CRYPTOSPORIDIUM HOMINIS  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE 
2oip:E   (LEU405) to   (GLY508)  CRYSTAL STRUCTURE OF THE S290G ACTIVE SITE MUTANT OF TS- DHFR FROM CRYPTOSPORIDIUM HOMINIS  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE 
3edw:X   (HIS196) to   (GLY300)  REPLACEMENT OF VAL3 IN HUMAN THYMIDYLATE SYNTHASE AFFECTS ITS KINETIC PROPERTIES AND INTRACELLULAR STABILITY  |   TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS 
1njc:A   (LEU201) to   (ASN303)  THYMIDYLATE SYNTHASE, MUTATION, N229D WITH 2'-DEOXYCYTIDINE 5'- MONOPHOSPHATE (DCMP)  |   TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE (METHYLTRANSFERASE) 
4h1i:B   (LEU198) to   (ILE298)  STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE AT LOW SALT CONDITIONS  |   NUCLEOTIDE METABOLISM, CANCER CHEMOTHERAPY TARGET, METHYL TRANSFERASE, TRANSFERASE 
4h1i:D   (LEU198) to   (HIS304)  STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE AT LOW SALT CONDITIONS  |   NUCLEOTIDE METABOLISM, CANCER CHEMOTHERAPY TARGET, METHYL TRANSFERASE, TRANSFERASE 
3ejl:A   (LEU198) to   (HIS304)  REPLACEMENT OF VAL3 IN HUMAN THYMIDYLATE SYNTHASE AFFECTS ITS KINETIC PROPERTIES AND INTRACELLULAR STABILITY  |   TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS 
3ejl:B   (ALA197) to   (GLY300)  REPLACEMENT OF VAL3 IN HUMAN THYMIDYLATE SYNTHASE AFFECTS ITS KINETIC PROPERTIES AND INTRACELLULAR STABILITY  |   TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS 
3ejl:C   (ALA197) to   (HIS304)  REPLACEMENT OF VAL3 IN HUMAN THYMIDYLATE SYNTHASE AFFECTS ITS KINETIC PROPERTIES AND INTRACELLULAR STABILITY  |   TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS 
3ejl:D   (GLN200) to   (GLY300)  REPLACEMENT OF VAL3 IN HUMAN THYMIDYLATE SYNTHASE AFFECTS ITS KINETIC PROPERTIES AND INTRACELLULAR STABILITY  |   TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS 
1b02:A   (TYR163) to   (ASN266)  CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE A FROM BACILLUS SUBTILIS  |   TRANSFERASE, METHYLTRANSFERASE 
2bbq:A   (ALA148) to   (GLY251)  STRUCTURAL BASIS FOR RECOGNITION OF POLYGLUTAMYL FOLATES BY THYMIDYLATE SYNTHASE  |   TRANSFERASE(METHYLTRANSFERASE) 
2bbq:B   (ALA148) to   (GLY251)  STRUCTURAL BASIS FOR RECOGNITION OF POLYGLUTAMYL FOLATES BY THYMIDYLATE SYNTHASE  |   TRANSFERASE(METHYLTRANSFERASE) 
1bdu:A   (ALA148) to   (GLY251)  E. COLI THYMIDYLATE SYNTHASE COMPLEXED WITH DURD  |   TRANSFERASE (METHYLTRANSFERASE), SUBSTRATE MODULES, METHYLTRANSFERASE 
1bjg:A   (ALA148) to   (GLY251)  D221(169)N MUTANT DOES NOT PROMOTE OPENING OF THE COFACTOR IMIDAZOLIDINE RING  |   TRANSFERASE, ACTIVE SITE MUTANT, REACTION INTERMEDIATE METHYLTRANSFERASE 
1bo8:A   (LEU201) to   (ASN303)  THYMIDYLATE SYNTHASE R178T MUTANT  |   TRANSFERASE (METHYLTRANSFERASE), TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS 
1bp6:A   (LEU201) to   (ASN303)  THYMIDYLATE SYNTHASE R23I, R179T DOUBLE MUTANT  |   TRANSFERASE (METHYLTRANSFERASE), TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS 
1bq1:B   (PHE149) to   (GLY251)  E. COLI THYMIDYLATE SYNTHASE MUTANT N177A IN COMPLEX WITH CB3717 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP)  |   TRANSFERASE, ACTIVE SITE MUTANT, REACTION INTERMEDIATE 
1bq2:A   (PHE149) to   (GLY251)  E. COLI THYMIDYLATE SYNTHASE MUTANT N177A  |   METHYLTRANSFERASE, TRANSFERASE, SUBSTRATE MODULES 
1ci7:B   (MET175) to   (ASN284)  TERNARY COMPLEX OF THYMIDYLATE SYNTHASE FROM PNEUMOCYSTIS CARINII  |   METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, HALF-SITES REACTIVITY 
4xsc:B   (LEU186) to   (HIS292)  COMPLEX STRUCTURE OF THYMIDYLATE SYNTHASE FROM VARICELLA ZOSTER VIRUS WITH A PHOSPHORYLATED BVDU  |   VZV, THYMIDYLATE SYNTHASE, HERPESVIRUS, TRANSFERASE 
4xsc:D   (THR185) to   (GLY288)  COMPLEX STRUCTURE OF THYMIDYLATE SYNTHASE FROM VARICELLA ZOSTER VIRUS WITH A PHOSPHORYLATED BVDU  |   VZV, THYMIDYLATE SYNTHASE, HERPESVIRUS, TRANSFERASE 
4xsd:A   (LEU186) to   (GLY288)  COMPLEX STRUCTURE OF THYMIDYLATE SYNTHASE FROM VARICELLA ZOSTER VIRUS WITH A DUMP  |   VZV, THYMIDYLATE SYNTHASE, HERPESVIRUS, VIRAL PROTEIN 
4xsd:B   (THR185) to   (GLY288)  COMPLEX STRUCTURE OF THYMIDYLATE SYNTHASE FROM VARICELLA ZOSTER VIRUS WITH A DUMP  |   VZV, THYMIDYLATE SYNTHASE, HERPESVIRUS, VIRAL PROTEIN 
4xse:C   (LEU186) to   (GLY288)  COMPLEX STRUCTURE OF THYMIDYLATE SYNTHASE FROM VARICELLA ZOSTER VIRUS  |   THYMIDYLATE SYNTHASE, HERPESVIRUS, VARICELLA ZOSTER VIRUS, VZV, VIRAL PROTEIN 
4xse:D   (CYS183) to   (ASP287)  COMPLEX STRUCTURE OF THYMIDYLATE SYNTHASE FROM VARICELLA ZOSTER VIRUS  |   THYMIDYLATE SYNTHASE, HERPESVIRUS, VARICELLA ZOSTER VIRUS, VZV, VIRAL PROTEIN 
4xse:A   (LEU186) to   (GLY288)  COMPLEX STRUCTURE OF THYMIDYLATE SYNTHASE FROM VARICELLA ZOSTER VIRUS  |   THYMIDYLATE SYNTHASE, HERPESVIRUS, VARICELLA ZOSTER VIRUS, VZV, VIRAL PROTEIN 
4iqq:A   (MET200) to   (ASP302)  CRYSTAL STRUCTURE OF C.ELEGANS THYMIDYLATE SYNTHASE IN COMPLEX WITH DUMP AND TOMUDEX  |   METHYLTRANSFERASE, INHIBITOR, ANTIFOLATE, PROTEIN DIMER, DEOXYNUCLEOTIDE BIOSYNTHESIS, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX 
4iqq:C   (MET200) to   (ASP302)  CRYSTAL STRUCTURE OF C.ELEGANS THYMIDYLATE SYNTHASE IN COMPLEX WITH DUMP AND TOMUDEX  |   METHYLTRANSFERASE, INHIBITOR, ANTIFOLATE, PROTEIN DIMER, DEOXYNUCLEOTIDE BIOSYNTHESIS, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX 
3gg5:C   (LEU198) to   (ILE298)  REPLACEMENT OF VAL3 IN HUMAN THYMIDYLATE SYNTHASE AFFECTS ITS KINETIC PROPERTIES AND INTRACELLULAR STABILITY  |   METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE 
3gh0:A   (HIS196) to   (GLY300)  REPLACEMENT OF VAL3 IN HUMAN THYMIDYLATE SYNTHASE AFFECTS ITS KINETIC PROPERTIES AND INTRACELLULAR STABILITY  |   TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS 
3gh2:X   (HIS196) to   (GLY300)  REPLACEMENT OF VAL3 IN HUMAN THYMIDYLATE SYNTHASE AFFECTS ITS KINETIC PROPERTIES AND INTRACELLULAR STABILITY  |   TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS 
3tms:A   (ALA148) to   (GLY251)  PLASTIC ADAPTATION TOWARD MUTATIONS IN PROTEINS: STRUCTURAL COMPARISON OF THYMIDYLATE SYNTHASES  |   TRANSFERASE (METHYLTRANSFERASE) 
2rd8:A   (LEU198) to   (HIS304)  HUMAN THYMIDYLATE SYNTHASE STABILIZED IN ACTIVE CONFORMATION BY R163K MUTATION: ASYMMETRY AND REACTIVITY OF CYS195  |   METHYL TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS 
2rd8:B   (LEU198) to   (GLY300)  HUMAN THYMIDYLATE SYNTHASE STABILIZED IN ACTIVE CONFORMATION BY R163K MUTATION: ASYMMETRY AND REACTIVITY OF CYS195  |   METHYL TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS 
2rda:A   (LEU198) to   (HIS304)  HUMAN THYMIDYLATE SYNTHASE STABILIZED IN ACTIVE CONFORMATION BY R163K MUTATION: ASYMMETRY AND REACTIVITY OF CYS195  |   METHYL TRANSFERASE, ASYMMETRIC, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS 
2rda:B   (LEU198) to   (HIS304)  HUMAN THYMIDYLATE SYNTHASE STABILIZED IN ACTIVE CONFORMATION BY R163K MUTATION: ASYMMETRY AND REACTIVITY OF CYS195  |   METHYL TRANSFERASE, ASYMMETRIC, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS 
2rda:C   (LEU198) to   (HIS304)  HUMAN THYMIDYLATE SYNTHASE STABILIZED IN ACTIVE CONFORMATION BY R163K MUTATION: ASYMMETRY AND REACTIVITY OF CYS195  |   METHYL TRANSFERASE, ASYMMETRIC, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS 
2rda:D   (LEU198) to   (GLY300)  HUMAN THYMIDYLATE SYNTHASE STABILIZED IN ACTIVE CONFORMATION BY R163K MUTATION: ASYMMETRY AND REACTIVITY OF CYS195  |   METHYL TRANSFERASE, ASYMMETRIC, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS 
2rda:E   (LEU198) to   (GLY300)  HUMAN THYMIDYLATE SYNTHASE STABILIZED IN ACTIVE CONFORMATION BY R163K MUTATION: ASYMMETRY AND REACTIVITY OF CYS195  |   METHYL TRANSFERASE, ASYMMETRIC, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS 
2tdd:A   (THR200) to   (ASN303)  STRUCTURES OF THYMIDYLATE SYNTHASE WITH A C-TERMINAL DELETION: ROLE OF THE C-TERMINUS IN ALIGNMENT OF D/UMP AND CH2H4FOLATE  |   TRANSFERASE (METHYLTRANSFERASE) 
2tdm:A   (THR200) to   (ASN303)  STRUCTURE OF THYMIDYLATE SYNTHASE  |   TRANSFERASE, METHYLTRANSFERASE 
2tsc:A   (PHE149) to   (GLY251)  STRUCTURE, MULTIPLE SITE BINDING, AND SEGMENTAL ACCOMODATION IN THYMIDYLATE SYNTHASE ON BINDING D/UMP AND AN ANTI-FOLATE  |   TRANSFERASE (METHYLTRANSFERASE) 
2tsc:B   (PHE149) to   (GLY251)  STRUCTURE, MULTIPLE SITE BINDING, AND SEGMENTAL ACCOMODATION IN THYMIDYLATE SYNTHASE ON BINDING D/UMP AND AN ANTI-FOLATE  |   TRANSFERASE (METHYLTRANSFERASE) 
2tsr:A   (LEU192) to   (GLY294)  THYMIDYLATE SYNTHASE FROM RAT IN TERNARY COMPLEX WITH DUMP AND TOMUDEX  |   THYMIDYLATE SYNTHASE, METHYLTRANSFERASE, DUMP, TOMUDEX, ANTIFOLATE 
2tsr:B   (LEU192) to   (GLY294)  THYMIDYLATE SYNTHASE FROM RAT IN TERNARY COMPLEX WITH DUMP AND TOMUDEX  |   THYMIDYLATE SYNTHASE, METHYLTRANSFERASE, DUMP, TOMUDEX, ANTIFOLATE 
2tsr:C   (ALA191) to   (GLY294)  THYMIDYLATE SYNTHASE FROM RAT IN TERNARY COMPLEX WITH DUMP AND TOMUDEX  |   THYMIDYLATE SYNTHASE, METHYLTRANSFERASE, DUMP, TOMUDEX, ANTIFOLATE 
2tsr:D   (LEU192) to   (HIS298)  THYMIDYLATE SYNTHASE FROM RAT IN TERNARY COMPLEX WITH DUMP AND TOMUDEX  |   THYMIDYLATE SYNTHASE, METHYLTRANSFERASE, DUMP, TOMUDEX, ANTIFOLATE 
1f28:A   (MET175) to   (ASN284)  CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE FROM PNEUMOCYSTIS CARINII BOUND TO DUMP AND BW1843U89  |   BETA-SHEET, PROTEIN-INHIBITOR COMPLEX, TRANSFERASE 
1f28:C   (MET175) to   (ASN284)  CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE FROM PNEUMOCYSTIS CARINII BOUND TO DUMP AND BW1843U89  |   BETA-SHEET, PROTEIN-INHIBITOR COMPLEX, TRANSFERASE 
1f4d:A   (ALA148) to   (GLY251)  CRYSTAL STRUCTURE OF E. COLI THYMIDYLATE SYNTHASE C146S, L143C COVALENTLY MODIFIED AT C143 WITH N-[TOSYL-D-PROLINYL]AMINO- ETHANETHIOL  |   CRYSTAL STRUCTURE OF E. COLI THYMIDYLATE SYNTHASE C146S, L143C COVALENTLY MODIFIED AT C143 WITH N-[TOSYL-D-PROLINYL]AMINO- ETHANETHIOL, TRANSFERASE 
3h9k:A   (LEU198) to   (HIS304)  STRUCTURES OF THYMIDYLATE SYNTHASE R163K WITH SUBSTRATES AND INHIBITORS SHOW SUBUNIT ASYMMETRY  |   TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS 
3h9k:B   (LEU198) to   (GLY300)  STRUCTURES OF THYMIDYLATE SYNTHASE R163K WITH SUBSTRATES AND INHIBITORS SHOW SUBUNIT ASYMMETRY  |   TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS 
3h9k:D   (LEU198) to   (HIS304)  STRUCTURES OF THYMIDYLATE SYNTHASE R163K WITH SUBSTRATES AND INHIBITORS SHOW SUBUNIT ASYMMETRY  |   TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS 
3h9k:E   (LEU198) to   (HIS304)  STRUCTURES OF THYMIDYLATE SYNTHASE R163K WITH SUBSTRATES AND INHIBITORS SHOW SUBUNIT ASYMMETRY  |   TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS 
3hb8:B   (LEU198) to   (GLY300)  STRUCTURES OF THYMIDYLATE SYNTHASE R163K WITH SUBSTRATES AND INHIBITORS SHOW SUBUNIT ASYMMETRY  |   TRANSFERASE, METHYL TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS 
3hb8:C   (LEU198) to   (HIS304)  STRUCTURES OF THYMIDYLATE SYNTHASE R163K WITH SUBSTRATES AND INHIBITORS SHOW SUBUNIT ASYMMETRY  |   TRANSFERASE, METHYL TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS 
3hb8:E   (LEU198) to   (GLY300)  STRUCTURES OF THYMIDYLATE SYNTHASE R163K WITH SUBSTRATES AND INHIBITORS SHOW SUBUNIT ASYMMETRY  |   TRANSFERASE, METHYL TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS 
3hbb:A   (LEU405) to   (ASP508)  STRUCTURES OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE OF TRYPANOSOMA CRUZI IN THE FOLATE-FREE STATE AND IN COMPLEX WITH TWO ANTIFOLATE DRUGS, TRIMETREXATE AND METHOTREXATE  |   BIFUNCTIONAL ENZYME IN COMPLEX WITH NADP AND TMQ, OXIDOREDUCTASE, TRANSFERASE 
3hbb:B   (LEU405) to   (TYR512)  STRUCTURES OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE OF TRYPANOSOMA CRUZI IN THE FOLATE-FREE STATE AND IN COMPLEX WITH TWO ANTIFOLATE DRUGS, TRIMETREXATE AND METHOTREXATE  |   BIFUNCTIONAL ENZYME IN COMPLEX WITH NADP AND TMQ, OXIDOREDUCTASE, TRANSFERASE 
3hbb:C   (LEU405) to   (PHE495)  STRUCTURES OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE OF TRYPANOSOMA CRUZI IN THE FOLATE-FREE STATE AND IN COMPLEX WITH TWO ANTIFOLATE DRUGS, TRIMETREXATE AND METHOTREXATE  |   BIFUNCTIONAL ENZYME IN COMPLEX WITH NADP AND TMQ, OXIDOREDUCTASE, TRANSFERASE 
3hbb:D   (LEU405) to   (TYR512)  STRUCTURES OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE OF TRYPANOSOMA CRUZI IN THE FOLATE-FREE STATE AND IN COMPLEX WITH TWO ANTIFOLATE DRUGS, TRIMETREXATE AND METHOTREXATE  |   BIFUNCTIONAL ENZYME IN COMPLEX WITH NADP AND TMQ, OXIDOREDUCTASE, TRANSFERASE 
3hj3:A   (VAL404) to   (GLY508)  CRYSTAL STRUCTURE OF THE CHTS-DHFR F207A NON-ACTIVE SITE MUTANT  |   TS, DHFR, ENZYME, CROSSOVER, NON-ACTIVE SITE, OXIDOREDUCTASE 
3um6:A   (LEU493) to   (HIS599)  DOUBLE MUTANT (A16V+S108T) PLASMODIUM FALCIPARUM DHFR-TS (T9/94) COMPLEXED WITH CYCLOGUANIL, NADPH AND DUMP  |   MALARIAL DHFR-TS, CYCLOGUANIL, ANTIFOLATE, NAPDH, DUMP, OXIDOREDUCTASE, TRANSFERASE-INHIBITOR COMPLEX 
3um8:A   (LEU493) to   (ASN595)  WILD-TYPE PLASMODIUM FALCIPARUM DHFR-TS COMPLEXED WITH CYCLOGUANIL AND NADPH  |   MALARIAL DHFR-TS, CYCLOGUANIL, ANTIFOLATE, NADPH, OXIDOREDUCTASE, TRANSFERASE-INHIBITOR COMPLEX 
3um8:B   (LEU493) to   (ASN595)  WILD-TYPE PLASMODIUM FALCIPARUM DHFR-TS COMPLEXED WITH CYCLOGUANIL AND NADPH  |   MALARIAL DHFR-TS, CYCLOGUANIL, ANTIFOLATE, NADPH, OXIDOREDUCTASE, TRANSFERASE-INHIBITOR COMPLEX 
1rts:A   (LEU192) to   (HIS298)  THYMIDYLATE SYNTHASE FROM RAT IN TERNARY COMPLEX WITH DUMP AND TOMUDEX  |   THYMIDYLATE SYNTHASE, METHYLTRANSFERASE, DUMP, TOMUDEX, ANTIFOLATE 
1rts:B   (LEU192) to   (PRO299)  THYMIDYLATE SYNTHASE FROM RAT IN TERNARY COMPLEX WITH DUMP AND TOMUDEX  |   THYMIDYLATE SYNTHASE, METHYLTRANSFERASE, DUMP, TOMUDEX, ANTIFOLATE 
2vet:A   (ALA148) to   (GLY251)  CRYSTAL STRUCTURE OF THE THYMIDYLATE SYNTHASE K48Q COMPLEXED WITH DUMP  |   REPRESSOR, CYTOPLASM, RNA-BINDING, TRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, DUMP SUBSTRATE, METHYLTRANSFERASE, THYMIDYLATE SYNTHASE, TRANSLATION REGULATION 
2vf0:B   (ALA148) to   (GLY251)  CRYSTAL STRUCTURE OF THE THYMIDYLATE SYNTHASE K48Q COMPLEXED WITH 5NO2DUMP AND BW1843U89  |   NUCLEOTIDE BIOSYNTHESIS, SUBSTRATE ANOLOGUE, ANTIFOLATE BINDING, RNA-BINDING, TRANSFERASE, METHYLTRANSFERASE, REPRESSOR, BW1843U89, CYTOPLASM, 5-NO2-DUMP, THYMIDYLATE SYNTHASE, TRANSLATION REGULATION 
3uwl:B   (THR199) to   (GLY302)  CRYSTAL STRUCTURE OF ENTEROCCOCUS FAECALIS THYMIDYLATE SYNTHASE (EFTS) IN COMPLEX WITH 5-FORMYL TETRAHYDROFOLATE  |   METHYLTRANSFERASE, TRANSFERASE 
3uwl:D   (MET200) to   (GLY302)  CRYSTAL STRUCTURE OF ENTEROCCOCUS FAECALIS THYMIDYLATE SYNTHASE (EFTS) IN COMPLEX WITH 5-FORMYL TETRAHYDROFOLATE  |   METHYLTRANSFERASE, TRANSFERASE 
1sej:A   (VAL404) to   (GLY508)  CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE FROM CRYPTOSPORIDIUM HOMINIS BOUND TO 1843U89/NADPH/DUMP  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE 
1sej:B   (VAL404) to   (GLY508)  CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE FROM CRYPTOSPORIDIUM HOMINIS BOUND TO 1843U89/NADPH/DUMP  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE 
1sej:C   (VAL404) to   (GLY508)  CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE FROM CRYPTOSPORIDIUM HOMINIS BOUND TO 1843U89/NADPH/DUMP  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE 
1sej:D   (VAL404) to   (GLY508)  CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE FROM CRYPTOSPORIDIUM HOMINIS BOUND TO 1843U89/NADPH/DUMP  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE 
1sej:E   (VAL404) to   (GLY508)  CRYSTAL STRUCTURE OF DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE FROM CRYPTOSPORIDIUM HOMINIS BOUND TO 1843U89/NADPH/DUMP  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE 
2g89:A   (THR200) to   (ASN303)  L. CASEI THYMIDYLATE SYNTHASE Y261A IN COMPLEX WITH SUBSTRATE, DUMP  |   ALPHA/BETA PROTEIN, BETA SHEET, DUMP-BINDING RESIDUE, DUMP COMPLEX, ACTIVE SITE MUTATION, TRANSFERASE 
2g8x:B   (PHE149) to   (GLY251)  ESCHERICHIA COLI Y209W APOPROTEIN  |   BETA SHEET, ALPHA/BETA PROTEIN, DTT, TRANSFERASE 
4ky4:A   (LEU492) to   (GLY597)  CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 2 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR  |   SYNTHASE, BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE 
4ky4:C   (LEU492) to   (GLY597)  CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 2 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR  |   SYNTHASE, BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE 
4ky4:H   (LEU492) to   (GLY597)  CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 2 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR  |   SYNTHASE, BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE 
4ky8:A   (VAL404) to   (GLY508)  CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, METHOTREXATE, FDUMP AND 4-((2-AMINO-6-METHYL-4-OXO-4,7- DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)THIO)-2-CHLOROPHENYL)-L- GLUTAMIC ACID  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE,OXIDOREDUCTASE-INHIBITOR COMPLEX 
4ky8:B   (VAL404) to   (GLY508)  CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, METHOTREXATE, FDUMP AND 4-((2-AMINO-6-METHYL-4-OXO-4,7- DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)THIO)-2-CHLOROPHENYL)-L- GLUTAMIC ACID  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE,OXIDOREDUCTASE-INHIBITOR COMPLEX 
4ky8:C   (VAL404) to   (GLY508)  CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, METHOTREXATE, FDUMP AND 4-((2-AMINO-6-METHYL-4-OXO-4,7- DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)THIO)-2-CHLOROPHENYL)-L- GLUTAMIC ACID  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE,OXIDOREDUCTASE-INHIBITOR COMPLEX 
4ky8:D   (VAL404) to   (GLY508)  CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, METHOTREXATE, FDUMP AND 4-((2-AMINO-6-METHYL-4-OXO-4,7- DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)THIO)-2-CHLOROPHENYL)-L- GLUTAMIC ACID  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE,OXIDOREDUCTASE-INHIBITOR COMPLEX 
4ky8:E   (VAL404) to   (GLY508)  CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, METHOTREXATE, FDUMP AND 4-((2-AMINO-6-METHYL-4-OXO-4,7- DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)THIO)-2-CHLOROPHENYL)-L- GLUTAMIC ACID  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE,OXIDOREDUCTASE-INHIBITOR COMPLEX 
4kya:B   (LEU491) to   (GLY597)  CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 3 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR  |   SYNTHASE, BIFUNCTIONAL, CHIMERA PROTEIN, OXIDOREDUCTASE, TRANSFERASE- INHIBITOR COMPLEX 
4kya:D   (LEU491) to   (GLY597)  CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 3 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR  |   SYNTHASE, BIFUNCTIONAL, CHIMERA PROTEIN, OXIDOREDUCTASE, TRANSFERASE- INHIBITOR COMPLEX 
4kya:F   (LEU491) to   (GLY597)  CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 3 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR  |   SYNTHASE, BIFUNCTIONAL, CHIMERA PROTEIN, OXIDOREDUCTASE, TRANSFERASE- INHIBITOR COMPLEX 
4kya:H   (LEU491) to   (GLY597)  CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 3 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR  |   SYNTHASE, BIFUNCTIONAL, CHIMERA PROTEIN, OXIDOREDUCTASE, TRANSFERASE- INHIBITOR COMPLEX 
1syn:B   (PHE149) to   (GLY251)  E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH BW1843U89 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP)  |   TRANSFERASE (METHYLTRANSFERASE) 
1tda:A   (THR200) to   (ASN303)  STRUCTURES OF THYMIDYLATE SYNTHASE WITH A C-TERMINAL DELETION: ROLE OF THE C-TERMINUS IN ALIGNMENT OF D/UMP AND CH2H4FOLATE  |   TRANSFERASE (METHYLTRANSFERASE) 
1tdu:B   (ALA148) to   (GLY251)  E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH CB3717 AND 2'- DEOXYURIDINE (DURD)  |   TRANSFERASE (METHYLTRANSFERASE), SUBSTRATE MODULES 
1thy:A   (LEU201) to   (ASN303)  REFINED STRUCTURES OF SUBSTRATE-BOUND AND PHOSPHATE-BOUND THYMIDYLATE SYNTHASE FROM LACTOBACILLUS CASEI  |   TRANSFERASE(METHYLTRANSFERASE) 
1tjs:A   (ALA148) to   (GLY251)  E. COLI THYMIDYLATE SYNTHASE  |   TRANSFERASE (METHYLTRANSFERASE), SUBSTRATE MODULES, METHYLTRANSFERASE 
3irm:A   (LEU405) to   (TYR512)  TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH CYCLOGUANIL  |   TRYPANOSOMA CRUZI, DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE 
3irm:B   (LEU405) to   (ASP508)  TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH CYCLOGUANIL  |   TRYPANOSOMA CRUZI, DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE 
3irm:C   (LEU405) to   (ASP508)  TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH CYCLOGUANIL  |   TRYPANOSOMA CRUZI, DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE 
3irm:D   (LEU405) to   (TYR512)  TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH CYCLOGUANIL  |   TRYPANOSOMA CRUZI, DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE 
3irn:A   (LEU405) to   (TYR512)  TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH NADPH AND CYCLOGUANIL  |   TRYPANOSOMA CRUZI,DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE 
3irn:B   (LEU405) to   (ASP508)  TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH NADPH AND CYCLOGUANIL  |   TRYPANOSOMA CRUZI,DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE 
3irn:C   (LEU405) to   (ASP508)  TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH NADPH AND CYCLOGUANIL  |   TRYPANOSOMA CRUZI,DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE 
3irn:D   (LEU405) to   (ASP508)  TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH NADPH AND CYCLOGUANIL  |   TRYPANOSOMA CRUZI,DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE 
3iro:A   (LEU405) to   (PHE495)  TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH NADPH AND Q-8 ANTIFOLATE  |   TRYPANOSOMA CRUZI, DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE 
3iro:B   (LEU406) to   (ASP508)  TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH NADPH AND Q-8 ANTIFOLATE  |   TRYPANOSOMA CRUZI, DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE 
3iro:C   (LEU405) to   (ASP508)  TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE COMPLEXED WITH NADPH AND Q-8 ANTIFOLATE  |   TRYPANOSOMA CRUZI, DHFR-TS ANTIFOLATE COMPLEX, METHYLTRANSFERASE, MULTIFUNCTIONAL ENZYME, NADP, NUCLEOTIDE BIOSYNTHESIS, ONE-CARBON METABOLISM, OXIDOREDUCTASE, TRANSFERASE 
1tlc:A   (ALA148) to   (GLY251)  THYMIDYLATE SYNTHASE COMPLEXED WITH DGMP AND FOLATE ANALOG 1843U89  |   METHYLTRANSFERASE 
1tlc:B   (ALA148) to   (GLY251)  THYMIDYLATE SYNTHASE COMPLEXED WITH DGMP AND FOLATE ANALOG 1843U89  |   METHYLTRANSFERASE 
1trg:A   (ALA148) to   (GLY251)  E. COLI THYMIDYLATE SYNTHASE IN SYMMETRIC COMPLEX WITH CB3717 AND 2'- DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP)  |   METHYLTRANSFERASE, SYMMETRIC TERNARY COMPLEX 
1tsd:A   (ALA148) to   (GLY251)  THYMIDYLATE SYNTHASE COMPLEX WITH 2'-DEOXYURIDINE 5'- MONOPHOSPHATE (DUMP) AND FOLATE ANALOG 1843U89  |   DUMP, 1843U89, TRANSFERASE (METHYLTRANSFERASE) 
1tsd:B   (ALA148) to   (GLY251)  THYMIDYLATE SYNTHASE COMPLEX WITH 2'-DEOXYURIDINE 5'- MONOPHOSPHATE (DUMP) AND FOLATE ANALOG 1843U89  |   DUMP, 1843U89, TRANSFERASE (METHYLTRANSFERASE) 
1tsl:A   (THR200) to   (ASN303)  L. CASEI THYMIDYLATE SYNTHASE WITH SPECIES SPECIFIC INHIBITOR  |   METHYLTRANSFERASE, SPECIES SPECIFICITY, STRUCTURE-BASED DRUG DESIGN, ANTIBIOTIC 
1tsm:A   (LEU201) to   (ASN303)  L. CASEI THYMIDYLATE SYNTHASE WITH SPECIES SPECIFIC INHIBITOR  |   METHYLTRANSFERASE, SPECIES SPECIFICITY, STRUCTURE-BASED DRUG DESIGN, ANTIBIOTIC 
1tsv:A   (LEU201) to   (ASN303)  THYMIDYLATE SYNTHASE R179A MUTANT  |   TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS 
1tsw:A   (LEU201) to   (ASN303)  THYMIDYLATE SYNTHASE R179A MUTANT  |   TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS 
1tsx:A   (LEU201) to   (ASN303)  THYMIDYLATE SYNTHASE R179E MUTANT  |   TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS 
1tsy:A   (THR200) to   (ASN303)  THYMIDYLATE SYNTHASE R179K MUTANT  |   TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS 
1tsz:A   (LEU201) to   (ASN303)  THYMIDYLATE SYNTHASE R179K MUTANT  |   TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS 
1tvu:A   (LEU201) to   (ASN303)  CONTRIBUTIONS OF ORIENTATION AND HYDROGEN BONDING TO CATALYSIS IN ASN- 229 MUTANTS OF THYMIDYLATE SYNTHASE  |   TRANSFERASE, METHYLTRANSFERASE 
1tvv:A   (THR200) to   (ASN303)  CONTRIBUTIONS OF ORIENTATION AND HYDROGEN BONDING TO CATALYSIS IN ASN- 229 MUTANTS OF THYMIDYLATE SYNTHASE  |   TRANSFERASE, METHYLTRANSFERASE 
1hvy:C   (LEU198) to   (GLY300)  HUMAN THYMIDYLATE SYNTHASE COMPLEXED WITH DUMP AND RALTITREXED, AN ANTIFOLATE DRUG, IS IN THE CLOSED CONFORMATION  |   TOMUDEX, RALTITREXED, TRANSFERASE 
1hvy:D   (LEU198) to   (GLY300)  HUMAN THYMIDYLATE SYNTHASE COMPLEXED WITH DUMP AND RALTITREXED, AN ANTIFOLATE DRUG, IS IN THE CLOSED CONFORMATION  |   TOMUDEX, RALTITREXED, TRANSFERASE 
1hw3:A   (GLN200) to   (GLY300)  STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE SUGGESTS ADVANTAGES OF CHEMOTHERAPY WITH NONCOMPETITIVE INHIBITORS  |   THYMIDYLATE SYNTHASE, METHYLTRANSFERASE, TRANSFERASE 
1hw4:A   (GLN200) to   (GLY300)  STRUCTURE OF THYMIDYLATE SYNTHASE SUGGESTS ADVANTAGES OF CHEMOTHERAPY WITH NONCOMPETITIVE INHIBITORS  |   THYMIDYLATE SYNTHASE, METHYLTRANSFERASE, TRANSFERASE 
1hzw:A   (LEU198) to   (HIS304)  CRYSTAL STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE  |   THYMIDYLATE SYNTHASE, HUMAN, UNCOMPLEXED, OPEN CONFORMATION, DELTA(7-29) MUTANT, TRANSFERASE 
1hzw:B   (LEU198) to   (HIS304)  CRYSTAL STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE  |   THYMIDYLATE SYNTHASE, HUMAN, UNCOMPLEXED, OPEN CONFORMATION, DELTA(7-29) MUTANT, TRANSFERASE 
1j3j:C   (CYS490) to   (HIS599)  DOUBLE MUTANT (C59R+S108N) PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (PFDHFR-TS) COMPLEXED WITH PYRIMETHAMINE, NADPH, AND DUMP  |   BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE 
1jmf:A   (LEU201) to   (ASN303)  CONTRIBUTIONS OF ORIENTATION AND HYDROGEN BONDING TO CATALYSIS IN ASN- 229 MUTANTS OF THYMIDYLATE SYNTHASE  |   TRANSFERASE, METHYLTRANSFERASE 
1jmg:A   (LEU201) to   (ASN303)  CONTRIBUTIONS OF ORIENTATION AND HYDROGEN BONDING TO CATALYSIS IN ASN- 229 MUTANTS OF THYMIDYLATE SYNTHASE  |   TRANSFERASE, METHYLTRANSFERASE 
1jmh:A   (LEU201) to   (ASN303)  CONTRIBUTIONS OF ORIENTATION AND HYDROGEN BONDING TO CATALYSIS IN ASN- 229 MUTANTS OF THYMIDYLATE SYNTHASE  |   TRANSFERASE, METHYLTRANSFERASE 
1jmi:A   (LEU201) to   (ASN303)  CONTRIBUTIONS OF ORIENTATION AND HYDROGEN BONDING TO CATALYSIS IN ASN- 229 MUTANTS OF THYMIDYLATE SYNTHASE  |   TRANSFERASE, METHYLTRANSFERASE 
1jtq:A   (ALA148) to   (GLY251)  E. COLI TS COMPLEX WITH DUMP AND THE PYRROLO(2,3-D)PYRIMIDINE-BASED ANTIFOLATE LY341770  |   ANTIFOLATE, CANCER, DRUG RESISTANCE, DTMP SYNTHESIS, TRANSFERASE 
1jtq:B   (ALA148) to   (GLY251)  E. COLI TS COMPLEX WITH DUMP AND THE PYRROLO(2,3-D)PYRIMIDINE-BASED ANTIFOLATE LY341770  |   ANTIFOLATE, CANCER, DRUG RESISTANCE, DTMP SYNTHESIS, TRANSFERASE 
1jtu:B   (ALA148) to   (GLY251)  E. COLI THYMIDYLATE SYNTHASE IN A COMPLEX WITH DUMP AND LY338913, A POLYGLUTAMYLATED PYRROLO(2,3-D)PYRIMIDINE-BASED ANTIFOLATE  |   ANTIFOLATE, DTMP SYNTHESIS, CANCER, DRUG RESISTANCE, POLYGLUTAMYLATION, TRANSFERASE 
1ju6:A   (ALA197) to   (GLY300)  HUMAN THYMIDYLATE SYNTHASE COMPLEX WITH DUMP AND LY231514, A PYRROLO(2,3-D)PYRIMIDINE-BASED ANTIFOLATE  |   ANTIFOLATE, DTMP SYNTHESIS, DRUG RESISTANCE, CANCER, TRANSFERASE 
1ju6:B   (ALA197) to   (GLY300)  HUMAN THYMIDYLATE SYNTHASE COMPLEX WITH DUMP AND LY231514, A PYRROLO(2,3-D)PYRIMIDINE-BASED ANTIFOLATE  |   ANTIFOLATE, DTMP SYNTHESIS, DRUG RESISTANCE, CANCER, TRANSFERASE 
1ju6:C   (ALA197) to   (GLY300)  HUMAN THYMIDYLATE SYNTHASE COMPLEX WITH DUMP AND LY231514, A PYRROLO(2,3-D)PYRIMIDINE-BASED ANTIFOLATE  |   ANTIFOLATE, DTMP SYNTHESIS, DRUG RESISTANCE, CANCER, TRANSFERASE 
1ju6:D   (ALA197) to   (GLY300)  HUMAN THYMIDYLATE SYNTHASE COMPLEX WITH DUMP AND LY231514, A PYRROLO(2,3-D)PYRIMIDINE-BASED ANTIFOLATE  |   ANTIFOLATE, DTMP SYNTHESIS, DRUG RESISTANCE, CANCER, TRANSFERASE 
1vza:A   (LEU201) to   (ASN303)  THYMIDYLATE SYNTHASE E60D MUTANT BINARY COMPLEX WITH 2'- DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP)  |   METHYLTRANSFERASE, NUCLEOTIDE SYNTHASE 
1vze:A   (LEU201) to   (ASN303)  L. CASEI THYMIDYLATE SYNTHASE MUTANT E60Q TERNARY COMPLEX WITH DUMP AND CB3717  |   METHYLTRANSFERASE, NUCLEOTIDE SYNTHASE 
5by6:A   (CYS191) to   (ASN294)  CRYSTAL STRUCTURE OF TRICHINELLA SPIRALIS THYMIDYLATE SYNTHASE COMPLEXED WITH DUMP  |   TRICHINELLA SPIRALIS, PARASITIC NEMATODE, PROTEIN-LIGAND COMPLEX, METHYLTRANSFERASE, TRANSFERASE 
5by6:B   (CYS191) to   (ASN294)  CRYSTAL STRUCTURE OF TRICHINELLA SPIRALIS THYMIDYLATE SYNTHASE COMPLEXED WITH DUMP  |   TRICHINELLA SPIRALIS, PARASITIC NEMATODE, PROTEIN-LIGAND COMPLEX, METHYLTRANSFERASE, TRANSFERASE 
5by6:C   (CYS191) to   (ASN294)  CRYSTAL STRUCTURE OF TRICHINELLA SPIRALIS THYMIDYLATE SYNTHASE COMPLEXED WITH DUMP  |   TRICHINELLA SPIRALIS, PARASITIC NEMATODE, PROTEIN-LIGAND COMPLEX, METHYLTRANSFERASE, TRANSFERASE 
2kce:A   (ALA148) to   (GLY251)  BINDING OF THE ANTICANCER DRUG ZD1694 TO E. COLI THYMIDYLATE SYNTHASE: ASSESSING SPECIFICITY AND AFFINITY  |   METHYLTRANSFERASE, REACTION INTERMEDIATE, ANTIFOLATE, DRUG DESIGN 
2kce:B   (ALA148) to   (GLY251)  BINDING OF THE ANTICANCER DRUG ZD1694 TO E. COLI THYMIDYLATE SYNTHASE: ASSESSING SPECIFICITY AND AFFINITY  |   METHYLTRANSFERASE, REACTION INTERMEDIATE, ANTIFOLATE, DRUG DESIGN 
1kce:A   (ALA148) to   (GLY251)  E. COLI THYMIDYLATE SYNTHASE MUTANT E58Q IN COMPLEX WITH CB3717 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP)  |   TRANSFERASE, REACTION INTERMEDIATE 
1kce:B   (ALA148) to   (GLY251)  E. COLI THYMIDYLATE SYNTHASE MUTANT E58Q IN COMPLEX WITH CB3717 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP)  |   TRANSFERASE, REACTION INTERMEDIATE 
4o1x:D   (SER195) to   (ILE298)  CRYSTAL STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE DOUBLE MUTANT C195S- Y202C  |   DIMER-DIMER INTERFACE MODIFICATION, ACTIVE CONFORMATION, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE 
3jsu:A   (GLN495) to   (ASN595)  QUADRUPLE MUTANT(N51I+C59R+S108N+I164L) PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE(PFDHFR-TS) COMPLEXED WITH QN254, NADPH, AND DUMP  |   ROSSMANN FOLD, OXIDOREDUCTASE, TRANSFERASE 
4o7u:A   (MET200) to   (GLY302)  ETHEROCOMPLEX OF ENTEROCCOCUS FAECALIS THYMIDYLATE SYNTHASE WITH 5- HYDROXYMETHILENE-6-HYDROFOLIC ACID AND THE PHTALIMIDIC INHIBITOR SS7  |   TRANSFERASE, FOLATE BINDING, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX 
4o7u:D   (THR199) to   (GLY302)  ETHEROCOMPLEX OF ENTEROCCOCUS FAECALIS THYMIDYLATE SYNTHASE WITH 5- HYDROXYMETHILENE-6-HYDROFOLIC ACID AND THE PHTALIMIDIC INHIBITOR SS7  |   TRANSFERASE, FOLATE BINDING, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX 
1lce:A   (THR200) to   (ASN303)  LACTOBACILLUS CASEI THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH DUMP AND CH2THF  |   NUCLEOTIDE SYNTHASE, TRANSFERASE (METHYLTRANSFERASE) 
3kgb:A   (LEU177) to   (HIS285)  CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE 1/2 FROM ENCEPHALITOZOON CUNICULI AT 2.2 A RESOLUTION  |   SSGCID, NIH, NIAID, SBRI, UW, DECODE, ENCEPHALITOZOON CUNICULI, THYMIDYLATE SYNTHASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE, STRUCTURAL GENOMICS, SEATTLE STRUCTURAL GENOMICS CENTER FOR INFECTIOUS DISEASE 
3kjs:A   (LEU405) to   (ASP508)  CRYSTAL STRUCTURE OF T. CRUZI DHFR-TS WITH 3 HIGH AFFINITY DHFR INHIBITORS: DQ1 INHIBITOR COMPLEX  |   OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE,TRANSFERASE 
3kjs:B   (LEU405) to   (TYR512)  CRYSTAL STRUCTURE OF T. CRUZI DHFR-TS WITH 3 HIGH AFFINITY DHFR INHIBITORS: DQ1 INHIBITOR COMPLEX  |   OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE,TRANSFERASE 
3kjs:C   (LEU405) to   (PHE495)  CRYSTAL STRUCTURE OF T. CRUZI DHFR-TS WITH 3 HIGH AFFINITY DHFR INHIBITORS: DQ1 INHIBITOR COMPLEX  |   OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE,TRANSFERASE 
3kjs:D   (LEU405) to   (TYR512)  CRYSTAL STRUCTURE OF T. CRUZI DHFR-TS WITH 3 HIGH AFFINITY DHFR INHIBITORS: DQ1 INHIBITOR COMPLEX  |   OXIDOREDUCTASE, TRANSFERASE, OXIDOREDUCTASE,TRANSFERASE 
1ypv:A   (GLN200) to   (GLY300)  STRUCTURE OF HUMAN THYMIDYLATE SYNTHASE AT LOW SALT CONDITIONS  |   THYMIDYLATE SYNTHASE, METHYLTRANSFERASE, TRANSFERASE 
4psg:B   (MET200) to   (ASP302)  CRYSTAL STRUCTURE OF C.ELEGANS THYMIDYLATE SYNTHASE IN COMPLEX WITH AN INHIBITOR N(4)OHDCMP  |   ENZYME, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, PROTEIN DIMER, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX 
4q0d:E   (VAL404) to   (GLY508)  CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP, METHOTREXATE AND 2-AMINO-4-OXO-4,7-DIHYDRO- PYRROLO[2,3-D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID.  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX 
4q0d:A   (VAL404) to   (GLY508)  CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP, METHOTREXATE AND 2-AMINO-4-OXO-4,7-DIHYDRO- PYRROLO[2,3-D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID.  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX 
4q0d:B   (VAL404) to   (GLY508)  CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP, METHOTREXATE AND 2-AMINO-4-OXO-4,7-DIHYDRO- PYRROLO[2,3-D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID.  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX 
4q0d:C   (VAL404) to   (GLY508)  CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP, METHOTREXATE AND 2-AMINO-4-OXO-4,7-DIHYDRO- PYRROLO[2,3-D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID.  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX 
4q0d:D   (VAL404) to   (GLY508)  CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP, METHOTREXATE AND 2-AMINO-4-OXO-4,7-DIHYDRO- PYRROLO[2,3-D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID.  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX 
1zpr:A   (ALA148) to   (GLY251)  E. COLI THYMIDYLATE SYNTHASE MUTANT E58Q IN COMPLEX WITH CB3717 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP)  |   TRANSFERASE, ACTIVE SITE MUTANT, REACTION INTERMEDIATE 
1zpr:B   (PHE149) to   (GLY251)  E. COLI THYMIDYLATE SYNTHASE MUTANT E58Q IN COMPLEX WITH CB3717 AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP)  |   TRANSFERASE, ACTIVE SITE MUTANT, REACTION INTERMEDIATE 
2a9w:B   (ALA148) to   (GLY251)  E. COLI TS COMPLEXED WITH DUMP AND INHIBITOR GA9  |   PROTEIN-INHIBITOR COMPLEX, TRANSFERASE 
3b5b:A   (ALA148) to   (GLY251)  CRYSTAL STRUCTURE OF THE THYMIDYLATE SYNTHASE K48Q  |   THYMIDYLATE SYNTHASE, 5-NO2-DUMP, SUBSTRATE ANOLOGUE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, REPRESSOR, RNA-BINDING, TRANSFERASE, TRANSLATION REGULATION 
3b5b:B   (ALA148) to   (GLY251)  CRYSTAL STRUCTURE OF THE THYMIDYLATE SYNTHASE K48Q  |   THYMIDYLATE SYNTHASE, 5-NO2-DUMP, SUBSTRATE ANOLOGUE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, REPRESSOR, RNA-BINDING, TRANSFERASE, TRANSLATION REGULATION 
2aaz:B   (MET189) to   (GLY304)  CRYPTOCOCCUS NEOFORMANS THYMIDYLATE SYNTHASE COMPLEXED WITH SUBSTRATE AND AN ANTIFOLATE  |   METHYL TRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE 
2aaz:C   (MET189) to   (GLY304)  CRYPTOCOCCUS NEOFORMANS THYMIDYLATE SYNTHASE COMPLEXED WITH SUBSTRATE AND AN ANTIFOLATE  |   METHYL TRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE 
2aaz:D   (MET189) to   (GLY304)  CRYPTOCOCCUS NEOFORMANS THYMIDYLATE SYNTHASE COMPLEXED WITH SUBSTRATE AND AN ANTIFOLATE  |   METHYL TRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE 
2aaz:E   (MET189) to   (GLY304)  CRYPTOCOCCUS NEOFORMANS THYMIDYLATE SYNTHASE COMPLEXED WITH SUBSTRATE AND AN ANTIFOLATE  |   METHYL TRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE 
2aaz:F   (MET189) to   (GLY304)  CRYPTOCOCCUS NEOFORMANS THYMIDYLATE SYNTHASE COMPLEXED WITH SUBSTRATE AND AN ANTIFOLATE  |   METHYL TRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE 
2aaz:G   (MET189) to   (GLY304)  CRYPTOCOCCUS NEOFORMANS THYMIDYLATE SYNTHASE COMPLEXED WITH SUBSTRATE AND AN ANTIFOLATE  |   METHYL TRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE 
2aaz:H   (MET189) to   (GLY304)  CRYPTOCOCCUS NEOFORMANS THYMIDYLATE SYNTHASE COMPLEXED WITH SUBSTRATE AND AN ANTIFOLATE  |   METHYL TRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE 
2aaz:I   (MET189) to   (GLY304)  CRYPTOCOCCUS NEOFORMANS THYMIDYLATE SYNTHASE COMPLEXED WITH SUBSTRATE AND AN ANTIFOLATE  |   METHYL TRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE 
2aaz:J   (MET189) to   (GLY304)  CRYPTOCOCCUS NEOFORMANS THYMIDYLATE SYNTHASE COMPLEXED WITH SUBSTRATE AND AN ANTIFOLATE  |   METHYL TRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE 
2aaz:K   (MET189) to   (GLY304)  CRYPTOCOCCUS NEOFORMANS THYMIDYLATE SYNTHASE COMPLEXED WITH SUBSTRATE AND AN ANTIFOLATE  |   METHYL TRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE 
2aaz:L   (MET189) to   (GLY304)  CRYPTOCOCCUS NEOFORMANS THYMIDYLATE SYNTHASE COMPLEXED WITH SUBSTRATE AND AN ANTIFOLATE  |   METHYL TRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE 
2aaz:M   (MET189) to   (GLY304)  CRYPTOCOCCUS NEOFORMANS THYMIDYLATE SYNTHASE COMPLEXED WITH SUBSTRATE AND AN ANTIFOLATE  |   METHYL TRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE 
2aaz:N   (MET189) to   (GLY304)  CRYPTOCOCCUS NEOFORMANS THYMIDYLATE SYNTHASE COMPLEXED WITH SUBSTRATE AND AN ANTIFOLATE  |   METHYL TRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE 
2aaz:O   (MET189) to   (GLY304)  CRYPTOCOCCUS NEOFORMANS THYMIDYLATE SYNTHASE COMPLEXED WITH SUBSTRATE AND AN ANTIFOLATE  |   METHYL TRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE 
2aaz:P   (MET189) to   (GLY304)  CRYPTOCOCCUS NEOFORMANS THYMIDYLATE SYNTHASE COMPLEXED WITH SUBSTRATE AND AN ANTIFOLATE  |   METHYL TRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE 
3b9h:A   (ALA148) to   (GLY251)  E. COLI THYMIDYLATE SYNTHASE COMPLEXED WITH 5-NITRO-2'-DEOXY URIDINE  |   BINARY COMPLEX, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, REPRESSOR, RNA-BINDING, TRANSFERASE, TRANSLATION REGULATION, ---- 
3bgx:A   (ALA148) to   (GLY251)  E. COLI THYMIDYLATE SYNTHASE C146S MUTANT COMPLEXED WITH DTMP AND MTF  |   METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, REPRESSOR, RNA-BINDING, TRANSLATION REGULATION, TRANSFERASE 
3bnz:A   (THR200) to   (ASN303)  CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH DUMP AND 8A INHIBITOR  |   THYMIDYLATE SYNTHASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE 
3clb:A   (LEU405) to   (ASP508)  STRUCTURE OF BIFUNCTIONAL TCDHFR-TS IN COMPLEX WITH TMQ  |   BIFUNCTIONAL ENZYME IN COMPLEX WITH NADP AND TMQ, OXIDOREDUCTASE- TRANSFERASE COMPLEX, OXIDOREDUCTASE, TRANSFERASE 
3clb:B   (LEU405) to   (TYR512)  STRUCTURE OF BIFUNCTIONAL TCDHFR-TS IN COMPLEX WITH TMQ  |   BIFUNCTIONAL ENZYME IN COMPLEX WITH NADP AND TMQ, OXIDOREDUCTASE- TRANSFERASE COMPLEX, OXIDOREDUCTASE, TRANSFERASE 
3clb:C   (LEU405) to   (PHE495)  STRUCTURE OF BIFUNCTIONAL TCDHFR-TS IN COMPLEX WITH TMQ  |   BIFUNCTIONAL ENZYME IN COMPLEX WITH NADP AND TMQ, OXIDOREDUCTASE- TRANSFERASE COMPLEX, OXIDOREDUCTASE, TRANSFERASE 
3clb:D   (LEU405) to   (ASP508)  STRUCTURE OF BIFUNCTIONAL TCDHFR-TS IN COMPLEX WITH TMQ  |   BIFUNCTIONAL ENZYME IN COMPLEX WITH NADP AND TMQ, OXIDOREDUCTASE- TRANSFERASE COMPLEX, OXIDOREDUCTASE, TRANSFERASE 
3ob7:A   (ALA197) to   (HIS304)  HUMAN THYMIDYLATE SYNTHASE R163K WITH CYS 195 COVALENTLY MODIFIED BY GLUTATHIONE  |   METHYLTRANSFERASE, TRANSFERASE 
3ob7:B   (LEU198) to   (GLY300)  HUMAN THYMIDYLATE SYNTHASE R163K WITH CYS 195 COVALENTLY MODIFIED BY GLUTATHIONE  |   METHYLTRANSFERASE, TRANSFERASE 
3ob7:D   (LEU198) to   (HIS304)  HUMAN THYMIDYLATE SYNTHASE R163K WITH CYS 195 COVALENTLY MODIFIED BY GLUTATHIONE  |   METHYLTRANSFERASE, TRANSFERASE 
3dg8:C   (CYS490) to   (ILE593)  QUADRUPLE MUTANT (N51I+C59R+S108N+I164L) PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (PFDHFR-TS) COMPLEXED WITH RJF670, NADPH, AND DUMP  |   ALPHA-BETA, METHYLTRANSFERASE, OXIDOREDUCTASE, TRANSFERASE 
3dg8:D   (LEU493) to   (ASN595)  QUADRUPLE MUTANT (N51I+C59R+S108N+I164L) PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (PFDHFR-TS) COMPLEXED WITH RJF670, NADPH, AND DUMP  |   ALPHA-BETA, METHYLTRANSFERASE, OXIDOREDUCTASE, TRANSFERASE 
3dga:C   (LEU493) to   (HIS599)  WILD-TYPE PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE- THYMIDYLATE SYNTHASE (PFDHFR-TS) COMPLEXED WITH RJF01302, NADPH, AND DUMP  |   ALPHA-BETA, METHYLTRANSFERASE, OXIDOREDUCTASE, TRANSFERASE 
3dga:D   (LEU493) to   (ASN595)  WILD-TYPE PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE- THYMIDYLATE SYNTHASE (PFDHFR-TS) COMPLEXED WITH RJF01302, NADPH, AND DUMP  |   ALPHA-BETA, METHYLTRANSFERASE, OXIDOREDUCTASE, TRANSFERASE 
3dl5:B   (VAL404) to   (GLY508)  CRYSTAL STRUCTURE OF THE A287F ACTIVE SITE MUTANT OF TS- DHFR FROM CRYPTOSPORIDIUM HOMINIS  |   ENZYME ACTIVE SITE MUTANT, ENZYME-LIGAND COMPLEX, , OXIDOREDUCTASE 
3dl5:C   (LEU405) to   (GLY508)  CRYSTAL STRUCTURE OF THE A287F ACTIVE SITE MUTANT OF TS- DHFR FROM CRYPTOSPORIDIUM HOMINIS  |   ENZYME ACTIVE SITE MUTANT, ENZYME-LIGAND COMPLEX, , OXIDOREDUCTASE 
3dl5:D   (VAL404) to   (GLY508)  CRYSTAL STRUCTURE OF THE A287F ACTIVE SITE MUTANT OF TS- DHFR FROM CRYPTOSPORIDIUM HOMINIS  |   ENZYME ACTIVE SITE MUTANT, ENZYME-LIGAND COMPLEX, , OXIDOREDUCTASE 
3dl6:B   (LEU405) to   (GLY508)  CRYSTAL STRUCTURE OF THE A287F/S290G ACTIVE SITE MUTANT OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS  |   ENZYME ACTIVE SITE MUTANT, ENZYME-LIGAND COMPLEX, OXIDOREDUCTASE 
3dl6:C   (VAL404) to   (GLY508)  CRYSTAL STRUCTURE OF THE A287F/S290G ACTIVE SITE MUTANT OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS  |   ENZYME ACTIVE SITE MUTANT, ENZYME-LIGAND COMPLEX, OXIDOREDUCTASE 
4dp3:A   (LEU493) to   (ASN595)  QUADRUPLE MUTANT (N51I+C59R+S108N+I164L) PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (PFDHFR-TS) COMPLEXED WITH P218 AND NADPH  |   ROSSMANN FOLD, REDUCTASE, OXIDOREDUCTASE, TRANSFERASE-INHIBITOR COMPLEX 
4dp3:B   (LEU493) to   (ASN595)  QUADRUPLE MUTANT (N51I+C59R+S108N+I164L) PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (PFDHFR-TS) COMPLEXED WITH P218 AND NADPH  |   ROSSMANN FOLD, REDUCTASE, OXIDOREDUCTASE, TRANSFERASE-INHIBITOR COMPLEX 
5hs3:A   (LEU198) to   (GLY300)  HUMAN THYMIDYLATE SYNTHASE COMPLEXED WITH DUMP AND 3-AMINO-2-BENZOYL- 4-METHYLTHIENO[2,3-B]PYRIDIN-6-OL  |   NHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX 
5hs3:D   (LEU198) to   (GLY300)  HUMAN THYMIDYLATE SYNTHASE COMPLEXED WITH DUMP AND 3-AMINO-2-BENZOYL- 4-METHYLTHIENO[2,3-B]PYRIDIN-6-OL  |   NHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX 
5hs3:E   (LEU198) to   (GLY300)  HUMAN THYMIDYLATE SYNTHASE COMPLEXED WITH DUMP AND 3-AMINO-2-BENZOYL- 4-METHYLTHIENO[2,3-B]PYRIDIN-6-OL  |   NHIBITOR, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX 
4up1:A   (ALA197) to   (HIS304)  CRYSTAL STRUCTURE OF NATIVE HUMAN THYMIDYLATE SYNTHASE IN ACTIVE FORM  |   TRANSFERASE, LOW-SALT CONDITIONS 
4up1:B   (LEU198) to   (GLY300)  CRYSTAL STRUCTURE OF NATIVE HUMAN THYMIDYLATE SYNTHASE IN ACTIVE FORM  |   TRANSFERASE, LOW-SALT CONDITIONS 
4up1:C   (ALA197) to   (GLY300)  CRYSTAL STRUCTURE OF NATIVE HUMAN THYMIDYLATE SYNTHASE IN ACTIVE FORM  |   TRANSFERASE, LOW-SALT CONDITIONS 
4up1:D   (CYS195) to   (GLY300)  CRYSTAL STRUCTURE OF NATIVE HUMAN THYMIDYLATE SYNTHASE IN ACTIVE FORM  |   TRANSFERASE, LOW-SALT CONDITIONS 
4e5o:E   (LEU192) to   (GLY294)  CRYSTAL STRUCTURE OF MOUSE THYMIDYLATE SYNTHASE IN COMPLEX WITH DUMP  |   PROTEIN-LIGAND COMPLEX, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE 
4ein:A   (LEU192) to   (HIS298)  CRYSTAL STRUCTURE OF MOUSE THYMIDYLATE SYNTHASE IN BINARY COMPLEX WITH A SUBSTRATE ANALOGUE AND STRONG INHIBITOR, N(4)-HYDROXY-2'- DEOXYCYTIDINE-5'-MONOPHOSPHATE  |   METHYLTRANSFERASE, BINDING SITE, CATALYSIS, DIMERIZATION, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX 
4f2v:B   (PHE149) to   (GLY251)  CRYSTAL STRUCTURE OF DE NOVO DESIGNED SERINE HYDROLASE, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET OR165  |   STRUCTURAL GENOMICS, PSI-BIOLOGY, PROTEIN STRUCTURE INITIATIVE, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM, NESG, DE NOVO DESIGN, DE NOVO PROTEIN 
3qj7:C   (ALA148) to   (ASN250)  CRYSTAL STRUCTURE OF THE MYCOBACTERIUM TUBERCULOSIS THYMIDYLATE SYNTHASE (THYA) BOUND TO DUMP  |   THYMIDILATE SYNTHASE, STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, TRANSFERASE 
5j7w:C   (THR199) to   (GLY302)  ENTEROCOCCUS FAECALIS THYMIDYLATE SYNTHASE COMPLEX WITH METHOTREXATE  |   ENTEROCOCCUS FAECALIS, THYMIDYLATE SYNTHASE, METHOTREXATE, COMPLEX, TRANSFERASE 
5j7w:D   (THR199) to   (GLY302)  ENTEROCOCCUS FAECALIS THYMIDYLATE SYNTHASE COMPLEX WITH METHOTREXATE  |   ENTEROCOCCUS FAECALIS, THYMIDYLATE SYNTHASE, METHOTREXATE, COMPLEX, TRANSFERASE 
4foa:A   (PHE149) to   (VAL248)  CRYSTAL STRUCTURE OF THE MTB THYA IN COMPLEX WITH 5-FLUORO-DUMP  |   STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, TRANSFERASE, THYMIDYLATE SYNTHASE 
4foa:B   (ALA148) to   (ASN250)  CRYSTAL STRUCTURE OF THE MTB THYA IN COMPLEX WITH 5-FLUORO-DUMP  |   STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, TRANSFERASE, THYMIDYLATE SYNTHASE 
4foa:C   (ALA148) to   (ASN250)  CRYSTAL STRUCTURE OF THE MTB THYA IN COMPLEX WITH 5-FLUORO-DUMP  |   STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, TRANSFERASE, THYMIDYLATE SYNTHASE 
4foa:D   (ALA148) to   (ASN250)  CRYSTAL STRUCTURE OF THE MTB THYA IN COMPLEX WITH 5-FLUORO-DUMP  |   STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, TRANSFERASE, THYMIDYLATE SYNTHASE 
4fog:D   (ALA148) to   (ASN250)  CRYSTAL STRUCTURE OF MTB THYA IN COMPLEX WITH 5-FLUORO-DUMP AND 5- METHYLTETRAHYDROFOLIC ACID  |   STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, TRANSFERASE, THYMIDYLATE SYNTHASE 
4fox:A   (ALA148) to   (ASN250)  CRYSTAL STRUCTURE OF MTB THYA IN COMPLEX WITH DUMP AND RALTITREXED  |   STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, TRANSFERASE, THYMIDYLATE SYNTHASE 
4fox:B   (ALA148) to   (ASN250)  CRYSTAL STRUCTURE OF MTB THYA IN COMPLEX WITH DUMP AND RALTITREXED  |   STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, TRANSFERASE, THYMIDYLATE SYNTHASE 
4fox:D   (ALA148) to   (ASN250)  CRYSTAL STRUCTURE OF MTB THYA IN COMPLEX WITH DUMP AND RALTITREXED  |   STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, TRANSFERASE, THYMIDYLATE SYNTHASE 
4fox:E   (ALA148) to   (VAL248)  CRYSTAL STRUCTURE OF MTB THYA IN COMPLEX WITH DUMP AND RALTITREXED  |   STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, TRANSFERASE, THYMIDYLATE SYNTHASE 
4fox:F   (ALA148) to   (ASN250)  CRYSTAL STRUCTURE OF MTB THYA IN COMPLEX WITH DUMP AND RALTITREXED  |   STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, TRANSFERASE, THYMIDYLATE SYNTHASE 
4fox:G   (ALA148) to   (ASN250)  CRYSTAL STRUCTURE OF MTB THYA IN COMPLEX WITH DUMP AND RALTITREXED  |   STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, TRANSFERASE, THYMIDYLATE SYNTHASE 
4fox:H   (ALA148) to   (ASN250)  CRYSTAL STRUCTURE OF MTB THYA IN COMPLEX WITH DUMP AND RALTITREXED  |   STRUCTURAL GENOMICS, TB STRUCTURAL GENOMICS CONSORTIUM, TBSGC, TRANSFERASE, THYMIDYLATE SYNTHASE 
4fqs:A   (ALA148) to   (ASN250)  CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYA IN COMPLEX WITH UMP AND PEMETREXED  |   TRANSFERASE, FOLATE BINDING, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX 
4fqs:B   (ALA148) to   (ASN250)  CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS THYA IN COMPLEX WITH UMP AND PEMETREXED  |   TRANSFERASE, FOLATE BINDING, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX 
4g2o:X   (HIS196) to   (GLY300)  HUMAN THYMIDYLATE SYNTHASE M190K WITH BOUND PURPUROGALLIN  |   METHYLTRANSFERASE, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX 
4g6w:X   (HIS196) to   (GLY300)  HUMAN THYMIDYLATE SYNTHASE M190K WITH BOUND 4-BROMOBENZENE-1,2,3-TRIOL  |   METHYLTRANSFERASE, TRANSFERASE 
3ed7:A   (HIS196) to   (GLY300)  REPLACEMENT OF VAL3 IN HUMAN THYMIDYLATE SYNTHASE AFFECTS ITS KINETIC PROPERTIES AND INTRACELLULAR STABILITY  |   TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS 
1nja:A   (THR200) to   (ASN303)  THYMIDYLATE SYNTHASE, MUTATION, N229C WITH 2'-DEOXYCYTIDINE 5'- MONOPHOSPHATE (DCMP)  |   TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE (METHYLTRANSFERASE) 
1njb:A   (LEU201) to   (LEU301)  THYMIDYLATE SYNTHASE  |   TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE (METHYLTRANSFERASE) 
2onb:A   (GLN200) to   (GLY300)  HUMAN THYMIDYLATE SYNTHASE AT LOW SALT CONDITIONS WITH PDPA BOUND  |   DIPHOSPHONIC ACID, FDUMP, ZD9331, HETEROINHIBITION, TRANSFERASE 
3egy:X   (GLN200) to   (GLY300)  CRYSTAL STRUCTURE OF HUMAN THYMIDYALTE SYNTHASE A191K WITH LOOP 181- 197 STABILIZED IN THE INACTIVE CONFORMATION  |   METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE 
1aiq:B   (ALA148) to   (GLY251)  CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE R126E MUTANT  |   TRANSFERASE, METHYLTRANSFERASE 
1an5:B   (ALA148) to   (GLY251)  E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH CB3717  |   TRANSFERASE (METHYLTRANSFERASE), SUBSTRATE MODULES 
1axw:A   (ALA148) to   (GLY251)  E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH METHOTREXATE (MTX) AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP)  |   METHYLTRANSFERASE, TRANSFERASE, INHIBITOR 
1axw:B   (ALA148) to   (GLY251)  E. COLI THYMIDYLATE SYNTHASE IN COMPLEX WITH METHOTREXATE (MTX) AND 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP)  |   METHYLTRANSFERASE, TRANSFERASE, INHIBITOR 
1bpj:A   (THR200) to   (ASN303)  THYMIDYLATE SYNTHASE R178T, R179T DOUBLE MUTANT  |   TRANSFERASE (METHYLTRANSFERASE), TRANSFERASE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS 
4irr:A   (MET200) to   (HIS306)  CRYSTAL STRUCTURE OF C.ELEGANS THYMIDYLATE SYNTHASE IN COMPLEX WITH DUMP  |   PROTEIN DIMER, DEOXYNUCLEOTIDE BIOSYNTHESIS, TRANSFERASE 
4irr:B   (MET200) to   (ASP302)  CRYSTAL STRUCTURE OF C.ELEGANS THYMIDYLATE SYNTHASE IN COMPLEX WITH DUMP  |   PROTEIN DIMER, DEOXYNUCLEOTIDE BIOSYNTHESIS, TRANSFERASE 
1dna:A   (ALA148) to   (GLY251)  D221(169)N MUTANT DOES NOT PROMOTE OPENING OF THE COFACTOR IMIDAZOLIDINE RING  |   TRANSFERASE, ACTIVE SITE MUTANT, REACTION INTERMEDIATE, METHYLTRANSFERASE 
1dna:B   (ALA148) to   (GLY251)  D221(169)N MUTANT DOES NOT PROMOTE OPENING OF THE COFACTOR IMIDAZOLIDINE RING  |   TRANSFERASE, ACTIVE SITE MUTANT, REACTION INTERMEDIATE, METHYLTRANSFERASE 
4isk:B   (ALA148) to   (GLY251)  CRYSTAL STRUCTURE OF E.COLI THYMIDYLATE SYNTHASE WITH DUMP AND THE BGC 945 INHIBITOR  |   ALPHA/BETA PROTEIN, METHYLASE, METHYLTRANSFERASE, DUMP SUBTRATE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX 
4isk:C   (ALA148) to   (GLY251)  CRYSTAL STRUCTURE OF E.COLI THYMIDYLATE SYNTHASE WITH DUMP AND THE BGC 945 INHIBITOR  |   ALPHA/BETA PROTEIN, METHYLASE, METHYLTRANSFERASE, DUMP SUBTRATE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX 
4isk:G   (ALA148) to   (GLY251)  CRYSTAL STRUCTURE OF E.COLI THYMIDYLATE SYNTHASE WITH DUMP AND THE BGC 945 INHIBITOR  |   ALPHA/BETA PROTEIN, METHYLASE, METHYLTRANSFERASE, DUMP SUBTRATE, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX 
4isw:A   (MET200) to   (HIS306)  CRYSTAL STRUCTURE OF PHOSPHORYLATED C.ELEGANS THYMIDYLATE SYNTHASE IN COMPLEX WITH DUMP  |   PHOSPHOPROTEIN, PROTEIN HOMODIMER, DEOXYNUCLEOTIDE BIOSYNTHESIS, PHOSPHORYLATION, TRANSFERASE 
4isw:B   (THR199) to   (ASP302)  CRYSTAL STRUCTURE OF PHOSPHORYLATED C.ELEGANS THYMIDYLATE SYNTHASE IN COMPLEX WITH DUMP  |   PHOSPHOPROTEIN, PROTEIN HOMODIMER, DEOXYNUCLEOTIDE BIOSYNTHESIS, PHOSPHORYLATION, TRANSFERASE 
1fwm:A   (ALA148) to   (GLY251)  CRYSTAL STRUCTURE OF THE THYMIDYLATE SYNTHASE R166Q MUTANT  |   METHYLTRANSFERASE, TRANSFERASE 
1fwm:B   (ALA448) to   (GLY551)  CRYSTAL STRUCTURE OF THE THYMIDYLATE SYNTHASE R166Q MUTANT  |   METHYLTRANSFERASE, TRANSFERASE 
2h2q:A   (LEU406) to   (PHE495)  CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI DIHYDROFOLATE REDUCTASE- THYMIDYLATE SYNTHASE  |   BIFUNCTIONAL ENZYME IN COMPLEX WITH NADP AND DUMP, OXIDOREDUCTASE, TRANSFERASE 
3ix6:A   (LEU149) to   (ASP250)  CRYSTAL STRUCTURE OF THYMIDYLATE SYNTHASE THYA FROM BRUCELLA MELITENSIS  |   NIAID, SSGCID, SEATTLE STRUCTURAL CENTER FOR INFECTIOUS DISEASE, BRUCELLOSIS, ORCHITIS, EPIDIDYMITIS, MASTITIS, THYMIDYLATE, METHYLTRANSFERASE, NUCLEOTIDE BIOSYNTHESIS, TRANSFERASE, STRUCTURAL GENOMICS, SEATTLE STRUCTURAL GENOMICS CENTER FOR INFECTIOUS DISEASE 
1jut:A   (ALA148) to   (GLY251)  E. COLI THYMIDYLATE SYNTHASE BOUND TO DUMP AND LY338529, A PYRROLO(2, 3-D)PYRIMIDINE-BASED ANTIFOLATE  |   ANTIFOLATE, DTMP SYNTHESIS, CANCER, DRUG RESISTANCE, TRANSFERASE 
1jut:B   (ALA148) to   (GLY251)  E. COLI THYMIDYLATE SYNTHASE BOUND TO DUMP AND LY338529, A PYRROLO(2, 3-D)PYRIMIDINE-BASED ANTIFOLATE  |   ANTIFOLATE, DTMP SYNTHESIS, CANCER, DRUG RESISTANCE, TRANSFERASE 
1kzj:C   (ALA148) to   (GLY251)  CRYSTAL STRUCTURE OF ECTS W80G/DUMP/CB3717 COMPLEX  |   ENZYME SUBSTRATE COFACTOR ANALOG COMPLEX, TRANSFERASE 
1kzj:E   (ALA148) to   (GLY251)  CRYSTAL STRUCTURE OF ECTS W80G/DUMP/CB3717 COMPLEX  |   ENZYME SUBSTRATE COFACTOR ANALOG COMPLEX, TRANSFERASE 
1lca:A   (LEU201) to   (ASN303)  LACTOBACILLUS CASEI THYMIDYLATE SYNTHASE TERNARY COMPLEX WITH DUMP AND CB3717  |   NUCLEOTIDE SYNTHASE, TRANSFERASE (METHYLTRANSFERASE) 
4q0e:A   (VAL404) to   (GLY508)  CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP AND 2-AMINO-4-OXO-4,7-DIHYDRO-PYRROLO[2,3- D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID.  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX 
4q0e:B   (VAL404) to   (GLY508)  CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP AND 2-AMINO-4-OXO-4,7-DIHYDRO-PYRROLO[2,3- D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID.  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX 
4q0e:C   (VAL404) to   (GLY508)  CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP AND 2-AMINO-4-OXO-4,7-DIHYDRO-PYRROLO[2,3- D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID.  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX 
4q0e:D   (VAL404) to   (GLY508)  CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP AND 2-AMINO-4-OXO-4,7-DIHYDRO-PYRROLO[2,3- D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID.  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX 
4q0e:E   (VAL404) to   (GLY508)  CRYSTAL STRUCTURE OF TS-DHFR FROM CRYPTOSPORIDIUM HOMINIS IN COMPLEX WITH NADPH, FDUMP AND 2-AMINO-4-OXO-4,7-DIHYDRO-PYRROLO[2,3- D]PYRIMIDINE-METHYL-PHENYL-L-GLUTAMIC ACID.  |   BIFUNCTIONAL ENZYME, TRANSFERASE, OXIDOREDUCTASE, TRANSFERASE- TRANSFERASE INHIBITOR COMPLEX 
4tms:A   (LEU201) to   (ASN303)  PLASTIC ADAPTATION TOWARD MUTATIONS IN PROTEINS: STRUCTURAL COMPARISON OF THYMIDYLATE SYNTHASES  |   TRANSFERASE (METHYLTRANSFERASE) 
4dph:B   (CYS490) to   (ASN595)  QUADRUPLE MUTANT (N51I+C59R+S108N+I164L) PLASMODIUM FALCIPARUM DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (PFDHFR-TS) COMPLEXED WITH P65 AND NADPH  |   PLASMODIUM FALCIPARUM, ANTIFOLATE, ROSSMANN FOLD, REDUCTASE, NADPH BINDING, OXIDOREDUCTASE, TRANSFERASE 
4eil:A   (LEU492) to   (GLY597)  CRYSTAL STRUCTURE OF THE LOOP TRUNCATED TOXOPLASMA GONDII TS-DHFR  |   BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE 
4eil:B   (LEU492) to   (GLY597)  CRYSTAL STRUCTURE OF THE LOOP TRUNCATED TOXOPLASMA GONDII TS-DHFR  |   BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE 
4eil:C   (LEU492) to   (GLY597)  CRYSTAL STRUCTURE OF THE LOOP TRUNCATED TOXOPLASMA GONDII TS-DHFR  |   BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE 
4eil:D   (LEU491) to   (GLY597)  CRYSTAL STRUCTURE OF THE LOOP TRUNCATED TOXOPLASMA GONDII TS-DHFR  |   BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE 
4eil:F   (LEU491) to   (GLY597)  CRYSTAL STRUCTURE OF THE LOOP TRUNCATED TOXOPLASMA GONDII TS-DHFR  |   BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE 
4eil:H   (LEU491) to   (GLY597)  CRYSTAL STRUCTURE OF THE LOOP TRUNCATED TOXOPLASMA GONDII TS-DHFR  |   BIFUNCTIONAL, OXIDOREDUCTASE, TRANSFERASE 
3qg2:A   (LEU493) to   (ILE593)  PLASMODIUM FALCIPARUM DHFR-TS QRADRUPLE MUTANT (N51I+C59R+S108N+I164L, V1/S) PYRIMETHAMINE COMPLEX  |   PYRIMETHAMINE, ANTIFOLATE RESISTANCE, PLASMODIUM FALCIPARUM, DIHYDROFOLATE REDUCTASE, OXIDOREDUCTASE, TRANSFERASE, TRANSFERASE- INHIBITOR COMPLEX